Effects of proglumetacin maleate and its major metabolites on allergic air pouch inflammation in rats.

abstract：:Liver plays an important role in bile synthesis, metabolic function, degradation of toxins, new substances synthesis in body. However, hepatopathy morbidity and mortality are increasing year by year around the world, which become a major public health problem. Traditional Chinese medicine (TCM) has a prominent role in...

journal_title：European journal of pharmacology

authors： Zhou M,Deng Y,Liu M,Liao L,Dai X,Guo C,Zhao X,He L,Peng C,Li Y

更新日期：2021-01-05 00:00:00

abstract：:Perhexiline, a "metabolic" anti-anginal agent currently under investigation in management of congestive heart failure and acute coronary syndromes improves platelet nitric oxide responsiveness in patients with impaired responsiveness. The current study investigated possible interactions between perhexiline and the nit...

journal_title：European journal of pharmacology

authors： Liberts EA,Willoughby SR,Kennedy JA,Horowitz JD

更新日期：2007-03-29 00:00:00

abstract：:In the present study, we investigated whether copper ions are involved in the decomposition of endogenous S-nitrosothiols by ultraviolet (UV) light irradiation in the mouse gastric fundus. The effects of copper ions and chelators of copper(I) and copper(II), neocuproine and cuprozine, respectively, were studied on rel...

journal_title：European journal of pharmacology

authors： Ogülener N,Ergün Y

更新日期：2004-02-06 00:00:00

abstract：:Clozapine, an atypical antipsychotic, is very effective in the treatment of resistant schizophrenia. However, cardiotoxicity of clozapine, particularly in young patients, has raised concerns about its safety. Increased catecholamines have been postulated to trigger an inflammatory response resulting in myocarditis, di...

journal_title：European journal of pharmacology

authors： Wang JF,Min JY,Hampton TG,Amende I,Yan X,Malek S,Abelmann WH,Green AI,Zeind J,Morgan JP

更新日期：2008-09-11 00:00:00

abstract：:The effects of cytosolic ATP on Ca2+-dependent K+ (K(Ca)) channel activation in cultured bovine adrenal chromaffin cells were investigated by using single-channel recording patch-clamp techniques. Application of ATP to the intracellular surface of excised inside-out patches activated K(Ca) channels in a dose-dependent...

journal_title：European journal of pharmacology

authors： Chen C,Houchi H,Tamaki T,Nakaya Y

更新日期：1998-06-05 00:00:00

abstract：:Cysteamine (420 mg/kg s.c.) increased gastric acid secretion in rats 3-6 h post-injection; duodenal pH fell from 6.0 +/- 0.2 (S.E.M.) at 0 time to 2.2 +/- 0.3 at 12 h. A high (60-80%) incidence of duodenal ulcerations was observed 18 h after cysteamine injection. Intracisternal (i.c.) administration of bombesin (1 mic...

journal_title：European journal of pharmacology

authors： Hernandez DE,Adcock JW,Nemeroff CB,Prange AJ Jr

更新日期：1982-10-22 00:00:00

abstract：:Gaboxadol (THIP; 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol) is an agonist at GABA(A) receptors. THIP concentrations (0.01-50 mM) were applied rapidly to Sf9 cells expressing the human alpha(1)beta(2)gamma(2S) GABA(A) receptors. The EC(50) values for the peak current in THIP alone or THIP plus 1 microM diazepam we...

journal_title：European journal of pharmacology

authors： Smith M,Lindquist CE,Birnir B

更新日期：2003-09-30 00:00:00

abstract：:Kappa- and mu-opioid binding site affinities of the kappa-selective ligand U62066 and its optical isomers, (+)-U63639 and (-)-U63640 were compared with those of the structurally related ligand PD117302 and its respective isomers, (+)-PD123497 and (-)-PD123475. The relative efficacies of each compound were also establi...

journal_title：European journal of pharmacology

authors： Meecham KG,Boyle SJ,Hunter JC,Hughes J

更新日期：1989-12-07 00:00:00

abstract：:As a flavonoid, naringin (Nar) has been shown to have multiple pharmacological effects including lowering blood cholesterol, reducing thrombus formation and improving microcirculation. However, effects of Nar on function and autophagy of vascular endothelial cells under high glucose and high fat (HG/HF) stress are lar...

journal_title：European journal of pharmacology

authors： Wang K,Peng S,Xiong S,Niu A,Xia M,Xiong X,Zeng G,Huang Q

更新日期：2020-05-05 00:00:00

abstract：:The prevention of the decrease in neostriatal tryptophan hydroxylase (TPH) activity with a single dose of methamphetamine (MA) was attempted by lesioning the nigrostriatal dopaminergic projections with bilateral nigral injections of 6-hydroxydopamine (6-OHDA). The rats were injected with MA (10 mg/kg) 11 days later, a...

