Abstract:
:Sprague-Dawley rats received oral doses of enalapril maleate (5 mg/kg), a potent, nonsulfhydryl, angiotensin converting enzyme inhibitor, or saline. Sixty min later, morphine sulfate, 5 mg/kg, or saline was injected subcutaneously. Response to a thermal stimulus was monitored before and up to 5 h ter morphine injection using the rat tail flick test. Serum ACE activity was greater than 90% inhibited by enalapril throughout the experiment. Enalapril did not exhibit analgesic activity nor did it potentiate morphine analgesia.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Mojaverian P,Swanson BN,Ferguson RKdoi
10.1016/0014-2999(84)90607-1subject
Has Abstractpub_date
1984-02-17 00:00:00pages
303-6issue
2eissn
0014-2999issn
1879-0712pii
0014-2999(84)90607-1journal_volume
98pub_type
杂志文章abstract::We are interested in the rat as an animal model for infant-mother attachment. In the first experiment we tried to distinguish between a preference for familiar animals (attachment theory) and a preference for genetically related animals (kin selection theory) with the use of an early cross-fostering procedure. Genetic...
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journal_title:European journal of pharmacology
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abstract::Recent successes as a pharmacological adjunct to exposure therapy has focused attention on the therapeutic potential of the glycine(B) receptor partial agonist, D-cycloserine (DCS), in certain clinical anxiety disorders. Although widely believed to reflect a facilitation of extinction learning, previous research with ...
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journal_title:European journal of pharmacology
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