Cross-tolerance to ethanol and gamma-hydroxybutyric acid.

abstract：:Intradermal application of nociceptin was used to investigate its in vivo effect on the inflammatory response in rats. Intradermal nociceptin (5 pmol/site-5 nmol/site) increased vascular permeability in a dose-dependent manner. The increased vascular permeability by nociceptin (5 nmol/site) was dose-dependently inhibi...

journal_title：European journal of pharmacology

authors： Kimura T,Kitaichi K,Hiramatsu K,Yoshida M,Ito Y,Kume H,Yamaki K,Suzuki R,Takagi K

更新日期：2000-11-03 00:00:00

abstract：:Ovarian cancer is the major cause of cancer death among female genital malignancies, and requires developing novel therapeutic measures. Immune escape and acquisition of tolerance by tumor cells are essential for cancer growth and progression. An immunoregulatory enzyme indoleamine 2,3-dioxygenase (IDO) overexpression...

journal_title：European journal of pharmacology

authors： Kobayashi A,Tanizaki Y,Kimura A,Ishida Y,Nosaka M,Toujima S,Kuninaka Y,Minami S,Ino K,Kondo T

更新日期：2015-11-05 00:00:00

abstract：:The effects of a 1,5-benzothiazepine derivative, (+)-cis-3-(acetyloxy)-5-[2-[[2-(3,4-dimethoxyphenyl)ethyl]-methyla mino]ethyl]-2,3-dihydro-2-(4-methyoxyphenyl)-1,5-benzothiazepine-4 (5H)-one (DTZ323), on membrane currents were investigated in guinea-pig ventricular myocytes using the whole-cell patch-clamp technique....

journal_title：European journal of pharmacology

authors： Kurokawa J,Adachi-Akahane S,Nagao T

更新日期：1997-05-01 00:00:00

abstract：:Attempts were made to find whether [3H]batrachotoxinin A 20-alpha-benzoate provides a specific probe for measuring interactions of local anesthetics with the sodium channel complex. [3H]Batrachotoxinin A 20-alpha-benzoate binding, [14C]guanidine and 22Na uptake were investigated in rat brain crude synaptosomal prepara...

journal_title：European journal of pharmacology

authors： Pauwels PJ,Leysen JE,Laduron PM

更新日期：1986-05-27 00:00:00

abstract：:The effects of 2,3-butanedione monoxime (BDM) and 5-[1-(3,4-dimethoxybenzoyl)-1,2,3,4-tetrahydro-6-quinolyl]-6-me thy l-3,6-dihydro-2H-1,3,4-thiadiazin-2-one (EMD 53998) on cardiac muscle were studied in skinned muscle fibres from the right ventricle of the porcine heart. BDM decreases the Ca2+ sensitivity (pCa50 for ...

journal_title：European journal of pharmacology

authors： Barth Z,Strauss JD,Dohet C,Ruegg JC

更新日期：1996-02-05 00:00:00

abstract：:Sprague-Dawley rats received oral doses of enalapril maleate (5 mg/kg), a potent, nonsulfhydryl, angiotensin converting enzyme inhibitor, or saline. Sixty min later, morphine sulfate, 5 mg/kg, or saline was injected subcutaneously. Response to a thermal stimulus was monitored before and up to 5 h ter morphine injectio...

journal_title：European journal of pharmacology

authors： Mojaverian P,Swanson BN,Ferguson RK

更新日期：1984-02-17 00:00:00

abstract：:The ontogenesis of kappa-opioid receptors has been studied in the postnatal period from day 5 to day 30 using the highly selective kappa-site ligand [3H]U-69593 in binding studies. Analyses of saturation curves revealed a marked increase in the binding capacities between day 5 and day 10 with no further increment in t...

journal_title：European journal of pharmacology

authors： Kitchen I,Kelly M,Viveros MP

更新日期：1990-01-03 00:00:00

abstract：:Migraine is a common painful neurovascular disorder usually associated with several symptoms, such as photophobia, phonophobia, nausea, vomiting and inflammation, and involves immune cells. Mast cells (MCs) are immune cells derived from hematopoietic pluripotent stem cells which migrate and mature close to epithelial,...

journal_title：European journal of pharmacology

authors： Conti P,D'Ovidio C,Conti C,Gallenga CE,Lauritano D,Caraffa A,Kritas SK,Ronconi G

更新日期：2019-02-05 00:00:00

abstract：:Nitric oxide (NO) is continuously produced in the lung and can be measured in exhaled gas of different species. To investigate a possible neuro-humoral regulation of pulmonary NO production in vivo we injected veratrine, an activator of Na(+) channels known to activate the sympathoadrenal system, in anaesthetized, mec...

