The effect of arachidonic acid and free fatty acids on vesicular uptake of glutamate and gamma-aminobutyric acid.

abstract：:The (+)-enantiomer of the dihydropyridine 202-791 produced coronary constrictor and positive inotropic effects in Langendorff-perfused rat hearts whereas (--)-202-791 showed coronary dilator and negative inotropic effects. Both enantiomers showed the vascular effects at lower concentrations than the myocardial effects...

journal_title：European journal of pharmacology

authors： Uematsu T,Cook NS,Hof RP,Vozeh S,Follath F

更新日期：1986-04-29 00:00:00

abstract：:Forskolin, a potent activator of adenylate cyclase, and isoprenaline, an unselective beta-adrenoceptor agonist, were studied in vitro on tissues from guinea-pig with respect to relaxation of the carbachol-contracted trachea, increase in the force of contraction of the papillary muscle and depression of subtetanic cont...

journal_title：European journal of pharmacology

authors： Waldeck B,Widmark E

更新日期：1985-06-19 00:00:00

abstract：:The affinity and intrinsic activity of dopamine receptor agonists were determined at the human dopamine hD21 and hD4.4 receptors. (-)-3-Hydroxy-N-n-propylpiperidine ((-)3-PPP) had an intrinsic activity of 46% and 83%, whereas (+)-N-propylnorapomorphine ((+)-NPA) had intrinsic activities of 61% and 58% at the dopamine ...

journal_title：European journal of pharmacology

authors： Lahti RA,Mutin A,Cochrane EV,Tepper PG,Dijkstra D,Wikström H,Tamminga CA

更新日期：1996-04-22 00:00:00

abstract：:The novel antiepileptic drug levetiracetam has been shown to reverse anxiogenic effects of benzodiazepine withdrawal in mice tested in an elevated plus-maze without altering the behaviour of normal mice in this model. This could suggest that the effect of levetiracetam is dependent upon the level of stress/anxiety of ...

journal_title：European journal of pharmacology

authors： Lamberty Y,Falter U,Gower AJ,Klitgaard H

更新日期：2003-05-23 00:00:00

abstract：:Dopamine (DA) is thought to have a neurotransmitter role in the spinal cord of the rat. Intrathecal administration of the DA receptor agonist apomorphine has previously been shown to reduce nocifensive responses. The present experiments investigated the site of action of apomorphine, and the mechanisms by which DA ago...

journal_title：European journal of pharmacology

authors： Barasi S,Duggal KN

更新日期：1985-11-19 00:00:00

abstract：:The effect of estrogen on neointimal formation in injured rat arteries has been reported to be a sexual dimorphic effect. Recently, it has been reported that 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) exhibit vasoprotective effects, which are independent of their cholesterol-lowerin...

journal_title：European journal of pharmacology

authors： Kurumazuka D,Mori T,Matsumoto N,Shirakawa H,Kimura S,Nakano D,Hayashi T,Kitaura Y,Matsumura Y

更新日期：2006-12-28 00:00:00

abstract：:Sabiporide, a new benzoguanidine, was characterized on fibroblasts stably expressing the Na(+)/H(+) exchanger isoforms NHE-1, NHE-2 and NHE-3. 22Na(+) uptake experiments show that this compound possesses a K(i) of 5+/-1.2 x 10(-8) M for NHE-1, and discriminates efficiently between the NHE-1, -2 and -3 isoforms (K(i) f...

journal_title：European journal of pharmacology

authors： Touret N,Tanneur V,Godart H,Seidler R,Taki N,Bürger E,Dämmgen J,Counillon L

更新日期：2003-01-17 00:00:00

abstract：:Experiments were performed in isolated guinea pig hearts, perfused at constant volume. Left ventricular pressure, left ventricular dp/dtmax, coronary vascular pressure and coronary venous pO2 were measured continuously. Indomethacin (1.4 X 10(-6) M) increased coronary vascular resistance by 15% over control (p less th...

journal_title：European journal of pharmacology

authors： Schrör K,Krebs R,Nookhwun C

更新日期：1976-09-01 00:00:00

abstract：:The pharmacological profile of the opioid antagonist norbinaltorphimine has been characterised in vitro and in vivo. In vitro, norbinaltorphimine reversibly antagonised the effects of kappa agonists with pA2 values of 10.2-10.4. Norbinaltorphimine was much less potent as an antagonist at mu and delta receptors, pA2 va...

journal_title：European journal of pharmacology

authors： Birch PJ,Hayes AG,Sheehan MJ,Tyers MB

更新日期：1987-12-15 00:00:00

abstract：:Rat and human alpha- and beta-calcitonin gene-related peptide (CGRP), in the concentration range 1-100 nM, produced sustained relaxations of longitudinal muscle from the rat fundus and guinea pig gastric corpus. The peptides were equipotent and equally effective. Tetrodotoxin, adrenoceptor and purine receptor antagoni...

