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Increase in the coronary vascular resistance by indomethacin in the isolated guinea pig heart preparation in the absence of changes in mechanical performance and oxygen consumption.

Abstract：

:Experiments were performed in isolated guinea pig hearts, perfused at constant volume. Left ventricular pressure, left ventricular dp/dtmax, coronary vascular pressure and coronary venous pO2 were measured continuously. Indomethacin (1.4 X 10(-6) M) increased coronary vascular resistance by 15% over control (p less than 0.01) without altering the myocardial contractile force. When PGE2 (1.4 X10(-8) M) was subsequently added, it abolished the indomethacin action and lowered the coronary vascular resistance below the pre-indomethacin control value. This increase in coronary vascular resistance caused by indomethacin was also seen when the animals were pretreated with reserpine and/or the adrenoceptor blocking agents phenoxybenzamine and propranolol, but was prevented completely by previous addition of PGE2 (1.4 X 10(-7) M). The results provide evidence for possible involvement of endogenous prostaglandin-like substances in the maintenance of coronary vascular resistance in the isolated guinea pig heart.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Schrör K,Krebs R,Nookhwun C

doi

10.1016/0014-2999(76)90124-2

subject

Has Abstract

pub_date

1976-09-01 00:00:00

pages

161-9

issue

1

eissn

0014-2999

issn

1879-0712

pii

0014-2999(76)90124-2

journal_volume

39

pub_type

杂志文章

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