The effects of surgical and chemical lesions on striatal [3H]threo-(+/-)-methylphenidate binding: correlation with [3H]dopamine uptake.

Abstract:

:The specific binding of [3H]threo-(+/-)-methylphenidate to membranes prepared from rat striatum was significantly reduced following either surgical lesions of the medial forebrain bundle or intracerebroventricular administration of 6-hydroxydopamine. The decrease in the density of [3H]threo-(+/-)-methylphenidate binding sites in striatum following chemical or surgical denervation was highly correlated with the decrease in [3H]dopamine uptake. In contrast, intracerebroventricular administration of 5,7-dihydroxytryptamine, AF64A, or chronic parenteral administration of reserpine did not alter either the number of apparent affinity of [3H]threo-(+/-)-methylphenidate binding sites. These data suggest that the specific binding sites for [3H]-threo-(+/-)-methylphenidate in striatum are localized to dopaminergic nerve terminals, and may be associated with the dopamine transport complex.

journal_name

Eur J Pharmacol

authors

Janowsky A,Schweri MM,Berger P,Long R,Skolnick P,Paul SM

doi

10.1016/0014-2999(85)90724-1

subject

Has Abstract

pub_date

1985-01-22 00:00:00

pages

187-91

issue

2

eissn

0014-2999

issn

1879-0712

pii

0014-2999(85)90724-1

journal_volume

108

pub_type

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