Evidence for the involvement of prostaglandins in modulation of acetylcholine release from canine bronchial tissue.

abstract：:The cardiovascular protecting effect of the grape fruit trans-resveratrol has been explained among other factors, through augmentation of nitric oxide (NO) production in cardiovascular tissues. Another effect of low resveratrol concentration is the inhibition of single-vesicle quantal release of catecholamine from bov...

journal_title：European journal of pharmacology

authors： Padín JF,de Diego AM,Fernández-Morales JC,Merino C,Maroto M,Calvo-Gallardo E,Arranz JA,Yáñez M,García AG

更新日期：2012-06-15 00:00:00

abstract：:Ginsenoside Rg3 (Rg3), one of the bioactive extracts found in ginseng root, was reported to have anti-cancer activity in various cancer models. The anti-proliferation effect of Rg3 on prostate cancer cells has been well reported. To test whether Rg3 has an anti-metastatic effect on prostate cancer, we treated a highly...

journal_title：European journal of pharmacology

authors： Pan XY,Guo H,Han J,Hao F,An Y,Xu Y,Xiaokaiti Y,Pan Y,Li XJ

更新日期：2012-05-15 00:00:00

abstract：:The specific, irreversible binding of [3H]beta-funaltrexamine (beta-FNA) to mu opioid receptors in slices from the corpus striatum and midbrain region containing the ventral tegmentum area (VTA) was accomplished by incubation with [3H]beta-FNA followed by a washing procedure with 1 microM unlabeled naltrexone in the w...

journal_title：European journal of pharmacology

authors： Takahashi M,Portoghese PS,Takemori AE

更新日期：1988-05-10 00:00:00

abstract：:The effect of propionyl-L-carnitine, an analogue of L-carnitine, and insulin on the oscillatory potentials of the electroretinogram was determined in rats with streptozotocin-induced diabetes. Propionyl-L-carnitine was administered at a daily dose of 0.5 g/kg by gavage for 4 weeks, while other rats were treated with s...

journal_title：European journal of pharmacology

authors： Hotta N,Koh N,Sakakibara F,Nakamura J,Hamada Y,Hara T,Fukasawa H,Kakuta H,Sakamoto N

更新日期：1996-09-12 00:00:00

abstract：:The present study concerns previously unreported effects of menthol, a cyclic terpene alcohol produced by the peppermint herb, on anion transporters in polarized human airway Calu-3 epithelia. Application of menthol (0.01-1mM) attenuated transepithelial anion transport, estimated as short-circuit currents (I(SC)), aft...

journal_title：European journal of pharmacology

authors： Morise M,Ito Y,Matsuno T,Hibino Y,Mizutani T,Ito S,Hashimoto N,Kondo M,Imaizumi K,Hasegawa Y

更新日期：2010-06-10 00:00:00

abstract：:The alpha 1-adrenoceptors present in the liver of rhesus monkeys was characterized using [3H]prazosin. This radioligand binds to monkey liver membranes with high affinity (KD 0.33 nM) to a moderately abundant number of sites (97 fmol/mg of protein). These sites were characterized pharmacologically, by binding competit...

journal_title：European journal of pharmacology

authors： García-Sáinz JA,Romero-Avila MT,González-Espinosa C

更新日期：1996-09-12 00:00:00

abstract：:The effects of intra- and extraluminal capsaicin administration were evaluated in isolated perfused rat mesenteric bed. Capsaicin (10 nM-1 microM) produced a potent concentration-dependent relaxation of the tonic vasoconstriction induced by norepinephrine (1 microM) but not by high-K+ (60 mM). The capsaicin-induced re...

journal_title：European journal of pharmacology

authors： Manzini S,Perretti F

更新日期：1988-03-29 00:00:00

abstract：:Antinociceptive effects of various neuroleptics in animal acute pain-models have been described, mediated trough different pathways including the opioid system. In this study, we assessed the antinociceptive effects of the atypical neuroleptic drug amisulpride, which acts as a selective blocker of dopamine D2 and D3 r...

journal_title：European journal of pharmacology

authors： Weizman T,Pick CG,Backer MM,Rigai T,Bloch M,Schreiber S

更新日期：2003-10-08 00:00:00

abstract：:5-HT and dopamine receptor antagonists have become widely used as atypical antipsychotics. Although 5-HT(2A) receptor antagonistic activity is thought to contribute to the atypical aspects of these agents, the precise mechanism remains unknown. M100907 (R(+)-alpha(2,3-dimethoxyphenyl)-1-[2(4-fluorophenyl)ethyl)]-4-pip...

journal_title：European journal of pharmacology

authors： Habara T,Hamamura T,Miki M,Ohashi K,Kuroda S

更新日期：2001-04-13 00:00:00

abstract：:Acid-sensing ion channels (ASICs), a family of proton-gated cation channels, are believed to mediate pain caused by extracellular acidification. Gastrodin is a main bioactive constituent of the traditional herbal Gastrodia elata Blume, which has been widely used in Oriental countries for centuries. As an analgesic, ga...

