当前位置： SCI文献检索 > EUROPEAN JOURNAL OF PHARMACOLOGY期刊下所有文献 > Interactive effects of MK-801 and morphine on EEG, EEG power spectra and behavior in rats: I. Morphine tolerance development.

Interactive effects of MK-801 and morphine on EEG, EEG power spectra and behavior in rats: I. Morphine tolerance development.

Abstract：

:This study investigated a potential interaction between MK-801 and morphine tolerance using electroencephalography (EEG), EEG spectral parameters and behavior in the rat. Rats were treated for 7 days with morphine alone or with morphine and MK-801. Control groups received chronic MK-801 alone or saline. On day 8 all rats received morphine alone. Co-treatment significantly accelerated the development of tolerance to morphine-induced total power and latency to sleep onset. Co-treatment, but not morphine alone, produced tolerance to morphine-induced complexity and edge frequency, and produced tolerance equal to that from morphine alone in duration of EEG bursting. MK-801 co-treatment decreased, where chronic morphine alone increased, the excitatory response to morphine. Our results support recent reports that chronic morphine treatment produces supersensitivity to glutamate in the rat cortex and alteration in mesolimbic dopamine levels that are modulated by glutamatergic activity.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Haberny KA,Young GA

doi

10.1016/0014-2999(94)90293-3

subject

Has Abstract

pub_date

1994-08-11 00:00:00

pages

1-9

issue

1-2

eissn

0014-2999

issn

1879-0712

pii

0014-2999(94)90293-3

journal_volume

261

pub_type

杂志文章

相关文献

EUROPEAN JOURNAL OF PHARMACOLOGY文献大全
  • Mineralocorticoid receptor antagonists attenuate pulmonary inflammation and bleomycin-evoked fibrosis in rodent models.

    abstract：:Accumulating evidence indicates protective actions of mineralocorticoid antagonists (MR antagonists) on cardiovascular pathology, which includes blunting vascular inflammation and myocardial fibrosis. We examined the anti-inflammatory and anti-fibrotic potential of MR antagonists in rodent respiratory models. In an ov...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2013.08.019

    authors： Lieber GB,Fernandez X,Mingo GG,Jia Y,Caniga M,Gil MA,Keshwani S,Woodhouse JD,Cicmil M,Moy LY,Kelly N,Jimenez J,Crawley Y,Anthes JC,Klappenbach J,Ma YL,McLeod RL

    更新日期：2013-10-15 00:00:00

  • Peroxisome proliferator-activated receptor gamma agonists as therapy for chronic airway inflammation.

    abstract：:Peroxisome proliferator-activated receptor gamma (PPARgamma) is a ligand-activated transcription factor belonging to the nuclear hormone receptor superfamily. PPARgamma regulates several metabolic pathways by binding to sequence-specific PPAR response elements in the promoter region of target genes, including lipid bi...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ejphar.2005.12.048

    authors： Belvisi MG,Hele DJ,Birrell MA

    更新日期：2006-03-08 00:00:00

  • Trans-ACPD inhibits cAMP formation via a pertussis toxin-sensitive G-protein.

    abstract：:In primary cultured striatal neurons we found that (+-)-trans-1-amino-cyclopentyl-1,3-dicarboxylate (trans-ACPD) could inhibit forskolin-induced cAMP formation in a dose-dependent manner (EC50 156 +/- 38 microM, n = 5, maximal inhibition 37.8 +/- 1.2, n = 37). The trans-ACPD-induced inhibition was totally abolished in...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0922-4106(92)90112-9

    authors： Manzoni O,Prezeau L,Sladeczek F,Bockaert J

    更新日期：1992-04-10 00:00:00

  • The picrotoxin-like action of a convulsant benzodiazepine, Ro5-3663.

