NMDA receptor 2C subunit is selectively decreased by MK-801 in the entorhinal cortex.

Abstract:

:Administration of the non-competitive NMDA receptor antagonist MK-801 (5-methyl-10,11-dihydro-5H-dibenzo[1,d]cyclohepten-5,10-imine) produces paradoxical neurotoxicity in limbic cortical regions which includes the entorhinal cortex. The expression of NMDAR-2C but not -2A, -2B or -2D subunits was significantly decreased in rat entorhinal cortex layer III following MK-801 administration. These results suggest an important role for the NMDAR-2C subunit in the response to MK-801-induced neurotoxicity in brain regions highly vulnerable to injury.

journal_name

Eur J Pharmacol

authors

Lindén AM,Väsäinen J,Wong G,Castrén E

doi

10.1016/s0014-2999(96)00933-8

subject

Has Abstract

pub_date

1997-01-14 00:00:00

pages

R1-2

issue

1

eissn

0014-2999

issn

1879-0712

pii

S0014-2999(96)00933-8

journal_volume

319

pub_type

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