Blockade of cannabinoid CB1 receptors alters contextual learning and memory.

abstract：:The effects on rat serum prolactin level of the two isomers constituting the racemic form of amisulpride were compared. (S-)-amisulpride induced hyperprolactinemia at lower doses (ED(50) = 0.09 +/- 0.01 mg/kg) than racemic- (ED(50) = 0.24 +/- 0.03 mg/kg) and (R+)-amisulpride (ED(50) = 4.13 +/- 0.05 mg/kg), in accord w...

journal_title：European journal of pharmacology

authors： Marchese G,Ruiu S,Casti P,Saba P,Gessa GL,Pani L

更新日期：2002-07-19 00:00:00

abstract：:In the present study we showed that the alpha-adrenoceptor antagonists phentolamine, yohimbine, prazosin, corynanthine and idazoxan, when cumulatively applied in high concentrations (1-100 mumol/l), can increase spontaneous myogenic activity in the rat portal vein. 5-Methyl-urapidil and rauwolscine were ineffective in...

journal_title：European journal of pharmacology

authors： Schwietert R,Wilhelm D,Wilffert B,Van Zwieten PA

更新日期：1992-01-28 00:00:00

abstract：:The effect of Bay K 8644 on contractile responses to angiotensin II (AII) was investigated in rabbit aorta. Bay K 8644 alone did not elicit contraction while contractile responses to AII were enhanced at low concentrations (10(-8), 3 X 10(-8), 10(-7) M) and depressed at a higher concentration (10(-6) M). The potentiat...

journal_title：European journal of pharmacology

authors： Roy F,Pruneau D

更新日期：1986-07-15 00:00:00

abstract：:The effects of almitrine on the contractile properties of isolated geniohyoid and sternohyoid muscles were determined in physiological salt solution at 30 degrees C in young and old rats. In young rats, almitrine had no effect on twitch or tetanic tension, twitch:tetanic tension ratio, contractile kinetics, active or ...

journal_title：European journal of pharmacology

authors： Cantillon D,Bradford A

更新日期：2001-01-26 00:00:00

abstract：:Saturable, high-affinity binding sites for [3H]saxitoxin were identified in equine portal vein smooth muscle membranes. These sites had a dissociation constant of 0.29 nM and a maximal binding capacity of 115 fmol.mg-1 of protein. A similar dissociation constant was obtained with cells prepared from rat portal vein. S...

journal_title：European journal of pharmacology

authors： Mironneau J,Martin C,Arnaudeau S,Jmari K,Rakotoarisoa L,Sayet I,Mironneau C

更新日期：1990-08-10 00:00:00

abstract：:The effects of chronic neuroleptic treatment on the concentrations of homovanillic acid (HVA) and 3,4-dihydroxy-phenylacetic acid (DOPAC) in the rat substantia nigra (SN) and corpus striatum (CS) were determined. Acute haloperidol and alpha-flupenthixol increased HVA and DOPAC in the CS but after chronic treatment no ...

journal_title：European journal of pharmacology

authors： Nicolaou NM

更新日期：1980-06-13 00:00:00

abstract：:In the rat distal colon, 5-hydroxytryptamine (5-HT)-induced Cl- secretion is seen as a rise in short circuit current (Isc). We investigated the 5-HT receptor mediating 5-HT-induced Cl- secretion in the rat distal colon. Rat distal colon was prepared either by stripping away the muscularis propria with the neural gangl...

journal_title：European journal of pharmacology

authors： Budhoo MR,Harris RP,Kellum JM

更新日期：1996-03-07 00:00:00

abstract：:The beta-antagonistic effects of celiprolol were assessed in isolated guinea-pig preparations. The pA2 values obtained were 7.84 +/- 0.07, 7.79 +/- 0.06 and 6.45 +/- 0.11 against the positive chronotropic and inotropic effects in the atria and relaxant effects in the trachea induced by isoproterenol, respectively, ind...

journal_title：European journal of pharmacology

authors： Ochi S,Nakazawa M,Kimura T,Nakagawa Y,Imai S

更新日期：1991-02-26 00:00:00

abstract：:The existence of neurogenic mediator candidates apart from noradrenaline and acetylcholine involved in the control of vascular tone has attracted enormous attention during the past few decades. One such mediator is neuropeptide Y (NPY), which is co-localized with noradrenaline in sympathetic perivascular nerves. Stimu...

journal_title：European journal of pharmacology

authors： Franco-Cereceda A,Liska J

更新日期：1998-05-15 00:00:00

abstract：:The repeated administration of N-methyl-beta-carboline-3-carboxamide (FG 7142) to mice leads to 'chemical kindling', i.e. the development of seizures in response to doses which were initially insufficient to produce convulsive activity. To determine if chemical kindling produced changes in the GABAA receptor/chloride ...

