In vivo modulation of benzodiazepine receptor function after inhibition of endogenous gamma-aminobutyyric acid synthesis.

abstract：:It has been documented cardiac fibroblasts as the predominant cell population undergoing senescence in heart. Calcitonin gene-related peptide (CGRP) exhibits a wide range of cardiovascular protective effects. Whether CGRP protects against cardiac fibroblasts senescence in cardiac fibrosis remains unknown. Here, we det...

journal_title：European journal of pharmacology

authors： Li WQ,Tan SL,Li XH,Sun TL,Li D,Du J,Wei SS,Li YJ,Zhang BK

更新日期：2019-01-15 00:00:00

abstract：:We investigated whether intracerebroventricular (i.c.v.) infusion of the nitric oxide synthase inhibitor, Nomega-nitro-L-arginine (N-Arg), impairs learning in male Sprague-Dawley rats (2-3 months old) in a 14-unit T-maze. Rats were pretrained in one-way active avoidance to a criterion of 13/15 avoidances of foot shock...

journal_title：European journal of pharmacology

authors： Ingram DK,Spangler EL,Kametani H,Meyer RC,London ED

更新日期：1998-01-02 00:00:00

abstract：:In vivo effects of histidine and carnosine against diabetic deterioration in diabetic Balb/cA mice were studied. Histidine and carnosine at 0.5, 1 g/l were added into drinking water. After 4 weeks intake of these agents, the content of histidine and carnosine in plasma, heart and liver significantly elevated (P < 0.05...

journal_title：European journal of pharmacology

authors： Lee YT,Hsu CC,Lin MH,Liu KS,Yin MC

更新日期：2005-04-18 00:00:00

abstract：:Osthole is a coumarin extracted from Cnidium monnieri (L.) Cusson. The medicinal plant is widely used in Vietnamese as well as Chinese traditional medicine as a vasodilating and antihypertensive agent. Here we have tested the proposition that the block of Ca(v)1.2 channels is mainly responsible for its vascular activi...

journal_title：European journal of pharmacology

authors： Fusi F,Sgaragli G,Ha le M,Cuong NM,Saponara S

更新日期：2012-04-05 00:00:00

abstract：:The effects of hyperosmotic solutions of xylitol were tested on acid and bicarbonate outputs from the rat stomach as well as on acid back-diffusion. Hyperosmotic solutions were instilled into anesthetized rats by an esophageal cannula and drained through a duodenal catheter. Spontaneously secreting and histamine-stimu...

journal_title：European journal of pharmacology

authors： Assouline G,Danon A

更新日期：1984-07-13 00:00:00

abstract：:Venenum Bufonis, a traditional Chinese medicine, is widely used in the treatment of liver cancer in modern Chinese medical practices. In our search for anti-hepatoma constituents in Venenum Bufonis, bufotalin, bufalin, telocinobufagin and cinobufagin were obtained. Bufotalin was the most potent active compound among t...

journal_title：European journal of pharmacology

authors： Zhang DM,Liu JS,Tang MK,Yiu A,Cao HH,Jiang L,Chan JY,Tian HY,Fung KP,Ye WC

更新日期：2012-10-05 00:00:00

abstract：:The effect of various concentrations of 4 beta-phorbol dibutyrate, (4-beta PDBu) phorbol myristate acetate (PMA), and 4 beta-phorbol didecanoate (4 beta-PDD) were studied on the guinea-pig parenchymal strip. The order of potency, 4 beta-PDBu greater than PMA greater than 4 beta-PDD, was the inverse of their lipid solu...

journal_title：European journal of pharmacology

authors： Dale MM,Obianime AW

更新日期：1987-09-02 00:00:00

abstract：:The pharmacological activity of N-methyl-actinodaphnine, isolated from Illigera luzonensis, was determined by functional and binding experiments with peripheral tissues. In a functional study, N-methyl-actinodaphnine was a simple competitive antagonist of contractions elicited by phenylephrine (pA2 = 7.11) in rat thor...

journal_title：European journal of pharmacology

authors： Guh JH,Ko FN,Yu SM,Wu YC,Teng CM

更新日期：1995-06-06 00:00:00

abstract：:Intravenous injection of ovalbumin into actively and passively sensitized guinea-pig resulted in acute circulatory collapse. The plasma level of immunoreactive endothelin rose from 22 +/- 2 to 40 +/- 7 fmol/ml (n = 12, P < 0.01) and 29 +/- 5 fmol/ml (n = 12, P < 0.01) in actively and passively sensitized animals, resp...

journal_title：European journal of pharmacology

authors： Filep JG,Télémaque S,Battistini B,Sirois P,D'Orléans-Juste P

更新日期：1993-08-03 00:00:00

abstract：:In rats, tolerance to the analgesic effect of intraventricular substance P (SP) develops quickly. In rats made tolerant to [D-Ala2, D-Leu5]enkephalin the analgesic efficacy of SP is reduced significantly. The latter result suggests some overlap in the sites of action of SP and [D-Ala2,D-Leu5] enkephalin. Since SP seem...

