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Insulin-induced relaxation of rat mesenteric artery is mediated by Ca(2+)-activated K(+) channels.

Abstract：

:We tested the hypothesis that relaxation of the rat mesenteric artery in response to insulin is mediated by K(+) channels. Two concentrations of insulin (10 and 100 mU/ml) induced relaxation of the artery by 6+/-1%, 24+/-3% (mean+/-S.E.M.). Denudation of the endothelium or precontraction by KCl (30 mM), clotrimazole (10 microM), a cytochrome P450 inhibitor, charybdotoxin (30 nM) an inhibitor of large-conductance Ca(2+)-activated K(+) channels, abolished the relaxation of the artery in response to insulin. However, N(omega)-nitro-L-arginine methyl ester (L-NAME; 100 microM), an inhibitor of nitric oxide synthase, apamin (1 microM), an inhibitor of small-conductance Ca(2+)-activated K(+) channels, or glibenclamide (10 microM), an ATP-sensitive K(+) channels blocker, did not attenuate the relaxation of the artery caused by insulin. These results suggest that the relaxation of rat mesenteric artery in response to insulin is mediated mostly by large-conductance Ca(2+)-activated K(+) channels, perhaps an endothelium-derived hyperpolarizing factor (EDHF).

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Iida S,Taguchi H,Watanabe N,Kushiro T,Kanmatsuse K

doi

10.1016/s0014-2999(00)00892-x

keywords:

subject

Has Abstract

pub_date

2001-01-05 00:00:00

pages

155-160

issue

1-2

eissn

0014-2999

issn

1879-0712

pii

S0014-2999(00)00892-X

journal_volume

411

pub_type

杂志文章

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