Felbamate reduces hypoxic-ischemic brain damage in vivo.

Abstract:

:The neuroprotective effects of felbamate were tested in a model of incomplete cerebral ischemia and hypoxia in 7-day-old rat pups. Felbamate pretreatment (300 mg/kg) reduced the surface of infarcted cortex following bilateral carotid ligation, by 42-49% compared to saline and dimethylsulfoxide (DMSO) controls, respectively. The number of necrotic neurons in the dentate gyrus was reduced by 77% over both DMSO controls and saline controls. These results suggest that felbamate deserves further evaluation for its therapeutic potential in hypoxia-ischemia.

journal_name

Eur J Pharmacol

authors

Wasterlain CG,Adams LM,Hattori H,Schwartz PH

doi

10.1016/0014-2999(92)90343-3

keywords:

subject

Has Abstract

pub_date

1992-03-03 00:00:00

pages

275-8

issue

2-3

eissn

0014-2999

issn

1879-0712

pii

0014-2999(92)90343-3

journal_volume

212

pub_type

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