journal_title：European journal of pharmacology

authors： Katsoulis S,Conlon JM

更新日期：1989-03-14 00:00:00

abstract：:The effects of riluzole, an anticonvulsant and neuroprotective compound, on excitatory amino acid-evoked currents were studied in Xenopus laevis oocytes injected with mRNA from rat whole brain or cortex. Responses to kainic acid were blocked by riluzole (IC50 = 167 microM) as well as by the quinoxalinedione antagonist...

journal_title：European journal of pharmacology

authors： Debono MW,Le Guern J,Canton T,Doble A,Pradier L

更新日期：1993-04-28 00:00:00

abstract：:Unilateral ureteral obstruction (UUO) is a well-established method to study interstitial fibrosis of the kidney. In this study, we investigated the effects of a calcium channel blocker, amlodipine, on UUO-induced renal interstitial fibrosis in mice. UUO significantly increased the fibrotic area in the obstructed kidne...

journal_title：European journal of pharmacology

authors： Honma S,Nakamura K,Shinohara M,Mitazaki S,Abe S,Yoshida M

更新日期：2016-06-05 00:00:00

abstract：:A bicarbonate-dependent organic cation transporter, unique from rOCT1 and rOCT2, primarily mediates amantadine uptake into renal proximal tubules. We examined whether intracellular pH regulates bicarbonate-dependent amantadine transporter function in these tubules. NH(4)Cl treatment resulted in immediate intracellular...

journal_title：European journal of pharmacology

authors： Goralski KB,Bose R,Sitar DS

更新日期：2006-07-10 00:00:00

abstract：:The main purpose of this study was to compare in vitro pharmacological properties of human αCGRP (CGRP) and a recently discovered metabolically stable CGRP analogue, SAX, in isolated rat and human artery segments. In rat, CGRP and SAX induced similar vasodilatory responses in isolated mesenteric artery with the potenc...

journal_title：European journal of pharmacology

authors： Sheykhzade M,Abdolalizadeh B,Koole C,Pickering DS,Dreisig K,Johansson SE,Abboud BK,Dreier R,Berg JO,Jeppesen JL,Sexton PM,Edvinsson L,Wootten D,Sams A

更新日期：2018-06-15 00:00:00

abstract：:Neurotoxins are harmful to nervous system and cause either neuronal cell death or impairment of synaptic activity, which contributes to Parkinson's disease or other neuronal disorders. Hippocampal synaptic plasticity was proposed as a cellular model for memory processing. In this study, we reported a novel effect of n...

journal_title：European journal of pharmacology

authors： Li J,Chen H,Wu S,Cheng Y,Li Q,Wang J,Zhu G

更新日期：2017-01-15 00:00:00

abstract：:Nitric oxide (NO) is present in the exhaled breath of humans and other mammalian species. It is generated in the lower airways by enzymes of the nitric oxide synthase (NOS) family, although nonenzymatic synthesis and consumptive processes may also influence levels of NO in exhaled breath. The biological properties of ...

journal_title：European journal of pharmacology

authors： Redington AE

更新日期：2006-03-08 00:00:00

abstract：:The significance of the blood pressure elevation caused by N(G)-nitro-L-arginine (L-NNA) to inhibitory mechanism of the drug on depressor responses to acetylcholine in anesthetized dogs was investigated. L-NNA (50 mg kg(-1), i.v.) elevated blood pressure to a plateau of 30-50 mm Hg above baseline level and shifted the...

journal_title：European journal of pharmacology

authors： Nakahara T,Nejishima H,Nakayama K,Ishii K

更新日期：1999-06-04 00:00:00

abstract：:The role of tuberoinfundibular and periventricular-hypophysial dopaminergic neurons in mediating rimcazole-induced decreases in plasma concentrations of prolactin and alpha-melanocyte stimulating hormone was assessed. Dopaminergic neuronal activity was estimated by measuring concentrations of 3,4-dihydroxyphenylacetic...

journal_title：European journal of pharmacology

authors： Eaton MJ,Lookingland KJ,Moore KE

更新日期：1996-03-28 00:00:00

abstract：:A neonatal cerebral cortical lesion was made in rats and the effects of diazepam on ultrasonic isolation calls in pups and footshock-elicited ultrasonic distress calls in young adult rats were assessed. There was no indication that the cortical lesion influenced the production of the ultrasonic distress calls in eithe...

journal_title：European journal of pharmacology

authors： Naito H,Arishima K,Tonoue T

更新日期：1995-01-16 00:00:00

abstract：:Fenfluramine + phentermine was a widely used combination for weight loss. Fenfluramine and phentermine are believed to act via serotonin and catecholamines, respectively. To what extent these drugs interact has not been well-established. We compared the anorectic efficacy of a range of doses of the combination (using ...