    abstract：:The potency and site of action of Ro5-3663 as a GABA antagonist were investigated in the rat cuneate slice in vitro. A Schild plot for Ro5-3663 was clearly non-linear but enabled a pA2 value of 3.97 to be calculated. Combination studies using the 'classical' GABA antagonists bicuculline and picrotoxin indicated that R...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(83)90064-x

    authors： Harrison NL,Simmonds MA

    更新日期：1983-01-28 00:00:00

  • Enhancing effect of dimethyl sulfoxide on nociceptive transmission in isolated spinal cord of newborn rat.

    abstract：:The effect of dimethyl sulfoxide (DMSO) on the slow ventral root potential, which is related to nociceptive transmission, was investigated in the isolated spinal cord of a newborn rat. DMSO at 0.3-1% (v/v) enhanced the slow ventral root potential, but not mono- and polysynaptic reflex discharges. DMSO at 1% also enhan...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0014-2999(98)00313-6

    authors： Kubota K,Fujibayashi K,Saito K

    更新日期：1998-06-19 00:00:00

  • Dopaminergic receptors in cat brain. Action of triton X-100 on [3H]spiroperidol binding and localization in relation to the synaptic region.

    abstract：:[3H]Spiroperidol binding was used to assay dopaminergic receptors in synaptosomal membranes isolated from basal ganglia of cat brain. In addition to the usual filtration, a special centrifugation technique was developed which has some advantages for ligands with high non-specific binding. The specific binding to contr...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(82)90568-4

    authors： Jimenez Aguilar C,De Robertis E

    更新日期：1982-04-08 00:00:00

  • Pharmacological properties of two recombinant splice variants of the PACAP type I receptor, transfected and stably expressed in CHO cells.

    abstract：:Two splice variants of the pituitary adenylate cyclase activating polypeptide (PACAP) type I receptor (PACAP receptor and PACAP/HOP receptor isoform) were stably expressed in Chinese hamster ovary (CHO) cells that did not express constitutively receptors for this family of peptides. The PACAP/HOP receptor protein had ...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0922-4106(95)90037-3

    authors： Ciccarelli E,Svoboda M,De Neef P,Di Paolo E,Bollen A,Dubeaux C,Vilardaga JP,Waelbroeck M,Robberecht P

    更新日期：1995-02-15 00:00:00

  • Opioid receptor binding characteristics of the non-equilibrium mu antagonist, beta-funaltrexamine (beta-FNA).

    abstract：:beta-Funaltrexamine (beta-FNA) bound to mouse brain membranes in a reversible and an irreversible (not removed by washing of the membrane) manner, and a portion of each type of binding was opioid-specific. Addition of 100 mM NaCl to the incubating medium enhanced the binding of beta-FNA to membranes. Using membranes p...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(85)90257-2

    authors： Ward SJ,Fries DS,Larson DL,Portoghese PS,Takemori AE

    更新日期：1985-01-08 00:00:00

  • Effect of arrhythmogenic doses of deslanoside on the uptake of monoamines in brain tissue and in cardiac tissue.

    abstract：:The purpose of our study was to determine whether a toxic arrhythmogenic dose of digitalis administered to an in vivo preparation would affect the neuronal uptake of norepinephrine, serotonin and dopamine in brain tissue and norepinephrine in cardiac tissue. This was investigated by intoxicating anesthetized cats with...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(78)90020-1

    authors： Helke CJ,Kellar KJ,Gillis RA

    更新日期：1978-11-01 00:00:00

  • Central inhibitory effects on feeding induced by the adipo-myokine irisin.

    abstract：:Irisin, the soluble secreted form of fibronectin type III domain containing 5 (FNDC5)-cleaved product, is a recently identified adipo-myokine that has been indicated as a possible link between physical exercise and energetic homeostasis. The co-localization of irisin with neuropeptide Y in hypothalamic sections of par...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2016.09.011

    authors： Ferrante C,Orlando G,Recinella L,Leone S,Chiavaroli A,Di Nisio C,Shohreh R,Manippa F,Ricciuti A,Vacca M,Brunetti L

