当前位置： SCI文献检索 > EUROPEAN JOURNAL OF PHARMACOLOGY期刊下所有文献 > Methoctramine, a selective M2 alpha muscarinic receptor antagonist, does not inhibit carbachol-induced drinking in the rat.

Methoctramine, a selective M2 alpha muscarinic receptor antagonist, does not inhibit carbachol-induced drinking in the rat.

Abstract：

:Methoctramine, a selective M2 alpha muscarinic receptor antagonist, was examined for its ability to inhibit carbachol-induced drinking in the rat. Intracerebroventricularly (i.c.v.) administered methoctramine was devoid of activity up to a dose of 100 nmol/rat, whereas higher doses were toxic under our experimental conditions. 4-DAMP, pirenzepine and hexahydrosiladifenidol were also tested. The rank potency order for the compounds (4-DAMP greater than pirenzepine = hexahydrosiladifenidol) was similar to that for their affinity at M1 receptors, as found in experiments in vitro. The putative M1 agonist McN-A-343 was inactive up to doses of 13.9 micrograms/rat. Our data suggest that M2 alpha receptors do not mediate cholinergic drinking in the rat. The question whether M1 or M2 beta muscarinic receptors are involved in this response still awaits a firm answer.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Massi M,Polidori C,Melchiorre C

doi

10.1016/0014-2999(89)90213-6

subject

Has Abstract

pub_date

1989-04-25 00:00:00

pages

387-91

issue

2-3

eissn

0014-2999

issn

1879-0712

pii

0014-2999(89)90213-6

journal_volume

163

pub_type

杂志文章

相关文献

EUROPEAN JOURNAL OF PHARMACOLOGY文献大全
  • C(5) modified uracil derivatives showing antiproliferative and erythroid differentiation inducing activities on human chronic myelogenous leukemia K562 cells.

    abstract：:The K562 cell line has been proposed as a useful experimental system to identify anti-tumor compounds acting by inducing terminal erythroid differentiation. K562 cells exhibit a low proportion of hemoglobin-synthesizing cells under standard cell growth conditions, but are able to undergo terminal erythroid differentia...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2011.09.024

    authors： Brognara E,Lampronti I,Breveglieri G,Accetta A,Corradini R,Manicardi A,Borgatti M,Canella A,Multineddu C,Marchelli R,Gambari R

    更新日期：2011-12-15 00:00:00

  • Effects of a seven-day continuous infusion of L-DOPA on daily rhythms in the rat.

    abstract：:The present study was conducted to evaluate the effect of L-3, 4-dihydroxyphenylalanine (L-DOPA) on the daily rhythms of temperature, heart rate and locomotor activity in rats that received a 7-day continuous infusion. Our results indicate that L-DOPA does not induce a loss of the daily rhythmicity of temperature, hea...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0014-2999(00)00422-2

    authors： Simon N,Mouchet J,Bruguerolle B

    更新日期：2000-07-28 00:00:00

  • Arachidonyl-2'-chloroethylamide, a highly selective cannabinoid CB1 receptor agonist, enhances the anticonvulsant action of valproate in the mouse maximal electroshock-induced seizure model.

    abstract：:Endogenous cannabinoid ligands and cannabinoid CB(1) receptor agonists have been shown to exert potent anticonvulsant effects in various experimental models of epilepsy. The purpose of this study was to determine the effects of arachidonyl-2'-chloroethylamide (ACEA; N-(2-chloroethyl)-5Z,8Z,11Z,14Z-eicosatetraenamide, ...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2006.07.037

    authors： Luszczki JJ,Czuczwar P,Cioczek-Czuczwar A,Czuczwar SJ

    更新日期：2006-10-10 00:00:00

  • Suppression of isoproterenol-induced cardiotoxicity in rats by raspberry ketone via activation of peroxisome proliferator activated receptor-α.

