Effect of putative melatonin receptor antagonists on melatonin-induced pigment aggregation in isolated Xenopus laevis melanophores.

abstract：:Local administration of amitriptyline into the rat hindpaw produces peripheral antinociception; this is reduced by adenosine receptor antagonists and appears to involve endogenous adenosine. The present study used peripheral microdialysis: (a) to determine whether amitriptyline could enhance extracellular tissue level...

journal_title：European journal of pharmacology

authors： Sawynok J,Reid AR,Liu XJ,Parkinson FE

更新日期：2005-08-22 00:00:00

abstract：:The inhibitory effect of cytochalasin B on contraction of smooth muscle cells isolated from guinea-pig taenia coli was investigated. Cytochalasin B (10-70 microM) inhibited the high K+ (70 mM)-induced contraction in a dose-dependent manner, and the maximum and the half-maximum effects were obtained at 50 and 15 microM...

journal_title：European journal of pharmacology

authors： Obara K,Yabu H

更新日期：1994-04-01 00:00:00

abstract：:Our previous studies demonstrated the ability of exogenous agmatine to inhibit tolerance to and physical dependence on morphine in mice, rats and monkeys. The present study further evaluated the effect of agmatine on the psychological dependence induced by morphine in conditioned place preference assay. Agmatine (0.75...

journal_title：European journal of pharmacology

authors： Wei XL,Su RB,Lu XQ,Liu Y,Yu SZ,Yuan BL,Li J

更新日期：2005-05-16 00:00:00

abstract：:This study aimed to investigate the effect of long-term oral nicotine administration on insulin resistance in an animal model of obesity. Eight-week-old male Zucker fatty rats (ZFRs) were administered nicotine tartrate dihydrate (4.6 mg/kg/day) in the drinking water. The control group was pair-fed. The body weights an...

journal_title：European journal of pharmacology

authors： Liu RH,Mizuta M,Matsukura S

更新日期：2003-01-01 00:00:00

abstract：:Kakkon-to is composed of seven medicinal herbs and exhibited novel antipyretic activity by suppressing interleukin-1alpha production responsive to interferon in a murine intranasal influenza virus infection model. Using this model, antipyretic compounds with such novel biological activities were characterized from the...

journal_title：European journal of pharmacology

authors： Kurokawa M,Kumeda CA,Yamamura J,Kamiyama T,Shiraki K

更新日期：1998-05-01 00:00:00

abstract：:The effects of bepridil and nifedipine, newly developed Ca2+ antagonists, were studied on the spontaneous action potentials of the true pacemaker cell preparations (0.5 X 0.5 mm) obtained from the rabbit sino-atrial (SA) node. At the lower concentrations, bepridil (10(-6) M) and nifedipine (10(-8) M) decreased the spo...

journal_title：European journal of pharmacology

authors： Goto J,Sperelakis N

更新日期：1984-03-23 00:00:00

abstract：:The binding characteristics of [3H]gabapentin, the radiolabelled analogue of the novel anticonvulsant gabapentin (1-(aminomethyl)cyclohexaneacetic acid) were studied using purified synaptic plasma membranes prepared from rat cerebral cortex. In 10 mM HEPES buffer [3H]gabapentin bound to a single population of sites wi...

journal_title：European journal of pharmacology

authors： Suman-Chauhan N,Webdale L,Hill DR,Woodruff GN

更新日期：1993-02-15 00:00:00

abstract：:Effects of (2RS, 3SR)-2-aminomethyl-2,3,7,8-tetrahydro-2,3,5,8, 8-pentamethyl-6H-furo-[2,3-e] indol-7-one hydrochloride (UK-1745), a novel cardiotonic drug with beta-adrenoceptor blocking property and antiarrhythmic activity, on the action potentials of isolated papillary muscles and the membrane currents of single ve...

journal_title：European journal of pharmacology

authors： Uemura H,Sakamoto N,Nakaya H

更新日期：1999-11-03 00:00:00

abstract：:The present investigation was designed to study the cardioprotective effects of nicorandil and pioglitazone preconditioning in myocardial ischemia/reperfusion-induced hemodynamic, biochemical and histological changes in rats. Oral doses of nicorandil (3 or 6 mg/kg) and pioglitazone (10 or 20mg/kg) were administered on...

journal_title：European journal of pharmacology

authors： Ahmed LA,Salem HA,Attia AS,Agha AM

更新日期：2011-08-01 00:00:00

abstract：:In pentobarbital (35.0 mg/kg) anaesthetised dogs, bolus injections of prazosin into the femoral artery (3.0--300.0 microgram) provoked a dose-related fall in the vascular resistance of the innervated hind limb. In contrast to papaverine, prazosin failed to produce the same effect in dogs under spinal anaesthesia even ...

journal_title：European journal of pharmacology

authors： Cavero I,Fenard S,Gomeni R,Lefevre F,Roach AG

更新日期：1978-06-01 00:00:00

abstract：:Prolactin blood level and apomorphine-induced yawning were studied in rats treated with the substituted benzamide amisulpride in association with bromocriptine or carmoxirole; two dopamine D(2) receptor agonists with high or low propensity to cross the brain-blood barrier, respectively. Administration of amisulpride p...

