Ontogenesis of kappa-opioid receptors in rat brain using [3H]U-69593 as a binding ligand.

abstract：:Effects of N-ethylmaleimide or forskolin on electrically evoked dopamine release were investigated in striatal slices of rats pretreated with methamphetamine. N-Ethylmaleimide and forskolin both enhanced the evoked dopamine release in a concentration-dependent manner. The enhancement by N-ethylmaleimide of spontaneous...

journal_title：European journal of pharmacology

authors： Yamada S,Yokoo H,Nishi S

更新日期：1994-05-23 00:00:00

abstract：:ATP, ADP, adenosine and AMP, but not adenine, inosine, or GMP, caused dose-related intestinal contractions when injected as intra-arterial bolus doses in vascularly perfused isolated segments of dog small bowel. The stimulatory effects of these agents were decreased by receptor densitization during exposure to high co...

journal_title：European journal of pharmacology

authors： Northway MG,Burks TF

更新日期：1980-07-11 00:00:00

abstract：:In the present study, the role of reactive oxygen species and the contribution of antioxidant defence in the time course of changes in acetylcholine-stimulated endothelium-dependent and sodium nitroprusside-stimulated endothelium-independent relaxation were investigated in aortic rings isolated from 6-month streptozot...

journal_title：European journal of pharmacology

authors： Karasu C

更新日期：2000-03-31 00:00:00

abstract：:The ability of putative melatonin receptor antagonists to antagonise melatonin-induced aggregation of pigment granules in cultured neural crest Xenopus laevis melanophores was examined. Neither ML 23 (N-(2,4-dinitrophenyl)-5-methoxytryptamine) nor 6-methoxy-2-benzoxazolinone showed agonist or antagonist activity. N-Ac...

journal_title：European journal of pharmacology

authors： Sugden D

更新日期：1992-03-31 00:00:00

abstract：:Pretreatment of rats with intraventricular 6-hydroxydopamine produced considerable destruction of noradrenergic and dopaminergic nerve terminals as indicated by depletions in synaptosomal catecholamine contents. However, 6-hydroxydopamine pretreatment did not result in diminished release of ATP during depolarization o...

journal_title：European journal of pharmacology

authors： Potter PE,White TD

更新日期：1982-05-07 00:00:00

abstract：:2-n-Butyl-4-chloro-5-hydroxymethyl-1-[(2'-(1H-tetrazol-5-yl)bip hen yl-4-yl)methyl]imidazole, potassium salt (Losartan) (previous name, DuP 753 or MK 954) is a nonpeptide angiotensin II receptor antagonist. This study was performed to investigate the ability of Losartan to inhibit the angiotensin II-induced stimulatio...

journal_title：European journal of pharmacology

authors： Ko Y,Görg A,Appenheimer M,Wieczorek AJ,Düsing R,Vetter H,Sachinidis A

更新日期：1992-10-01 00:00:00

abstract：:The effect of idebenone on the changes in adenosine and nucleotide metabolism occurring in hippocampal slices after ischemia-like conditions (superfusion with glucose-free Krebs solution gassed with 95% N2-5% CO2) and during reperfusion with normal Krebs solution was investigated by measuring adenosine and inosine out...

journal_title：European journal of pharmacology

authors： Latini S,Pedata F,Pepeu G

更新日期：1993-11-02 00:00:00

abstract：:Immunopharmacology is one of the most dynamic areas in pharmacology encompassing classical immunosuppressive drugs which reveal completely new clues concerning their mode of action as well as novel molecular biology approaches for treating inflammatory and autoimmune diseases, infections and cancer. This article focus...

journal_title：European journal of pharmacology

authors： Pfeilschifter J,Mühl H

更新日期：1999-06-30 00:00:00

abstract：:Lithium is widely used for the management of neuropsychiatric symptoms in bipolar disorders. A variety of hypotheses have been invoked to explain the mechanism of action of lithium. To determine if lithium exerts direct cardiac protection, in the present study perfused rat heart model was used. The mechanism of lithiu...

journal_title：European journal of pharmacology

authors： Faghihi M,Mirershadi F,Dehpour AR,Bazargan M

更新日期：2008-11-12 00:00:00

abstract：:Presynaptic cholinergic markers could be used for estimating the integrity of the cholinergic systems in the human brain with brain imaging techniques such as Single-photon emission computed tomography (SPECT). Vesamicol, an inhibitor of the vesicular acetylcholine transporter, and some of its derivatives have been su...

journal_title：European journal of pharmacology

authors： Custers FG,Leysen JE,Stoof JC,Herscheid JD

更新日期：1997-11-05 00:00:00

abstract：:In follicle-enclosed Xenopus oocytes, extracellular application of cromakalim (a K+ channel opener) or intracellular injection of cAMP induces the smooth outward K+ current which is inactivated by glibenclamide. We found that cromakalim- or cAMP-induced K+ currents in the oocytes were rapidly, reversibly and dose-depe...

