Epidermal growth factor-induced rapid relaxation of the isolated rabbit mesenteric artery.

Abstract:

:Epidermal growth factor (EGF) (10-100 ng ml-1) induced a rapidly developing relaxation of precontracted rabbit mesenteric artery rings within 30 min of exposure. Indomethacin or protein synthesis inhibitors prevented or acutely reversed the effect of EGF on the preparation and an erbstatin analogue significantly reduced it. It is concluded that the EGF-mediated relaxation may be induced by the rapid production of prostanoids via a cascade of biochemical events initiated by the tyrosine-kinase activity of the receptors for EGF. One or more proteins rapidly produced and rapidly depleted appear to be involved in the activation of arachidonate metabolism.

journal_name

Eur J Pharmacol

authors

Petitclerc E,Poubelle PE,Marceau F

doi

10.1016/0014-2999(94)90164-3

subject

Has Abstract

pub_date

1994-06-23 00:00:00

pages

91-4

issue

1

eissn

0014-2999

issn

1879-0712

pii

0014-2999(94)90164-3

journal_volume

259

pub_type

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