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Direct evidence that capsaicin-induced plasma protein extravasation is mediated through tachykinin NK1 receptors.

Abstract：

:The involvement of tachykinin NK1 receptors in the plasma protein extravasation (measured by the Evans blue leakage technique) produced by intravenous administration of capsaicin was investigated in the urinary bladder and trachea of anesthetized rats. Capsaicin-induced plasma extravasation was markedly inhibited by (+/-)-CP-96,345, a novel and potent non-peptide antagonist of tachykinin NK1 receptors. The same dose of (+/-)-CP-96,345 markedly inhibited the plasma protein extravasation induced by the selective NK1 receptor agonist, [Sar9]substance P sulfone, but had no effect on the response to histamine.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Eglezos A,Giuliani S,Viti G,Maggi CA

doi

10.1016/0014-2999(91)90183-q

subject

Has Abstract

pub_date

1991-12-17 00:00:00

pages

277-9

issue

3

eissn

0014-2999

issn

1879-0712

pii

0014-2999(91)90183-Q

journal_volume

209

pub_type

杂志文章

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