Effect of colchicine on jejunal adenylate cyclase activity, PGE2 and cAMP contents.

abstract：:In the present study, the inhibitory effects of hesperetin (HSP) on human cardiac Kv1.5 channels expressed in HEK 293 cells and the ultra-rapid delayed rectifier K(+) current (Ikur) in human atrial myocytes were examined by using the whole-cell configuration of the patch-clamp techniques. We found that hesperetin rapi...

journal_title：European journal of pharmacology

authors： Wang H,Wang HF,Wang C,Chen YF,Ma R,Xiang JZ,Du XL,Tang Q

更新日期：2016-10-15 00:00:00

abstract：:The cardiovascular and biochemical responses during acute oxidative stress induced by D,L-buthionine-(S,R)-sulfoximine (BSO) were investigated in Sprague-Dawley rats. Mean arterial pressure, heart rate and vascular reactivity were measured after subcutaneous injection of BSO (4 mmol/kg). Control rats received saline. ...

journal_title：European journal of pharmacology

authors： Ganafa AA,Socci RR,Eatman D,Silvestrova N,Abukhalaf IK,Bayorh MA

更新日期：2002-11-15 00:00:00

abstract：:The interaction of 5 alpha-pregnane-3 alpha-ol-20-one (5 alpha 3 alpha P), a progesterone metabolite, with the GABAA receptor chloride channel complex was investigated at the pituitary level. In nanomolar concentrations this steroid potentiated the inhibitory effect of muscimol (a GABAA agonist) on prolactin release f...

journal_title：European journal of pharmacology

authors： Vincens M,Shu C,Moguilewsky M,Philibert D

更新日期：1989-09-01 00:00:00

abstract：:We examined the effects of taurine on levels of low-density lipoprotein (LDL) cholesterol and glucose, and an endothelium-dependent relaxation in response to acetylcholine in cholesterol-fed or streptozotocin-induced diabetic mice. The acetylcholine-induced concentration-dependent relaxation was significantly attenuat...

journal_title：European journal of pharmacology

authors： Kamata K,Sugiura M,Kojima S,Kasuya Y

更新日期：1996-05-06 00:00:00

abstract：:Perhexiline, a "metabolic" anti-anginal agent currently under investigation in management of congestive heart failure and acute coronary syndromes improves platelet nitric oxide responsiveness in patients with impaired responsiveness. The current study investigated possible interactions between perhexiline and the nit...

journal_title：European journal of pharmacology

authors： Liberts EA,Willoughby SR,Kennedy JA,Horowitz JD

更新日期：2007-03-29 00:00:00

abstract：:The kappa-opioid receptor agonist, U50,488H (trans-(+-)-3,4-dichloro-N-methyl-[2-(1-pyrrolidinyl)-cyclohexyl]- benzeneacetamide), has recently been reported to induce dystonia after s.c. administration of 5-10 mg/kg in guinea pigs. The dystonic movements observed in response to U50,488H resembled those previously repo...

journal_title：European journal of pharmacology

authors： Richter A,Löscher W

更新日期：1993-05-19 00:00:00

abstract：:The release of [3H]5-hydroxytryptamine ([3H]5-HT) evoked by 15 mM KCl in superfused rat cerebellum synaptosomes was inhibited by 5-HT (pEC30 = 8.73). Methiothepin antagonized 5-HT (pA2 = 9.28); ketanserin, methysergide, cinanserin and spiperone were ineffective. The receptors involved were activated (pEC30 = 8.90) by ...

journal_title：European journal of pharmacology

authors： Bonanno G,Maura G,Raiteri M

更新日期：1986-07-31 00:00:00

abstract：:Cutaneous arteries are known to constrict in response to cooling via α2C-adrenoceptors. The involvement of α1-adrenoceptors in the cooling response has also recently been suggested by in vivo studies in mice. The present study was thus aimed to confirm it in the isolated mouse cutaneous plantar artery. Changes in vess...

journal_title：European journal of pharmacology

authors： Goto K,Saito SY,Ishikawa T

更新日期：2014-11-05 00:00:00

abstract：:Overexpression of Cav3.2 T-type Ca2+ channels in L4 dorsal root ganglion (DRG) participates in neuropathic pain after L5 spinal nerve cutting (L5SNC) in rats. The L5SNC-induced neuropathic pain also involves high mobility group box 1 (HMGB1), a damage-associated molecular pattern protein, and its target, the receptor ...

journal_title：European journal of pharmacology

authors： Tomita S,Sekiguchi F,Kasanami Y,Naoe K,Tsubota M,Wake H,Nishibori M,Kawabata A

更新日期：2020-12-05 00:00:00

abstract：:Galantamine is a reversible inhibitor of acetylcholinesterase and an allosteric-potentiating ligand of the nicotinic acetylcholine receptors. It is used for treating mild-to-moderate Alzheimer's disease. Interestingly, QT interval prolongation on the electrocardiogram (ECG), malignant ventricular arrhythmias and synco...

