Functional evidence for the existence of adenosine receptors in the human heart.

abstract：:In addition to S(-)-nicotine, several minor tobacco alkaloids ((+/-)-nornicotine, anabaseine, S(-)-anabasine, and S(-)-N-methylanabasine) are present in tobacco smoke. This study demonstrates that these alkaloids increase fractional 3H release in a concentration-dependent manner from rat striatal slices preloaded with...

journal_title：European journal of pharmacology

authors： Dwoskin LP,Teng L,Buxton ST,Ravard A,Deo N,Crooks PA

更新日期：1995-03-24 00:00:00

abstract：:The sulfonylurea compounds glisoxepide and glibenclamide inhibit the uptake of bile acids into isolated rat hepatocytes. The Ki values for the inhibition of cholate uptake was 9 microM with glibenclamide and 200 microM with glisoxepide. The inhibition of cholate uptake by both sulfonylureas was noncompetitive. Uptake ...

journal_title：European journal of pharmacology

authors： Fückel D,Petzinger E

更新日期：1992-03-31 00:00:00

abstract：:A new analogue of ANF (atrial natriuretic factor), NNC 70-0270, was tested in various isolated artery preparations. In the rabbit aorta and renal artery NNC 70-0270 was compared with atriopeptin III and the relative inhibitory potency against noradrenaline-induced contractions (atriopeptin III = 1) was found to be 5 a...

journal_title：European journal of pharmacology

authors： Weis J

更新日期：1991-11-19 00:00:00

abstract：:Effects of chelerythrine and bisindolylmaleimide I on action potential duration and on voltage-activated K(+) and Ca(2+) currents in rat ventricular myocytes were studied using perforated patch-clamp technique. The action potentials were markedly prolonged after application of 20 microM chelerythrine or 100 nM bisindo...

journal_title：European journal of pharmacology

authors： Voutilainen-Myllylä S,Tavi P,Weckström M

更新日期：2003-04-11 00:00:00

abstract：:We explored the effects of contractile arrest maintained for 24-72 h in the presence of 2,3-butanedione monoxime or a Ca(2+) channel blocker (nifedipine or verapamil) on contractile activity, Ca(i)(2+) transients, and myofibrillar protein content and ultrastructure in long-term cultures of spontaneously beating adult ...

journal_title：European journal of pharmacology

authors： Horackova M,Byczko Z,Morash B

更新日期：2000-09-22 00:00:00

abstract：:The effects of Bay K 8644 and of nifedipine on histamine-induced mechanical and electrical responses were studied in the longitudinal smooth muscle of the ileum and in the taenia coli isolated from the guinea-pig. Nifedipine (10(-9)-10(-7) M) depressed the tonic and phasic components of histamine contraction. Phasic t...

journal_title：European journal of pharmacology

authors： Morel N,Hardy JP,Godfraind T

更新日期：1987-03-03 00:00:00

abstract：:Calcitonin gene-related peptide (CGRP) released from vasodilator nerves is implicated in the gastroprotective action of capsaicin. This experimental paradigm was used to prove the effectiveness of a monoclonal anti-CGRP antibody. The experiments were performed in anaesthetized rats in which intragastric capsaicin (0.5...

journal_title：European journal of pharmacology

authors： Peskar BM,Wong HC,Walsh JH,Holzer P

更新日期：1993-11-30 00:00:00

abstract：:Foot shocks applied to the rat on a grid floor caused brain noradrenaline depletion. Hemicholinium-3 injected intracerebroventricularly (i.c.v.) blocked the noradrenaline depletion and this blockade was reversed by choline (i.c.v.). Physostigmine (i.c.v.) had different effects according to the age of the rats: "young"...

journal_title：European journal of pharmacology

authors： Campos HA,Romero E

更新日期：1977-08-01 00:00:00

abstract：:The influence of degradation by peptidases on concentration-response relationships for peptide agonists of the tachykinin and bombesin-like families was investigated. The combined presence of three peptidase inhibitors, phosphoramidon (1 microM), captopril (1 microM) and bestatin (100 microM), had no significant effec...

journal_title：European journal of pharmacology

authors： Hall JM,Fox AJ,Morton IK

更新日期：1990-02-06 00:00:00

abstract：:The effects of the alpha-agonists clonidine and guanfacine on rat cortical norepinephrine turnover during morphine withdrawal were assessed. Cortical norepinephrine levels were measured, after administration of alpha-methyl-p-tyrosine, by fluorometric assay. Chronic treatment with morphine did not affect norepinephrin...

journal_title：European journal of pharmacology

authors： Zigun JR,Bannon MJ,Roth RH

更新日期：1981-04-09 00:00:00

abstract：:Removal of the epithelium increased the responsiveness of isolated guinea-pig trachea to the contractile effects of endothelin. This phenomenon was observed in the presence of indomethacin (5 microM), captopril (10 microM), bacitracin (20 micrograms/ml) or leupeptin (50 microM), but was inhibited by phosphoramidon (10...