journal_title：European journal of pharmacology

authors： Sakuta H,Sekiguchi M,Okamoto K,Sakai Y

更新日期：1992-07-01 00:00:00

abstract：:The purpose of the present study was to characterize the nature of the behavioural response to substance P (SP) infusion into the substantia nigra and to evaluate this response in 6-hydroxydopamine (6-OHDA) caudate lesioned rats. The effects of SP infusions (3 microgram in 1 microliter bilaterally) were assessed in an...

journal_title：European journal of pharmacology

authors： Kelley AE,Iversen SD

更新日期：1979-12-07 00:00:00

abstract：:Administration of drugs activating cannabinoid CB(1) receptors in the brain induces memory deficit in rodents, and blockade of these receptors may restore memory capacity in these animals. Central administration of beta-amyloid or beta-amyloid fragments may also lead to memory disturbances. This study was undertaken t...

journal_title：European journal of pharmacology

authors： Mazzola C,Micale V,Drago F

更新日期：2003-09-23 00:00:00

abstract：:The aim of the present investigation was to evaluate the antidiabetic activity of cycloart-23-ene-3beta, 25-diol (called as B2) isolated from stem bark of Pongamia pinnata in streptozotocin-nicotinamide induced diabetic mice. Diabetes was induced in mice by injecting streptozotocin (200mg/kg, i.p.) after 15 min nicoti...

journal_title：European journal of pharmacology

authors： Badole SL,Bodhankar SL

更新日期：2010-04-25 00:00:00

abstract：:Antibodies against the neurite outgrowth inhibitor Nogo-A enhance axonal regeneration following spinal cord injury. However, antibodies directed against myelin components can also enhance CNS inflammation. The present study was designed to assess the efficacy of DNA vaccination for generating antibodies against Nogo-A...

journal_title：European journal of pharmacology

authors： Bourquin C,van der Haar ME,Anz D,Sandholzer N,Neumaier I,Endres S,Skerra A,Schwab ME,Linington C

更新日期：2008-06-24 00:00:00

abstract：:Depletion of catecholamines by pretreatment with the tyrosine hydroxylase inhibitor alpha-methyl-para-tyrosine attenuated the ability of the selective D-2 dopamine receptor agonist quinpirole to inhibit rat nucleus accumbens neurons when applied directly by microiontophoresis. Concurrent iontophoretic administration o...

journal_title：European journal of pharmacology

authors： White FJ

更新日期：1987-03-03 00:00:00

abstract：:Fibroblast growth factor 21 (FGF21) has been identified as a potent and robust metabolic regulator. Administration of recombinant FGF21 protein to rodents and rhesus monkeys exerts strong anti-diabetic effects. Previous studies have demonstrated that FGF21 inhibits glucose output in the rat H4IIE hepatoma cell line. W...

journal_title：European journal of pharmacology

authors： Kong LJ,Feng W,Wright M,Chen Y,Dallas-yang Q,Zhou YP,Berger JP

更新日期：2013-02-28 00:00:00

abstract：:The characteristics of [3H]gamma-aminobutyric acid (GABA) uptake by slices of the rabbit oviduct were studied, and the GABA-accumulating structures were identified by histoautoradiography. A high-affinity (Km = 5 microM), sodium-dependent GABA uptake system was demonstrated which showed significant segmental variation...

journal_title：European journal of pharmacology

authors： Erdö SL,Amenta F

更新日期：1986-11-04 00:00:00

abstract：:Various opiate ligands were bound to brain membranes of mice of the Recombinant Inbred System. The specific binding of low levels of [3H]naloxone, [3H]dihydromorphine and [3H]ethylketocyclazocine was disturbed in a similar fashion among the inbred strains, and in a pattern different from that observed for [3H](D-Ala2,...

journal_title：European journal of pharmacology

authors： Reith ME,Sershen H,Vadasz C,Lajtha A

更新日期：1981-09-24 00:00:00

abstract：:The effect of an antisense oligonucleotide to the K+ channel coding mKv1.1 mRNA on antinociception induced by the tricyclic antidepressants, clomipramine (20-35 mg kg(-1) s.c.) and amitriptyline (10-25 mg kg(-1) s.c.), was investigated in the mouse hot-plate test. Antisense oligonucleotide (0.5-1.0-2.0-3.0 nmol per i....

journal_title：European journal of pharmacology

authors： Galeotti N,Ghelardini C,Capaccioli S,Quattrone A,Nicolin A,Bartolini A

更新日期：1997-07-02 00:00:00

abstract：:Several reports suggest that enteric cholinergic neurons are subject to a tonic inhibitory modulation, whereas few studies are available concerning the role of facilitatory pathways. Glutamate, the main excitatory neurotransmitter in the central nervous system (CNS), has recently been described as an excitatory neurot...