journal_title：European journal of pharmacology

authors： Vigneault P,Bourgault S,Kaddar N,Caillier B,Pilote S,Patoine D,Simard C,Drolet B

更新日期：2012-04-15 00:00:00

abstract：:The effect of intrathecal clonidine on thermal nociception and hindlimb flexion was assessed in acute and chronic spinally transected rats. After an acute, 1-day spinalization, there was no change in the antinociceptive dose-response function to clonidine, relative to intact rats. However, there was a significant incr...

journal_title：European journal of pharmacology

authors： Advokat C

更新日期：2002-02-15 00:00:00

abstract：:The cardiovascular effects of atriopeptins (AP) I, II and III were compared in spontaneously beating or electrically stimulated guinea pig atria and in rabbit aortic strips precontracted by various agonists. Atriopeptins did not significantly affect sinus nodal rate or atrial contractility. AP II and III, although mor...

journal_title：European journal of pharmacology

authors： Bergey JL,Kotler D

更新日期：1985-04-02 00:00:00

abstract：:Three peptide components of atrial natriuretic factor (ANF) caused relaxation of carbachol-contracted guinea-pig isolated tracheal smooth muscle. These were the 1-28, 5-28 and 5-27 peptide sequences (ANF(1-28), ANF-(5-28) and ANF-(5-27)). The peptides were 10-30 times more potent in epithelium-denuded than in epitheli...

journal_title：European journal of pharmacology

authors： Fernandes LB,Preuss JM,Goldie RG

更新日期：1992-03-03 00:00:00

abstract：:The effect of 5,8-dimethyl-4-(2-di-n-propylaminoethyl)carbazol monohydrochloride (FH-510) on the binding of sigma ligands such as [3H](+)-3-(3-hydroxyphenyl)-N-(1-propyl)piperidine ([3H](+)-3-PPP) and [3H]1,3-di-o-tolylguanidine ([3H]DTG) to rat brain membranes was studied. The inhibitory effect of FH-510 on [3H](+)-3...

journal_title：European journal of pharmacology

authors： Chaki S,Tanaka M,Muramatsu M,Otomo S

更新日期：1993-11-30 00:00:00

abstract：:A decrease of 30% was observed in the density of peripheral-type benzodiazepine binding sites in platelets of nine schizophrenics maintained on chronic neuroleptic treatment as compared to platelets of six untreated schizophrenics and 15 healthy volunteers. The equilibrium dissociation constant for binding by [3H]PK 1...

journal_title：European journal of pharmacology

authors： Gavish M,Weizman A,Karp L,Tyano S,Tanne Z

更新日期：1986-02-18 00:00:00

abstract：:Angiotensin AT1 receptor antagonists represent a novel class of cardiovascular drugs. In conscious, normotensive rats, irbesartan ((2-n-butyl-3-[(2'-(1H-tetrazol-5-yl)-biphenyl-4-yl) methyl]-1,3-diaza-spiro[4,4]non) and losartan ((2 n-butyl-4-chloro-5-hydroxymethyl-1-[(2'-(1H-tetrazol-5-yl)biphenyl -4-yl) methyl] imid...

journal_title：European journal of pharmacology

authors： Culman J,von Heyer C,Piepenburg B,Rascher W,Unger T

更新日期：1999-02-19 00:00:00

abstract：:Morphine is known to produce mydriasis in mice. We have found that enkephalins caused a similar effect. Morphine was twice as active as D-Ala-D-Leu-enkephalin (BW-180C), 5 times as active as Met-enkephalin and 7 times as active as Leu-enkephalin. The time course of the effect was shortest for the enkephalins ( t 1/2 =...

journal_title：European journal of pharmacology

authors： Korczyn AD,Eshel Y,Keren O

更新日期：1980-07-25 00:00:00

abstract：:Dopamine (DA) is thought to have a neurotransmitter role in the spinal cord of the rat. Intrathecal administration of the DA receptor agonist apomorphine has previously been shown to reduce nocifensive responses. The present experiments investigated the site of action of apomorphine, and the mechanisms by which DA ago...

journal_title：European journal of pharmacology

authors： Barasi S,Duggal KN

更新日期：1985-11-19 00:00:00

abstract：:Rat hearts were perfused at 37 degrees C with three clearly-defined protocols: the Ca2+ paradox, the O2 paradox and with 20 mM caffeine. Each protocol involved an initial priming (stage 1) and a subsequent full activation (stage 2) of the damage system of the sarcolemma. Raising [K+]o from 5.4 to 6.5 mM in the Ca2+ pa...

journal_title：European journal of pharmacology

authors： Harding RJ,Duncan CJ

更新日期：1996-12-05 00:00:00

abstract：:Discovery in the early 1990s of caveolin-1, the structural protein responsible for maintaining the ohm shape of caveolae, greatly enhanced investigations to elucidate the role of these little caves in the plasma membrane. Perhaps one of the most important realizations concerning caveolae and caveolin is that these ele...