journal_title：European journal of pharmacology

authors： Lewin E,Peris J,Bleck V,Zahniser NR,Harris RA

更新日期：1989-01-24 00:00:00

abstract：:We have investigated the effects of the ethacrynic acid derivative 4-(2-butyl-6,7-dichloro-2-cyclopentyl-indan-1-on-5-yl) oxobutyric acid (DCPIB), an inhibitor of the volume-sensitive anion channel (VSAC), on electrical activity and insulin secretion in rat pancreatic beta-cells. DCPIB inhibited whole-cell VSAC curren...

journal_title：European journal of pharmacology

authors： Best L,Yates AP,Decher N,Steinmeyer K,Nilius B

更新日期：2004-04-05 00:00:00

abstract：:Endogenous hydrogen sulfide is produced by cystathionine-γ-lyase and cystathionine-β-synthase in a variety of tissues and has recently been implicated in the regulation of cardiac functions. Acceleration of the heart rate in response to catecholamines is impaired in patients with cirrhosis. The present study was aimed...

journal_title：European journal of pharmacology

authors： Babaei-Karamshahlou M,Hooshmand B,Hajizadeh S,Mani AR

更新日期：2012-12-05 00:00:00

abstract：:The effect of i.v. morphine on the spinal nociceptive flexor reflex was examined in decerebrate, unanesthetized rats in which the spinal cord was acutely or chronically transected. In acutely spinalized rats i.v. morphine dose dependently depressed the flexor reflex with an ED50 of 1.4 mg/kg. In rats in which the spin...

journal_title：European journal of pharmacology

authors： Hao JX,Wiesenfeld-Hallin Z,Xu XJ

更新日期：1990-12-04 00:00:00

abstract：:We examined the effects of intrarenal infusion of EXP3174, a non-peptide angiotensin II receptor antagonist, in order to evaluate the physiological role of endogenous angiotensin II in regulating renal hemodynamics and urine formation and to assess the possibility of a tubular site(s) of action of endogenous angiotens...

journal_title：European journal of pharmacology

authors： Tamaki T,Nishiyama A,Yoshida H,He H,Fukui T,Yamamoto A,Aki Y,Kimura S,Iwao H,Miyatake A

更新日期：1993-05-12 00:00:00

abstract：:The neuroprotective effects of felbamate were tested in a model of incomplete cerebral ischemia and hypoxia in 7-day-old rat pups. Felbamate pretreatment (300 mg/kg) reduced the surface of infarcted cortex following bilateral carotid ligation, by 42-49% compared to saline and dimethylsulfoxide (DMSO) controls, respect...

journal_title：European journal of pharmacology

authors： Wasterlain CG,Adams LM,Hattori H,Schwartz PH

更新日期：1992-03-03 00:00:00

abstract：:Neuropeptides represent by far the most common signalling molecules in the central nervous system. They are involved in a wide range of physiological functions and can act as neurotransmitters, neuromodulators or hormones in the central nervous system and in the periphery. Accumulating evidence during the past 40 year...

journal_title：European journal of pharmacology

authors： Ogren SO,Kuteeva E,Elvander-Tottie E,Hökfelt T

更新日期：2010-01-10 00:00:00

abstract：:The stress-induced hyperthermia procedure, in which effects of drugs on basal (T(1)) and stress-induced body temperature (T(2)) are measured, predicts anxiolytic drug effect. Serotonergic drugs alter these responses and here, we studied the role of 5-HT(1A) receptors in stress-induced hyperthermia by using 5-HT(1A) re...

journal_title：European journal of pharmacology

authors： Van Bogaert M,Oosting R,Toth M,Groenink L,van Oorschot R,Olivier B

更新日期：2006-11-21 00:00:00

abstract：:Dihydropyridine Ca(2+) channel antagonists (DHPs) block Ca(V)1.2 L-type Ca(2+) channels (LTCCs) by stabilizing their voltage-dependent inactivation (VDI); however, it is still not clear how DHPs allosterically interact with the kinetically distinct (fast and slow) VDI. Thus, we analyzed the effect of a prototypical DH...

journal_title：European journal of pharmacology

authors： Sheng X,Nakada T,Kobayashi M,Kashihara T,Shibazaki T,Horiuchi-Hirose M,Gomi S,Hirose M,Aoyama T,Yamada M

更新日期：2012-06-15 00:00:00

abstract：:Existing antimuscarinic drugs for overactive bladder have high affinity for M(3)/M(1) muscarinic receptors and consequently produce M(3)/M(1)-mediated adverse effects including dry mouth, constipation, mydriasis and somnolence. TD-6301 is a M(2/4) muscarinic receptor-selective antagonist developed for the treatment of...

journal_title：European journal of pharmacology

authors： McNamara A,Pulido-Rios MT,Sweazey S,Obedencio GP,Thibodeaux H,Renner T,Armstrong SR,Steinfeld T,Hughes AD,Wilson RD,Jasper JR,Mammen M,Hegde SS

更新日期：2009-03-01 00:00:00

abstract：:The vasoinhibitory effects of MCI-154 (MCI), a new pyridazione derivative, on contractile responses to alpha 1- and alpha 2-adrenoceptor agonists were examined in isolated rabbit aorta. MCI (10(-8)-10(-5) M) inhibited the maximum contractile responses to clonidine and BHT-920 (BHT) in a concentration-dependent manner,...