    更新日期：2016-11-15 00:00:00

  • Increase in renal phorbol ester receptors in rats with cyclosporine A-induced nephrotoxicity.

    abstract：:Treatment of rats with cyclosporine A (50 mg/kg i.p.) for 4 days resulted in the impairment of renal function. Renal membrane and soluble phorbol ester receptor densities were significantly higher in cyclosporine A-treated rats compared to vehicle-treated rats. These data suggest that increased phorbol ester receptor ...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(91)90396-8

    authors： Nambi P,Pullen M,Wu HL,Brooks DP

    更新日期：1991-03-19 00:00:00

  • Autoradiographic distribution of adrenomedullin receptors in the rat brain.

    abstract：:The autoradiographic distribution of putative brain adrenomedullin receptors was investigated using [125I]human adrenomedullin(13-52) as a new radioligand. Specific [125I]human adrenomedullin(13-52) binding sites were very discretely distributed in the rat brain with enrichment seen in the choroid plexus and linings o...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0014-2999(01)01021-4

    authors： Juaneda C,Dumont Y,Chabot JG,Quirion R

    更新日期：2001-06-08 00:00:00

  • Antifibrillatory actions of bepridil and butyl-MDI, two intracellular calcium antagonists.

    abstract：:The antifibrillatory and electrophysiologic actions of bepridil and butyl-methylenedioxyindene (BU-MDI), two intracellular calcium antagonists, were examined in anesthetized dogs. The administration of bepridil (1.0-10.0 mg/kg i.v.) significantly increased the electrical threshold for ventricular fibrillation determin...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(85)90107-4

    authors： Lynch JJ,Rahwan RG,Lucchesi BR

    更新日期：1985-04-23 00:00:00

  • The central vs. peripheral effects of clonidine on ACTH, corticosterone and glucose release.

    abstract：:The role of central vs. peripheral actions of clonidine was investigated in the rat following the separate and combined administration of clonidine and 2-deoxy-D-glucose (2-DG). Clonidine or 2-DG alone stimulated serum glucose and corticosterone but hypothalamic noradrenaline neuronal activity and ACTH release were st...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(85)90651-x

    authors： Smythe GA,Bradshaw JE,Gleeson RM,Grunstein HS,Nicholson MV

    更新日期：1985-05-20 00:00:00

  • Adenosine 5'-triphosphate release evoked by electrical nerve stimulation from the guinea-pig gallbladder.

    abstract：:The endogenous release of adenosine 5'-triphosphate (ATP) from strips of guinea-pig gallbladder during transmural stimulation (TS) was measured with a firefly luciferine-luciferase reaction. TS (15V, 1 ms, 0.5-5 Hz, for 1 min) caused a rapid and marked increase of ATP release in a frequency-dependent manner. Both ATP ...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(87)90133-6

    authors： Takahashi T,Kusunoki M,Ishikawa Y,Kantoh M,Yamamura T,Utsunomiya J

    更新日期：1987-01-28 00:00:00

  • The inflammatory reaction in an experimental model of open wounds in the rat. The effect of arachidonic acid metabolites.

    abstract：:The study concerned the effect of arachidonic acid metabolites on the inflammatory reaction in granulation tissue of open wounds in rats. Metabolites or inhibitors were applied in a wound chamber attached to circular, open, full-thickness skin wounds 5 days post-wounding. The adjacent wound served as control. Blood fl...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(84)90454-0

    authors： Lundberg C,Gerdin B

    更新日期：1984-01-27 00:00:00

  • Expression of inducible nitric oxide synthase in mice: pharmacological evaluation of adenosine receptor agonists.

    abstract：:Inhibition of inducible nitric oxide (NO) synthase during endotoxaemia may be of therapeutic value. We have previously shown that pretreatment of mice with adenosine receptor agonists 1 h before lipopolysaccharide administration results in a dose-dependent reduction of plasma nitrite and nitrate (NOx-) levels. This re...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0014-2999(96)00677-2

    authors： Moochhala SM,Hon WM,Chhatwal VJ,Khoo HE

    更新日期：1996-12-05 00:00:00

  • Involvement of a NO-cyclic GMP-PKG signaling pathway in nitrous oxide-induced antinociception in mice.

