Trichloroethanol inhibits ATP-induced membrane currents in cultured HEK 293-hP2X3 cells.

abstract：:Animal studies reveal that diverse environmental stimuli that generate anxiety-like behaviors also induce antinociception; conversely, clinical data show that pain perception is reduced under anxiolysis. This study was conducted to investigate the influence of pharmacologically induced-anxiety on nociception and antin...

journal_title：European journal of pharmacology

authors： Jiménez-Velázquez G,Fernández-Guasti A,López-Muñoz FJ

更新日期：2006-10-10 00:00:00

abstract：:Specific binding of [3H]imipramine to its recognition sites in frontal cortex and levels of serotonin (5-HT), 5-hydroxyindoleacetic acid (5-HIAA) and norepinephrine (NE) as well as uptake of serotonin by crude synaptosomal (P2) fraction were determined in a group of rats chronically (for 21 days) treated with differen...

journal_title：European journal of pharmacology

authors： Hrdina PD

更新日期：1987-06-19 00:00:00

abstract：:The present study was aimed to evaluate the antihypertensive effect of diosmin in deoxycorticosterone acetate (DOCA)-salt induced hypertension in male Wistar rats. Hypertension was induced in uninephrectomized rats by weekly twice subcutaneous injection of DOCA (25 mg/kg body weight) and 1% NaCl in the drinking water ...

journal_title：European journal of pharmacology

authors： Silambarasan T,Raja B

更新日期：2012-03-15 00:00:00

abstract：:The psychotropic actions of crude ginseng saponins, pure ginsenoside Rb1 (GS-Rb1) and ginsenoside Rg1 (GS-Rg1) obtained from the root of Panax ginseng, were evaluated from their effects on agonistic behavior in mice. A resident-intruder test situation was used. When the resident mouse was treated with crude ginseng sa...

journal_title：European journal of pharmacology

authors： Yoshimura H,Watanabe K,Ogawa N

更新日期：1988-02-09 00:00:00

abstract：:The role of endogenous enkephalins in behavioural control in mice was investigated by i.v. injection of RB 101 (N-[(R,S)-2-benzyl-3[(S)(2-amino-4- methylthio)butyl dithio]-1-oxopropyl]-L-phenylalanine benzyl ester). RB 101 is a recently reported systemically active mixed inhibitor prodrug of the two enzymes which meta...

journal_title：European journal of pharmacology

authors： Baamonde A,Daugé V,Ruiz-Gayo M,Fulga IG,Turcaud S,Fournié-Zaluski MC,Roques BP

更新日期：1992-06-05 00:00:00

abstract：:IRL1620, a specific endothelin ETB receptor agonist, induced relaxation followed by contraction in the guinea-pig ileum, as did endothelin-1. Both components of the response were concentration-dependent in the range studied. Repeated administration of IRL1620 induced tachyphylaxis only of the contractile component, wh...

journal_title：European journal of pharmacology

authors： Miasiro N,Karaki H,Paiva AC

更新日期：1995-10-24 00:00:00

abstract：:We have shown that the major active agent of Cannabis sativa, Delta(9)-tetrahydrocannabinol, activates peroxisome proliferator-activated receptor gamma [PPARgamma, O'Sullivan, S.E., Tarling, E.J., Bennett, A.J., Kendall, D.A., Randall, M.D., 2005c. Novel time-dependent vascular actions of delta9-tetrahydrocannabinol m...

journal_title：European journal of pharmacology

authors： O'Sullivan SE,Sun Y,Bennett AJ,Randall MD,Kendall DA

更新日期：2009-06-10 00:00:00

abstract：:Gastrins and cholecystokinins contract the isolated taenia coli of the guinea-pig. Porcine CCK-39 produced the greatest contractile response and human gastrin-17 I and -34 the weakest. Pentagastrin had the highest affinity to the receptors and non-sulphated CCK-8 the lowest. The contractions produced by the CCK peptid...

journal_title：European journal of pharmacology

authors： Nilsson S,Leander S,Vallgren S,Håkanson R

更新日期：1983-06-03 00:00:00

abstract：:The administration to mice of 1-methyl-4-(2'-methylphenyl)-1,2,3, 6-tetrahydropyridine (2'-CH3-MPTP), a substituted analog of the dopaminergic neurotoxin MPTP caused even more dopaminergic toxicity than MPTP itself. Under conditions in which MPTP was relatively ineffective (i.e. two injections per day of 0.113 mmol/kg...

journal_title：European journal of pharmacology

authors： Youngster SK,Duvoisin RC,Hess A,Sonsalla PK,Kindt MV,Heikkila RE

更新日期：1986-03-18 00:00:00

abstract：:Concanavalin A-induced hepatitis is often used as a model of liver injury. In this model, plasma tumor necrosis factor-alpha (TNF-alpha) level increased in concanavalin A-injected mice. Prophylactic treatment with Y-40138, N-[1-(4-[4-(pyrimidin-2-yl)piperazin-1-yl]methyl phenyl)cyclopropyl] acetamide.HCl, significantl...