journal_title：European journal of pharmacology

authors： Hay DW

更新日期：1989-11-21 00:00:00

abstract：:To determine the role of neurokinin A and tachykinin NK2 receptors in processing of nociceptive information at the spinal level, the selective NK2 receptor antagonist, SR 48968 (S)-N-methyl-N [4-(4-acetylamino-4-[phenyl piperidino)-2-(3,4-dichlorophenyl)-butyl] benzamide, was tested for its effects on the hyperalgesia...

journal_title：European journal of pharmacology

authors： Yashpal K,Hui-Chan CW,Henry JL

更新日期：1996-07-11 00:00:00

abstract：:Administration of the 5-HT1C/5-HT2 receptor agonist 1-(2,5-dimethoxy-4- iodophenyl)-2-aminopropane (DOI, 0.125-2.0 mg/kg i.v.) triggered dose-dependent increases in plasma glucose; plasma insulin levels remained unchanged. Pretreatment with the 5-HT1C/5-HT2 receptor antagonists LY 53857, ritanserin, or the mixed 5-HT2...

journal_title：European journal of pharmacology

authors： Chaouloff F,Laude D,Baudrie V

更新日期：1990-10-23 00:00:00

abstract：:In Jurkat T cells, S-triethylphosphinegold(I)-2,3,4,6-tetra-O-acetyl-1-thio-beta-d-glucopyranoside (auranofin) and triethylphosphine gold(I) chloride (TepAu) induced apoptosis, as estimated by DNA fragmentation and visualised by fluorescence microscopy. Apoptosis was characterised by mitochondrial cytochrome c release...

journal_title：European journal of pharmacology

authors： Rigobello MP,Folda A,Dani B,Menabò R,Scutari G,Bindoli A

更新日期：2008-03-17 00:00:00

abstract：:The effects of cytosolic ATP on Ca2+-dependent K+ (K(Ca)) channel activation in cultured bovine adrenal chromaffin cells were investigated by using single-channel recording patch-clamp techniques. Application of ATP to the intracellular surface of excised inside-out patches activated K(Ca) channels in a dose-dependent...

journal_title：European journal of pharmacology

authors： Chen C,Houchi H,Tamaki T,Nakaya Y

更新日期：1998-06-05 00:00:00

abstract：:Calcium entry blockers can effectively preserve high-energy phosphates in ischemic heart. However, little is known about the optimal timing of drug therapy. The moment of nisoldipine administration in relation to its protective efficacy during ischemia and reperfusion was studied in rat hearts. Nisoldipine (50 nM), gi...

journal_title：European journal of pharmacology

authors： De Jong JW

更新日期：1985-11-26 00:00:00

abstract：:Cytotrienin A, a member of the triene-ansamycin family, was initially identified to be an inducer of apoptosis and recently shown to be an inhibitor of translation that interferes with eukaryotic elongation factor 1A function. In human lung carcinoma A549 cells, cytotrienin A was found to inhibit more strongly the cel...

journal_title：European journal of pharmacology

authors： Yamada Y,Taketani S,Osada H,Kataoka T

更新日期：2011-09-30 00:00:00

abstract：:A deamination product of histidine, urocanic acid, accumulates in the skin of mammals as trans-urocanic acid. Ultraviolet (UV) irradition converts it to the cis-isomer that is an important mediator in UV-induced immunosuppression. We have recently shown that urocanic acid interferes with the agonist binding to GABA(A)...

journal_title：European journal of pharmacology

authors： Uusi-Oukari M,Soini SL,Heikkilä J,Koivisto A,Neuvonen K,Pasanen P,Sinkkonen ST,Laihia JK,Jansén CT,Korpi ER

更新日期：2000-07-14 00:00:00

abstract：:The occurrence and characteristics of binding sites specific for gamma-aminobutyric acid (GABA) and muscimol in the rat stomach were examined by biochemical and autoradiographic techniques, and the effects of GABAergic model compounds on gastric ulceration induced by chemical irritation was studied in intact and unila...

journal_title：European journal of pharmacology

authors： Erdö SL,Ezer E,Matuz J,Wolff JR,Amenta F

更新日期：1989-06-08 00:00:00

abstract：:Existing antimuscarinic drugs for overactive bladder have high affinity for M(3)/M(1) muscarinic receptors and consequently produce M(3)/M(1)-mediated adverse effects including dry mouth, constipation, mydriasis and somnolence. TD-6301 is a M(2/4) muscarinic receptor-selective antagonist developed for the treatment of...

journal_title：European journal of pharmacology

authors： McNamara A,Pulido-Rios MT,Sweazey S,Obedencio GP,Thibodeaux H,Renner T,Armstrong SR,Steinfeld T,Hughes AD,Wilson RD,Jasper JR,Mammen M,Hegde SS