journal_title：European journal of pharmacology

authors： Johnson M,Stone DM,Hanson GR,Gibb JW

更新日期：1987-03-17 00:00:00

abstract：:[N-methyl-Nle 28,31)]cholecystokinin-(26-33) (SNF 8702) is a highly selective ligand for the CCKB type of receptor present in the vertebrate central nervous system. Radioligand binding data showing that SNF 8702 binding affinity is reduced by the GTP analog guanylyl-imidodiphosphate suggest that SNF 8702 is an agonist...

journal_title：European journal of pharmacology

authors： Knapp RJ,Malatynska E,Peterson P,Zalewska T,Fang S,Hruby VJ,Smith TL,Yamamura HI

更新日期：1994-10-14 00:00:00

abstract：:It has been well documented that nordihydroguaiaretic acid (NDGA), a phenolic lignan isolated from the creosote bush, Larrea tridentate, has anti-cancer activity in vitro and in vivo. Several mechanisms have been identified that could contribute to these actions, as NDGA directly inhibits metabolic enzymes and recepto...

journal_title：European journal of pharmacology

authors： Li F,Pham JD,Anderson MO,Youngren JF

更新日期：2009-08-15 00:00:00

abstract：:This study examined whether a clinically relevant concentration of the volatile anaesthetic halothane modifies the endothelium-dependent relaxation produced by acetylcholine (3 nM-10 microM), histamine (1 pM-0.1 microM) and anti-human immunoglobulin E (1:1000) in human isolated pulmonary arteries submaximally precontr...

journal_title：European journal of pharmacology

authors： Higueras J,Sarría B,Ortiz JL,Cortijo J,Maruenda A,Barberá M,Morcillo EJ

更新日期：1997-05-20 00:00:00

abstract：:Alopecia is resulted from various factors that can decrease the regeneration capability of hair follicles and affect hair cycles. This process can be devastating physically and psychologically. Nevertheless, the available treatment strategies are limited, and the therapeutic outcomes are not satisfactory. According to...

journal_title：European journal of pharmacology

authors： Yuan AR,Bian Q,Gao JQ

更新日期：2020-08-15 00:00:00

abstract：:Vascular hypertrophy occurs during chronic hypertension and contributes to the elevation of peripheral vascular resistance in hypertension. In this study, we examined whether acute pressure overloading of the vascular wall produces activation of mitogen-activated protein (MAP) kinases, enzymes believed to be involved ...

journal_title：European journal of pharmacology

authors： Kubo T,Hosokawa H,Kambe T,Fukumori R

更新日期：2000-03-17 00:00:00

abstract：:We found that pergolide, a dopamine D1/D2 receptor agonist used in the clinical therapy of Parkinson's disease, protects SH-SY5Y neuroblastoma cells from cell death induced by a brief pulse (15 min) of 1 mM H(2)O(2). Neuroprotection was found when pergolide was added to the culture medium either simultaneously with (E...

journal_title：European journal of pharmacology

authors： Uberti D,Piccioni L,Colzi A,Bravi D,Canonico PL,Memo M

更新日期：2002-01-02 00:00:00

abstract：:Icariin is a major active component of the traditional herb Epimedium, also known as Horny Goat Weed. It has been extensively studied throughout the past several years and is known to exert anti-oxidative, anti-neuroinflammatory, and anti-apoptotic effects. It is now being considered as a potential therapeutic agent f...

journal_title：European journal of pharmacology

authors： Jin J,Wang H,Hua X,Chen D,Huang C,Chen Z

更新日期：2019-01-05 00:00:00

abstract：:The effects of rat calcitonin gene-related peptide (CGRP) on superfused rat aortic smooth muscle cells in cell culture were investigated. Exposure of the cells for 10 min to CGRP (10(-7) M), with or without pretreatment with pertussis toxin, stimulated the release of cyclic AMP but not of prostacyclin, as judged by ra...

journal_title：European journal of pharmacology

authors： Vallotton MB,Dolci W,Gerber-Wicht C,Fischer JA

更新日期：1989-07-18 00:00:00

abstract：:In this work, the involvement of ionotropic glutamatergic receptors and nitric oxide on striatal dopamine release induced by anatoxin-a was investigated in conscious and freely-moving rats. To study the participation of glutamatergic receptors, the effects of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (A...

journal_title：European journal of pharmacology

authors： Campos F,Alfonso M,Vidal L,Faro LR,Durán R

更新日期：2006-10-24 00:00:00

abstract：:The breakdown of inositol phospholipid (PI) stimulated by hippocampal noradrenaline in rat miniprisms in vitro was used as an index of alpha 1-adrenoceptor function after selective noradrenergic denervation. Selective denervation was produced by microinjections of 6-hydroxydopamine (6-OHDA) into either the dorsal nora...