journal_title：European journal of pharmacology

authors： Fukuda T,Mogami A,Hisadome M,Komatsu H

更新日期：2005-10-31 00:00:00

abstract：:The suitability of various neurokinin-2 (NK2) receptor agonists and routes of administration to elicit on-demand voiding of the bladder and bowel, as future therapy for individuals with spinal cord injury, was examined using a rat model. The current study examined the feasibility of alternative routes of administratio...

journal_title：European journal of pharmacology

authors： Marson L,Thor KB,Katofiasc M,Burgard EC,Rupniak NMJ

更新日期：2018-01-15 00:00:00

abstract：:We investigated the effects of an L-type and N-type Ca(2+) channel blocker, cilnidipine, on neurally mediated chronotropic responses to clarify the anti-autonomic profile of cilnidipine in anesthetized dogs. Pretreatment with cilnidipine (0.3, 1.0 and 3.0 microg/kg, i.v.), which decreased mean blood pressure by 5 to 3...

journal_title：European journal of pharmacology

authors： Konda T,Takahara A,Maeda K,Dohmoto H,Yoshimoto R

更新日期：2001-02-09 00:00:00

abstract：:The qualitative and quantitative effects of the (+)-S and (-)-R enantiomers and of the racemic mixture of the Ca2+ channel antagonist, nicardipine, were compared on the isolated porcine coronary artery with intact and removed endothelium. All three forms of nicardipine inhibited the contractions induced by KCl (5-90 m...

journal_title：European journal of pharmacology

authors： Japelj I,Budihna MV,Stanovnik L,Krisch I

更新日期：1999-03-12 00:00:00

abstract：:Acute administration of an opiate has been suggested to result in the development of supersensitive dopamine receptors. This hypothesis was tested in mice by determining the effect of a single administration of morphine or levorphanol on dopamine agonist-induced stereotypic behaviors and [3H]spiroperidol binding. Admi...

journal_title：European journal of pharmacology

authors： Martin JR,Takemori AE

更新日期：1985-12-10 00:00:00

abstract：:The novel CCK antagonist L364,718 was tested on caerulein- and morphine-induced antinociception in rat using the paw pressure test. Caerulein-induced antinociception (ED50 = 30 micrograms/kg) was significantly inhibited by L354,718 (200 micrograms/kg i.p.) which on its own did not affect paw pressure threshold. In con...

journal_title：European journal of pharmacology

authors： Rattray M,Jordan CC,De Belleroche J

更新日期：1988-07-26 00:00:00

abstract：:Overexpression of Cav3.2 T-type Ca2+ channels in L4 dorsal root ganglion (DRG) participates in neuropathic pain after L5 spinal nerve cutting (L5SNC) in rats. The L5SNC-induced neuropathic pain also involves high mobility group box 1 (HMGB1), a damage-associated molecular pattern protein, and its target, the receptor ...

journal_title：European journal of pharmacology

authors： Tomita S,Sekiguchi F,Kasanami Y,Naoe K,Tsubota M,Wake H,Nishibori M,Kawabata A

更新日期：2020-12-05 00:00:00

abstract：:In the present study, the role of reactive oxygen species and the contribution of antioxidant defence in the time course of changes in acetylcholine-stimulated endothelium-dependent and sodium nitroprusside-stimulated endothelium-independent relaxation were investigated in aortic rings isolated from 6-month streptozot...

journal_title：European journal of pharmacology

authors： Karasu C

更新日期：2000-03-31 00:00:00

abstract：:The structure-activity relationships of 35 novel derivatives of 2-(carboxypropyl)-3-amino-4-methyl-6-phenyl pyridazine (SR 95103) were examined as gamma-aminobutyric acid (GABA) antagonists in the flap preparation of the parasitic nematode, Ascaris suum, using a two-microelectrode current-clamp technique. All but one ...

journal_title：European journal of pharmacology

authors： Martin RJ,Sitamze JM,Duittoz AH,Wermuth CG

更新日期：1995-03-24 00:00:00

abstract：:The pharmacological effects of Neuropeptide FF (NPFF) analogs exhibiting different selectivities towards Neuropeptide FF1 (NPFF1) and Neuropeptide FF2 (NPFF2) receptors were investigated after supraspinal administration in mice. Injected into the third ventricle, VPNLPQRF-NH2, which is selective for Neuropeptide FF1 r...

journal_title：European journal of pharmacology

authors： Quelven I,Roussin A,Zajac JM

更新日期：2005-01-31 00:00:00

abstract：:The existence of neurogenic mediator candidates apart from noradrenaline and acetylcholine involved in the control of vascular tone has attracted enormous attention during the past few decades. One such mediator is neuropeptide Y (NPY), which is co-localized with noradrenaline in sympathetic perivascular nerves. Stimu...