更新日期：2009-03-01 00:00:00

abstract：:Recently, it has been revealed that angiotensin II type 1 receptor (AT(1)) antagonists act as antiarrhythmic agents and that the T-type Ca2+ channel plays an important role in arrhythmia. However, it remains unclear how the T-type Ca2+ channel expression system is involved in angiotensin II-mediated arrhythmogenesis i...

journal_title：European journal of pharmacology

authors： Morishima M,Wang Y,Akiyoshi Y,Miyamoto S,Ono K

更新日期：2009-05-01 00:00:00

abstract：:The Nuclear factor (erythroid 2-derived)-like 2 (Nrf2) plays a key role in inflammation which is implicated in the pathophysiology of depression. The Nrf2 activators have antidepressant effects in animal models of depression. The present study was undertaken to examine whether TBE-31 [(±)-(4bS,8aR,10aS)-10a-ethynyl-4b...

journal_title：European journal of pharmacology

authors： Yao W,Zhang JC,Ishima T,Ren Q,Yang C,Dong C,Ma M,Saito A,Honda T,Hashimoto K

更新日期：2016-12-15 00:00:00

abstract：:In the present study, we investigated whether copper ions are involved in the decomposition of endogenous S-nitrosothiols by ultraviolet (UV) light irradiation in the mouse gastric fundus. The effects of copper ions and chelators of copper(I) and copper(II), neocuproine and cuprozine, respectively, were studied on rel...

journal_title：European journal of pharmacology

authors： Ogülener N,Ergün Y

更新日期：2004-02-06 00:00:00

abstract：:The binding affinity of olanzapine, clozapine and atropine for muscarinic receptor subtypes in clonal Chinese hamster ovary (CHO) cell lines was compared in intact cells in physiological media to disrupted cells in hypotonic buffer. The affinity of olanzapine and clozapine, but not atropine, for muscarinic receptor su...

journal_title：European journal of pharmacology

authors： Bymaster FP,Falcone JF

更新日期：2000-03-03 00:00:00

abstract：:The effects of RX 781094, a new and potent alpha 2-adrenoceptor antagonist, on locus coeruleus (LC) unit activity were examined. Low doses of RX 781094 produced suppression of spontaneous LC unit activity which could be reversed with yohimbine. The increase in LC firing produced by WB 4101 could also be reversed with ...

journal_title：European journal of pharmacology

authors： Goldstein JM,Knobloch LC,Malick JB

更新日期：1983-07-15 00:00:00

abstract：:Factor Xa inhibitors reduce stroke in patients with atrial fibrillation. Pulmonary veins (PVs) and the sinoatrial node (SAN) are crucial for genesis of atrial fibrillation. However, the electrophysiological effects of factor Xa inhibitors (edoxaban and rivaroxaban) on PVs and the SAN remain unclear. Conventional micro...

journal_title：European journal of pharmacology

authors： Chang CJ,Cheng CC,Chen YC,Higa S,Huang JH,Chen SA,Chen YJ

更新日期：2018-08-15 00:00:00

abstract：:In our continuing search to discover bioactive compounds from natural products, we isolated six new clerodane diterpenes, caseamembrins A to F, from Casearia membranacea and examined their antiproliferative activities in human hormone-resistant prostate cancer PC-3 cells. All of these compounds displayed effective ant...

journal_title：European journal of pharmacology

authors： Huang DM,Shen YC,Wu C,Huang YT,Kung FL,Teng CM,Guh JH

更新日期：2004-10-25 00:00:00

abstract：:Clinical evidence indicates an antiarrhythmic effect of sulfonylureas, which might be blunted by their vascular action. We wanted to investigate the effect of glibenclamide and the new sulfonylthiourea compound 1-[[5-[2-(5-chloro-o-anisamido)ethyl]-2-methoxyphenyl]-sulfonyl]-3 -me thylthiourea (HMR1883) on cardiac ele...

journal_title：European journal of pharmacology

authors： Dhein S,Pejman P,Krüsemann K

更新日期：2000-06-16 00:00:00

abstract：:Parkinson's disease is a neuropathological disorder involving the degeneration of dopamine neurons in the substantia nigra, with the resultant loss of their terminals in the striatum. This dopamine loss causes most of the motor disturbances associated with the disease. One animal model of Parkinson's disease involves ...

journal_title：European journal of pharmacology

authors： Boules M,Warrington L,Fauq A,McCormick D,Richelson E

更新日期：2001-10-05 00:00:00

abstract：:The non N-methyl-D-aspartate (NMDA) receptor antagonists dinitroquinoxaline-2,3-dione (DNQX) and 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX), both inhibit the visually driven response of sustained ganglion cells in the cat retina in vivo. In contrast to these findings, the potent NMDA receptor antagonist 3-[+/- )-2-ca...

journal_title：European journal of pharmacology

authors： Kay CD,Ikeda H

更新日期：1989-05-19 00:00:00