当前位置： SCI文献检索 > EUROPEAN JOURNAL OF PHARMACOLOGY期刊下所有文献 > Augmented thromboxane generation by mesenteric arteries from pancreatectomized diabetic dogs is coincident with the vascular tone enhancement evoked by Na arachidonate and prostacyclin.

Augmented thromboxane generation by mesenteric arteries from pancreatectomized diabetic dogs is coincident with the vascular tone enhancement evoked by Na arachidonate and prostacyclin.

Abstract：

:We studied the relationships between arachidonic acid (AA) metabolism and contractile responses to Na arachidonate (NaA) and the prostaglandins (PGs) in mesenteric arteries isolated from sham-operated and totally pancreatectomized dogs. PGE2 and PGF2 alpha produced a similar dose-dependent relaxation of mesenteric arteries from normal and diabetic dogs. On the contrary, NaA and prostacyclin (PGI2) enhanced the resting basal tone of arteries from pancreatectomized animals but depressed it in arteries from intact normal control or from sham-operated groups. Inhibitors of thromboxane A2 (TXA2) biosynthesis abolished in vitro the vasoconstricting effect of NaA and PGI2 in diabetics whereas inhibitors of PGI2 biosynthesis blocked the vasodilating influence of NaA in normal mesenteric vessels. Additionally, antagonists of cyclooxygenase activity prevented both the vasoconstricting and the vasodilating actions of NaA in normal and in diabetic arteries, respectively, as well as the PGI2 tone enhancement in vessels from diabetics. In arteries from pancreatectomized animals treated with insulin, PGI2 induced a biphasic (constriction and relaxation) effect of a magnitude between that of effects seen in normal controls or sham-operated and those in untreated diabetic animals. The basal radioconversion of exogenous [1-14C]AA, showed that mesenteric arteries from diabetic dogs generated more TXB2 than did vessels from intact normal control or sham-operated dogs. Moreover, in the presence of exogenous PGI2, the vascular production of TXB2 from AA in the diabetic group was significantly greater than that of preparations not exposed to PGI2. The % conversion of AA into PGI2 (assessed as 6-oxo-PGF1 alpha) was similar in normal controls, in sham-operated and in diabetic vessels. Insulin given in vivo abolished the greater basal conversion of AA into TBX2 by mesenteric arteries from diabetic dogs and significantly attenuated the enhanced prostacyclin-evoked generation of thromboxane. The present results strongly suggest that the abnormal constricting response evoked by NaA and PGI2 in mesenteric arteries from diabetic dogs could be related to the generation of TXA2 by vessel walls.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Sterin-Borda L,Franchi AM,Borda ES,Del Castillo E,Gimeno MF,Gimeno AL

doi

10.1016/0014-2999(84)90480-1

subject

Has Abstract

pub_date

1984-08-17 00:00:00

pages

211-21

issue

3-4

eissn

0014-2999

issn

1879-0712

pii

0014-2999(84)90480-1

journal_volume

103

pub_type

杂志文章

相关文献

EUROPEAN JOURNAL OF PHARMACOLOGY文献大全
  • Allosteric modulation of 5-HT3 serotonin receptors.

    abstract：:[(3)H]Granisetron binding to 5-HT(3) type serotonin receptors was examined in homogenates of rat forebrain and NG 108-15 cells. We have applied an allosteric model to 5-HT(3) receptor binding for the first time. Slope factors of displacement improved the modelling. Serotonin displaced [(3)H]granisetron binding with mi...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2005.03.019

    authors： Maksay G,Bíró T,Bugovics G

    更新日期：2005-05-02 00:00:00

  • In vitro aggregation facilities beta-amyloid peptide-(25-35)-induced amnesia in the rat.

    abstract：:The beta-amyloid peptide-(25-35) fragment, but not beta-amyloid peptide-(1-28), shares with beta-amyloid protein-(1-42) the ability to self-aggregate and to induce neurotoxicity in vitro. This study examined the induction of amnesia in rats given intracerebroventricularly soluble or aggregated beta-amyloid peptide-(25...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0014-2999(96)00922-3

    authors： Delobette S,Privat A,Maurice T

    更新日期：1997-01-14 00:00:00

  • The impact of GABAB receptors and their pharmacological stimulation on cocaine reinforcement and drug-seeking behaviors in a rat model of depression.

