Strain differences in opiate receptors in mouse brain.

abstract：:Sirolimus and paclitaxel eluted from stents inhibit cell proliferation and other cellular processes by dramatically different mechanisms. In this study, the effects of sirolimus and paclitaxel on cultured human coronary artery smooth muscle and endothelial cell function or cell cycle changes in balloon-injured arterie...

journal_title：European journal of pharmacology

authors： Parry TJ,Brosius R,Thyagarajan R,Carter D,Argentieri D,Falotico R,Siekierka J

更新日期：2005-11-07 00:00:00

abstract：:The kappa-opioid receptor agonist, U50,488H (trans-(+-)-3,4-dichloro-N-methyl-[2-(1-pyrrolidinyl)-cyclohexyl]- benzeneacetamide), has recently been reported to induce dystonia after s.c. administration of 5-10 mg/kg in guinea pigs. The dystonic movements observed in response to U50,488H resembled those previously repo...

journal_title：European journal of pharmacology

authors： Richter A,Löscher W

更新日期：1993-05-19 00:00:00

abstract：:The potency and site of action of Ro5-3663 as a GABA antagonist were investigated in the rat cuneate slice in vitro. A Schild plot for Ro5-3663 was clearly non-linear but enabled a pA2 value of 3.97 to be calculated. Combination studies using the 'classical' GABA antagonists bicuculline and picrotoxin indicated that R...

journal_title：European journal of pharmacology

authors： Harrison NL,Simmonds MA

更新日期：1983-01-28 00:00:00

abstract：:The effects of 2,3-butanedione monoxime (BDM) and 5-[1-(3,4-dimethoxybenzoyl)-1,2,3,4-tetrahydro-6-quinolyl]-6-me thy l-3,6-dihydro-2H-1,3,4-thiadiazin-2-one (EMD 53998) on cardiac muscle were studied in skinned muscle fibres from the right ventricle of the porcine heart. BDM decreases the Ca2+ sensitivity (pCa50 for ...

journal_title：European journal of pharmacology

authors： Barth Z,Strauss JD,Dohet C,Ruegg JC

更新日期：1996-02-05 00:00:00

abstract：:We have studied the effects of benextramine on the U46619 (11 alpha,9 alpha-epoxymethano-15S-hydroxy-prosta-5Z,13E-dienoic acid)-mediated contraction of the rat isolated small mesenteric artery. U46619 (10 nM-10 microM) produced a concentration-dependent contraction of the small mesenteric artery. The selective prosta...

journal_title：European journal of pharmacology

authors： Van der Graaf PH,Stam WB,Saxena PR

更新日期：1996-04-11 00:00:00

abstract：:Two inhibitors of the cellular uptake of the endocannabinoid anandamide, (R)-N-oleoyl-(1'-hydroxybenzyl)-2'-ethanolamine and (S)-N-oleoyl-(1'-hydroxybenzyl)-2'-ethanolamine (OMDM-1 and OMDM-2, respectively), were recently synthesized, and their in vitro pharmacological activity described. Here we have assessed their a...

journal_title：European journal of pharmacology

authors： de Lago E,Ligresti A,Ortar G,Morera E,Cabranes A,Pryce G,Bifulco M,Baker D,Fernandez-Ruiz J,Di Marzo V

更新日期：2004-01-26 00:00:00

abstract：:Rats were trained to discriminate between the stimulus properties of intraperitoneal 0.16 mg/kg apomorphine and saline in a two-lever, food-motivated operant task. Once trained, the rats were tested with the ED50 of apomorphine (0.02 mg/kg) or saline before and 1-22 days after a ten-day regimen of daily 2.0 mg/kg admi...

journal_title：European journal of pharmacology

authors： Schechter MD

更新日期：1981-09-24 00:00:00

abstract：:The function of multidrug resistance-associated protein 2 (Mrp2) in the intestine and liver, as well as intestinal Mrp2 expression, was analyzed in CCl(4)-induced acute hepatic failure rats with hyperbilirubinemia. The plasma level of bilirubin glucuronides, endogenous Mrp2-substrates, was 26 microM at 24 h after CCl(...

journal_title：European journal of pharmacology

authors： Yokooji T,Murakami T,Yumoto R,Nagai J,Takano M

更新日期：2006-09-28 00:00:00

abstract：:This study examined the hemodynamic responses elicited by the beta-adrenoceptor agonist, isoproterenol (1 and 10 microg/kg, i.v.) before and after administration of (i) peroxynitrite (10 x 10 micromol/kg, i.v.), (ii) the thiol chelator, para-hydroxymercurobenzoic acid (pHMBA, 75 micromol/kg, i.v.), and (iii) the elect...

journal_title：European journal of pharmacology

authors： Lewis SJ,Hoque A,Walton TM,Kooy NW

更新日期：2005-08-22 00:00:00

abstract：:We investigated the mechanism of action of a novel 'high ceiling' diuretic, M17055, in in vivo clearance studies with anesthetized dogs during water diuresis and in vitro microperfusion studies of isolated rabbit renal tubules. In the clearance study, intravenous infusion of M17055 (1 mg/kg per h) decreased free water...

