当前位置： SCI文献检索 > EUROPEAN JOURNAL OF PHARMACOLOGY期刊下所有文献 > Inhibition by heparin of platelet activation induced by neutrophil-derived cathepsin G.

Inhibition by heparin of platelet activation induced by neutrophil-derived cathepsin G.

Abstract：

:Heparin is the most widely used anticoagulant drug for prevention and treatment of thrombosis. However, inhibition of blood coagulation might not fully explain the antithrombotic activity of this drug. The present study shows that different heparin preparations (50 nM) completely prevent human platelet aggregation, serotonin release and thromboxane B2 production induced by purified neutrophil-derived cathepsin G (E.C. No. 3.4.21.20). This inhibitory effect was not related to the anticoagulant property of the compounds, since a heparin preparation with an inactivated active for antithrombin III was also effective. Heparins inhibited the protease activity of the enzyme over the same range of concentrations. Since the effect of cathepsin G on platelets requires an intact proteolytic active site, the inhibitory effect of the drugs on cathepsin G-induced platelet activation may be explained by a blockade of protease activity. Heparins were also shown to reduce platelet activation induced by cathepsin G released from activated polymorphonuclear leucocytes in mixed cell suspensions. As polymorphonuclear leucocytes might contribute to both arterial and venous thrombosis through platelet activation induced by the release of cathepsin G, this novel property of heparin could be used to optimize its antithrombotic efficacy.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Evangelista V,Piccardoni P,Maugeri N,De Gaetano G,Cerletti C

doi

10.1016/0014-2999(92)90437-9

keywords:

subject

Has Abstract

pub_date

1992-06-17 00:00:00

pages

401-5

issue

3

eissn

0014-2999

issn

1879-0712

pii

0014-2999(92)90437-9

journal_volume

216

pub_type

杂志文章

相关文献

EUROPEAN JOURNAL OF PHARMACOLOGY文献大全
  • Blockade of cannabinoid CB1 receptors alters contextual learning and memory.

    abstract：:The endocannabinoid system appears to have an important role in specific aspects of learning and memory, yet there has been no systematic study of the role of cannabinoid receptors in contextual fear conditioning. The present study examined the effects of cannabinoid CB(1) receptor blockade on the acquisition, consoli...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2006.04.017

    authors： Arenos JD,Musty RE,Bucci DJ

    更新日期：2006-06-13 00:00:00

  • Acute and chronic bupropion treatment does not prevent morphine-induced conditioned place preference in mice.

    abstract：:A substantial barrier to the treatment of Opioid Use Disorder (OUD) is the elevated relapse rates in affected patients, and a significant contributor to these events of relapse is exposure to cues and contexts that are intensely associated with prior drug abuse. The neurotransmitter dopamine plays a key role in reward...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2020.173638

    authors： McKendrick G,Sharma S,Sun D,Randall PA,Graziane NM

    更新日期：2020-12-15 00:00:00

  • Chronic high dose P2X7 receptor inhibition exacerbates cancer-induced bone pain.

    abstract：:The functional role of P2X7 receptor (P2X7R) inhibition in cancer-induced bone pain has been highly contradictory. Whereas knockout studies have suggested pro-nociceptive effects, pharmacological studies suggest anti-nociceptive or no effect. The discrepancy is likely linked to the highly polymorphic nature of the P2X...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2018.12.032

    authors： Falk S,Appel CK,Bennedbæk HB,Al-Dihaissy T,Unger A,Dinkel K,Heegaard AM

    更新日期：2019-02-15 00:00:00

  • Paeoniflorin inhibits imiquimod-induced psoriasis in mice by regulating Th17 cell response and cytokine secretion.

    abstract：:Paeoniflorin (PF) is the main active ingredients of radix paeoniae rubra and radix paeoniae alba, which are used widely in Traditional Chinese Medicine. This study aimed to assess the capacity of PF to inhibit imiquimod (IMQ)-induced psoriasis. Mice treated with IMQ were divided into four groups and administered 240mg...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2015.12.040

    authors： Zhao J,Di T,Wang Y,Wang Y,Liu X,Liang D,Li P

    更新日期：2016-02-05 00:00:00

  • Caprolactam-barbiturate interaction at the GABAA receptor complex in the guinea-pig intestine.

