Abstract:
:Histamine, 4-methylhistamine and dimaprit induced a dose-dependent increase in the cyclic AMP content of chopped canine parotid gland in the presence of 3-isobutyl-1-methylxanthine. Metiamide, but not mepyramine, inhibited the effect of these agonists dose-dependently. The cyclic AMP content was also increased by 2-(2-pyridyl)ethylamine. This effect was completely blocked by propranolol. These results indicate that the cyclic AMP response to histamine in canine parotid gland is mediated by H2-receptors. Mepyramine enhanced the effect of histamine. However, 2-(2-pyridyl)ethylamine had no significant inhibitory effect on the cyclic AMP response to 4-methylhistamine. A combination of aminoguanidine and quinacrine potentiated the effect of histamine, though no difference was observed in the histamine concentration of the media with or without these inhibitors when determined at the end of incubation. This suggests that there exist active histamine-metabolizing systems in canine parotid gland.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Nishibori Mdoi
10.1016/0014-2999(81)90101-1subject
Has Abstractpub_date
1981-12-17 00:00:00pages
309-16issue
4eissn
0014-2999issn
1879-0712pii
0014-2999(81)90101-1journal_volume
76pub_type
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journal_title:European journal of pharmacology
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journal_title:European journal of pharmacology
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