journal_title：European journal of pharmacology

authors： Shinkawa T,Yamasaki F,Notsu T,Nakakuki M,Nishijima K,Yoshitomi K,Imai M

更新日期：1993-07-20 00:00:00

abstract：:The function of gamma-aminobutyric acid type A receptors (GABA(A) receptors) is enhanced by various clinically important drugs including benzodiazepines that act on an allosteric site formed at the interface between the alpha and gamma subunits. In contrast to classical benzodiazepines, the novel pyrazolopyrimidine in...

journal_title：European journal of pharmacology

authors： Wegner F,Deuther-Conrad W,Scheunemann M,Brust P,Fischer S,Hiller A,Diekers M,Strecker K,Wohlfarth K,Allgaier C,Steinbach J,Hoepping A

更新日期：2008-02-02 00:00:00

abstract：:Calcitonin gene-related peptide (CGRP), a 37-amino acid neuropeptide, is found in the central nervous system as well as in the heart. CGRP shows high sequence homology with amylin, salmon calcitonin, and adrenomedullin. This study aimed to investigate the effect of CGRP on atrial hemodynamics and atrial natriuretic pe...

journal_title：European journal of pharmacology

authors： Piao FL,Cao C,Han JH,Kim SZ,Kim SH

更新日期：2004-01-12 00:00:00

abstract：:Mouse gastric fundus strips were relaxed by ultraviolet light (UV) irradiation, exogenous nitric oxide (NO), isoproterenol, S-nitrosoglutathione, S-nitroso-L-cysteine and S-nitroso-N-acetyl-penicillamine. Glutathione did not affect relaxations in response to UV irradiation, exogenous NO and isoproterenol while inhibit...

journal_title：European journal of pharmacology

authors： Ogülener N,Ergün Y

更新日期：2002-08-30 00:00:00

abstract：:Dexmedetomidine is a highly specific alpha2-adrenoreceptor agonist, which is now clinically used to induce sedation in patients in the intensive care units. Behavioural effects of dexmedetomidine have been little studied so far. The drug was reported to reduce behaviour such as locomotion or measures of anxiety or agg...

journal_title：European journal of pharmacology

authors： Votava M,Hess L,Slíva J,Krsiak M,Agová V

更新日期：2005-10-31 00:00:00

abstract：:Clozapine, an atypical antipsychotic, is very effective in the treatment of resistant schizophrenia. However, cardiotoxicity of clozapine, particularly in young patients, has raised concerns about its safety. Increased catecholamines have been postulated to trigger an inflammatory response resulting in myocarditis, di...

journal_title：European journal of pharmacology

authors： Wang JF,Min JY,Hampton TG,Amende I,Yan X,Malek S,Abelmann WH,Green AI,Zeind J,Morgan JP

更新日期：2008-09-11 00:00:00

abstract：:The pharmacological treatment of mood and anxiety disorders has for long relied on the serendipitous findings of monoaminergic and benzodiazepine drugs more than 50 years ago. These treatments, however, are therapeutically insufficient and even though more recently developed drugs are particularly improving side effec...

journal_title：European journal of pharmacology

authors： de Mooij-van Malsen AJ,Olivier B,Kas MJ

更新日期：2008-05-13 00:00:00

abstract：:The present study was conducted with an aim to explore the possible role of naringin against ischemia reperfusion induced-neurobehavioral alterations, oxidative damage, cellular and histopathological alterations in cortex, striatum, hippocampus areas of brain. Male Wistar rats (200-220 g) were subjected to bilateral c...

journal_title：European journal of pharmacology

authors： Gaur V,Aggarwal A,Kumar A

更新日期：2009-08-15 00:00:00

abstract：:Metformin administration has been reported to influence the carotid intima-media thickness (CIMT) in humans. However, since previously conducted studies have yielded inconsistent results, the exact effect of metformin on CIMT remains unclear. Causes that could lead to inconsistency in reported research could be the du...

journal_title：European journal of pharmacology

authors： Chen Y,Li H,Ye Z,Găman MA,Tan SC,Zhu F

更新日期：2020-11-05 00:00:00

abstract：:Single myelinated nerve fibres of Rana esculenta were investigated under current and potential clamp conditions at 20 degrees C. Under 2.5 mM phenobarbital, the amplitude of the action potential was reversibly reduced to 85.5 +/- 5% (n = 6), and the threshold potential was raised by 32% of the control in Ringer soluti...

journal_title：European journal of pharmacology

authors： Schwarz JR

更新日期：1979-06-01 00:00:00

abstract：:K(+)-channel blocker properties have been reported for mast cell-degranulating peptide (MCD) in the central nervous system, but its action mechanism in mast cells remains unknown. We studied the effect of MCD on the membrane potential of rat peritoneal mast cells using the fluorescent probe bis-oxonol. Unexpectedly, M...