    abstract：:4,6,6-Trimethylcaprolactam antagonised GABAA receptor-mediated contractile responses in guinea-pig isolated ileum, displacing the GABA dose-response curve to the right in a non-parallel manner, and causing a depression of the maximum response. Pentobarbitone not only potentiated the GABAA receptor-mediated contraction...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(86)90146-9

    authors： Kerr DI,Ong J,Prager RH,Ward DA

    更新日期：1986-05-13 00:00:00

  • Effects of CS-518, a thromboxane synthase inhibitor, on eosinophil function.

    abstract：:The effects of CS-518 (sodium 2-(1-imidazolylmethyl)-4,5-dihydrobenzo[b]thiophene-6-carboxylate) , a thromboxane A2 synthase inhibitor, on eosinophil accumulation and activation were investigated in an experimental asthmatic guinea pig model and several cellular models. In the in vivo studies, CS-518 inhibited the bip...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(93)90989-u

    authors： Itoh K,Mukaiyama O,Satoh Y,Yamaguchi T,Iizuka Y

    更新日期：1993-08-03 00:00:00

  • Imidazoline I2 receptors: target for new analgesics?

    abstract：:Pain remains a major clinical challenge because there are no effective analgesics for some pain conditions and the mainstay analgesics for severe pain, opioids, have serious unwanted effects. There is a dire need for novel analgesics in the clinic. Imidazoline receptors are a family of three receptors (I(1), I(2) and ...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ejphar.2011.02.038

    authors： Li JX,Zhang Y

    更新日期：2011-05-11 00:00:00

  • Valproic acid promotes the epithelial-to-mesenchymal transition of breast cancer cells through stabilization of Snail and transcriptional upregulation of Zeb1.

    abstract：:Histone deacetylases (HDACs) can regulate cancer progression and its inhibitors (HDACIs) have been widely used for cancer therapy. Valproic acid (VPA, 2-propylpentanoic acid) can inhibit the class I HDAC and suppress the malignancy of solid cancers. Our present study revealed that 1 mM VPA, which has no effect on cell...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2019.172745

    authors： Zhang S,Tang Z,Qing B,Tang R,Duan Q,Ding S,Deng D

    更新日期：2019-12-15 00:00:00

  • Enhanced endothelial nitric oxide activity contributes to the reduced responsiveness of vascular alpha1-adrenoceptors following aortic barodenervation.

    abstract：:We have recently shown that short-term aortic barodenervation diminishes constrictor responses to activation of alpha1-adrenoceptors in rat aortic smooth muscle. This study investigated the potential role of vascular endothelium and its derived vasoactive substances, nitric oxide and prostaglandins, in the reduced alp...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0014-2999(97)01283-1

    authors： El-Mas MM,Daabees TT,El-Gowelli HM,Abdel-Galil AG

    更新日期：1997-10-22 00:00:00

  • [3H]rauwolscine labels alpha 2-adrenoceptors and 5-HT1A receptors in human cerebral cortex.

    abstract：:[3H]Rauwolscine binds with high affinity to alpha 2-adrenoceptors (Kd = 4.8 +/- 1.3 nM, Bmax = 79 +/- 26 fmol/mg protein, micromolar affinity for 5-HT) as well as to 5-HT1-like receptors (Kd = 13 +/- 2.7 nM, Bmax = 147 +/- 11.4 fmol/mg protein, nanomolar affinity for 5-HT) in human brain cortex membranes. The Ki value...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(89)90163-5

    authors： Convents A,De Keyser J,De Backer JP,Vauquelin G

    更新日期：1989-01-17 00:00:00

  • An inhibitory effect of A20 on NF-kappaB activation in airway epithelium upon influenza virus infection.