    abstract：:The peroxisome proliferator-activated receptor-α (PPAR-α) controls the lipid and glucose metabolism and also affects inflammation, cell proliferation and apoptosis during cardiovascular disease. Raspberry ketone (RK) is a red raspberry (Rubusidaeus, Family-Rosaceae) plant constituent, which activates PPAR-α. This stud...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2018.10.034

    authors： Khan V,Sharma S,Bhandari U,Sharma N,Rishi V,Haque SE

    更新日期：2019-01-05 00:00:00

  • Antidepressants enhance the antinociceptive effects of carbamazepine in the acetic acid-induced writhing test in mice.

    abstract：:Some antidepressants, as well as antiepileptics, are effective for treating pain of varying etiology. The present study was designed to characterize the antinociceptive effects of imipramine, a tricyclic antidepressant, fluvoxamine, a selective serotonin reuptake inhibitor, milnacipran, a serotonin noradrenaline reupt...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2006.08.049

    authors： Aoki M,Tsuji M,Takeda H,Harada Y,Nohara J,Matsumiya T,Chiba H

    更新日期：2006-11-21 00:00:00

  • Prednisolone-3, 20-bisguanylhydrazone: Na+, K+-ATPase inhibition and positive inotropic action.

    abstract：:The relationship between two known actions of prednisolone-3, 20-bisguanylhydrazone (PBGH); Na+, K+-ATPase inhibition and positive inotropic effects, was investigated. In electrically driven left atrial preparations of guinea pig heart, the positive inotropic action of PBGH was not affected by beta-adrenergic or hista...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(78)90068-7

    authors： Yamamoto S,Akera T,Brody TM

    更新日期：1978-05-15 00:00:00

  • Bortezomib influences the expression of malignant plasma cells membrane antigens.

    abstract：:Multiple myeloma cells can be characterized immunophenotypically as the expression levels of several membrane antigens differ from those of normal plasma cells. These antigens are important for making a diagnostic of multiple myeloma; they have a significant role in survival and proliferation of multiple myeloma cells...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2013.02.002

    authors： Tagoug I,Plesa A,Dumontet C

    更新日期：2013-04-15 00:00:00

  • Characterization of scratching behavior induced by intradermal administration of morphine and fentanyl in mice.

    abstract：:Itching is known as a commonly side effect of opioid administration. However, the relationship of opioid receptors to itching is unclear. In this study, we examined the effect of intradermal injection of morphine and fentanyl on the itching sensation. When injected intradermally into the rostral back of mice, morphine...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2009.10.066

    authors： Yamamoto A,Kuyama S,Kamei C,Sugimoto Y

    更新日期：2010-02-10 00:00:00

  • Pinacidil-postconditioning is equivalent to ischemic postconditioning in defeating cardiac ischemia-reperfusion injury in rat.

    abstract：:Ischemic postconditioning (IPO) had been reported as a promising method against myocardial ischemia-reperfusion (I/R) injury, but IPO was later proved with poor clinical benefit. In this study, we compared the protective effects of pinacidil-postconditioning (PPO) and IPO against myocardial I/R injury. Langendorff rat...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2016.03.027

    authors： Yang YH,Zhang Y,Chen W,Wang Y,Cao S,Yu T,Wang H

    更新日期：2016-06-05 00:00:00

  • Nicorandil normalizes prolonged repolarisation in the first transgenic rabbit model with Long-QT syndrome 1 both in vitro and in vivo.

    abstract：:Transgenic rabbits expressing loss-of-function pore mutants of the human gene KCNQ1 (K(v)LQT1-Y315S) have a Long QT-Syndrome 1 (LQT1) phenotype. We evaluated for the first time the effect of nicorandil, an opener of ATP-sensitive potassium channels, and of isoproterenol on cardiac action potential duration and heart r...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2010.10.016

    authors： Biermann J,Wu K,Odening KE,Asbach S,Koren G,Peng X,Zehender M,Bode C,Brunner M

    更新日期：2011-01-10 00:00:00

  • Characterization and localization of high-affinity GABA uptake in slices of the rabbit oviduct.

