Abstract:
:Peroxisome proliferator-activated receptor gamma (PPARgamma) is a ligand-activated transcription factor belonging to the nuclear hormone receptor superfamily. PPARgamma regulates several metabolic pathways by binding to sequence-specific PPAR response elements in the promoter region of target genes, including lipid biosynthesis and glucose metabolism. Synthetic PPARgamma agonists have been developed, such as the thiazolidinediones rosiglitazone and pioglitazone. These act as insulin sensitizers and are used in the treatment of type 2 diabetes. Recently however, PPARgamma ligands have been implicated as regulators of cellular inflammatory and immune responses. They are thought to exert anti-inflammatory effects by negatively regulating the expression of pro-inflammatory genes. Several studies have demonstrated that PPARgamma ligands possess anti-inflammatory properties and that these properties may prove helpful in the treatment of inflammatory diseases of the airways. This review will outline the anti-inflammatory effects of synthetic and endogenous PPARgamma ligands and discuss their potential therapeutic effects in animal models of inflammatory airway disease.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Belvisi MG,Hele DJ,Birrell MAdoi
10.1016/j.ejphar.2005.12.048keywords:
subject
Has Abstractpub_date
2006-03-08 00:00:00pages
101-9issue
1-3eissn
0014-2999issn
1879-0712pii
S0014-2999(05)01377-4journal_volume
533pub_type
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