Abstract:
:The neuroprotective effects of felbamate were tested in a model of incomplete cerebral ischemia and hypoxia in 7-day-old rat pups. Felbamate pretreatment (300 mg/kg) reduced the surface of infarcted cortex following bilateral carotid ligation, by 42-49% compared to saline and dimethylsulfoxide (DMSO) controls, respectively. The number of necrotic neurons in the dentate gyrus was reduced by 77% over both DMSO controls and saline controls. These results suggest that felbamate deserves further evaluation for its therapeutic potential in hypoxia-ischemia.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Wasterlain CG,Adams LM,Hattori H,Schwartz PHdoi
10.1016/0014-2999(92)90343-3keywords:
subject
Has Abstractpub_date
1992-03-03 00:00:00pages
275-8issue
2-3eissn
0014-2999issn
1879-0712pii
0014-2999(92)90343-3journal_volume
212pub_type
杂志文章abstract::Ischemia reperfusion (I/R) injury is a cellular damage in a hypoxic organ following the restoration of oxygen delivery. It may occur during organ transplantation, trauma and hepatectomies. Nitric oxide (NO) effects during hepatic I/R are complicated. The iNOS-derived NO has a deleterious effect, whereas eNOS-derived N...
journal_title:European journal of pharmacology
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journal_title:European journal of pharmacology
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