    abstract：:Depression and cocaine use disorder represent frequent co-current diagnoses and the GABAB receptors are involved in both conditions. This research involved the application of the animal model of depression (bulbectomy, OBX) and cocaine use disorder (self-administration) to assess the efficiency of GABAB receptor agoni...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2020.173324

    authors： Gawlińska K,Jastrzębska J,Gamberini S,Gawliński D,Pieniążek R,Suder A,Wydra K,Frankowska M

    更新日期：2020-09-15 00:00:00

  • Desensitization of endogenous angiotensin II receptors in Xenopus oocytes: a role of protein kinase C.

    abstract：:The inward chloride current induced by angiotensin II (AII) in Xenopus oocytes shows strong and homologous desensitization, and was suggested to be mediated by phosphatidylinositol (PI) hydrolysis (Sakuta et al., 1991, Eur. J. Pharmacol. Mol. Pharmacol. 208, 31). As a model of agonist-induced desensitization of recept...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0922-4106(91)90049-n

    authors： Sakuta H,Sekiguchi M,Okamoto K,Sakai Y

    更新日期：1991-09-12 00:00:00

  • Blood pressure and heart rate effects of kynuramine in pithed rats.

    abstract：:Kynuramine increased heart rate and blood pressure in pithed rats. Heart rate responses were blocked by beta-adrenoceptor antagonists and reserpine pretreatment. Both of these treatments reduced the pressor responses to kynuramine. Remaining pressor activity was inhibited by phentolamine. The pressor responses to kynu...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(83)90346-1

    authors： Johnson TD,Clarke DE

    更新日期：1983-02-18 00:00:00

  • Selective cytotoxicity of the antibacterial peptide ABP-dHC-Cecropin A and its analog towards leukemia cells.

    abstract：:Some cationic antibacterial peptides, with typical amphiphilic α-helical conformations in a membrane-mimicking environment, exhibit anticancer properties as a result of a similar mechanism of action towards both bacteria and cancer cells. We previously reported the cDNA sequence of the antimicrobial peptide ABP-dHC-Ce...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2017.03.054

    authors： Sang M,Zhang J,Zhuge Q

    更新日期：2017-05-15 00:00:00

  • MicroRNA-301b promotes the proliferation and invasion of glioma cells through enhancing activation of Wnt/β-catenin signaling via targeting Glypican-5.

    abstract：:Accumulating evidence has suggested that Glypican-5 (GPC5) is a tumor suppressor gene in many types of cancers. However, whether GPC5 is involved in glioma remains unknown. This study was designed to explore the expression, biological function and regulatory mechanism of GPC5 in glioma. Our results demonstrated that G...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2019.03.057

    authors： Hong X,Zhang Z,Pan L,Ma W,Zhai X,Gu C,Zhang Y,Bi X,Huang W,Pei H,Liu Z

    更新日期：2019-07-05 00:00:00

  • Ziprasidone suppresses olanzapine-induced increases in ingestive behaviour in the rat.

    abstract：:Many atypical antipsychotic drugs, such as olanzapine, induce significant weight gain. However, ziprasidone produces minimal weight gain, the mechanism of which remains unclear. The aim of the present study was to investigate whether ziprasidone would reduce the acute effect of olanzapine on feeding behaviour. The res...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2004.10.015

    authors： Kirk SL,Neill JC,Jones DN,Reynolds GP

    更新日期：2004-11-28 00:00:00

  • Binding sites for [3H]tetracaine in synaptosomal sodium channel preparations from mouse brain.

    abstract：:The present study was an attempt to answer the question whether the local anesthetic [3H]tetracaine labels sodium channels in mouse brain synaptosomes. Binding of [3H]tetracaine had a Kd of 0.19 microM and a Bmax ranging from 3.7 to 5.2 pmol/mg of protein. Local anesthetics other than tetracaine and cocaine-related co...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(87)90530-9

    authors： Reith ME,Kim SS,Lajtha A

    更新日期：1987-11-10 00:00:00

  • Dantrolene and the neuromuscular junction: evidence for intracellular calcium stores.