    abstract：:Influenza is a major disease in humans. The reemergence of avian influenza A viruses has indicated that hyperinflammatory responses are closely related to the severity of disease. Influenza virus infection induces nuclear transcription factor kappaB (NF-kappaB) activation. NF-kappaB and NF-kappaB-dependent gene produc...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2006.03.073

    authors： Onose A,Hashimoto S,Hayashi S,Maruoka S,Kumasawa F,Mizumura K,Jibiki I,Matsumoto K,Gon Y,Kobayashi T,Takahashi N,Shibata Y,Abiko Y,Shibata T,Shimizu K,Horie T

    更新日期：2006-07-17 00:00:00

  • Anti-tumor necrosis factor agent PEG-sTNFRI improves the growth hormone/insulin-like growth factor-I system in adjuvant-induced arthritic rats.

    abstract：:Adjuvant-induced arthritis is associated with body weight loss and decreased pituitary growth hormone (GH) and hepatic insulin-like growth factor-I (IGF-I) synthesis. Cytokines as tumor necrosis factor (TNF) mediate wasting associated with chronic inflammation. The aim of this study was to analyse whether the inhibiti...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2006.02.035

    authors： Granado M,Priego T,Martín AI,Vara E,López-Calderón A,Angeles Villanúa M

    更新日期：2006-04-24 00:00:00

  • Phenylmethimazole and a thiazole derivative of phenylmethimazole inhibit IL-6 expression by triple negative breast cancer cells.

    abstract：:Inhibition of interleukin-6 (IL-6) holds significant promise as a therapeutic approach for triple negative breast cancer (TNBC). We previously reported that phenylmethimazole (C10) reduces IL-6 expression in several cancer cell lines. We have identified a more potent derivative of C10 termed COB-141. In the present wo...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2017.03.049

    authors： Noori MS,O'Brien JD,Champa ZJ,Deosarkar SP,Lanier OL,Qi C,Burdick MM,Schwartz FL,Bergmeier SC,McCall KD,Goetz DJ

    更新日期：2017-05-15 00:00:00

  • Felbamate reduces hypoxic-ischemic brain damage in vivo.

    abstract：:The neuroprotective effects of felbamate were tested in a model of incomplete cerebral ischemia and hypoxia in 7-day-old rat pups. Felbamate pretreatment (300 mg/kg) reduced the surface of infarcted cortex following bilateral carotid ligation, by 42-49% compared to saline and dimethylsulfoxide (DMSO) controls, respect...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(92)90343-3

    authors： Wasterlain CG,Adams LM,Hattori H,Schwartz PH

    更新日期：1992-03-03 00:00:00

  • A dopamine mechanism is implied in the acquisition and expression of amphetamine and stress-induced effects observed in the lymphocyte subpopulations.

    abstract：:Drugs of abuse and stress are associated with changes in circulating cell populations and reductions in cell-mediated immune responses. The main goal of this study was to determine the influence of repeated and acute d-amphetamine treatments on the foot-shock stress-induced effects on the peripheral lymphocyte subpopu...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2008.02.007

    authors： Assis MA,Pacchioni AM,Collino C,Paz MC,Sotomayor C,Basso AM,Cancela LM

    更新日期：2008-04-28 00:00:00

  • LK 204-545, a highly selective beta1-adrenoceptor antagonist at human beta-adrenoceptors.

    abstract：:LK 204-545 ((+/-)-1-(2-(3-(2-cyano-4-(2-cyclopropyl-methoxy-ethoxy)phenoxy)-2-hydro xy-propyl-amino)-ethyl)-3-(4-hydrxy-phenyl) urea), an antagonist that possesses high beta1-/beta2-selectivity in the rat, and a range of cardio-selective and non-selective beta-adrenoceptor antagonists were examined to compare their ra...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0014-2999(99)00019-9

    authors： Louis SN,Nero TL,Iakovidis D,Jackman GP,Louis WJ

    更新日期：1999-02-19 00:00:00

  • Analgesic synergy between topical opioids and topical non-steroidal anti-inflammatory drugs in the mouse model of thermal pain.

