Abstract：
:5-methoxy-N,N-dimethyltryptamine (5-MeODMT) produced a dose-dependent decrease in the discharge rate of serotonin-containing neurons in the dorsal raphe nucleus of freely moving cats. This ranged from a 15% decrease at 10 microgran/kg, i.m., to a virtual complete depression of activity at 250 microgram/kg. 5-MeODMT's effects on raphe units occurred with a very short latency (3-5 min) and its duration of action was dose-dependent and limited to an hour or less. The degree of depression of raphe unit activity was directly related to the frequency of occurrence of a number of hallucinogen-specific cat behaviors such as limb flick and abortive groom. There was also a close temporal correlation between the depression of raphe unit activity and the occurrence of these behaviors. These data indicate that the effects of 5-MeODMT may be primarily dependent on its actions upon brain serotonin neurons.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Trulson ME,Jacobs BLdoi
10.1016/0014-2999(79)90406-0subject
Has Abstractpub_date
1979-02-15 00:00:00pages
43-50issue
1-2eissn
0014-2999issn
1879-0712pii
0014-2999(79)90406-0journal_volume
54pub_type
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journal_title：European journal of pharmacology
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