    abstract：:Dantrolene sodium (DaNa) markedly depressed the frequency of spontaneous miniature potentials at the frog neuromuscular junction. Its action is still observed at low [Ca2+]o and is little affected by temperature; its effect is not readily reversible. Theophylline antagonises the action of DaNa. DaNa prevents the stimu...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(76)90122-9

    authors： Statham HE,Duncan CJ

    更新日期：1976-09-01 00:00:00

  • Drug-induced alterations in the efflux of 5-hydroxytryptamine and of 5-hydroxyindoleacetic acid into superfusates of the rat spinal cord.

    abstract：:The effect of dl-p-chloroamphetamine, fluoxetine and probenecid on the efflux of endogenous 5-hydroxytryptamine (5HT) and 5-hydroxyindoleacetic acid (5HIAA) into superfusates of the spinal cord of anesthetized rats was examined. Mean basal efflux of 5HT and 5HIAA was 0.27 and 15.56 ng/ml superfusate, respectively. The...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(83)90083-3

    authors： Hammond DL,Tyce GM,Yaksh TL

    更新日期：1983-03-04 00:00:00

  • Rapid human melanoma cell death induced by sanguinarine through oxidative stress.

    abstract：:Sanguinarine is a natural isoquinoline alkaloid derived from the root of Sanguinaria canadensis and from other poppy fumaria species, and is known to have a broad spectrum of pharmacological properties. Here we have found that sanguinarine, at low micromolar concentrations, showed a remarkably rapid killing activity a...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2013.02.035

    authors： Burgeiro A,Bento AC,Gajate C,Oliveira PJ,Mollinedo F

    更新日期：2013-04-05 00:00:00

  • Vasorelaxant effect of taurine is diminished by tetraethylammonium in rat isolated arteries.

    abstract：:Although the vasorelaxant effects of taurine have been studied in rabbit ear artery, rat isolated aorta and mesenteric artery, its pharmacological properties in other vascular beds and underlying mechanism(s) are still not well clarified. The present study was designed to observe the effects of taurine on the contract...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2007.10.039

    authors： Niu LG,Zhang MS,Liu Y,Xue WX,Liu DB,Zhang J,Liang YQ

    更新日期：2008-02-02 00:00:00

  • Rho kinase activation mediates adrenergic and cholinergic smooth muscle contractile responses in the mouse prostate gland.

    abstract：:With age an increase in prostatic smooth muscle tone mediated by α1L-adrenoceptors contributes to the lower urinary tract symptoms associated with benign prostatic hyperplasia. Current treatments for benign prostatic hyperplasia include α1-adrenoceptor antagonists which inhibit smooth muscle contraction. However, musc...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2013.09.012

    authors： White CW,Short JL,Ventura S

    更新日期：2013-12-05 00:00:00

  • G-protein coupled estrogen receptor-mediated non-genomic facilitatory effect of estrogen on cooling-induced reduction of skin blood flow in mice.

    abstract：:An enhanced vasoconstrictor activity of cutaneous arteries participates in the reduction of skin blood flow induced by cooling stimulation. Raynaud's phenomenon, which is characterized by intense cooling-induced constriction of cutaneous arteries, is more common in women during the period from menarche to menopause. W...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2017.01.013

    authors： Serizawa I,Iwasaki N,Ishida H,Saito SY,Ishikawa T

    更新日期：2017-02-15 00:00:00

  • The binding interactions of Ro 40-5967 at the L-type Ca2+ channel in cardiac tissue.

    abstract：:Ro 40-5967 [(1S,2S)-2-[2[3-(2-benzamidopropyl]- methylamino]ethyl]-6-fluoro-1,2,3,4-tetrahydro-1-isopropyl-2-naphthyl- methoxyacetate] is a new Ca2+ channel antagonist active at L-type channels. Radioligand binding studies in cardiac tissue show that Ro 40-5967 does not inhibit 1,4-dihydropyridine binding, but does in...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(95)00194-p

    authors： Rutledge A,Triggle DJ

    更新日期：1995-07-04 00:00:00

  • The mechanism of epristeride against benign prostatic hyperplasia.