journal_title：European journal of pharmacology

authors： Roth JD,Rowland NE

更新日期：1999-06-04 00:00:00

abstract：:The arteriovenous fistula model of circulation can produce a high output and low peripheral resistance situation. Here, we have examined the effects of noradrenaline, vasopressin and sodium nitroprusside on cardiac index, mean arterial blood pressure, venous tone, resistance to venous return, arterial resistance, and ...

journal_title：European journal of pharmacology

authors： Guo L,Tabrizchi R

更新日期：2008-05-31 00:00:00

abstract：:5-HT and dopamine receptor antagonists have become widely used as atypical antipsychotics. Although 5-HT(2A) receptor antagonistic activity is thought to contribute to the atypical aspects of these agents, the precise mechanism remains unknown. M100907 (R(+)-alpha(2,3-dimethoxyphenyl)-1-[2(4-fluorophenyl)ethyl)]-4-pip...

journal_title：European journal of pharmacology

authors： Habara T,Hamamura T,Miki M,Ohashi K,Kuroda S

更新日期：2001-04-13 00:00:00

abstract：:Binding sites for the sigma ligand [3H]di-o-tollylguanidine ([3H]DTG) have been reported to be altered in the brains of genetically dystonic rats. In the present study, selective sigma 1 and sigma 2 assay conditions were utilized in an effort to define which subpopulation of [3H]DTG binding sites is altered in the dys...

journal_title：European journal of pharmacology

authors： Weissman AD,McCann DJ,Lorden JF,Su TP

更新日期：1993-12-07 00:00:00

abstract：:The neuroprotective effects of verbascoside, one of phenylpropanoid glucoside isolated from the Chinese herbal medicine Buddleja officinalis Maxim, on 1-methyl-4-phenylpyridinium ion (MPP(+)) induced apoptosis and oxidative stress in PC12 neuronal cells were investigated. Treatment of PC12 cells with MPP(+) for 48 h i...

journal_title：European journal of pharmacology

authors： Sheng GQ,Zhang JR,Pu XP,Ma J,Li CL

更新日期：2002-09-13 00:00:00

abstract：:The effect of potassium on the binding of digoxin or digoxigenin to isolated Na+, K+-ATPase was compared with that of potassium on the positive inotropic action of the agents in guinea-pig hearts. The binding of digoxigenin to the enzyme in vitro was reduced to a greater extent by potassium than was the binding of dig...

journal_title：European journal of pharmacology

authors： Akera T,Wiest SA,Brody TM

更新日期：1979-08-15 00:00:00

abstract：:The effect of ouabain (10(-3) M) on contractile responses of SHR (spontaneously hypertensive rat) and WKY (Wistar-Kyoto rat) aortas and mesenteric arteries was studied. Ouabain addition caused a rapid contraction of aortic strips with a steeper rate of rise and a larger maximal force development in strips from SHR tha...

journal_title：European journal of pharmacology

authors： Morita S,Iwasaki T,Nagai K,Miyata S,Kawai Y

更新日期：1988-07-14 00:00:00

abstract：:The contribution of tyrosine kinase activity to vasoreactivity in normotensive Wistar-Kyoto (WKY) and spontaneously hypertensive (SHR) rats was investigated on isolated aortic preparations by the use of two tyrosine kinase inhibitors: methyl-2,5-dihydroxycinnamate (30 microM) and genistein (30 microM). The pretreatmen...

journal_title：European journal of pharmacology

authors： Zerrouk A,Auguet M,Dabiré H,Brisac AM,Safar M,Chabrier PE

更新日期：1999-06-11 00:00:00

abstract：:Amphetamine increases extracellular dopamine and induces locomotor and stereotypical behaviors in rats. This study examined the effect of the dopamine D2/D3 receptor antagonist sulpiride (50 mg/kg s.c.) on the dopaminergic response to amphetamine (0.5, 2.0, or 8.0 mg/kg i.p.) in male Sprague-Dawley rats. Extracellular...

journal_title：European journal of pharmacology

authors： Jaworski JN,Gonzales RA,Randall PK

更新日期：2001-04-27 00:00:00

abstract：:The characteristics of beta-adrenoceptors on frog and chick erythrocytes have been compared to those present on rat erythrocyte, lung and cerebral cortical membranes. The receptors have been examined using the specific ligand [3H]dihydroalprenolol ([3H]DHA) with conventional filtration techniques. The equilibrium diss...

journal_title：European journal of pharmacology

authors： Dickinson KE,Nahorski SR

更新日期：1981-08-27 00:00:00

abstract：:Fructose-2,6-bisphosphate is a potent activator of 6-phosphofructo-1-kinase, a key enzyme in glycolysis. We previously revealed that sulfonylureas stimulate fructose-2,6-bisphosphate production in the rat liver by activating 6-phosphofructo-2-kinase. In the present study, we show that CS-045, a new antidiabetic agent,...

journal_title：European journal of pharmacology

authors： Murano K,Inoue Y,Emoto M,Kaku K,Kaneko T

更新日期：1994-03-21 00:00:00