Lack of effect of 6-hydroxydopamine pretreatment on depolarization-induced release of ATP fron rat brain synaptosomes.

Abstract:

:Pretreatment of rats with intraventricular 6-hydroxydopamine produced considerable destruction of noradrenergic and dopaminergic nerve terminals as indicated by depletions in synaptosomal catecholamine contents. However, 6-hydroxydopamine pretreatment did not result in diminished release of ATP during depolarization of synaptosomes with either elevated extracellular K+ or veratridine. These findings suggest that most of the ATP released during the depolarization of rat brain synaptosomal preparations is not co-released with noradrenaline or dopamine but must originate from other sources.

journal_name

Eur J Pharmacol

authors

Potter PE,White TD

doi

10.1016/0014-2999(82)90191-1

subject

Has Abstract

pub_date

1982-05-07 00:00:00

pages

143-7

issue

1

eissn

0014-2999

issn

1879-0712

pii

0014-2999(82)90191-1

journal_volume

80

pub_type

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