    abstract：:The main aim of the study was to examine analgesic effects of the topical opioids and non-steroidal anti-inflammatory drugs (NSAIDs) in a radiant heat tail-flick nociception model. Also, we have tested whether the addition of lauric acid to propylene glycol improves skin permeation for the opioids and NSAIDs. We found...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2007.10.014

    authors： Kolesnikov Y,Sõritsa D

    更新日期：2008-01-28 00:00:00

  • Vasopressin V1A receptor mediates cell proliferation through GRK2-EGFR-ERK1/2 pathway in A7r5 cells.

    abstract：:Abnormal proliferation and hypertrophy of vascular smooth muscle (VSMC), as the main structural component of the vasculature, is an important pathological mechanism of hypertension. Recently, increased levels of arginine vasopressin (AVP) and copeptin, the C-terminal fragment of provasopressin, have been shown to corr...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2016.10.023

    authors： Zhang L,Wang X,Cao H,Chen Y,Chen X,Zhao X,Xu F,Wang Y,Woo AY,Zhu W

    更新日期：2016-12-05 00:00:00

  • Intrathecal Raf-1-selective siRNA attenuates sustained morphine-mediated thermal hyperalgesia.

    abstract：:Studies have demonstrated that long-term opioid treatment leads to an increased sensitivity to painful (hyperalgesia) or normally innocuous (allodynia) stimuli. The molecular mechanisms that lead to paradoxical pain sensitization upon chronic opioid treatment are not completely understood. Enhanced excitatory pain neu...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2008.10.033

    authors： Tumati S,Milnes TL,Yamamura HI,Vanderah TW,Roeske WR,Varga EV

    更新日期：2008-12-28 00:00:00

  • Inhibitory and stimulatory actions of danazol in rat ovarian and uterine tissues.

    abstract：:We examined whether danazol has a direct action on ovarian steroid secretion and/or uterine prostaglandin (PG) F2 alpha catabolic activity in immature rats in which the first ovulation was induced and in adult ovariectomized rats. The preovulatory surge of estradiol and progesterone was markedly suppressed together wi...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(92)90264-5

    authors： Kogo H,Takasaki K,Yatabe Y,Nishikawa M,Takeo S,Tamura K

    更新日期：1992-01-28 00:00:00

  • Cobalt(II) β-ketoaminato complexes as novel inhibitors of neuroinflammation.

    abstract：:Neuroinflammation contributes to the pathogenesis of neurological disorders including stroke, head trauma, multiple sclerosis, amyotrophic lateral sclerosis as well as age-associated neurodegenerative disorders including Alzheimer's and Parkinson's diseases. Therefore, anti-inflammatory drugs could be used to slow the...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2011.11.038

    authors： Madeira JM,Beloukhina N,Boudreau K,Boettcher TA,Gurley L,Walker DG,McNeil WS,Klegeris A

    更新日期：2012-02-15 00:00:00

  • Emerging drug targets for pain treatment.

    abstract：:Pain is a global health challenge. For decades, we have been primarily relying upon opioids and nonsteroidal anti-inflammatory drugs (NSAIDs) for pain management. However, adverse effects related to opioid and NSAID use are severe and often lead to forced drug discontinuation and inadequate pain relief. Despite decade...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ejphar.2012.01.017

    authors： Li JX,Zhang Y

    更新日期：2012-04-15 00:00:00

  • Antidiabetic effect of T-1095, an inhibitor of Na(+)-glucose cotransporter, in neonatally streptozotocin-treated rats.

    abstract：:3-(Benzo[b]furan-5-yl)-2', 6'-dihydroxy-4'-methylpropiophenone-2'-O-(6-O-methoxycarbonyl)-bet a-D -glucopyranoside (T-1095) is a derivative of phlorizin, a potent inhibitor of Na(+)-glucose cotransporters. We determined the antidiabetic effect of T-1095 in neonatally streptozotocin-treated diabetic rats. Orally admini...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0014-2999(00)00016-9

    authors： Oku A,Ueta K,Nawano M,Arakawa K,Kano-Ishihara T,Matsumoto M,Saito A,Tsujihara K,Anai M,Asano T

    更新日期：2000-03-10 00:00:00

  • Allosteric interactions of three muscarine antagonists at bovine tracheal smooth muscle and cardiac M2 receptors.