    abstract：:The antinociceptive effect of nitrous oxide (N(2)O) is dependent on nitric oxide (NO); however, the next step in the pathway activated by NO is undetermined. The present study was conducted to test the hypothesis that a N(2)O action involves sequential activation of NO synthase, soluble guanylyl cyclase and protein ki...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2011.01.006

    authors： Zhang Y,Quock LP,Chung E,Ohgami Y,Quock RM

    更新日期：2011-03-11 00:00:00

  • Scopolamine-induced passive avoidance memory retrieval deficit is accompanied with hippocampal MMP2, MMP-9 and MAPKs alteration.

    abstract：:Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive loss of memory and cognitive deficit. The observed amnesia in the early stages of AD is suggested to be a retrieval problem, rather than encoding and consolidation deficit. According to the cholinergic hypothesis of AD, scopolamine i...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2017.12.007

    authors： Moosavi M,SoukhakLari R,Moezi L,Pirsalami F

    更新日期：2018-01-15 00:00:00

  • Tricyclic antidepressants inhibit homomeric Cys-loop receptors by acting at different conformational states.

    abstract：:Tricyclic antidepressants not only inhibit monoamine reuptake but also modulate Cys-loop receptors. However, it is not understood how this modulation is involved in their therapeutic effects. We analyzed the mechanisms of inhibition of homomeric 5-HT(3A) and alpha7-5HT(3A) receptors by tricyclic antidepressants at the...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2008.01.023

    authors： Gumilar F,Bouzat C

    更新日期：2008-04-14 00:00:00

  • Relaxing effects induced by the soluble guanylyl cyclase stimulator BAY 41-2272 in human and rabbit corpus cavernosum.

    abstract：:5-Cyclopropyl-2-[1-(2-fluoro-benzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-pyrimidin-4-ylamine (BAY 41-2272) is a potent soluble guanylyl cyclase stimulator in a nitric oxide (NO)-independent manner. The relaxant effect of BAY 41-2272 was investigated in rabbit and human corpus cavernosum in vitro. BAY 41-2272 (0.01-10 micr...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2003.08.012

    authors： Baracat JS,Teixeira CE,Okuyama CE,Priviero FB,Faro R,Antunes E,De Nucci G

    更新日期：2003-09-12 00:00:00

  • A novel, highly-water-soluble apigenin derivative provides neuroprotection following ischemia in male rats by regulating the ERK/Nrf2/HO-1 pathway.

    abstract：:6"-O-succinylapigenin [apigenin-7-O-(6'-O-succinyl)-glucoside], a novel compound, is identified in chamomile. Although it is highly produced by Bacillus amyloliquefaciens FJ18, its bioactivity remains unknown. The neuroprotective effects and antioxidative mechanism of 6''-O-succcinylapigenin in the middle cerebral art...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2019.03.024

    authors： Zhang S,Xu S,Duan H,Zhu Z,Yang Z,Cao J,Zhao Y,Huang Z,Wu Q,Duan J

    更新日期：2019-07-15 00:00:00

  • Effects and mechanisms of aloe-emodin on cell death in human lung squamous cell carcinoma.

    abstract：:Aloe-emodin (1,8-dihydroxy-3-(hydroxymethyl)-anthraquinone) is an active component from the root and rhizome of Rheum palmatum. The study investigated the effects and mechanisms of aloe-emodin-induced cell death in human lung squamous cell carcinoma cell line CH27. Aloe-emodin (40 microM)-induced CH27 cell apoptosis w...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0014-2999(01)01467-4

    authors： Lee HZ,Hsu SL,Liu MC,Wu CH

    更新日期：2001-11-23 00:00:00

  • Effects of hemicholinium-3 or physostigmine on rat brain noradrenaline depletion induced by foot shocks.

