Chelation of dietary iron prevents iron accumulation and macrophage infiltration in the type I diabetic kidney.

Abstract:

:We previously reported that the functional deletion of p21, a cyclin-dependent kinase inhibitor, in mice attenuated renal cell senescence in streptozotocin (STZ)-induced type 1 diabetic mice. In the present study, we investigated the effect of iron chelation on renal cell senescence and inflammation in the type 1 diabetic kidney. STZ-treated mice showed increase in iron accumulation, tubular cell senescence and macrophage infiltration at week 28 in the kidney. Administering deferasirox, which removes only dietary iron, significantly attenuated iron accumulation in proximal tubules and the number of infiltrating F4/80-positive cells without effecting blood glucose, hematocrit or hemoglobin levels. In contrast however, deferasirox did not influence renal cell senescence. The lack of p21 decreased the renal tubular iron accumulation and did not change tubular cell senescence. Interestingly, the STZ-treated animals showed an increase in p16, another cyclin-dependent kinase inhibitor. The results suggest that type 1 diabetes increases renal tubular iron accumulation and macrophage infiltration through a p21-dependent mechanism, and that the chelation of dietary iron attenuates these responses.

journal_name

Eur J Pharmacol

authors

Morita T,Nakano D,Kitada K,Morimoto S,Ichihara A,Hitomi H,Kobori H,Shiojima I,Nishiyama A

doi

10.1016/j.ejphar.2015.03.053

subject

Has Abstract

pub_date

2015-06-05 00:00:00

pages

85-91

eissn

0014-2999

issn

1879-0712

pii

S0014-2999(15)00282-4

journal_volume

756

pub_type

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