Hippocampal NMDA/phencyclidine receptor binding sites are reduced following forebrain ischaemia in the gerbil.

abstract：:We investigated sex differences in the motor responses to the full and selective dopamine D1-like receptor agonist, (+/-)-6-chloro-7,8-dihydroxyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide (SKF-81297; 0.3, 3, and 10 mg/kg, s.c.), in non-habituated adult rats. In general, SKF-81297 produced a biphasic ef...

journal_title：European journal of pharmacology

authors： Heijtz RD,Beraki S,Scott L,Aperia A,Forssberg H

更新日期：2002-06-07 00:00:00

abstract：:Morphine and aspartic acid were administered separately and in combination to 80 rats divided into 8 groups. Ten and 20 min following the injections, brain, liver and kidney L-asparaginase activity was determined. Morphine decreased brain and liver L-asparaginase activity and increased that of kidney. Aspartic acid co...

journal_title：European journal of pharmacology

authors： Koyuncuoğlu H,Keyer-Uysal M,Berkman K,Güngör M,Genç EM

更新日期：1979-12-20 00:00:00

abstract：:Anandamide (AEA), an endogenous cannabinoid and vanilloid receptor ligand, possesses anti-inflammatory properties. Transport of AEA through cytoplasm is facilitated by heat shock protein (HSP) Hsp70, which enhances the rate of cellular AEA uptake, possibly via direct interactions. In lungs, increased HSP expression is...

journal_title：European journal of pharmacology

authors： Kopczyńska B,Sulejczak D,Wełniak-Kamińska M,Gietka A,Grieb P

更新日期：2011-10-01 00:00:00

abstract：:Inhibition of inducible nitric oxide (NO) synthase during endotoxaemia may be of therapeutic value. We have previously shown that pretreatment of mice with adenosine receptor agonists 1 h before lipopolysaccharide administration results in a dose-dependent reduction of plasma nitrite and nitrate (NOx-) levels. This re...

journal_title：European journal of pharmacology

authors： Moochhala SM,Hon WM,Chhatwal VJ,Khoo HE

更新日期：1996-12-05 00:00:00

abstract：:Cultured chick hepatocytes were used to investigate the hepatotoxicity of methotrexate alone and in combination with paracetamol. Treatment with methotrexate alone at concentrations as high as 1 mg/ml resulted in no toxicity in cultured chick hepatocytes, as indicated by no detachment of cells and no effect on protein...

journal_title：European journal of pharmacology

authors： Lindenthal J,Sinclair JF,Howell S,Cargill I,Sinclair PR,Taylor T

更新日期：1993-04-01 00:00:00

abstract：:The effect of moguisteine, a novel peripherally acting non-narcotic antitussive drug, on allergic coughs was examined in guinea pigs. Male Hartley guinea pigs were actively sensitized to ovalbumin. The number of coughs elicited over 5 min following a 2-min exposure to ovalbumin was counted. Exposure of sensitized guin...

journal_title：European journal of pharmacology

authors： Kamei J,Morita K,Kashiwazaki T,Ohsawa M

更新日期：1998-04-24 00:00:00

abstract：:SR 57746A, 4-(3-trifluoromethylphenyl)-N-[2-(naphth-2-yl)ethyl]-1,2,3,6- tetrahydropyridine HCl, was studied for its specific 5-HT1A receptor agonist action and antidepressant-like effects in the rat. The compound showed a high affinity for 5-HT1A specific binding sites in the rat hippocampus (IC50 3 nM), moderate aff...

journal_title：European journal of pharmacology

authors： Cervo L,Bendotti C,Tarizzo G,Cagnotto A,Skorupska M,Mennini T,Samanin R

更新日期：1994-02-21 00:00:00

abstract：:Impairment of nitric oxide (NO) - cyclic GMP signaling pathway is likely to contribute to human begnin prostate hyperplasia (BPH). In the present study we have used a model of chronic NO synthesis inhibition to evaluate the functional alterations of prostate smooth muscle (PSM) machinery, and involvement of Rho-kinase...

journal_title：European journal of pharmacology

authors： Calmasini FB,Leiria LO,Alves Junior MJ,Báu FR,Alexandre EC,Silva FH,Mónica FZ,Antunes E

更新日期：2015-07-05 00:00:00

abstract：:The effects of seganserin, a specific 5HT2 antagonist, on human sleep were assessed in two experiments and compared to the effects of temazepam and sleep deprivation. During daytime recovery sleep after sleep deprivation, seganserin did not significantly enhance visually scored slow wave sleep (SWS, stages 3 + 4) or t...

journal_title：European journal of pharmacology

authors： Dijk DJ,Beersma DG,Daan S,van den Hoofdakker RH

更新日期：1989-11-21 00:00:00

abstract：:FK-33,824 (Tyr-D-Ala-Gly-MePhe-Met(O)-ol) and metkephamid (Tyr-D-Ala-Gly-Phe-N(Me)Met-CONH2; LY 127623) are two parenterally active synthetic analogues of the endogenous morphinomimetic pentapeptide, [Met5]-enkephalin. Acute s.c. administration of each analogue raised the seizure threshold in a dose-related manner in ...