journal_title：European journal of pharmacology

authors： Mousli M,Bronner C,Bueb JL,Landry Y

更新日期：1991-07-12 00:00:00

abstract：:The beta-carboline FG7142 is a partial inverse agonist at benzodiazepine receptors. We have shown previously that a single dose of this drug causes an upregulation of cortical beta-adrenoceptor numbers in mouse cerebral cortex. This rise was seen seven days, but not 15-30 min or 24 h after FG7142 administration. We no...

journal_title：European journal of pharmacology

authors： Stanford SC,Taylor SC,Little HJ

更新日期：1987-07-09 00:00:00

abstract：:This study compared the peripheral analgesic effects of a novel opioid agonist 14-O-methylmorphine-6-O-sulfate (14-O-MeM6SU), to that of non-peptide (morphine, fentanyl) and peptide opioid agonists (Met-enkephalin; met-ENK and β-endorphin; β-END) in a model of localized inflammatory pain evoked by intraplantar (i.pl.)...

journal_title：European journal of pharmacology

authors： Khalefa BI,Mousa SA,Shaqura M,Lackó E,Hosztafi S,Riba P,Schäfer M,Ferdinandy P,Fürst S,Al-Khrasani M

更新日期：2013-08-05 00:00:00

abstract：:Experiments were conducted to explore the effects of Neuropeptide FF acting at spinal and supraspinal sites in models of chronic inflammatory or neuropathic pain and of acute pain. Neuropeptide FF was administered intrathecally (i.t.; 10.0, 25.0 and 50.0 nmol) or intracerebroventricularly (i.c.v.; 10.0, 12.5 and 15.0 ...

journal_title：European journal of pharmacology

authors： Altier N,Dray A,Ménard D,Henry JL

更新日期：2000-11-03 00:00:00

abstract：:The muscarinic agonists, xanomeline and carbachol, displayed similar intrinsic activities in stimulating neuronal nitric oxide synthase at muscarinic M1 receptors in Chinese hamster ovary (CHO) cells, with xanomeline being more potent. Pre-incubation (1 h) with 1 microM xanomeline, followed by extensive washing, resul...

journal_title：European journal of pharmacology

authors： Christopoulos A,El-Fakahany EE

更新日期：1997-09-03 00:00:00

abstract：:The limited removal of metabolic waste products in dialyzed kidney patients leads to high morbidity and mortality. One powerful solution for a more complete removal of those metabolites might be offered by a bioartificial kidney device (BAK), which contains a hybrid "living membrane" with functional proximal tubule ep...

journal_title：European journal of pharmacology

authors： Chevtchik NV,Fedecostante M,Jansen J,Mihajlovic M,Wilmer M,Rüth M,Masereeuw R,Stamatialis D

更新日期：2016-11-05 00:00:00

abstract：:Propofol is generally used for the induction and maintenance of anesthesia in clinical procedures via activation of γ -aminobutyric acid A (GABAA) receptors. When administered at the clinical dose, propofol use is associated with movement disorders, including dystonia and ataxia, suggesting that propofol administratio...

journal_title：European journal of pharmacology

authors： Zhang XY,Zhang YD,Cui BR,Jin R,Chu CP,Jin XH,Qiu DL

更新日期：2020-11-15 00:00:00

abstract：:The locations of the vascular resistance sites which regulate vascular tone in the hepatic arterial and portal venous vasculatures of the rat liver were identified using a new, in vitro, dual-perfused liver preparation. Twelve livers of male Wistar rats were perfused via the hepatic artery and portal vein at fixed flo...

journal_title：European journal of pharmacology

authors： Yang W,Benjamin IS,Alexander B

更新日期：1999-01-01 00:00:00

abstract：:The response of lymph vessels, arterioles and venules in the exteriorized rat mesentery to endothelin-1, vasopressin and norepinephrine was examined with the aid of high-resolution television microscopy. On a molar basis, endothelin-1 was more potent than vasopressin to contract the three types of vessels. Norepinephr...

journal_title：European journal of pharmacology

authors： Fortes ZB,Scivoletto R,Garcia-Leme J

更新日期：1989-10-24 00:00:00

abstract：:The inhibitory effects of adenosine, ATP, 5'-adenylyl methylene diphosphonate (beta, gamma-meATP) and adenosine 5'-alpha, beta-methylene triphosphonate (alpha, beta-meATP) were compared on the cholinergic twitch responses to transmural stimulation of the guinea-pig ileum. Adenosine, ATP and beta, gamma-meATP reduced t...

journal_title：European journal of pharmacology

authors： Moody CJ,Burnstock G

更新日期：1982-01-08 00:00:00

abstract：:The effects of the endothelin ET(A), (BQ-123) and endothelin ET(A/B) (PD161721) receptor antagonists were investigated on ischaemia-induced arrhythmias and on the maximum following frequency. The study was carried out in Langendorff perfused rat hearts subjected to coronary artery occlusion in which the severity of ar...

journal_title：European journal of pharmacology

authors： Crockett TR,Scott GA,McGowan NW,Kane KA,Wainwright CL

更新日期：2001-11-30 00:00:00