    abstract：:Foot shocks applied to the rat on a grid floor caused brain noradrenaline depletion. Hemicholinium-3 injected intracerebroventricularly (i.c.v.) blocked the noradrenaline depletion and this blockade was reversed by choline (i.c.v.). Physostigmine (i.c.v.) had different effects according to the age of the rats: "young"...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(77)90067-x

    authors： Campos HA,Romero E

    更新日期：1977-08-01 00:00:00

  • A new technique for selective cannulation of the sino-atrial node artery.

    abstract：:The electrical activity of the sino-atrial node was studied after the selective cannulation of its artery in the intact open-chest dog. After tetrodotoxin infusion and despite cardiac arrest, a slow rhythmic activity was recorded from the sinus epicardial electrode. ...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(78)90227-3

    authors： Adamantidis M,Vincent A,Dupuis B

    更新日期：1978-05-01 00:00:00

  • Effects of antidepressant drugs on different receptors in the brain.

    abstract：:Radioligand receptor binding techniques were used to characterize the effects of different structural types of antidepressant drugs on neurotransmitter receptors. The tricyclic antidepressants more or less potently inhibited the binding to rat brain preparations of several different radiolabelled ligands [3H]WB4101, [...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(81)90172-2

    authors： Hall H,Ogren SO

    更新日期：1981-03-26 00:00:00

  • Activation of P2Y receptors by ATP and by its analogue, ADPbetaS, triggers two calcium signal pathways in the longitudinal muscle of mouse distal colon.

    abstract：:Our previous research showed that ATP and adenosine 5'-O-2-thiodiphosphate (ADPbetaS) induce contractile effects in the longitudinal muscle of mouse distal colon via activation of P2Y receptors which are not P2Y(1) or P2Y(12) subtypes. This study investigated the nature of the P2Y receptor subtype(s) and the mechanism...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2008.07.057

    authors： Zizzo MG,Mulè F,Serio R

    更新日期：2008-10-24 00:00:00

  • The rat anococcygeus muscle is a convenient bioassay organ for the airway epithelium-derived relaxant factor.

    abstract：:The response to epithelium-derived relaxant factor (EpDRF) released from guinea-pig trachea by acetylcholine was studied in the precontracted rat anococcygeus muscle in a coaxial bioassay system. Acetylcholine caused no relaxation of rat anococcygeus muscle which was precontracted with phenylephrine. When the same mus...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(88)90119-7

    authors： Güc MO,Ilhan M,Kayaalp SO

    更新日期：1988-04-13 00:00:00

  • Further analyses of mechanisms underlying the antinociceptive effect of the triterpene 3β, 6β, 16β-trihydroxylup-20(29)-ene in mice.

    abstract：:The present study investigated the mechanisms involved in the antinociception produced by the triterpene 3β, 6β, 16β-trihydroxylup-20(29)-ene (TTHL) in mice. TTHL administered by intra-gastric (i.g.) gavage inhibited glutamate-induced nociception with an ID(50) of 19.0 (13.2-27.5) mg/kg. This action started 60 min (in...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2010.11.028

    authors： Longhi-Balbinot DT,Martins DF,Lanznaster D,Silva MD,Facundo VA,Santos AR

    更新日期：2011-02-25 00:00:00

  • Behavioural and electrocortical power spectrum effects of 5-methoxytryptoline and other analogs after intraventricular administration in rats.

    abstract：:The behavioural and electrocortical power spectrum effects of tryptoline and the 5-hydroxy and 5-methoxy derivatives were studied after microinjection of the drugs into the third cerebral ventricle in freely moving rats. The three compounds produced a dose-dependent desynchronication in electrocortical activity with a...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(87)90660-1

    authors： Nistico G,De Sarro GB,Langer SZ

    更新日期：1987-10-06 00:00:00