journal_title：European journal of pharmacology

authors： Cowan A,Tortella FC,Adler MW

更新日期：1981-04-24 00:00:00

abstract：:We investigated the effects of L-arginine and NG-nitro-L-arginine methyl ester (L-NAME) on macromolecule extravasation in the microcirculation of awake hamsters by computer-assisted image analysis of the distribution of FITC (fluorescein isothiocyanate)-dextran fluorescence in dorsal fold skin preparations. This analy...

journal_title：European journal of pharmacology

authors： Gimeno G,Carpentier PH,Desquand-Billiald S,Hanf R,Finet M

更新日期：1998-04-10 00:00:00

abstract：:The histamine H3 agonist, (R)-alpha-methylhistamine (alpha-MeHA, 10(-10) to 10(-5) M), caused a concentration-dependent inhibition of the sympathetic contractile response to electrical field stimulation of guinea pig isolated atria, but alpha-MeHA did not alter the basal tension or the contraction induced by exogenous...

journal_title：European journal of pharmacology

authors： Luo XX,Tan YH,Sheng BH

更新日期：1991-11-12 00:00:00

abstract：:Methotrexate is a disease modifying anti-rheumatic drug that is widely used for the treatment of rheumatoid arthritis. Nimesulide is a non-steroidal anti-inflammatory drug which is frequently used as adjuvant therapy for symptomatic alleviation of rheumatoid arthritis. In this study, we have evaluated the potential in...

journal_title：European journal of pharmacology

authors： Al-Abd AM,Inglis JJ,Nofal SM,Khalifa AE,Williams RO,El-Eraky WI,Abdel-Naim AB

更新日期：2010-10-10 00:00:00

abstract：:The therapeutic efficacy of antidepressant drugs that inhibit the reuptake of serotonin (5-hydroxytryptamine, 5-HT) may be enhanced by blocking their indirect activation of 5-HT(1A) autoreceptors, which mediate feedback inhibition of serotonergic neuronal activity. In this study, we examined the effects of venlafaxine...

journal_title：European journal of pharmacology

authors： Bjorvatn B,Fornal CA,Martín FJ,Metzler CW,Jacobs BL

更新日期：2000-09-15 00:00:00

abstract：:The existence of neurogenic mediator candidates apart from noradrenaline and acetylcholine involved in the control of vascular tone has attracted enormous attention during the past few decades. One such mediator is neuropeptide Y (NPY), which is co-localized with noradrenaline in sympathetic perivascular nerves. Stimu...

journal_title：European journal of pharmacology

authors： Franco-Cereceda A,Liska J

更新日期：1998-05-15 00:00:00

abstract：:A substantial proportion of depressed patients do not respond to current antidepressant drug therapies. So far, antidepressant drugs have been developed based on the "monoaminergic hypothesis" of depression, which considers a synaptic deficiency in 5-hydroxytryptamine (5-HT; serotonin) or noradrenaline as main cause. ...

journal_title：European journal of pharmacology

authors： Leggio GM,Salomone S,Bucolo C,Platania C,Micale V,Caraci F,Drago F

更新日期：2013-11-05 00:00:00

abstract：:Intravenous amiodarone (Amiodarone i.v.) is widely used to treat cardiac arrhythmias. The most frequent clinical adverse event associated with Amiodarone i.v. administration is systemic hypotension which has been attributed to the cosolvents used in the formulation, polysorbate 80 and benzyl alcohol. To minimize hypot...

journal_title：European journal of pharmacology

authors： Cushing DJ,Kowey PR,Cooper WD,Massey BW,Gralinski MR,Lipicky RJ

更新日期：2009-04-01 00:00:00

abstract：:The effect of carbachol (10(-3)M) on the membrane potential of rat diaphragm muscle fibres near and remote from the endplate has been investigated by means of a microelectrode technique. In the endplate region a rather slow depolarization was observed followed by spontaneous repolarization. Outside the endplate region...

journal_title：European journal of pharmacology

authors： Mooij JJ,Evers CD,Ras R

更新日期：1976-06-01 00:00:00

abstract：:The cell adhesion molecules N-, VE- and OB-cadherin have been implicated as regulators of tumor growth and metastasis. We discuss evidence that N- and VE-cadherin play a key role in promoting blood vessel formation and stability, processes which are essential for tumor growth. Secondly, we describe the potential invol...

journal_title：European journal of pharmacology

authors： Blaschuk OW,Devemy E

更新日期：2009-12-25 00:00:00

abstract：:A single dose of methamphetamine (25 mg/kg i.p.) was administered to young adult gerbils (Meriones unguiculatus) aged 90 days and the number of spices was determined along 40-microns segments of basal, lateral and apical dendrites of pyramidal cells in layers III and V of the prefrontal cortex, after 1.5, 7, 20 and 30...

