Abstract:
:The novel CCK antagonist L364,718 was tested on caerulein- and morphine-induced antinociception in rat using the paw pressure test. Caerulein-induced antinociception (ED50 = 30 micrograms/kg) was significantly inhibited by L354,718 (200 micrograms/kg i.p.) which on its own did not affect paw pressure threshold. In contrast, morphine-induced antinociception was significantly potentiated by L364,718. Since L364,718 is highly selective for 'peripheral' receptors which are found in tissue such as pancreas and gallbladder and a few discrete areas of brain, this receptor is likely to be implicated in the antinociceptive effect of caerulein.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Rattray M,Jordan CC,De Belleroche Jdoi
10.1016/0014-2999(88)90849-7subject
Has Abstractpub_date
1988-07-26 00:00:00pages
163-6issue
1-2eissn
0014-2999issn
1879-0712pii
0014-2999(88)90849-7journal_volume
152pub_type
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