Abstract:
:Administration of the non-competitive NMDA receptor antagonist MK-801 (5-methyl-10,11-dihydro-5H-dibenzo[1,d]cyclohepten-5,10-imine) produces paradoxical neurotoxicity in limbic cortical regions which includes the entorhinal cortex. The expression of NMDAR-2C but not -2A, -2B or -2D subunits was significantly decreased in rat entorhinal cortex layer III following MK-801 administration. These results suggest an important role for the NMDAR-2C subunit in the response to MK-801-induced neurotoxicity in brain regions highly vulnerable to injury.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Lindén AM,Väsäinen J,Wong G,Castrén Edoi
10.1016/s0014-2999(96)00933-8subject
Has Abstractpub_date
1997-01-14 00:00:00pages
R1-2issue
1eissn
0014-2999issn
1879-0712pii
S0014-2999(96)00933-8journal_volume
319pub_type
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journal_title:European journal of pharmacology
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journal_title:European journal of pharmacology
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journal_title:European journal of pharmacology
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journal_title:European journal of pharmacology
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