    abstract：:The characteristics of [3H]gamma-aminobutyric acid (GABA) uptake by slices of the rabbit oviduct were studied, and the GABA-accumulating structures were identified by histoautoradiography. A high-affinity (Km = 5 microM), sodium-dependent GABA uptake system was demonstrated which showed significant segmental variation...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(86)90280-3

    authors： Erdö SL,Amenta F

    更新日期：1986-11-04 00:00:00

  • Effective suppression of donor specific antibody production by Cathepsin S inhibitors in a mouse transplantation model.

    abstract：:Donor-specific antibodies (DSA) are a major risk factor for antibody-mediated rejection (ABMR) in solid organ transplantation, and ABMR remains a medical challenge. Therefore, effective anti-ABMR therapies are needed to improve overall graft survival. Cathepsin S (Cat S) is an essential protease for antigen peptide lo...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2018.09.007

    authors： Kubo K,Kawato Y,Nakamura K,Nakajima Y,Nakagawa TY,Hanaoka K,Oshima S,Fukahori H,Inami M,Morokata T,Higashi Y

    更新日期：2018-11-05 00:00:00

  • Effects of fluoroquinolones on HERG currents.

    abstract：:We have investigated the effects of four fluoroquinolones on the human ether-à-go-go-related gene (HERG) mediated K(+) currents to evaluate their potential to induce QT-prolongation. HERG currents were measured from stably transfected Chinese hamster ovary (CHO) cells by means of the patch-clamp technique. Bath applic...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0014-2999(00)00693-2

    authors： Bischoff U,Schmidt C,Netzer R,Pongs O

    更新日期：2000-10-20 00:00:00

  • Antagonism of beta-adrenoceptor-mediated relaxations of human bronchial smooth muscle by carbachol.

    abstract：:Activation of muscarinic M2 receptors has been suggested to account, in part, for the reduced relaxant potency of beta-adrenoceptor agonists in canine and guinea-pig tracheal smooth muscle pre-contracted with muscarinic agonists as compared to histamine. The aim of the present study was to determine whether the potenc...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(95)00048-p

    authors： Watson N,Magnussen H,Rabe KF

    更新日期：1995-03-14 00:00:00

  • In vitro modulation by SQ 20009 and SQ 65396 of GABA receptor binding in rat CNS membranes.

    abstract：:SQ 20009 and SQ 65396, two new pyrazolopyridines with anxiolytic properties in animals, reversibly increased Na+-independent 3H-GABA binding to rat cerabral cortex membranes in vitro. This modulation was partially chloride dependent and sensitive to Triton-X 100. Kinetic analysis of 3H-muscimol binding revealed an inc...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(80)90281-2

    authors： Placheta P,Karobath M

    更新日期：1980-03-21 00:00:00

  • Biochemical and pharmacological characterization of FR134043, a novel elastase inhibitor.

    abstract：:FR134043, disodium(Z,1S,15S,8S,24S,27R,29S,34S,37R)-29-ben zyl-21-ethylidene-27-hydroxy-15-isobutyrylamino-34-isopropyl-31,37 -dimethyl-10,16,19,22,30,32,35,38-octaoxo-36-oxa-9,11,17,20,23,28, 31,33-octaazatetracyclo[16.13.6.1(24),(28).0(3),(8)]octatricont a-3,5,7-trien-5,6-diyl disulfate, is a water-soluble inhibitor...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0014-2999(98)00028-4

    authors： Shinguh Y,Yamazaki A,Inamura N,Fujie K,Okamoto M,Nakahara K,Notsu Y,Okuhara M,Ono T

    更新日期：1998-03-26 00:00:00

  • Cerebroprotective properties of SM-20220, a potent Na(+)/H(+) exchange inhibitor, in transient cerebral ischemia in rats.

    abstract：:The aim of this study was to investigate the contribution of the Na(+)/H(+) exchanger to cerebral ischemia using SM-20220 (N-(aminoiminomethyl)-1-methyl-1H-indole-2-carboxamide methanesulfonate), a newly synthesized compound. In in vitro experiments, we evaluated the inhibitory effect of SM-20220 on the Na(+)/H(+) exc...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0014-2999(99)00645-7

    authors： Kuribayashi Y,Itoh N,Kitano M,Ohashi N

    更新日期：1999-10-27 00:00:00

  • Effects of cenobamate (YKP3089), a newly developed anti-epileptic drug, on voltage-gated sodium channels in rat hippocampal CA3 neurons.

