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Cadherins as novel targets for anti-cancer therapy.

Abstract：

:The cell adhesion molecules N-, VE- and OB-cadherin have been implicated as regulators of tumor growth and metastasis. We discuss evidence that N- and VE-cadherin play a key role in promoting blood vessel formation and stability, processes which are essential for tumor growth. Secondly, we describe the potential involvement of N- and OB-cadherin in the metastatic process. Finally, studies concerning the effects of the N-cadherin antagonist designated ADH-1 on tumor growth are presented. Collectively, these observations suggest that antagonists of N-, VE- and OB-cadherin would be useful as anti-cancer agents.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Blaschuk OW,Devemy E

doi

10.1016/j.ejphar.2009.05.033

subject

Has Abstract

pub_date

2009-12-25 00:00:00

pages

195-8

issue

1-3

eissn

0014-2999

issn

1879-0712

pii

S0014-2999(09)00873-5

journal_volume

625

pub_type

杂志文章,评审

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