journal_title：European journal of pharmacology

authors： Fowler CJ,Magnusson O,Mohammed AK,Danysz W,Archer T

更新日期：1986-04-29 00:00:00

abstract：:This study investigated sex-related differences in rat papillary muscle force generation in response to altered extracellular [Ca2+] ([Ca2+](o), 0.2 to 5.0 mM) and to L-type Ca2+ channel modulators (nifedipine and Bay K8644). At all [Ca2+]o examined, contractile force was significantly greater in male than female papi...

journal_title：European journal of pharmacology

authors： Curl CL,Delbridge LM,Wendt IR

更新日期：2008-05-31 00:00:00

abstract：:The effects of 26 anesthetic agents were studied on the rhythmical discharge activity of a single isolated neuron (crayfish stretch receptor). Many of these agents produced concentration-dependent biphasic responses (excitation and depression), and some also induced altered discharge patterns (burst activity). The dom...

journal_title：European journal of pharmacology

authors： MacIver MB,Roth SH

更新日期：1987-07-02 00:00:00

abstract：:In the present study, the development of tolerance to the motor impairing effects of gamma-hydroxybutyric acid (GHBA) and ethanol was compared (Experiment 1). Rats were required to perform a motor coordination task daily shortly after ethanol (3.5 g/kg) and GHBA (1.0 g/kg) administration for 9 consecutive days. Tolera...

journal_title：European journal of pharmacology

authors： Colombo G,Agabio R,Lobina C,Reali R,Fadda F,Gessa GL

更新日期：1995-02-06 00:00:00

abstract：:Behaviors induced in mice by intrathecal injections of either N-methyl-D-aspartate (NMDA) or kainic acid are modulated by NH2-terminal fragments of substance P, such as substance P-(1-7). The action of substance P-(1-7) on kainic acid depends on sigma receptor activity. The present study was designed to test the hypot...

journal_title：European journal of pharmacology

authors： Hornfeldt CS,Kitto KF,Larson AA

更新日期：1996-06-13 00:00:00

abstract：:After prolonged stimulation, the delta-opioid receptor becomes desensitized by regulatory mechanisms such as receptor phosphorylation, internalization and down-regulation. In this study, we demonstrate that morphine treatment causes phosphorylation of S363 in the C-terminus of the human delta-opioid receptor. Morphine...

journal_title：European journal of pharmacology

authors： Navratilova E,Eaton MC,Stropova D,Varga EV,Vanderah TW,Roeske WR,Yamamura HI

更新日期：2005-09-20 00:00:00

abstract：:The inhibitory effects of the new bradykinin antagonist HOE 140 (D-Arg-Arg-Pro-Hyp-Gly-Thi-Ser-D-Tic-Oic-Arg) on depressor responses to exogenous bradykinin were investigated in conscious rats and compared with those of the bradykinin antagonist B4146 (D-Arg-Hyp-Pro-Gly-Thi-Ser-D-Pro-Thi-Arg). HOE 140 showed a 250-700...

journal_title：European journal of pharmacology

authors： Bao G,Qadri F,Stauss B,Stauss H,Gohlke P,Unger T

更新日期：1991-07-23 00:00:00

abstract：:Sanguinarine is a natural isoquinoline alkaloid derived from the root of Sanguinaria canadensis and from other poppy fumaria species, and is known to have a broad spectrum of pharmacological properties. Here we have found that sanguinarine, at low micromolar concentrations, showed a remarkably rapid killing activity a...

journal_title：European journal of pharmacology

authors： Burgeiro A,Bento AC,Gajate C,Oliveira PJ,Mollinedo F

更新日期：2013-04-05 00:00:00

abstract：:Troxypyrrolidinium, a choline uptake inhibitor, reduced but failed to abolish responses of the rat urinary bladder to electrical stimulation at 1-100 Hz although it reduced acetylcholine output during stimulation at 10 Hz to a level similar to that of spontaneous release. Inhibition of the response to stimulation was ...

journal_title：European journal of pharmacology

authors： Choo LK,Mitchelson F

更新日期：1980-02-08 00:00:00

abstract：:Nitric oxide (NO) is present in the exhaled breath of humans and other mammalian species. It is generated in the lower airways by enzymes of the nitric oxide synthase (NOS) family, although nonenzymatic synthesis and consumptive processes may also influence levels of NO in exhaled breath. The biological properties of ...

journal_title：European journal of pharmacology

authors： Redington AE

更新日期：2006-03-08 00:00:00

abstract：:The involvement of the GABA(A)-benzodiazepine receptor complex in rat pup ultrasonic vocalisations was studied by testing benzodiazepine receptor ligands with varying intrinsic activity and selectivity for benzodiazepine subtype receptors. Ultrasonic vocalisations were recorded under two temperature conditions (37 deg...

journal_title：European journal of pharmacology

authors： Olivier B,Molewijk E,van Oorschot R,van der Heyden J,Ronken E,Mos J

更新日期：1998-10-02 00:00:00