Antitussive effects of Ca2+ channel antagonists.

abstract：:A novel compound, FR64822(N-(4-pyridylcarbamoyl)amino 1,2,3,6,-tetrahydropyridine), displays antinociceptive activities in a variety of assays with mice and rats. It has a strong antinociceptive activity in the acetic acid writhing test (ED50 = 1.8 mg/kg p.o.), whereas it has little antinociceptive activity in the tai...

journal_title：European journal of pharmacology

authors： Ohkubo Y,Nomura K,Yamaguchi I

更新日期：1991-11-05 00:00:00

abstract：:Heparin is the most widely used anticoagulant drug for prevention and treatment of thrombosis. However, inhibition of blood coagulation might not fully explain the antithrombotic activity of this drug. The present study shows that different heparin preparations (50 nM) completely prevent human platelet aggregation, se...

journal_title：European journal of pharmacology

authors： Evangelista V,Piccardoni P,Maugeri N,De Gaetano G,Cerletti C

更新日期：1992-06-17 00:00:00

abstract：:The effects of 2,3-butanedione monoxime (BDM) and 5-[1-(3,4-dimethoxybenzoyl)-1,2,3,4-tetrahydro-6-quinolyl]-6-me thy l-3,6-dihydro-2H-1,3,4-thiadiazin-2-one (EMD 53998) on cardiac muscle were studied in skinned muscle fibres from the right ventricle of the porcine heart. BDM decreases the Ca2+ sensitivity (pCa50 for ...

journal_title：European journal of pharmacology

authors： Barth Z,Strauss JD,Dohet C,Ruegg JC

更新日期：1996-02-05 00:00:00

abstract：:The aim of this study was to examine the therapeutic effect of oxymatrine, a monomer isolated from the medicinal plant Sophora flavescens Ait, on the hepatic lipid metabolism in non-alcoholic fatty liver (NAFLD) rats and to explore the potential mechanism. Rats were fed with high fructose diet for 8 weeks to establish...

journal_title：European journal of pharmacology

authors： Shi LJ,Shi L,Song GY,Zhang HF,Hu ZJ,Wang C,Zhang DH

更新日期：2013-08-15 00:00:00

abstract：:The effect of treatment with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on juvenile (6-8 months), young adult (2-4 years) and aged (8-10 years) common marmosets were compared. Juvenile marmosets were more resistant to the actions of MPTP and required a greater cumulative dose over a longer period to induce th...

journal_title：European journal of pharmacology

authors： Rose S,Nomoto M,Jackson EA,Gibb WR,Jaehnig P,Jenner P,Marsden CD

更新日期：1993-01-12 00:00:00

abstract：:Nomifensine, at a dose of 40 mg/kg, slightly but significantly increased rat striatal acetylcholine 60 min after i.p. administration without affecting choline levels or choline O-acetyltransferase and cholinesterase activities. This drug had no effect on brainstem acetylcholine. In contrast, d-amphetamine and desipram...

journal_title：European journal of pharmacology

authors： Garattini S,Consolo S,Chittò G,Peri G,Ladinsky H

更新日期：1976-01-01 00:00:00

abstract：:In many vascular smooth muscle cells, physiological and pharmacological agonists initiate oscillatory fluctuations in intracellular Ca(2+) to initiate and maintain vasoconstriction. These oscillations are supported by the underlying cellular ultrastructure, particularly the close apposition between the plasma membrane...

journal_title：European journal of pharmacology

authors： Dai JM,Syyong H,Navarro-Dorado J,Redondo S,Alonso M,van Breemen C,Tejerina T

更新日期：2010-03-10 00:00:00

abstract：:The characteristics of [3H](+)-pentazocine and [3H]1,3-di(2-tolyl) guanidine (DTG) binding to mouse whole brain, cortex, cerebellum and spinal cord membranes were investigated in radioreceptor assays. [3H](+)-Pentazocine bound to a single, high affinity site (Kd = 1.2-1.6 nM) with increasing density along the neuraxis...

journal_title：European journal of pharmacology

authors： Kovács KJ,Larson AA

更新日期：1995-10-16 00:00:00

abstract：:Several contractile responses of longitudinal muscles of the guinea-pig digestive tract to exogenously applied ATP (10-300 micrometer), including "rebound" contractions, were inhibited by indomethacin (3-20 micrometer) or polyphloretin phosphate (10-100 microgram/ml). Relaxations to ATP in stomach and large intestina...

journal_title：European journal of pharmacology

authors： Kamikawa Y,Serizawa K,Shimo Y

更新日期：1977-09-15 00:00:00

abstract：:The effects of amiloride on contraction evoked by perivascular nerve stimulation were studied in a ring preparation of rat mesenteric artery. The contraction evoked by nerve stimulation was abolished by tetrodotoxin or prazosin. Amiloride depressed the nerve-induced contraction concentration dependently. Noradrenaline...