journal_title：European journal of pharmacology

authors： Naranjo JR,Fernandez-Tome MP,Del Rio J

更新日期：1984-02-10 00:00:00

abstract：:In this study, the elevated zero-maze model of anxiety was used to investigate CCK receptor antagonist effects on the behaviour of male Lister-hooded rats and to demonstrate, by administering antagonists in the presence or absence of selective 5-hydroxytryptamine (5-HT) re-uptake inhibitors, the involvement of 5-HT in...

journal_title：European journal of pharmacology

authors： Bickerdike MJ,Marsden CA,Dourish CT,Fletcher A

更新日期：1994-12-27 00:00:00

abstract：:Emodin, 1,3,8-trihydroxy-6-methyl-anthraquinone, is an anthraquinone derivative from the roots of Rheum officinale Baill that has been used to treat many diseases in digestive system for thousands of years. This study is to disclose the mechanism of Emodin to treat cholestatic hepatitis via anti-inflammatory pathway. ...

journal_title：European journal of pharmacology

authors： Ding Y,Zhao L,Mei H,Zhang SL,Huang ZH,Duan YY,Ye P

更新日期：2008-08-20 00:00:00

abstract：:Nitric oxide (NO) plays an important role in the cytotoxic activity of macrophages towards tumour cells and microbial pathogens. We investigated whether alteration of intracellular thiol levels modulates the cytotoxic effects of different NO donors and lipopolysaccharide-induced NO in the murine macrophage cell lin J7...

journal_title：European journal of pharmacology

authors： Zamora R,Matthys KE,Herman AG

更新日期：1997-02-19 00:00:00

abstract：:The aim of the present study was to investigate the contribution of extracellular signal regulated kinase-1/2 (ERK1/2) to pulmonary artery contraction in response to 4-aminopyridione (4-AP), an inhibitor of a voltage-gated K(+) channels that regulate pulmonary vascular tone. Pulmonary artery rings 1-1.5 mm in diameter...

journal_title：European journal of pharmacology

authors： Han W,Tang X,Wu H,Liu Y,Zhu D

更新日期：2007-08-13 00:00:00

abstract：:Our recent clinical study indicated that etidronate may inhibit the progression of aortic calcification in hemodialysis patients. To determine whether etidronate inhibits aortic calcification in renal failure rats, renal failure was induced by subtotal nephrectomy, in which 5/6 of the kidneys were removed. Significant...

journal_title：European journal of pharmacology

authors： Tamura K,Suzuki Y,Matsushita M,Fujii H,Miyaura C,Aizawa S,Kogo H

更新日期：2007-03-08 00:00:00

abstract：:Denudatin B is an antiplatelet agent isolated from the flower buds of Magnolia fargesii. We studied the effects of denudatin B on the vasoconstriction of rat thoracic aorta induced by high potassium (K+) solution, norepinephrine (NE) and caffeine, and to elucidate its mode of action. The contraction of rat aorta cause...

journal_title：European journal of pharmacology

authors： Yu SM,Chen CC,Huang YL,Tsai CW,Lin CH,Huang TF,Teng CM

更新日期：1990-10-02 00:00:00

abstract：:Acute benzodiazepine administration has been reported to antagonize the effect of cholecystokinin both in the periphery and in the central nervous system. A two-week treatment with either diazepam (5 mg/kg per day) or flurazepam (15 mg/kg per day) markedly reduced the excitatory effect of microiontophoretically applie...

journal_title：European journal of pharmacology

authors： Bouthillier A,De Montigny C

更新日期：1988-06-22 00:00:00

abstract：:The mesolimbic dopaminergic innervation is supposed to be involved in the mechanisms of central effects exerted by various classes of psychotropic drugs. Antidepressants have been found to interact with the brain dopaminergic system as well, although the precise central location of this interaction is unknown. Some da...

journal_title：European journal of pharmacology

authors： Plaznik A,Kostowski W

更新日期：1987-03-31 00:00:00

abstract：:Intake of nicotine has been related in many cases to acute or chronic hypertension. Using the patch-clamp technique the effect of nicotine on voltage-dependent K+ channel currents in rat tail artery smooth muscle cells was studied. Nicotine at concentrations of 1-100 microM or 0.3-3 mM increased or decreased, respecti...

journal_title：European journal of pharmacology

authors： Tang G,Hanna ST,Wang R

更新日期：1999-01-08 00:00:00

abstract：:The effects of ICS 205-930 [3 alpha-tropanyl)-1H-indole-3-carboxylic acid ester), an antagonist of 5-HT at neuronal M receptors, were examined in anaesthetised greyhounds subject to acute coronary artery occlusion and reperfusion. Intravenous administration of 0.3 or 2.0 mg kg-1 of ICS 205-930 did not significantly al...

