当前位置： SCI文献检索 > EUROPEAN JOURNAL OF PHARMACOLOGY期刊下所有文献 > Effects of atriopeptins I, II and III on atrial contractility, sinus nodal rate (guinea pig) and agonist-induced tension in rabbit aortic strips.

Effects of atriopeptins I, II and III on atrial contractility, sinus nodal rate (guinea pig) and agonist-induced tension in rabbit aortic strips.

Abstract：

:The cardiovascular effects of atriopeptins (AP) I, II and III were compared in spontaneously beating or electrically stimulated guinea pig atria and in rabbit aortic strips precontracted by various agonists. Atriopeptins did not significantly affect sinus nodal rate or atrial contractility. AP II and III, although more potent than nitroprusside, exhibited similar vasorelaxant profiles against vascular strips maximally stimulated by norepinephrine, high [K+]0 or Ca2+ ionophore A23187. The ability of atriopeptins and nitroprusside to relax ionophore-induced vascular tension implies an intracellular mechanism of action.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Bergey JL,Kotler D

doi

10.1016/0014-2999(85)90224-9

subject

Has Abstract

pub_date

1985-04-02 00:00:00

pages

277-81

issue

2

eissn

0014-2999

issn

1879-0712

pii

0014-2999(85)90224-9

journal_volume

110

pub_type

杂志文章

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