journal_title：European journal of pharmacology

authors： Shimamura K,Zou LB,Moriyama K,Yamamoto K,Sekiguchi F,Sunano S

更新日期：1997-02-05 00:00:00

abstract：:The origin of the thrombocytopenia and leucopenia induced by protamine-heparin complexes is unknown. We studied the biochemical and cellular effects of protamine (6 mg x kg-1, i.v.) injected after heparin (5 mg x kg-1, i.v.) in New Zealand rabbits. After protamine injection (0.5 min) increases in blood platelet-activa...

journal_title：European journal of pharmacology

authors： Aïssa J,Nathan N,Arnoux B,Benveniste J

更新日期：1996-04-29 00:00:00

abstract：:Capsaicin (1-3 microM) and electrical stimulation of mesenteric nerves in the presence of hexamethonium and guanethidine antidromically stimulate extrinsic sensory nerve fibers to produce a specific slow depolarizing response of myenteric neurons and a contractile response of muscles in the isolated guinea-pig ileum, ...

journal_title：European journal of pharmacology

authors： Takaki M,Namba T,Fujii W,Suga H

更新日期：1993-06-11 00:00:00

abstract：:This work evaluates the antinociceptive and constipating effects of the combination of 3.2 mg/kg s.c. morphine with 177.8 mg/kg s.c. metamizol in acutely and chronically treated (once a day for 12 days) rats. On the 13th day, antinociceptive effects were assessed using a model of inflammatory nociception, pain-induced...

journal_title：European journal of pharmacology

authors： Hernández-Delgadillo GP,Ventura Martínez R,Díaz Reval MI,Domínguez Ramírez AM,López-Muñoz FJ

更新日期：2002-04-26 00:00:00

abstract：:Acute respiratory and metabolic acidosis as well as metabolic alkalosis increased (by 11, 11, 21%) whereas respiratory alkalosis antagonized (by 10%) the partial steady state block produced by pipecuronium infusion on the anterior tibialis muscle of the cat. The duration of neuromuscular block following six successive...

journal_title：European journal of pharmacology

authors： Biró K

更新日期：1988-09-23 00:00:00

abstract：:The present study examined the effects of histamine on somatostatin-like immunoreactivity levels, binding of 125I-[Tyr11]somatostatin to its specific receptors, somatostatin inhibition of basal and forskolin-stimulated adenylyl cyclase activity and inhibitory guanine-nucleotide binding protein (Gi) function in the rat...

journal_title：European journal of pharmacology

authors： Puebla L,Arilla E

更新日期：1995-04-28 00:00:00

abstract：:Schild plots for (-)-propranolol, timolol and IPS 339, but not penbutolol or carazolol, as antagonists of isoproterenol in the isolated, field-stimulated rat vas deferens exhibited biphasic curves indicating the presence of both high and low affinity sites for these agents in this preparation. Schild plots determined ...

journal_title：European journal of pharmacology

authors： Lotti VJ,Kling P,Cerino D

更新日期：1982-10-22 00:00:00

abstract：:Procaine and procainamide were covalently bound to acryloyl monomers and polymers. The dose-response and time-action parameters of the cardiac antiarrhythmic protection afforded by the prototype drugs and their acryloyl derivatives against chloroform-hypoxia-induced cardiac arrhythmias in unanesthetized mice and epine...

journal_title：European journal of pharmacology

authors： Erker EF,Baker T,Okamoto M,Udenfriend S,Riker WF Jr

更新日期：1985-08-27 00:00:00

abstract：:Opioids are the most effective and widely used drugs for pain treatment. Morphine is an archetypal opioid and is an opioid receptor agonist. Unfortunately, the clinical usefulness of morphine is limited by adverse effects such as analgesic tolerance and addiction. Therefore, it is important to study the development of...

journal_title：European journal of pharmacology

authors： Nikaido Y,Kurosawa A,Saikawa H,Kuroiwa S,Suzuki C,Kuwabara N,Hoshino H,Obata H,Saito S,Saito T,Osada H,Kobayashi I,Sezutsu H,Takeda S

更新日期：2015-11-15 00:00:00

abstract：:Adenosine added to isolated electrically driven preparations of human ventricular heart muscle antagonized the positive inotropic effect of isoprenaline (mean EC50 19 mumol 1(-1), n = 9). Similar effects were observed with the adenosine receptor agonist (-)-N6-phenylisopropyladenosine (mean EC50 0.5 mumol 1(-1), n = 7...

journal_title：European journal of pharmacology

authors： Böhm M,Meyer W,Mügge A,Schmitz W,Scholz H

更新日期：1985-10-22 00:00:00

abstract：:Acanthoic acid, a pimaradiene diterpene isolated from Acanthopanax koreanum, has been reported to have anti-inflammatory activities. However, the effects of acanthoic acid on LPS-induced acute lung injury have not been reported. The purpose of this study was to investigate the protective effect of acanthoic acid on LP...