journal_title：European journal of pharmacology

authors： Shibata S,Satake N,Hester RK,Kurahashi K,Ito M

更新日期：1988-01-12 00:00:00

abstract：:[14C]Guanidinium ion influx into Na+ channel preparations from mouse and rat cerebral cortex (purified synaptosomes, and synaptoneurosomes) was characterized and its properties were compared with those for 22Na+ influx. Tetrodotoxin-sensitive influx of [14C]guanidinium ion was stimulated by aconitine, veratridine, and...

journal_title：European journal of pharmacology

authors： Reith ME

更新日期：1990-01-23 00:00:00

abstract：:Bone marrow stem cells are able to differentiate into nervous and endothelial cells. In our study, we found that administration of a bone marrow-stimulating factor (granulocyte colony-stimulating factor; G-CSF 50 microg/kg) decrease the brain infarct volume and enhance survival rate in a model of cerebral ischemia. Ta...

journal_title：European journal of pharmacology

authors： Six I,Gasan G,Mura E,Bordet R

更新日期：2003-01-05 00:00:00

abstract：:Activated factor X (FXa) is an important player in the coagulation cascade responsible for thrombin generation, which is activated during atrial fibrillation. Increasing evidence suggests that FXa influences cell signalling in various cell types by activating protease-activated receptors (PARs). It is so far not known...

journal_title：European journal of pharmacology

authors： Bukowska A,Zacharias I,Weinert S,Skopp K,Hartmann C,Huth C,Goette A

更新日期：2013-10-15 00:00:00

abstract：:The mechanism of the anti-inflammatory effect of proglumetacin maleate, a novel indomethacin derivative, was examined in vivo in an allergic air pouch inflammation model in rats. Proglumetacin maleate did not affect the volume of pouch exudate 6 h after immunological challenge, irrespective of whether it was administe...

journal_title：European journal of pharmacology

authors： Ono N,Sunami A,Yamasaki Y,Yamamoto N,Miyake H

更新日期：1987-10-13 00:00:00

abstract：:An excess of lipids may accumulate in the kidney in conditions such as diabetes and hypertension, and can potentially cause renal injury. We previously reported that an infusion of angiotensin II into a rat induced deposition of lipids in the renal tubular epithelial cells. Here we have examined the effect of pioglita...

journal_title：European journal of pharmacology

authors： Sakamoto A,Hongo M,Saito K,Nagai R,Ishizaka N

更新日期：2012-05-05 00:00:00

abstract：:We investigated the involvement of p160ROCK (a Rho-associated coiled coil-forming protein kinase), one of Rho kinases on superoxide anion production (O(2)(-) production), aggregation and adhesion of human polymorphonuclear leukocytes under physiological condition, using a selective p160ROCK inhibitor, (+)-(R)-trans-4-...

journal_title：European journal of pharmacology

authors： Kawaguchi A,Ohmori M,Harada K,Tsuruoka S,Sugimoto K,Fujimura A

更新日期：2000-09-08 00:00:00

abstract：:The use-dependent effects of bunazosin on the maximal rate of rise (Vmax) of the action potential and conduction velocity were studied in isolated papillary muscles of guinea-pig. Standard microelectrode techniques were used to monitor the conduction and action potential of the muscles. In the presence of 30 microM bu...

journal_title：European journal of pharmacology

authors： Hasegawa J,Noguchi N,Sawaguchi M,Doi T,Hisatome I,Kotake H,Mashiba H

更新日期：1990-12-04 00:00:00

abstract：:Computer analysis of [125I]iodocyanopindolol competition studies using the relatively selective beta 1-adrenoceptor antagonist, ICI 89406, and the beta 2-selective antagonist, ICI 118551, on rabbit mononuclear leukocyte plasmalemmal preparations favored a two-site model indicating that both beta 1- and beta 2-adrenoce...

journal_title：European journal of pharmacology

authors： Tenner TE Jr,Earley KJ,Young JA

更新日期：1989-01-31 00:00:00

abstract：:The basic symptoms of Alzheimer's dementia, i.e., a loss in cognitive function, are due to impaired nicotinic cholinergic neurotransmission. To compensate for this impairment by drug treatment, blockers of the acetylcholine-degrading enzyme acetylcholinesterase are applied, even though this approach obviously is prone...

journal_title：European journal of pharmacology

authors： Maelicke A,Albuquerque EX

更新日期：2000-03-30 00:00:00

abstract：:The ability of angiotensin II (A II) and 5-hydroxytryptamine (5-HT) to depolarise the rat isolated nodose ganglion preparation was examined. 5-HT depolarised the nodose ganglion, both at room temperature (20-24 degrees C) and at 35-37 degrees C. However, A II depolarised the nodose ganglion only under the latter condi...

journal_title：European journal of pharmacology

authors： Widdop RE,Krstew E,Jarrott B

更新日期：1990-08-21 00:00:00