journal_title：European journal of pharmacology

authors： Coker SJ,Dean HG,Kane KA,Parratt JR

更新日期：1986-08-15 00:00:00

abstract：:This study was designed to determine how the contractility of rat detrusor smooth muscle strips changes in the presence of low concentrations of hydrogen peroxide (H(2)O(2)). The strips were dissected from the base of Sprague-Dawley rat bladders and their contractile responses to a cumulative increase in H(2)O(2) conc...

journal_title：European journal of pharmacology

authors： Han JH,Lee MY,Lee SY,Chang IH,Kim HJ,Kim W,Myung SC

更新日期：2010-07-25 00:00:00

abstract：:Treatment of rats with cyclosporine A (50 mg/kg i.p.) for 4 days resulted in the impairment of renal function. Renal membrane and soluble phorbol ester receptor densities were significantly higher in cyclosporine A-treated rats compared to vehicle-treated rats. These data suggest that increased phorbol ester receptor ...

journal_title：European journal of pharmacology

authors： Nambi P,Pullen M,Wu HL,Brooks DP

更新日期：1991-03-19 00:00:00

abstract：:Vasodilatory responses to bradykinin (BK) and acetylcholine (ACh) were compared in phenylephrine preconstricted perfused kidneys from 30-week-old male stroke-prone spontaneously hypertensive rats (SHRSP) and normotensive Wistar-Kyoto rats (WKY). Responses to ACh did not differ between kidneys from SHRSP and WHY. BK-in...

journal_title：European journal of pharmacology

authors： Stier CT Jr,Selig N,Itskovitz HD

更新日期：1992-01-14 00:00:00

abstract：:The middle ear epithelium functions to maintain a fluid-free middle ear cavity. Dysfunction of the middle ear epithelial ion and fluid transport is implicated in the pathogenesis of fluid collection in the middle ear cavity, characteristic of otitis media with effusion. The efficacy of steroid therapy for the treatmen...

journal_title：European journal of pharmacology

authors： Son EJ,Kim SH,Park HY,Kim SJ,Yoon JH,Chung HP,Choi JY

更新日期：2009-01-14 00:00:00

abstract：:Some antidepressants, as well as antiepileptics, are effective for treating pain of varying etiology. The present study was designed to characterize the antinociceptive effects of imipramine, a tricyclic antidepressant, fluvoxamine, a selective serotonin reuptake inhibitor, milnacipran, a serotonin noradrenaline reupt...

journal_title：European journal of pharmacology

authors： Aoki M,Tsuji M,Takeda H,Harada Y,Nohara J,Matsumiya T,Chiba H

更新日期：2006-11-21 00:00:00

abstract：:Rat pheochromocytoma PC12W cell membranes have previously been shown to exclusively contain the AT2 receptor subtype. The present study extended these binding data and explored the functional expression of these binding sites. Our binding competition studies show a potency series of Ang II = Ang III greater than saral...

journal_title：European journal of pharmacology

authors： Leung KH,Roscoe WA,Smith RD,Timmermans PB,Chiu AT

更新日期：1992-09-01 00:00:00

abstract：:Endogenous Nitric Oxide (NO) plays a key role in the physiological regulation of airway functions. In response to various stimuli activated inflammatory cells (e.g., eosinophils and neutrophils) generate oxidants ("oxidative stress") which in conjunction with exaggerated enzymatic release of NO and augmented NO metabo...

journal_title：European journal of pharmacology

authors： Ricciardolo FL,Di Stefano A,Sabatini F,Folkerts G

更新日期：2006-03-08 00:00:00

abstract：:Recently, it has been revealed that angiotensin II type 1 receptor (AT(1)) antagonists act as antiarrhythmic agents and that the T-type Ca2+ channel plays an important role in arrhythmia. However, it remains unclear how the T-type Ca2+ channel expression system is involved in angiotensin II-mediated arrhythmogenesis i...

journal_title：European journal of pharmacology

authors： Morishima M,Wang Y,Akiyoshi Y,Miyamoto S,Ono K

更新日期：2009-05-01 00:00:00

abstract：:We have shown previously in dogs with right heart failure that the reduction of myocardial beta-adrenoceptor density occurs only in the failing right ventricle, while cardiac inotropic responses to beta-adrenergic stimulation are reduced in both the right and left ventricles. The purpose of the present study was to de...

journal_title：European journal of pharmacology

authors： Lai LP,Suematsu M,Elam H,Liang CS

更新日期：1996-08-08 00:00:00

abstract：:There is controversy concerning the inhibitory effect of arginine-vasopressin (AVP) on human platelet adenylate cyclase activity, which putatively involves Gi as the G-protein. To clarify this point, the effects of AVP on human platelet membranes were studied by measuring the activities of the high-affinity GTPase, as...

journal_title：European journal of pharmacology

authors： Vittet D,Mathieu MN,Cantau B,Chevillard C

更新日期：1988-06-10 00:00:00