journal_title：European journal of pharmacology

authors： Adding LC,Agvald P,Artlich A,Gustafsson LE

更新日期：2001-01-12 00:00:00

abstract：:Our goal was to determine if venlafaxine has a negative effect on bone metabolism. Rats were divided into three groups. The sham-operated control group (SHAM), the control group after orchidectomy (ORX), and the experimental group after orchidectomy received venlafaxine (VEN ORX) in standard laboratory diet (SLD) for ...

journal_title：European journal of pharmacology

authors： Fekete S,Simko J,Mzik M,Karesova I,Zivna H,Zivny P,Pavliková L,Palicka V

更新日期：2015-08-15 00:00:00

abstract：:The effects of serotonin (5-HT) on a beta-adrenergic response were studied, using the voltage clamp technique, in Xenopus laevis oocytes surrounded by their follicular cells. noradrenaline induced marked hyperpolarization, with a specific increase in the permeability of the membrane toward K+. Application of 10 microM...

journal_title：European journal of pharmacology

authors： Fujita R,Tamazawa Y,Barnard EA,Matsumoto M

更新日期：1993-08-24 00:00:00

abstract：:The functional role of metabotropic glutamate (mGlu) receptors in the rat dentate gyrus was investigated. By using extracellular recording techniques in slices, it was found that the depression induced by the mGlu receptor agonist (1S,3R)-1-amino-cyclopentane-1,3-dicarboxylate (ACPD) was mediated through the mGlu grou...

journal_title：European journal of pharmacology

authors： Ugolini A,Bordi F

更新日期：1995-12-29 00:00:00

abstract：:The object of the present paper was to investigate the in vivo pharmacological profile of the dihydropyridine neuropeptide Y Y(1) receptor antagonist 1,4-Dihydro-4-[3-[[[[3-[spiro(indene-4,1'-piperidin-1-yl)]propyl]amino]carbonyl]amino]phenyl]-2,6-dimethyl-3,5-pyridine dicarboxylic acid, dimethylester (H 394/84). The ...

journal_title：European journal of pharmacology

authors： Malmström RE,Balmér KC,Weilitz J,Nordlander M,Sjölander M

更新日期：2001-04-20 00:00:00

abstract：:The purposes of the present study were to clarify whether some Cl(-) channels exist in rat pleural mesothelial cells, and to investigate functional and molecular characteristics of these channels. Electrophysiological recordings were performed at room temperature using the whole-cell configuration of the patch-clamp t...

journal_title：European journal of pharmacology

authors： Yoshise Y,Ito K,Tsubone H,Kuwahara M

更新日期：2009-07-01 00:00:00

abstract：:Behaviors induced in mice by intrathecal injections of either N-methyl-D-aspartate (NMDA) or kainic acid are modulated by NH2-terminal fragments of substance P, such as substance P-(1-7). The action of substance P-(1-7) on kainic acid depends on sigma receptor activity. The present study was designed to test the hypot...

journal_title：European journal of pharmacology

authors： Hornfeldt CS,Kitto KF,Larson AA

更新日期：1996-06-13 00:00:00

abstract：:Neuropeptide Y has direct vasoconstrictor actions and potentiates the effects of other vasoconstrictor agents. To find out whether both effects of neuropeptide Y are mediated via the same receptor and intracellular mechanism, the interaction between neuropeptide Y and angiotensin II was studied in rabbit femoral arter...

journal_title：European journal of pharmacology

authors： Cressier F,Criscione L,Hofbauer KG

更新日期：1995-01-05 00:00:00

abstract：:The effects of menatetrenone, a vitamin K2 homologue, on osteoclast-like cell formation in mouse bone marrow culture were investigated. After 7 days of incubation, menatetrenone at 10(-6) M, 3 x 10(-6) M and 10(-5) M dose dependently inhibited the tartrate-resistant acid phosphatase-positive multinucleated cell format...

journal_title：European journal of pharmacology

authors： Akiyama Y,Hara K,Tajima T,Murota S,Morita I

更新日期：1994-09-22 00:00:00

abstract：:7-Nitroindazole (a selective neuronal nitric oxide (NO) synthase inhibitor) at 25 and 50 mg/kg, 30 min before the test, did not influence the electroconvulsive threshold. However, at 50 mg/kg, it enhanced the anticonvulsive activity of phenobarbital against maximal electroshock and did not affect that of carbamazepine...

journal_title：European journal of pharmacology

authors： Borowicz KK,Kleinrok Z,Czuczwar SJ

更新日期：1997-07-23 00:00:00

abstract：:The existence of neurogenic mediator candidates apart from noradrenaline and acetylcholine involved in the control of vascular tone has attracted enormous attention during the past few decades. One such mediator is neuropeptide Y (NPY), which is co-localized with noradrenaline in sympathetic perivascular nerves. Stimu...

journal_title：European journal of pharmacology

authors： Franco-Cereceda A,Liska J

更新日期：1998-05-15 00:00:00

abstract：:Anorexia and muscle wasting are frequently observed in cancer patients and influence their clinical outcome. The better understanding of the mechanisms underlying behavioral changes and altered metabolism yielded to the development of specialized nutritional support, which enhances utilization of provided calories and...