    abstract：:Epristeride, a 5alpha-reductase inhibitor, decreases prostate size and improves symptoms in men with benign prostatic hyperplasia. However, little is known about the histopathology of the prostate after treatment with epristeride. To study the relationship between apoptosis and the mechanism of epristeride in the trea...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0014-2999(99)00109-0

    authors： Sun ZY,Wu HY,Wang MY,Tu ZH

    更新日期：1999-04-29 00:00:00

  • In vivo pharmacological profile of S 38093, a novel histamine H3 receptor inverse agonist.

    abstract：:S 38093, a novel histamine H3 receptor inverse agonist, was tested in a series of neurochemical and behavioral paradigms designed to evaluate its procognitive and arousal properties. In intracerebral microdialysis studies performed in rats, S 38093 dose-dependently increased histamine extracellular levels in the prefr...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2017.03.008

    authors： Panayi F,Sors A,Bert L,Martin B,Rollin-Jego G,Billiras R,Carrié I,Albinet K,Danober L,Rogez N,Thomas JY,Pira L,Bertaina-Anglade V,Lestage P

    更新日期：2017-05-15 00:00:00

  • Increase in P-glycoprotein levels in the blood-brain barrier of partial portal vein ligation /chronic hyperammonemia rats is medicated by ammonia/reactive oxygen species/ERK1/2 activation: In vitro and in vivo studies.

    abstract：:Liver failure altered P-glycoprotein (P-gp) function and expression at blood-brain barrier (BBB), partly owing to hyperammonemia. We aimed to examine the effects of partial portal vein ligation (PVL) plus chronic hyperammonemia (CHA) on P-gp function and expression at rat BBB. Experimental rats included sham-operation...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2019.01.005

    authors： Zhou Y,Zhou J,Li P,Xie Q,Sun B,Li Y,Chen Y,Zhao K,Yang T,Zhu L,Xu J,Liu X,Liu L

    更新日期：2019-03-05 00:00:00

  • Endomorphin-1 and endomorphin-2 are partial agonists at the human mu-opioid receptor.

    abstract：:Recently two tetrapeptide ligands that bind preferentially to the mu-opioid receptor were identified and named endomorphin-1 and endomorphin-2. We examined the ability of these peptides to stimulate G protein activation in human mu-opioid receptor transfected B82 fibroblasts as measured by [35S]GTPgammaS binding to ce...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0014-2999(98)00117-4

    authors： Hosohata K,Burkey TH,Alfaro-Lopez J,Varga E,Hruby VJ,Roeske WR,Yamamura HI

    更新日期：1998-04-03 00:00:00

  • Opioidergic and adrenergic modulation of formalin-evoked spinal c-fos mRNA expression and nocifensive behavior in the rat.

    abstract：:Fos protein expression has been used to reflect neuronal activation in pain processing pathways although analgesics may uncouple behavioral and Fos responses. We determine whether formalin-induced spinal c-fos mRNA expression (Northern blotting) correlates with nocifensive behavior following pretreatment with morphine...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0014-2999(99)00463-x

    authors： Sawamura S,Fujinaga M,Kingery WS,Belanger N,Davies MF,Maze M

    更新日期：1999-08-27 00:00:00

  • New achievements and pharmacotherapeutic approaches in the treatment of alcohol dependence.

    abstract：:The treatment of alcohol dependence mainly consists of psychological, social, and pharmacotherapeutic interventions aiming to reduce physical withdrawal, craving, and alcohol relapse. During the last years, it has become increasingly clear that adjuvant pharmacotherapy is efficacious especially in rehabilitation progr...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ejphar.2005.09.028

    authors： Kiefer F,Mann K

    更新日期：2005-12-05 00:00:00

  • Vagal apnea and hypotension evoked by systemic injection of an antinociceptive analogue of endomorphin-2.

    abstract：:PK20M (Dmt-D-Lys-Phe-Phe-OH) is a novel modified endomorphin-2 (EM-2) peptide producing strong dose- and time-dependent antinociceptive activity. Yet its prototype, endogenous EM-2, has been reported to trigger respiratory and vascular effects such as apnea and hypotension. The purpose of this study was to investigate...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2020.173514

    authors： Wojciechowski P,Kleczkowska P,Mollica A,Stefanucci A,Kaczyńska K

    更新日期：2020-10-15 00:00:00

  • dextro-Morphine attenuates the morphine-produced conditioned place preference via the sigma(1) receptor activation in the rat.

