Abstract:
:The structure-activity relationships of 35 novel derivatives of 2-(carboxypropyl)-3-amino-4-methyl-6-phenyl pyridazine (SR 95103) were examined as gamma-aminobutyric acid (GABA) antagonists in the flap preparation of the parasitic nematode, Ascaris suum, using a two-microelectrode current-clamp technique. All but one of the potent antagonists displaced GABA dose-response curves to the right without reduction in the maximum response. The dissociation constants of the more potent competitive antagonists were described using a model which assumed that two molecules of GABA were required to open the ion channel but that only one molecule of antagonist acted on each ion channel. By exploring the structure-activity relationship, the potency of the antagonist was increased from a KB of 64 microM for SR 95103 to a KB of 4.7 microM for NCS 281-93 (2-(3-carboxypropyl)-3-amino-4-phenylpropyl-6-phenyl pyridazine).
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Martin RJ,Sitamze JM,Duittoz AH,Wermuth CGdoi
10.1016/0014-2999(94)00778-6subject
Has Abstractpub_date
1995-03-24 00:00:00pages
9-19issue
1-2eissn
0014-2999issn
1879-0712pii
0014-2999(94)00778-6journal_volume
276pub_type
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