    abstract：:New, more effective pharmacologic treatments for epilepsy are needed, as a substantial portion of patients (>30%) are refractory to currently available anti-epileptic drugs. Cenobamate (YKP3089) is an investigational anti-epileptic drug in clinical development. Two completed adequate and well-controlled studies demons...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2019.05.007

    authors： Nakamura M,Cho JH,Shin H,Jang IS

    更新日期：2019-07-15 00:00:00

  • Hippocampal NMDA/phencyclidine receptor binding sites are reduced following forebrain ischaemia in the gerbil.

    abstract：:The binding of [3H]N-(1-[2-thienyl]cyclohexyl)piperidine (TCP) to N-methyl-D-aspartate (NMDA) receptor sites in synaptic membranes prepared from the dorsal hippocampus of the ischaemic gerbil, has been studied. Forebrain ischaemia was induced by 10 min bilateral carotid occlusion and receptor binding determined in the...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(88)90855-2

    authors： Leach MJ,Hollox KJ,O'Donnell RA,Miller AA

    更新日期：1988-07-26 00:00:00

  • Mediation of glutamatergic receptors and nitric oxide on striatal dopamine release evoked by anatoxin-a. An in vivo microdialysis study.

    abstract：:In this work, the involvement of ionotropic glutamatergic receptors and nitric oxide on striatal dopamine release induced by anatoxin-a was investigated in conscious and freely-moving rats. To study the participation of glutamatergic receptors, the effects of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (A...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2006.07.044

    authors： Campos F,Alfonso M,Vidal L,Faro LR,Durán R

    更新日期：2006-10-24 00:00:00

  • [3H]N-[4-(3,4-dihydro-6,7-dimethoxyisoquinolin-2(1H)-yl)butyl]-2-methoxy-5-methylbenzamide: a novel sigma-2 receptor probe.

    abstract：:N-[4-(3,4-dihydro-6,7-dimethoxyisoquinolin-2(1H)-yl)butyl]-2-methoxy-5-methyl-benzamide (RHM-1) and N-[2-(3,4-dihydro-6,7-dimethoxyisoquinolin-2(1H)-yl)ethyl]-2-methoxy-5-methylbenzamide (RHM-2), two conformationally flexible benzamide analogues, were radiolabeled with tritium (specific activity=80 Ci/mmol) and the bi...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2005.09.063

    authors： Xu J,Tu Z,Jones LA,Vangveravong S,Wheeler KT,Mach RH

    更新日期：2005-11-21 00:00:00

  • Peripheral antagonistic action of trimebutine and kappa opioid substances on acoustic stress-induced gastric motor inhibition in dogs.

    abstract：:The effects of intracerebroventricular (i.c.v.), intravenous (i.v.) and oral (p.o.) administration of trimebutine on the gastric motor inhibition induced by acoustic stress were investigated in fasted dogs fitted with strain-gauge transducers on the antrum and proximal jejunum. Started 40-50 min after the last migrati...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(88)90486-4

    authors： Gué M,Pascaud X,Hondé C,Junien JL,Buéno L

    更新日期：1988-01-27 00:00:00

  • Mechanisms of orexin 2 receptor-mediated depolarization in the rat paraventricular nucleus of the hypothalamus.

    abstract：:The paraventricular nucleus of the hypothalamus (PVN) contains dense orexin 2 (OX2) receptor. We examined the mechanisms of OX2 receptor-mediated excitation on electrophysiologically identified type I (putative magnocellular), low-threshold spikes (LTS)-expressing type II (putative preautonomic), and non-LTS type II (...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2019.172802

    authors： Dai YE,Lee YH,Li TL,Hwang LL

    更新日期：2020-02-15 00:00:00

  • BHT-920 and LY-171555 (quinpirole) have similar affinities for striatal D-2 dopamine receptors, and similar affinities for striatal D-1 dopamine receptors.

