Abstract:
:Analogues of the C-terminal octapeptide of cholecystokinin (CCK) modified in the Met28-Gly29 region, were tested for their ability to interact with peripheral cholecystokinin receptors on rat pancreatic acini and to stimulate amylase secretion. These analogues were further evaluated for their ability to recognize central CCK receptors on guinea pig brain membranes. The behavioral effect of these analogues was also tested after intrastriatal injection into mice. It appeared that these analogues were full CCK agonists in the peripheral system. Although some induced dopaminomimetic effects after intrastriatal injection into mice, being as potent as the C-terminal octapeptide of cholecystokinin (CCK-8), others did not have any effect and were able to antagonize CCK-8 actions in the striatum. The results of this study confirm that one can obtain very potent CCK analogues by modifying the peptide bond between Met28 and Gly29, and that this modification can produce either CCK agonists or antagonists of CCK-induced dopamine transmission in the striatum.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Mendre C,Rodriguez M,Lignon MF,Galas MC,Gueudet C,Worms P,Martinez Jdoi
10.1016/0014-2999(90)90436-asubject
Has Abstractpub_date
1990-09-21 00:00:00pages
213-22issue
2-3eissn
0014-2999issn
1879-0712pii
0014-2999(90)90436-Ajournal_volume
186pub_type
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