journal_title：European journal of pharmacology

authors： Qiu F,Liu TT,Qu ZW,Qiu CY,Yang Z,Hu WP

更新日期：2014-05-15 00:00:00

abstract：:This study uses immediate early transcription factor gene expression to map neuronal activation after a single exposure to the elevated X-maze. Exposure to this novel environment leads to widespread upregulation in the gene expression of c-fos, NGFI-A and NGFI-B (the nerve growth factor induced genes), but not c-jun n...

journal_title：European journal of pharmacology

authors： Hinks GL,Brown P,Field M,Poat JA,Hughes J

更新日期：1996-09-26 00:00:00

abstract：:Imatinib (IMA) is the standard treatment for CML; however, stopping IMA sometimes results in disease relapse, which suggests that leukemic stem cells (LSCs) remain in such patients, even after complete molecular remission has been achieved. Therefore, new strategies will be required to eradicate LSCs. The Janus kinase...

journal_title：European journal of pharmacology

authors： Yagi K,Shimada A,Sendo T

更新日期：2018-04-15 00:00:00

abstract：:Multidrug resistance phenotype in mammalian cells is often correlated with overexpression of P-glycoprotein or Multidrug Resistance-Associated protein (MRP(1)). Both proteins are energy-dependent drug efflux pumps that efficiently reduce the intracellular accumulation and hence the cytotoxicity of many natural cytotox...

journal_title：European journal of pharmacology

authors： Marbeuf-Gueye C,Salerno M,Quidu P,Garnier-Suillerot A

更新日期：2000-03-17 00:00:00

abstract：:An enhanced vasoconstrictor activity of cutaneous arteries participates in the reduction of skin blood flow induced by cooling stimulation. Raynaud's phenomenon, which is characterized by intense cooling-induced constriction of cutaneous arteries, is more common in women during the period from menarche to menopause. W...

journal_title：European journal of pharmacology

authors： Serizawa I,Iwasaki N,Ishida H,Saito SY,Ishikawa T

更新日期：2017-02-15 00:00:00

abstract：:This study presents a direct comparison of the ligand binding and signaling profiles of a mammalian and non-mammalian mu opioid receptor. Opioid ligand binding and agonist potencies were determined for an amphibian (Rana pipiens) mu opioid receptor (rpMOR) and the human mu opioid receptor (hMOR) in transfected, intact...

journal_title：European journal of pharmacology

authors： Brasel CM,Sawyer GW,Stevens CW

更新日期：2008-12-03 00:00:00

abstract：:Administration of endothelin to inactin-anesthetized rats resulted in a significant renal vasoconstriction as evidenced by a reduction in both renal plasma flow and glomerular filtration rate. Infusion of the novel nonpeptide endothelin ETA/ETB receptor antagonist, (+/-)-SB 209670, [(1RS-2SR,3RS)-3-(2-carboxymethoxy-4...

journal_title：European journal of pharmacology

authors： Brooks DP,Contino LC

更新日期：1995-12-29 00:00:00

abstract：:The recovery of the muscarinic cholinergic receptor (mAChR) from its down-regulation by long-term exposure to ACh was investigated. This was done to obtain information about regulation of the mAChR. Exposure of guinea-pig vas deferens to 30 microM ACh for 24 h decreased the amount of mAChR to 30% of the initial level,...

journal_title：European journal of pharmacology

authors： Higuchi H,Uchida S,Yoshida H

更新日期：1985-02-26 00:00:00

abstract：:A previous report showed that transforming growth factor-beta1 (TGF-beta1) can induce heme oxygenase-1 (HO-1) expression, attenuate cellular injury, and maintain tissue homeostasis. In this study, we investigated the involvement of phosphoinositide-3-OH-kinase (PI3K)/Akt and the nuclear factor-kappaB (NF-kappaB) signa...

journal_title：European journal of pharmacology

authors： Lin CC,Chiang LL,Lin CH,Shih CH,Liao YT,Hsu MJ,Chen BC

更新日期：2007-04-10 00:00:00

abstract：:In isolated rabbit aortae, imidazole (10(-4)M) caused a unique nonspecific potentiation of the contractile responses to prostaglandins, norepinephrine, 5-hydroxytryptamine, histamine and potassium only at low concentrations. Imidazole had no effect on the dose-response relationship for Ca2+ in the presence of potassiu...

journal_title：European journal of pharmacology

authors： Suzuki Y,Ishida Y,Hester RK,Shibata S

更新日期：1982-09-24 00:00:00

abstract：:The pathological changes of parasympathetic nerves are considered as an independent prognostic factor of the survival rate for patients with chronic liver disease. The non-selective muscarinic acetylcholine receptors (mAchR) agonists and antagonists can affect the proliferation of hepatocytes, but little is known abou...