    abstract：:An unbiased conditioned place preference paradigm was used to evaluate the effect of dextro-morphine on the morphine-produced reward in male CD rats. Morphine sulfate (1-10 mg/kg) given intraperitoneally dose-dependently produced the conditioned place preference. Pretreatment with dextro-morphine at a dose from 0.1 to...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2007.01.083

    authors： Wu HE,Schwasinger ET,Terashvili M,Tseng LF

    更新日期：2007-05-21 00:00:00

  • Modulation of ischemia-evoked release of excitatory and inhibitory amino acids by adenosine A1 receptor agonist.

    abstract：:Adenosine has been reported to have beneficial effects against ischemic brain damage, although the mechanisms are not fully clarified. To examine the role of adenosine on the ischemia-evoked release of neurotransmitters, we applied a highly selective agonist for adenosine A1 receptor, 2-chloro-N6-cyclopentyladenosine ...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0014-2999(98)00559-7

    authors： Goda H,Ooboshi H,Nakane H,Ibayashi S,Sadoshima S,Fujishima M

    更新日期：1998-09-18 00:00:00

  • Ca2+ sensors modulate asthmatic symptoms in an allergic model for asthma.

    abstract：:We previously described two novel peptides, Ca2+-like peptide (CALP) 1 and CALP2, which interact with Ca2+-binding EF hand motifs, and therefore have the characteristics to define the role of the Ca2+-sensing regulatory protein calmodulin in asthma. In the present study, the effects of the calcium-like peptides were i...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0014-2999(03)02016-8

    authors： Ten Broeke R,Brandhorst MC,Leusink-Muis T,Villain M,De Clerck F,Blalock JE,Nijkamp FP,Folkerts G

    更新日期：2003-08-22 00:00:00

  • The effect of chronic administration of caffeine on morphine-induced analgesia, tolerance and dependence in mice.

    abstract：:Morphine-induced analgesia, and the development of morphine-induced tolerance and dependence was determined in mice which had drunk caffeinated water (1 mg/ml) for 14 days or in mice which had received (-)-N6-(phenylisopropyl)-adenosine (PIA) 1 mg/kg i.p. for 14 days. Analgesia was assessed by the tail flick assay. Th...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(86)90635-7

    authors： Ahlijanian MK,Takemori AE

    更新日期：1986-01-14 00:00:00

  • Eugenol protects nicotine-induced superoxide mediated oxidative damage in murine peritoneal macrophages in vitro.

    abstract：:The present work is aimed at evaluating the protective effect of eugenol against in vitro nicotine-induced toxicity in murine peritoneal macrophages, compared with N-acetylcysteine. Eugenol was isolated from Ocimum gratissimum and characterized by HPLC, FTIR, (1)H NMR. To establish most effective protective support, w...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2009.09.019

    authors： Kar Mahapatra S,Chakraborty SP,Majumdar S,Bag BG,Roy S

    更新日期：2009-11-25 00:00:00

  • The differential contractile responses to capsaicin and anandamide in muscle strips isolated from the rat urinary bladder.

    abstract：:The contractile responses to capsaicin and anandamide, exogenous and endogenous agonists for transient receptor potential vanilloid receptor 1 (TRPV1), respectively, were investigated in muscle strips isolated from the rat urinary bladder. Capsaicin and anandamide produced concentration-dependent contractions of the m...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2007.05.016

    authors： Saitoh C,Kitada C,Uchida W,Chancellor MB,de Groat WC,Yoshimura N

    更新日期：2007-09-10 00:00:00

  • Targeting CD52 does not affect murine neuron and microglia function.

    abstract：:The humanized anti-CD52 antibody alemtuzumab is successfully used in the treatment of multiple sclerosis (MS) and is thought to exert most of its therapeutic action by depletion and repopulation of mainly B and T lymphocytes. Although neuroprotective effects of alemtuzumab have been suggested, direct effects of anti-C...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2020.172923

    authors： Ellwardt E,Vogelaar CF,Maldet C,Schmaul S,Bittner S,Luchtman D

    更新日期：2020-03-15 00:00:00