当前位置： SCI文献检索 > EUROPEAN JOURNAL OF PHARMACOLOGY期刊下所有文献 > Involvement of GABAA receptors in the regulation of the prefrontal cortex on dopamine release in the rat dorsolateral striatum.

Involvement of GABAA receptors in the regulation of the prefrontal cortex on dopamine release in the rat dorsolateral striatum.

Abstract：

:The characteristics of the prefrontal cortex regulation of dopamine release in the rat dorsolateral striatum were investigated in focusing on the corticostriatal pathway, using dual-probe microdialysis in combination with simple behavioral procedures. Intracortical perfusion of the GABA(A) receptor antagonist bicuculline (0.03 and 0.1 mM) increased the striatal dopamine release, whereas the GABA(A) receptor agonist muscimol (0.1 and 1 mM) reduced the release dose dependently. Co-perfusion of muscimol (0.01 mM), which did not by itself affect the dopamine release, completely prevented the glutamate (1 mM)-stimulated dopamine release and behavioral activities, including locomotion and rearing. Muscimol (0.01 mM) also prevented the N-methyl-D-aspartate (NMDA; 1 mM)-induced increases in glutamate, as well as dopamine levels. These findings suggest that the prefrontal cortex functionally regulates dopamine release in the dorsolateral striatum, which is mediated via GABA(A) receptors. This cortical GABAergic system underlying the prefrontal cortex regulatory mechanism appears to be associated with the corticostriatal pathway.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Matsumoto M,Kanno M,Togashi H,Ueno K,Otani H,Mano Y,Yoshioka M

doi

10.1016/j.ejphar.2003.10.003

keywords:

subject

Has Abstract

pub_date

2003-12-15 00:00:00

pages

177-84

issue

1-3

eissn

0014-2999

issn

1879-0712

pii

S0014299903025214

journal_volume

482

pub_type

杂志文章

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