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Modulation of cocaine intravenous self-administration in drug-naive animals by dihydropyridine Ca2+ channel modulators.

Abstract：

:The dihydropyridine Ca2+ channel blocker nimodipine and the dihydropyridine Ca2+ channel activator BayK 8644 (1,4-dihydropyridine-2,6-dimethyl-3-nitro-4-(2-trifluoromethylphenyl)-py ridine- 5-carboxylate) were administered to drug-naive mice and rats that were tested for intravenous cocaine self-administration. A range of cocaine doses was tested to investigate the nature of the effect. The results indicate that nimodipine and BayK 8644 shifted the dose-response curve for cocaine's reinforcing action to the right and left, respectively. Thus, the Ca2+ channel blocker nimodipine decreases the sensitivity of mice and rats to the reinforcing effects of cocaine while the Ca2+ channel activator BayK 8644 makes the animals more sensitive to cocaine reward. The results suggest that a dihydropyridine-sensitive mechanism is implicated in the initiation of cocaine self-administration.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Kuzmin A,Semenova S,Ramsey NF,Zvartau EE,Van Ree JM

doi

10.1016/0014-2999(95)00630-3

subject

Has Abstract

pub_date

1996-01-04 00:00:00

pages

19-25

issue

1

eissn

0014-2999

issn

1879-0712

pii

0014299995006303

journal_volume

295

pub_type

杂志文章

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