journal_title：European journal of pharmacology

authors： Giaroni C,Zanetti E,Chiaravalli AM,Albarello L,Dominioni L,Capella C,Lecchini S,Frigo G

更新日期：2003-08-22 00:00:00

abstract：:Methoctramine, a selective M2 alpha muscarinic receptor antagonist, was examined for its ability to inhibit carbachol-induced drinking in the rat. Intracerebroventricularly (i.c.v.) administered methoctramine was devoid of activity up to a dose of 100 nmol/rat, whereas higher doses were toxic under our experimental co...

journal_title：European journal of pharmacology

authors： Massi M,Polidori C,Melchiorre C

更新日期：1989-04-25 00:00:00

abstract：:Acute lung injury (ALI) is a common severe clinical syndrome in intensive care unit. Inflammation has been reported to play a critical role in the development of ALI. Cordycepin, an active component isolated from Cordyceps militaris, has been reported to have anti-inflammatory effects. However, the anti-inflammatory e...

journal_title：European journal of pharmacology

authors： Lei J,Wei Y,Song P,Li Y,Zhang T,Feng Q,Xu G

更新日期：2018-01-05 00:00:00

abstract：:Striatal neurons in primary culture express a wide variety of adenylate cyclase-coupled receptors, and particularly dopamine (DA) D1 receptors, which are known to induce an increase in cyclic AMP production. To study desensitization of those receptor-mediated responses, neurons were incubated in the presence of satura...

journal_title：European journal of pharmacology

authors： Chneiweiss H,Glowinski J,Premont J

更新日期：1990-10-30 00:00:00

abstract：:The effects of a highly selective kappa antagonist, nor-binaltorphimine (nor-BNI), on the development of tolerance to morphine analgesia and physical dependence on morphine were examined. Pretreatment with nor-BNI (5 mg/kg s.c.) 2 h prior to injection of morphine or a selective kappa agonist, U-50,488H, significantly ...

journal_title：European journal of pharmacology

authors： Suzuki T,Narita M,Takahashi Y,Misawa M,Nagase H

更新日期：1992-03-17 00:00:00

abstract：:The effect of high helium pressure on inhibitory synaptic transmission was studied in rat hippocampal slices with extracellular recordings. Both feed-forward and recurrent GABAergic inhibition were tested in the CA1 region with paired-pulse stimulation paradigms. The efficiency of both types of inhibition decreased un...

journal_title：European journal of pharmacology

authors： Zinebi F,Fagni L,Hugon M

更新日期：1988-08-24 00:00:00

abstract：:The influence of the anti-epileptic drug, valproate, on K conductance (gK) was investigated in voltage-clamped Ranvier nodes of Xenopus laevis. A double pulse method was used in order to eliminate the effect of accumulation of potassium ions in the perinodal space, thus enabling the determination of the 'true' magnitu...

journal_title：European journal of pharmacology

authors： Van Erp MG,Van Dongen AM,Van den Berg RJ

更新日期：1990-08-02 00:00:00

abstract：:Cannabidiol, the major psycho-inactive component of cannabis, has substantial anti-inflammatory and immunomodulatory effects. This study investigated its therapeutic potential on neuropathic (sciatic nerve chronic constriction) and inflammatory pain (complete Freund's adjuvant intraplantar injection) in rats. In both ...

journal_title：European journal of pharmacology

authors： Costa B,Trovato AE,Comelli F,Giagnoni G,Colleoni M

更新日期：2007-02-05 00:00:00

abstract：:The effects of nicotine, carbachol, hexamethonium and scopolamine were investigated on distress vocalizations (DBs) of acutely isolated domestic chicks. Nicotine attenuated, while the antimuscarinic scopolamine increased the frequency of separation-induced DVs. Furthermore, the stress attenuating effects of nicotine w...

journal_title：European journal of pharmacology

authors： Sahley TL,Panksepp J,Zolovick AJ

更新日期：1981-06-19 00:00:00

abstract：:The effect of KC 2450 (racemic 3,5-cis-3-methylamino-2,3,4,5-tetrahydro-1-benzoxepine-5-ol hydrochloride) on lower esophageal sphincter pressure in pentobarbital-anesthetized dogs was determined and compared to the effect of metoclopramide. The ED20 value (i.e. the dose that increased lower esophageal sphincter pressu...

journal_title：European journal of pharmacology

authors： Fowler PJ,Nelson AH,Price WJ,Sarau HM,Grous M,Lombardi DM,Barone FC,Ormsbee HS 3rd

更新日期：1987-10-13 00:00:00