    abstract：:The kinetics of [3H]dexetimide dissociation from muscarine receptors in bovine cardiac left ventricular and tracheal smooth muscle membranes were studied in the absence and presence of three muscarine antagonists. It was found that [3H]dexetimide dissociation from cardiac muscarine receptors was monophasic and very fa...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0922-4106(89)90045-x

    authors： Roffel AF,Elzinga CR,Meurs H,Zaagsma J

    更新日期：1989-03-07 00:00:00

  • Modification of effects of chronic electroconvulsive shock by voltage-dependent Ca2+ channel blockade with nifedipine.

    abstract：:A single electroconvulsive shock produced analgesia (expressed as prolongation of hot-plate latency) in Wistar rats 45 min after the shock. The analgesic action was prevented by administration of nifedipine, 5 mg/kg i.p., 15 min before the electroconvulsive shock, while nifedipine injection after electroconvulsive sho...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(94)90363-8

    authors： Antkiewicz-Michaluk L,Michaluk J,Vetulani J

    更新日期：1994-03-11 00:00:00

  • Stereoselectivity of procyclidine binding to muscarinic receptor subtypes M1, M2 and M4.

    abstract：:The goals of the present study were: (1) to investigate the binding properties of (R)- and (S)-procyclidine and two achiral derivatives of muscarinic M1, M2 and M4 receptor subtypes and (2) to identify the interactions which allow these receptors to discriminate between the two stereoisomers. (R)-Procyclidine showed a...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0922-4106(90)90017-r

    authors： Waelbroeck M,Camus J,Tastenoy M,Lambrecht G,Mutschler E,Tacke R,Christophe J

    更新日期：1990-09-18 00:00:00

  • Cannabidiol administration reduces sublesional cancellous bone loss in rats with severe spinal cord injury.

    abstract：:Patients with spinal cord injury (SCI) undergo severe loss of bone mineral below the level of lesion, and data on available treatment options after SCI is scarce. The aim of this work was to investigate the therapeutic effect of cannabidiol (CBD), a non-psychoactive cannabis, on sublesional bone loss in a rat model of...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2017.05.011

    authors： Li D,Lin Z,Meng Q,Wang K,Wu J,Yan H

    更新日期：2017-08-15 00:00:00

  • Exploration of Emodin to treat alpha-naphthylisothiocyanate-induced cholestatic hepatitis via anti-inflammatory pathway.

    abstract：:Emodin, 1,3,8-trihydroxy-6-methyl-anthraquinone, is an anthraquinone derivative from the roots of Rheum officinale Baill that has been used to treat many diseases in digestive system for thousands of years. This study is to disclose the mechanism of Emodin to treat cholestatic hepatitis via anti-inflammatory pathway. ...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2008.06.044

    authors： Ding Y,Zhao L,Mei H,Zhang SL,Huang ZH,Duan YY,Ye P

    更新日期：2008-08-20 00:00:00

  • GABAergic blockade of cocaine-associated cue-induced increases in nucleus accumbens dopamine.

    abstract：:Environments previously associated with drug use can become one of the most common factors triggering relapse to drug-seeking behavior. To better understand the neurochemical mechanisms potentially mediating these cues, we measured nucleus accumbens dopamine levels in animals exposed to environmental cues previously p...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0014-2999(01)00800-7

    authors： Gerasimov MR,Schiffer WK,Gardner EL,Marsteller DA,Lennon IC,Taylor SJ,Brodie JD,Ashby CR Jr,Dewey SL

    更新日期：2001-03-02 00:00:00

  • The aetiology of gastric ulceration induced by electrical vagal stimulation in rats.

    abstract：:Histamine and serotonin levels in gastric secretion and the effects of pharmacological antagonists were studied in rats in which stomach ulceration was induced by electrical vagal stimulation. Electrical vagal stimulation (2 and 5 V) produced a graded increase in haemorrhagic glandular mucosal ulcers. NaHCO3 perfusion...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(85)90213-4

    authors： Cho CH,Hung KM,Ogle CW

    更新日期：1985-04-02 00:00:00