journal_title：European journal of pharmacology

authors： Qiushi W,Guanghua L,Guangquan X

更新日期：2015-03-05 00:00:00

abstract：:A microcomputer-based system has been used to apply the technique of excitability testing to the study of the actions of a range of pharmacological agents on the excitability of single primary afferent terminals in the mouse spinal cord in vitro. GABAA analogues all evoked increases in excitability that were bicuculli...

journal_title：European journal of pharmacology

authors： Yu YB,Duchen MR,Biscoe TJ

更新日期：1987-09-23 00:00:00

abstract：:Synaptic transmission in intact pieces of the Torpedo electric organ treated with vesamicol (2-(4-phenylpiperidino)cyclohexanol, formerly AH5183) was elicited by trains of repetitive electrical stimulation at different frequencies. When the frequency of stimulation was increased from 10 to 50 or 100 Hz, micromolar con...

journal_title：European journal of pharmacology

authors： Girod R,Loctin F,Dunant Y

更新日期：1991-03-19 00:00:00

abstract：:Numerous studies have demonstrated the stimulatory effect of 5-HT1A receptor agonists, such as 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), on plasma corticotrophin (ACTH) levels in the rat. However, until recently the lack of a selective 5-HT1A receptor antagonist has hampered mechanistic studies in this area....

journal_title：European journal of pharmacology

authors： Critchley DJ,Childs KJ,Middlefell VC,Dourish CT

更新日期：1994-10-13 00:00:00

abstract：:Conscious guinea-pigs received platelet activating factor (PAF, 0.03-0.25 microgram/kg, i.v.) and colloidal carbon (C, tracer for microvascular leakage). Fifteen min later the animal was killed and C-labelled microvessels (leakage) were detected in the mucosal/submucosal region of tracheal and bronchial sections. PAF ...

journal_title：European journal of pharmacology

authors： O'Donnell SR,Barnett CJ

更新日期：1987-06-26 00:00:00

abstract：:The spasmolytic activity of synthetic alpha-human atrial natriuretic peptide (alpha-hANP) and its related peptides was determined in vitro using the chick rectum and the rat aorta. Natriuretic activity was also measured in the anesthetized rat, alpha-hANP-(7-28), with the NH2-terminal hexapeptide truncated, had greate...

journal_title：European journal of pharmacology

authors： Watanabe TX,Noda Y,Chino N,Nishiuchi Y,Kimura T,Sakakibara S,Imai M

更新日期：1988-02-16 00:00:00

abstract：:Docetaxel is a first line chemotherapy agent, which stabilizes microtubules in metastatic prostate cancer (PCa). Resistance to Docetaxel and its side effects remain as obstacle for its efficacy in monotherapy. Recently, combination with novel adjuvants have been emerged as a beneficial alternative strategy, which targ...

journal_title：European journal of pharmacology

authors： Eftekhari S,Montazeri H,Tarighi P

更新日期：2020-07-05 00:00:00

abstract：:Dichlorobenzamil, phenamil and other amiloride analogs (1-100 microM) elicit transient tension in rabbit skinned muscle fibers. Tension requires preloading of Ca(2+) into the sarcoplasmic reticulum, is facilitated by low-[Mg(2+)] solutions, abolished by ruthenium red or by functional disruption of the sarcoplasmic ret...

journal_title：European journal of pharmacology

authors： Ponte CG,Estrela RC,Suarez-Kurtz G

更新日期：2000-03-10 00:00:00

abstract：:In cystic fibrosis respiratory epithelial cells, the absence or dysfunction of the chloride channel CFTR (Cystic Fibrosis Transmembrane conductance Regulator) results in reduced chloride ion transport. In contrast, Ca2+-stimulated Cl- secretion is intact in cystic fibrosis airway epithelia. One possible target for dru...

journal_title：European journal of pharmacology

authors： Norez C,Vandebrouck C,Antigny F,Dannhoffer L,Blondel M,Becq F

更新日期：2008-09-11 00:00:00

abstract：:3-(Benzo[b]furan-5-yl)-2', 6'-dihydroxy-4'-methylpropiophenone-2'-O-(6-O-methoxycarbonyl)-bet a-D -glucopyranoside (T-1095) is a derivative of phlorizin, a potent inhibitor of Na(+)-glucose cotransporters. We determined the antidiabetic effect of T-1095 in neonatally streptozotocin-treated diabetic rats. Orally admini...

journal_title：European journal of pharmacology

authors： Oku A,Ueta K,Nawano M,Arakawa K,Kano-Ishihara T,Matsumoto M,Saito A,Tsujihara K,Anai M,Asano T

更新日期：2000-03-10 00:00:00

abstract：:The effects of 2-methylthio ATP, an ATP analogue that is more specific for the P2Y receptor, were investigated on insulin secretion in the anesthetized dog in vivo. 2-Methylthio ATP was infused directly into the pancreaticoduodenal artery for 15 min. The infusion was performed so as to obtain a pancreaticoduodenal art...

journal_title：European journal of pharmacology

authors： Ribes G,Bertrand G,Petit P,Loubatières-Mariani MM

更新日期：1988-10-11 00:00:00