journal_title：European journal of pharmacology

authors： Franco-Cereceda A,Liska J

更新日期：1998-05-15 00:00:00

abstract：:N(G)-(Nitro-L-arginine (L-NOARG), an inhibitor of nitric oxide synthase, induces catalepsy in mice. The objective of the present work was to investigate if serotonergic drugs are able to modulate this effect. Results showed that the cataleptogenic effect of L-NOARG (40 mg/kg) in male albino-Swiss mice was enhanced by ...

journal_title：European journal of pharmacology

authors： Nucci-da-Silva LP,Guimarães FS,Del Bel EA

更新日期：1999-08-20 00:00:00

abstract：:We previously reported the synthesis of three new opioid agonists as well as their in vitro and in vivo activity [Girón, R., Abalo, R., Goicoechea, C., Martín, M.I., Callado, L.F., Cano, C., Goya, P., Jagerovic, N. 2002. Synthesis and opioid activity of new fentanyl analogs. Life Sci. 71, 1023-1034]. One of them, N-[1...

journal_title：European journal of pharmacology

authors： Goicoechea C,Sánchez E,Cano C,Jagerovic N,Martín MI

更新日期：2008-10-24 00:00:00

abstract：:In pentobarbital (35.0 mg/kg) anaesthetised dogs, bolus injections of prazosin into the femoral artery (3.0--300.0 microgram) provoked a dose-related fall in the vascular resistance of the innervated hind limb. In contrast to papaverine, prazosin failed to produce the same effect in dogs under spinal anaesthesia even ...

journal_title：European journal of pharmacology

authors： Cavero I,Fenard S,Gomeni R,Lefevre F,Roach AG

更新日期：1978-06-01 00:00:00

abstract：:The binding of the bisquaternary muscarine receptor antagonist heptane-1,7-bis(dimethyl-3'-phthalimidopropyl)-ammonium bromide (C7/3-phth) was investigated at a number of cholinergic binding sites using (-)-[3H]nicotine, [3H]pirenzepine and (-)-[3H]quinuclidinyl benzilate ([3H]QNB) in both central and peripheral tissu...

journal_title：European journal of pharmacology

authors： Christopoulos A,Loiacono R,Mitchelson F

更新日期：1993-06-15 00:00:00

abstract：:We have earlier shown that the glucagon-like peptide 1 receptor agonist exendin-4 stimulates neurogenesis in the subventricular zone and excerts anti-parkinsonian behavior. The aim of this study was to assess the effects of exendin-4 treatment on hippocampus-associated cognitive and mood-related behavior in adult rode...

journal_title：European journal of pharmacology

authors： Isacson R,Nielsen E,Dannaeus K,Bertilsson G,Patrone C,Zachrisson O,Wikström L

更新日期：2011-01-10 00:00:00

abstract：:Ovarian cancer is the leading cause of death among gynecologic cancer patients. Although platinum-based chemotherapy as a frontline treatment for ovarian cancer has been widely used in clinical settings, its clinical efficacy is not satisfactory due to the resistance of ovarian cancer cells to apoptosis. Therefore, it...

journal_title：European journal of pharmacology

authors： Pang HF,Li XX,Zhao YH,Kang JK,Li JY,Tian W,Wang CM,Hou HX,Li DR

更新日期：2020-11-05 00:00:00

abstract：:Right ventricular papillary muscles of the guinea-pig heart were electrically stimulated. Cromakalim 10-100 microM and Ro 31-6930 3 microM depressed the contractile force and shortened the duration of action potentials. Glibenclamide 0.3-3 microM, ATP 100 microM and alpha, beta-methylene ATP (alpha, beta-meATP) 30 mic...

journal_title：European journal of pharmacology

authors： Bott A,Eltze M,Illes P

更新日期：1992-03-17 00:00:00

abstract：:Endotoxin (Escherichia coli lipopolysaccharide 0111:B4, 3 mg/kg i.v.) induced the expression of a calcium-independent nitric oxide (NO) synthase, determined after 5 h in cardiac, hepatic, pulmonary and renal tissues, as assessed by the conversion of radiolabelled L-arginine to L-citrulline. This widespread induction o...

journal_title：European journal of pharmacology

authors： László F,Whittle BJ,Evans SM,Moncada S

更新日期：1995-09-05 00:00:00

abstract：:This study investigated a potential interaction between MK-801 and morphine tolerance using electroencephalography (EEG), EEG spectral parameters and behavior in the rat. Rats were treated for 7 days with morphine alone or with morphine and MK-801. Control groups received chronic MK-801 alone or saline. On day 8 all r...

journal_title：European journal of pharmacology

authors： Haberny KA,Young GA

更新日期：1994-08-11 00:00:00

abstract：:The bisquaternary compound dequalinium has been tested for its ability to inhibit the loss of K+ which angiotensin II causes in guinea-pig hepatocytes and which occurs through apamin-sensitive Ca(2+)-activated K+ (SKCa) channels. Dequalinium blocked angiotensin II-evoked K+ loss with an IC50 of 1.5 +/- 0.1 microM and ...

journal_title：European journal of pharmacology

authors： Castle NA,Haylett DG,Morgan JM,Jenkinson DH

更新日期：1993-05-19 00:00:00