journal_title：European journal of pharmacology

authors： Marchese G,Ruiu S,Casti P,Bartholini F,Saba P,Gessa GL,Pani L

更新日期：2002-06-28 00:00:00

abstract：:We investigated whether estrogen protects the ischemic myocardium in oophorectomized female rabbits fed with a cholesterol-enriched diet, whether the addition of a progestin compound attenuates the beneficial effect of estrogen and whether raloxifene also limits myocardial necrosis. We treated 32 female oophorectomize...

journal_title：European journal of pharmacology

authors： Sbarouni E,Iliodromitis EK,Bofilis E,Kyriakides ZS,Kremastinos DT

更新日期：2003-04-25 00:00:00

abstract：:We have investigated the influence of physico-chemical parameters (chemical structure and lipophilicity), biochemical properties (catabolism, affinity for 3H-etorphine binding sites and 3H-(D-Ala)2-Leu5-enkephalin amide binding sites) and biological activity in isolated organs (guinea-pig ileum and mouse vas deferens)...

journal_title：European journal of pharmacology

authors： Audigier Y,Mazarguil H,Gout R,Cros J

更新日期：1980-04-11 00:00:00

abstract：:The present study was undertaken to investigate the involvement of chemical mediators in nasal allergic responses using histidine decarboxylase knockout (HDC-KO) mice. An allergic rhinitis model was developed in HDC-KO and wild-type mice by the intraperitoneal injection of ovalbumin, aluminum hydroxide gel and pertuss...

journal_title：European journal of pharmacology

authors： Rahman MA,Inoue T,Ishikawa T,Yatsuzuka R,Ohtsu H,Kamei C

更新日期：2007-07-19 00:00:00

abstract：:The effects of tacrine (5 mg/kg i.p.) in lithium chloride (LiCl; 12 mEq/kg i.p.)-pretreated (24 h beforehand) animals and of kainate (10 mg/kg i.p.) on brain citrulline, the co-product of nitric oxide (NO) synthesis, were studied in rats. High performance liquid chromatography analysis of whole brain tissue homogenate...

journal_title：European journal of pharmacology

authors： Bagetta G,Rodinò P,Paoletti AM,Arabia A,Massoud R,Nisticò G

更新日期：1995-12-27 00:00:00

abstract：:We have recently shown that responses to pressor nerve stimulation in the pithed rat are mediated by α(1A)- and α(1D)-adrenoceptors, with no evidence for α(2)-adrenoceptor involvement, and that responses previously identified as α(2)-adrenoceptor mediated are actually α(1D)-adrenoceptor mediated. We have now re-examin...

journal_title：European journal of pharmacology

authors： Docherty JR

更新日期：2012-03-15 00:00:00

abstract：:ICI 169,369 is a chemically novel 5-HT antagonist that has higher affinity for the 5-HT2 binding sites in rat cortex than it has for 5-HT1 sites (Ki 1.79 x 10(-8) and 1.58 x 10(-6) M, respectively). In isolated tissue preparations ICI 169,369 was shown to be a competitive antagonist of 5-HT on the rabbit aorta, pig co...

journal_title：European journal of pharmacology

authors： Blackburn TP,Thornber CW,Pearce RJ,Cox B

更新日期：1988-06-10 00:00:00

abstract：:Jolkinolide B (JB), which is isolated from the dried root of Euphorbia fischeriana Steud., has been reported to possess various therapeutic effects, such as treatment of edema and abdominal distention and protection against acute lung injury, and it has also been reported to have anti-inflammatory even antitumor prope...

journal_title：European journal of pharmacology

authors： Yan Y,Wang Y,Wang X,Liu D,Wu X,Xu C,Chen C,Li Z

更新日期：2019-01-05 00:00:00

abstract：:Electrophysiological and pharmacological studies have shown that peripheral-type benzodiazepine receptors modulate voltage-sensitive calcium channels in the heart. We have compared these binding sites with binding sites for [3H]dihydropyridines, which are believed to label such channels. Although no direct or alloster...

journal_title：European journal of pharmacology

authors： Doble A,Benavides J,Ferris O,Bertrand P,Menager J,Vaucher N,Burgevin MC,Uzan A,Gueremy C,Le Fur G

更新日期：1985-12-17 00:00:00

abstract：:Acute leukemia is a malignant clonal hematopoietic stem cell disease. In the current study, we examined the effects of bryostatin 5 on acute monocytic leukemia cells in vitro and in vivo. We also explored the mechanisms and pathways underlying the increase in apoptosis induced by bryostatin 5. Bryostatin 5 inhibited t...

journal_title：European journal of pharmacology

authors： Wang Y,Zhang J,Wang Q,Zhang T,Yang Y,Yi Y,Gao G,Dong H,Zhu H,Li Y,Lin H,Tang H,Chen X

更新日期：2013-10-15 00:00:00

abstract：:The objective of the present studies was to investigate the effect of voluntary ethanol consumption for 21 days on the brain beta-endorphin system of C57BL/6 (alcohol-preferring) and DBA/2 (alcohol-avoiding) strains of mice. As expected, C57BL/6 mice consumed a significantly higher quantity of the 10% ethanol solution...