    abstract：:The affinity of LY-171555 (quinpirole) and BHT-920 for both states of rat striatal dopamine D-1 and D-2 receptors was determined. Although these drugs have different pharmacological effects in experimental animals, we found that they had similar affinities for both D-1 and D-2 receptors. ...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(89)90072-1

    authors： Ferré S,Guix T,Sallés J,Cuffí L,Badia A,Casas M

    更新日期：1989-07-18 00:00:00

  • Mechanism of mustard oil-induced skin inflammation in mice.

    abstract：:We examined the mechanism of the inflammatory response induced by topical application of mustard oil (0.5-20.0%/20 microliters per ear) to the mouse ear compared to that of the response to capsaicin. The dose-dependent increases in plasma extravasation and ear thickness reached a maximum at approximately 30 min after ...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0014-2999(97)01040-6

    authors： Inoue H,Asaka T,Nagata N,Koshihara Y

    更新日期：1997-08-27 00:00:00

  • Cycloheximide prevents apomorphine-induced yawning, penile erection and genital grooming in rats.

    abstract：:Apomorphine (50 micrograms/kg) induced repeated episodes of yawning, penile erection and genital grooming in rats. A dose of cycloheximide, which inhibited brain protein synthesis by 50% totally prevented apomorphine-induced yawning and reduced by approximately 50% the occurrence of episodes of penile erection and gen...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(82)90327-2

    authors： Serra G,Fratta W,Collu M,Napoli-Farris L,Gessa GL

    更新日期：1982-12-24 00:00:00

  • Effects of the putative lithium mimetic ebselen on pilocarpine-induced neural activity.

    abstract：:Lithium, commonly used to treat bipolar disorder, potentiates the ability of the muscarinic agonist pilocarpine to induce seizures in rodents. As this potentiation by lithium is reversed by the administration of myo-inositol, the potentiation may be mediated by inhibition of inositol monophosphatase (IMPase), a known ...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2020.173377

    authors： Singh N,Serres F,Toker L,Sade Y,Blackburn V,Batra AS,Saiardi A,Agam G,Belmaker RH,Sharp T,Vasudevan SR,Churchill GC

    更新日期：2020-09-15 00:00:00

  • Myosin phosphorylation and Ca2+ sensitization in porcine coronary arterial smooth muscle stimulated with endothelin-1.

    abstract：:We examined the mechanism of endothelin-1-induced contraction in the porcine coronary artery by assessing the changes in myosin light chain phosphorylation and cytosolic Ca2+ concentration ([Ca2+]i) determined by fura-2 and front-surface fluorometry. Endothelin-1 induced a rapid phosphorylation of myosin both in the p...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0922-4106(94)90011-6

    authors： Kodama M,Yamamoto H,Kanaide H

    更新日期：1994-12-15 00:00:00

  • The distribution of 5-HT3 recognition sites in the marmoset brain.

    abstract：:The distribution of the binding of [3H]GR65630 (0.2 nM) to putative 5-HT3 recognition sites in the brain of the common marmoset was assessed using autoradiography. Specific binding was heterogeneously distributed with the highest densities found in discrete nuclei of the lower medulla (nucleus tractus solitarii, dorsa...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(92)90609-8

    authors： Jones DN,Barnes NM,Costall B,Domeney AM,Kilpatrick GJ,Naylor RJ,Tyers MB

    更新日期：1992-04-29 00:00:00

  • The antinociceptive effect of leukotriene D(4) receptor antagonist, MK-571, in mice: possible involvement of opioidergic mechanism.

    abstract：:The effect of a leukotriene D(4) receptor antagonist, (3-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl(3-dimethyl amino-3-oxo propyl)thio)methyl)thio) propanoic acid (L-660,711; MK-571), was investigated on nociceptive responses in mice using three different assays: acetic-acid-induced abdominal constrictions, formalin ...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0014-2999(99)00756-6

    authors： Gök S,Onal A,Cinar MG,Evinç A

    更新日期：1999-12-15 00:00:00