journal_title：European journal of pharmacology

authors： Xu Y,Buikema H,van Gilst WH,Henning RH

更新日期：2008-05-13 00:00:00

abstract：:The effect of various concentrations of 4 beta-phorbol dibutyrate, (4-beta PDBu) phorbol myristate acetate (PMA), and 4 beta-phorbol didecanoate (4 beta-PDD) were studied on the guinea-pig parenchymal strip. The order of potency, 4 beta-PDBu greater than PMA greater than 4 beta-PDD, was the inverse of their lipid solu...

journal_title：European journal of pharmacology

authors： Dale MM,Obianime AW

更新日期：1987-09-02 00:00:00

abstract：:Cocaine and a cocaine analog, WIN 36,065-2, were administered daily for 3 or 4 days. Both compounds developed sensitization to their locomotor stimulatory effects, with similarly shaped dose-response curves. Dosages giving optimal sensitization were 25 mg/kg per day for cocaine and 3 mg/kg for WIN 35,065-2. At 40 mg/k...

journal_title：European journal of pharmacology

authors： Reith ME

更新日期：1986-10-14 00:00:00

abstract：:Tardive dyskinesia is a serious motor side effect of chronic neuroleptic therapy. Chronic treatment or rats with neuroleptics leads to the development of abnormal oral movements called vacuous chewing movements. Vacuous chewing movements in rats are widely accepted as an animal model of tardive dyskinesia. Atypical an...

journal_title：European journal of pharmacology

authors： Naidu PS,Kulkarni SK

更新日期：2001-09-28 00:00:00

abstract：:Accumulating evidence indicates the role of microglial activation and sustained neuroinflammation in the pathogenesis of cognitive dysfunction, a common feature associated with depressive disorders. It also indicates the role of Wnt/β-catenin pathway in regulation of microglia-mediated neuroinflammation. Amisulpride e...

journal_title：European journal of pharmacology

authors： Mohamed AM,Habib MZ,Ebeid MA,Abdelraouf SM,El Faramawy Y,Aboul-Fotouh S,Magdy Y

更新日期：2020-10-15 00:00:00

abstract：:The increased plasma protein extravasation in the airways of Fisher 344 rats upon stimulation of sensory nerves is in part due to the degranulation of mast cells. In this study, we examined the role of 5-HT and histamine receptors in the capsaicin-induced increase in plasma protein extravasation in Fisher 344 rat airw...

journal_title：European journal of pharmacology

authors： Germonpré PR,Joos GF,Mekeirele K,Pauwels RA

更新日期：1997-04-18 00:00:00

abstract：:Although a number of studies have shown that perivascular adipose tissue (PVAT) attenuates arterial contraction through the release of perivascular-derived relaxation factors (PVRF), the role of PVAT in modulating venous function and its mechanism(s) remained unknown. Here we examined the role of PVAT in the modulatio...

journal_title：European journal of pharmacology

authors： Lu C,Zhao AX,Gao YJ,Lee RM

更新日期：2011-04-25 00:00:00

abstract：:We have previously proposed that pro-inflammatory cytokines and nitric oxide (NO) contributed to reversible myocardial depression in patients with sepsis and congestive heart failure. Sepsis and heart failure are also associated with refractoriness to beta-adrenoceptor agonists. Therefore, the chronotropic effects of ...

journal_title：European journal of pharmacology

authors： Oddis CV,Finkel MS

更新日期：1997-02-12 00:00:00

abstract：:Dexmedetomidine (DMED) is a potent and highly selective α2-adrenergic receptor agonist and is widely used for short-term sedation. However, the mechanism of DMED-induced sedation has not been deciphered. In the present study, we investigated the mechanism of Gαi and Gβγ subunits on DMED-induced sedation. An ED50 of DM...

journal_title：European journal of pharmacology

authors： Liu M,Yang Y,Tan B,Li Y,Zhou P,Su R

更新日期：2018-07-15 00:00:00

abstract：:Oxidative stress is usually considered as an important factor to the pathogenesis of various diseases. Peroxynitrite (ONOO(-)) and hypochlorite (OCl(-)) are formed in immune cells as a part of the innate host defense system, but excessive reactive oxygen species generation can cause progressive inflammation and tissue...

journal_title：European journal of pharmacology

authors： Ren X,Ding Y,Lu N

更新日期：2016-03-15 00:00:00

abstract：:As methamphetamine-induced neurotoxicity has been proposed to involve oxidative stress, reduced and oxidized glutathione (GSH and GSSG, respectively), vitamin E and ascorbate were measured in the striata of rats killed 2 or 24 h after a neurotoxic regimen of methamphetamine. At 2 h, methamphetamine increased GSH and G...

journal_title：European journal of pharmacology

authors： Harold C,Wallace T,Friedman R,Gudelsky G,Yamamoto B

更新日期：2000-07-14 00:00:00