journal_title：European journal of pharmacology

authors： Luo L,Xi C,Xu T,Zhang G,Qun E,Zhang W

更新日期：2017-07-15 00:00:00

abstract：:The effect of chronic administration of various monoamine oxidase (MAO) inhibitors on the ability of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) to inhibit forskolin-stimulated adenylate cyclase activity was studied. Groups of 12 rats were given either saline, (E)-beta-fluoromethylene-m-tyrosine (MDL 72394 0.25...

journal_title：European journal of pharmacology

authors： Sleight AJ,Marsden CA,Palfreyman MG,Mir AK,Lovenberg W

更新日期：1988-09-23 00:00:00

abstract：:Cholera toxin, stereotaxically injected into the medial septal nucleus of the rat, leads within 24 h to a dramatic decrease in body weight and an increase in septal adenylate cyclase activity. Toxin-treated rats drink one-third the water of vehicle-treated animals while excreting two-and-one half times the urine. Food...

journal_title：European journal of pharmacology

authors： Neckers LM,Neff NH,Garrison-Gund CK,Wyatt RJ

更新日期：1978-09-15 00:00:00

abstract：:Intracerebroventricular injection into rats of mast-cell degranulating peptide (MCD), dendrotoxin I (DTXI) and 4-aminopyridine (4-AP), three blockers of a subclass of K+ channels, elicited epileptiform wave bursts and convulsions. Three different types of L-type Ca2+ channel inhibitors (+)PN 200-110, a 1,4-dihydropyri...

journal_title：European journal of pharmacology

authors： Gandolfo G,Gottesmann C,Bidard JN,Lazdunski M

更新日期：1989-01-24 00:00:00

abstract：:In anaesthetised guinea-pigs, bronchoconstriction induced by vagal nerve stimulation was potentiated by low doses of the antimuscarinic bronchodilator drug, ipratropium (0.01-1.0 microgram/kg); the maximum effect was obtained with 1.0 microgram/kg which doubled the bronchoconstriction. When the dose was increased abov...

journal_title：European journal of pharmacology

authors： Fryer AD,Maclagan J

更新日期：1987-07-09 00:00:00

abstract：:We have reported previously that ugonin K, a flavonoid isolated from Helminthostachys zeylanica (L.) Hook, potently induces cell differentiation and mineralization of MC3T3-E1 mouse osteoblast-like cells. Here we aimed to elucidate whether ugonin K evoked osteogenesis required interaction with estrogen receptor. Resul...

journal_title：European journal of pharmacology

authors： Lee CH,Huang YL,Liao JF,Chiou WF

更新日期：2012-02-15 00:00:00

abstract：:There is experimental evidence indicating that chronic moderate ethanol consumption delays the age-dependent increase in blood pressure. Since the brain natriuretic peptide (BNP) is a potent hypotensive hormone, the effect of chronic ethanol treatment on the heart BNP system was investigated, using spontaneously hyper...

journal_title：European journal of pharmacology

authors： Guillaume P,Jankowski M,Gutkowska J,Gianoulakis C

更新日期：1996-11-28 00:00:00

abstract：:Piceatannol (3,3',4,5'-tetrahydroxy-trans-stilbene) is a polyphenol present in grapes and wine. By means of alkaline phosphatase activity and osteocalcin enzyme-linked immunosorbent assay (ELISA), we have shown that piceatannol exhibits a significant induction of differentiation in immortalized fetal osteoblasts (hFOB...

journal_title：European journal of pharmacology

authors： Chang JK,Hsu YL,Teng IC,Kuo PL

更新日期：2006-12-03 00:00:00

abstract：:In cultured rat heart muscle cells, reversible long-term ATP depletion induces a decrease in beta-adrenoceptor density and a fall in isoproterenol- as well as forskolin-stimulated cAMP formation. However, isoproterenol-stimulated adenylyl cyclase activity in membrane preparations is not reduced after ATP depletion. Th...

journal_title：European journal of pharmacology

authors： Wagenknecht B,Beuttler C

更新日期：1991-11-13 00:00:00

abstract：:Posttraumatic nerve recovery remains a challenge in regenerative medicine. As such, there is a need for agents that limit nerve damage and enhance nerve regeneration. Here we investigate rosuvastatin, a 3-hydroxy-3-methylglutaryl coenzyme (HMG-CoA) reductase inhibitor, with anti-inflammatory and antioxidant properties...

journal_title：European journal of pharmacology

authors： Abdolmaleki A,Zahri S,Bayrami A

更新日期：2020-09-05 00:00:00

abstract：:Experiments were performed in isolated guinea pig hearts, perfused at constant volume. Left ventricular pressure, left ventricular dp/dtmax, coronary vascular pressure and coronary venous pO2 were measured continuously. Indomethacin (1.4 X 10(-6) M) increased coronary vascular resistance by 15% over control (p less th...

journal_title：European journal of pharmacology

authors： Schrör K,Krebs R,Nookhwun C

更新日期：1976-09-01 00:00:00