journal_title：European journal of pharmacology

authors： Dawirs RR,Teuchert-Noodt G,Molthagen M

更新日期：1993-09-07 00:00:00

abstract：:Some behavioural effects of flunitrazepam were investigated in two sets of experiments in C57BL/6 mice. In the first set, flunitrazepam administration (0.025 or 0.05 mg/kg) enhanced the locomotor activity of mice. In the second set, memory impairments were observed following posttraining (immediately or 30 min, but no...

journal_title：European journal of pharmacology

authors： Castellano C,Filibeck U,Pavone F

更新日期：1984-09-03 00:00:00

abstract：:The integrity of endothelial cell monolayers, a critical requirement for barrier maintenance, is needed for the prevention of edema formation. To investigate the mechanisms by which 2-phenyl-4-quinolone (YT-1) provided protection against serotonin-induced exudation, rat heart endothelial cell cultures were used. In th...

journal_title：European journal of pharmacology

authors： Lee HZ

更新日期：1997-09-24 00:00:00

abstract：:Cardiac remodeling after myocardial infarction is in part triggered and maintained by reactive oxygen species. Antioxidants such as probucol have shown positive short-term effects on these cardiac interstitial changes in different experimental models after intraperitoneal administration or after per-oral administratio...

journal_title：European journal of pharmacology

authors： Betge S,Lutz K,Roskos M,Figulla HR

更新日期：2007-03-08 00:00:00

abstract：:Aloe-emodin (1,8-dihydroxy-3-(hydroxymethyl)-anthraquinone) is an active component from the root and rhizome of Rheum palmatum. The study investigated the effects and mechanisms of aloe-emodin-induced cell death in human lung squamous cell carcinoma cell line CH27. Aloe-emodin (40 microM)-induced CH27 cell apoptosis w...

journal_title：European journal of pharmacology

authors： Lee HZ,Hsu SL,Liu MC,Wu CH

更新日期：2001-11-23 00:00:00

abstract：:Radioligand receptor binding techniques were used to characterize the effects of different structural types of antidepressant drugs on neurotransmitter receptors. The tricyclic antidepressants more or less potently inhibited the binding to rat brain preparations of several different radiolabelled ligands [3H]WB4101, [...

journal_title：European journal of pharmacology

authors： Hall H,Ogren SO

更新日期：1981-03-26 00:00:00

abstract：:The effect of cannabinoid receptor activation and blockade on the propulsive activity in the mouse small intestine was assessed in the present study by measuring the transit of an orally administered, non-absorbable marker. The cannabinoid receptor agonist WIN 55,212-2 (R(+)-[2,3-dihydro-5-methyl-3[(morpholinyl)methyl...

journal_title：European journal of pharmacology

authors： Colombo G,Agabio R,Lobina C,Reali R,Gessa GL

更新日期：1998-02-26 00:00:00

abstract：:Single myelinated nerve fibres of Rana esculenta were investigated under current and potential clamp conditions at 20 degrees C. Under 2.5 mM phenobarbital, the amplitude of the action potential was reversibly reduced to 85.5 +/- 5% (n = 6), and the threshold potential was raised by 32% of the control in Ringer soluti...

journal_title：European journal of pharmacology

authors： Schwarz JR

更新日期：1979-06-01 00:00:00

abstract：:It has been shown that galanin plays a role in central cardiovascular regulation. Galanin administered centrally induces an increase of heart rate and a weak vasodepressor response, whereas the N-terminal galanin fragment (1-15) elicits vasopressor effects and tachycardia. Furthermore, it has been shown that galanin-(...

journal_title：European journal of pharmacology

authors： Narváez JA,Díaz-Cabiale Z,Hedlund PB,Aguirre JA,Coveñas R,González-Barón S,Fuxe K

更新日期：2000-07-07 00:00:00

abstract：:The influence of decreased endogenous gamma-aminobutyric acid (GABA) concentration on benzodiazepine receptor function was studied in the brain of living baboons. Positron emission tomography and the radiotracer [11C]flumazenil combined with electroencephalography were used to determine the pharmacological properties ...

journal_title：European journal of pharmacology

authors： Bottlaender M,Schmid L,Fuseau C,Fournier D,Brouillet E,Mazière M

更新日期：1997-02-19 00:00:00

abstract：:Continuous monitoring of the foetal electrocorticogram, eye movements and heart rate in ewes during the last month of gestation showed rapid placental transfer from the mother to the foetus of phenothiazine derivatives (acepromazine maleate), short-acting barbiturates (thiopental sodium) and narcotic analgesics (meper...

journal_title：European journal of pharmacology

authors： Ruckebusch Y,Gaujoux M,Eghbali B

更新日期：1976-05-01 00:00:00