journal_title：European journal of pharmacology

authors： De Waele JP,Gianoulakis C

更新日期：1994-06-02 00:00:00

abstract：:Oxidative stress has been implicated in the pathogenesis of acute myocarditis. The imbalance between the occurrence of reactive oxygen species and the cellular antioxidant defense mechanism plays a key role in myocardial injury of viral myocarditis. Carvedilol, a nonselective beta-adrenoceptor antagonist with addition...

journal_title：European journal of pharmacology

authors： Li YC,Ge LS,Yang PL,Tang JF,Lin JF,Chen P,Guan XQ

更新日期：2010-08-25 00:00:00

abstract：:The present study was undertaken to evaluate the effects of an adenylate cyclase activator N,N-dimethyl-beta-alanine[3R-(3alpha, 4alphabeta, 5beta, 6beta, 6aalpha, 10alpha, 10abeta, 10balpha)]-5(acetyloxy)-3-ethenyldodecahydro-10, 10b-dihydroxy-3, 4a, 7, 7, 10a-pentamethyl-1-oxo-1H-naphtho [2,1-b] pyran-6-yl ester hyd...

journal_title：European journal of pharmacology

authors： Tanahashi M,Hara S,Yoshida M,Suzuki-Kusaba M,Yokoyama H,Hosono M,Hisa H,Satoh S

更新日期：1999-05-21 00:00:00

abstract：:PCA 50941 is a novel 1,4-dihydropyridine derivative. Its vasoconstricting effects prompted a systematic comparison with the prototypic Ca2+ channel activator, Bay K 8644. The two compounds exhibit marked analogies and differences in their cardiovascular profiles. PCA 50941 exhibits a pronounced vascular over cardiac s...

journal_title：European journal of pharmacology

authors： Priego J,González-Morales MA,Cillero FJ,Villarroya M,Sunkel C,de Casa-Juana MF,López MG,Artalejo CR,de Pascual R,García AG

更新日期：1993-10-12 00:00:00

abstract：:In our previous study, it was found that linoleoyl ethanolamide (LE) is present in sake lees, which are produced as a byproduct during the making of Japanese sake. LE is a fatty acid ethanolamide, which have been demonstrated to exert a variety of biological functions, and in this study, the anti-inflammatory effects ...

journal_title：European journal of pharmacology

authors： Ishida T,Nishiumi S,Tanahashi T,Yamasaki A,Yamazaki A,Akashi T,Miki I,Kondo Y,Inoue J,Kawauchi S,Azuma T,Yoshida M,Mizuno S

更新日期：2013-01-15 00:00:00

abstract：:Chronic Obstructive Pulmonary Disease (COPD) is a major incurable global health burden and is the 4th leading cause of death worldwide. It is believed that an exaggerated inflammatory response to cigarette smoke causes progressive airflow limitation. This inflammation, where macrophages, neutrophils and T lymphocytes ...

journal_title：European journal of pharmacology

authors： Vlahos R,Bozinovski S

更新日期：2015-07-15 00:00:00

abstract：:The effect of papaverine on the positive inotropic response to isopreqaline and to calcium was studied on the rabbit isolated papillary muscle; theophylline and the calcium antagonistic D600 were used for comparison. The dose-response curve for isoprenaline was shifted to the left by papaverine (3 times 10- minus 6 to...

journal_title：European journal of pharmacology

authors： Endoh M,Schümann HJ

更新日期：1975-02-01 00:00:00

abstract：:The mechanisms underlying the capsaicin-induced relaxation of the acetylcholine- as well as KCl-contraction were studied by measuring isometric force and phosphorylation of 20-kDa regulatory light chain subunit of myosin (MLC(20)) in ileal longitudinal smooth muscles of rats. Capsaicin relaxed acetylcholine- and KCl-s...

journal_title：European journal of pharmacology

authors： Fujimoto S,Mori M

更新日期：2004-03-08 00:00:00

abstract：:The cellular localisation and distribution of mRNAs encoding beta-adrenoceptor subtypes in human lung were studied by in situ hybridisation and Northern blot analysis. The 851-bp SmaI/PvuII fragment of human beta 1-adrenoceptor cDNA, the 439-bp SmaI fragment of human beta 2-adrenoceptor cDNA and the 975-bp SmaI fragme...

journal_title：European journal of pharmacology

authors： Mak JC,Nishikawa M,Haddad EB,Kwon OJ,Hirst SJ,Twort CH,Barnes PJ

更新日期：1996-04-29 00:00:00

abstract：:Intracellular accumulation of calcium is thought to play an integral role in the progression of ischemic injury and cell death. We infused the calcium entry blocker, nitrendipine (1.5 micrograms/kg per min), into cats in order to investigate the importance of extracellular Ca2+ influx during hemorrhagic shock. Nitrend...

journal_title：European journal of pharmacology

authors： Hock CE,Su JY,Lefer AM

更新日期：1984-01-13 00:00:00