journal_title：European journal of pharmacology

authors： Laviano A,Seelaender M,Sanchez-Lara K,Gioulbasanis I,Molfino A,Rossi Fanelli F

更新日期：2011-09-01 00:00:00

abstract：:The autoradiographic distribution of putative brain adrenomedullin receptors was investigated using [125I]human adrenomedullin(13-52) as a new radioligand. Specific [125I]human adrenomedullin(13-52) binding sites were very discretely distributed in the rat brain with enrichment seen in the choroid plexus and linings o...

journal_title：European journal of pharmacology

authors： Juaneda C,Dumont Y,Chabot JG,Quirion R

更新日期：2001-06-08 00:00:00

abstract：:Renal mesangial cells exposed to inflammatory cytokines produce high concentrations of nitric oxide (NO) which may exert cytotoxic actions. We report here that glomerular mesangial cells, endothelial cells and epithelial cells in culture are themselves targets for NO and undergo apoptotic cell death upon exposure to h...

journal_title：European journal of pharmacology

authors： Mühl H,Sandau K,Brüne B,Briner VA,Pfeilschifter J

更新日期：1996-12-12 00:00:00

abstract：:Rhesus monkeys were trained to discriminate saline from an injection of ketamine. In tests of stimulus generalization, phencyclidine (PCP) produced dose-related ketamine-appropriate responding in each monkey. Two monohydroxylated PCP metabolites also produced ketamine-like discriminative effects, although only at cons...

journal_title：European journal of pharmacology

authors： Solomon RE,Herling S,Woods JH

更新日期：1982-08-27 00:00:00

abstract：:Benzodiazepines (BDZs) and non-BDZ sedative-hypnotics are effective for the management of chronic insomnia; however, they are associated with adverse effects such as headache, dizziness, and palpitations. Furthermore, long-term use of these medications is associated with decreased blood pressure (BP) or depressed baro...

journal_title：European journal of pharmacology

authors： Kagota S,Morikawa K,Ishida H,Chimoto J,Maruyama-Fumoto K,Yamada S,Shinozuka K

更新日期：2021-02-05 00:00:00

abstract：:Cardiovascular and behavioral responses induced by intravenous administration of the serotonin (5-HT)1A receptor agonist, 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), were studied in conscious normotensive rats either after a single administration, after repeated subcutaneous treatments (1 mg/kg daily for 3 day...

journal_title：European journal of pharmacology

authors： Kolbasa KP,McCall RB,Ludens JH

更新日期：1991-02-14 00:00:00

abstract：:We have investigated the effects of substituting extracellular Na+ by choline or K+ on responses of quin2- and fura-2-loaded human platelets to thrombin and platelet-activating factor (PAF). Na+ substitution by choline did not affect the extent of the rise in [Ca2+]i evoked by either agonist. The response to thrombin,...

journal_title：European journal of pharmacology

authors： Sage SO,Rink TJ

更新日期：1986-08-22 00:00:00

abstract：:Peroxynitrite is a potent oxidant formed endogenously by the near diffusion-limited reaction of nitric oxide with superoxide anion. Peroxynitrite specifically adds a nitro group to the ortho position of the phenolic ring of free and protein-associated tyrosines to form the stable product 3-nitro-L-tyrosine. Systemic a...

journal_title：European journal of pharmacology

authors： Kooy NW,Lewis SJ

更新日期：1996-11-14 00:00:00

abstract：:Omeprazole, besides suppressing gastric acid, causes delayed gastric emptying, which may be associated with aggravated dyspeptic symptoms. Effects of omeprazole on small intestinal transit are unknown. In this study, we evaluated in mice if (a) omeprazole affects transit of a meal through the stomach and small intesti...

journal_title：European journal of pharmacology

authors： Cowan A,Earnest DL,Ligozio G,Rojavin MA

更新日期：2005-07-04 00:00:00

abstract：:N-Methyl-D-aspartate (NMDA)-induced pial artery dilation is reversed to vasoconstriction following fluid percussion brain injury (FPI). This study investigated the contribution of activation of protein tyrosine kinase (PTK) and the extracellular signal-regulated kinase (ERK) and p38 isoforms of mitogen-activated prote...

journal_title：European journal of pharmacology

authors： Armstead WM

更新日期：2003-08-08 00:00:00

abstract：:The direct positive inotropic effect of histamine was studied on paced left atrial preparation from guinea pigs. Histamine (10(-8) to 10(-4) M) increased the maximum tension developed in left atria incubated at 35degreesC and driven at 2 Hz. The maximum increase in tension was 60% of that observed with norepinephrine....

journal_title：European journal of pharmacology

authors： Steinburg MI,Holland DR

更新日期：1975-11-01 00:00:00