Ca2+ channel blockers prevent seizures induced by a class of K+ channel inhibitors.

abstract：:Some behavioural effects of flunitrazepam were investigated in two sets of experiments in C57BL/6 mice. In the first set, flunitrazepam administration (0.025 or 0.05 mg/kg) enhanced the locomotor activity of mice. In the second set, memory impairments were observed following posttraining (immediately or 30 min, but no...

journal_title：European journal of pharmacology

authors： Castellano C,Filibeck U,Pavone F

更新日期：1984-09-03 00:00:00

abstract：:Apoptosis or programmed cell death has been suggested as an important mode of neurodegeneration in Alzheimer's disease pathogenesis. The present study explored the neuroprotective effect of 2-ethoxy-4,5-diphenyl-1,3-oxazine-6-one (EDPOO) against H(2)O(2)-induced cell death in rat pheochromocytoma (PC12) cells. We foun...

journal_title：European journal of pharmacology

authors： Ansari N,Khodagholi F,Amini M

更新日期：2011-05-11 00:00:00

abstract：:The effects of indapamide on contractile responses in various isolated artery rings and on spontaneous mechanical activity in portal vein segments were investigated. Arteries used were: rabbit aorta, mesenteric (fifth branch), femoral and basilar, and sheep coronary arteries. 45Ca2+ uptake was also analysed in rabbit ...

journal_title：European journal of pharmacology

authors： Del Rio M,Chulia T,Gonzalez P,Tejerina T

更新日期：1993-11-30 00:00:00

abstract：:Epristeride, a 5alpha-reductase inhibitor, decreases prostate size and improves symptoms in men with benign prostatic hyperplasia. However, little is known about the histopathology of the prostate after treatment with epristeride. To study the relationship between apoptosis and the mechanism of epristeride in the trea...

journal_title：European journal of pharmacology

authors： Sun ZY,Wu HY,Wang MY,Tu ZH

更新日期：1999-04-29 00:00:00

abstract：:Activation of P2X7 receptors by endogenous ATP contributes to the development of inflammatory hyperalgesia. Given the clinical importance of mechanical hyperalgesia in inflammatory states, we hypothesized that the activation of the P2X7 receptor by endogenous ATP contributes to carrageenan-induced mechanical hyperalge...

journal_title：European journal of pharmacology

authors： Teixeira JM,Oliveira MC,Parada CA,Tambeli CH

更新日期：2010-10-10 00:00:00

abstract：:Rats were treated with ethanol for 11-15 days, after which the brain neurotransmitter receptors for dopamine, acetylcholine, serotonin and noradrenaline were measured. The rats were intubated at 12 h intervals with 4 g/kg ethanol, and sacrificed 10 h after the last intubation. After ethanol treatment, the specific bin...

journal_title：European journal of pharmacology

authors： Muller P,Britton RS,Seeman P

更新日期：1980-07-11 00:00:00

abstract：:The decrease in blood flow in response to dopamine (DA) injected intraarterially (i.a.) into the femoral or renal vascular beds was examined in the anaesthetised dog. DA or noradrenaline (NA) were 10 times more potent as vasoconstrictor agents in the femoral than in the renal vasculature. In the femoral bed, the DA in...

journal_title：European journal of pharmacology

authors： Duval N,Hicks PE,Langer SZ

更新日期：1985-02-05 00:00:00

abstract：:The administration of ethyl beta-carboline-3-carboxylate (beta-CCE), a ligand for benzodiazepine receptors, did not affect the cerebellar cyclic GMP level in mice, but giving beta-CCE together with diazepam significantly inhibited the diazepam-induced decrease in cyclic GMP. The fact that no antagonism was observed wh...

journal_title：European journal of pharmacology

authors： Fujimoto M,Kawasaki K,Matsushita A,Okabayashi T

更新日期：1982-05-21 00:00:00

abstract：:Nitric oxide (NO) has been described to exert various anti-atherogenic actions. However, NO, in some cases, has been shown to stimulate the oxidation of low-density lipoprotein (LDL), which constitute an important triggering event in atherosclerosis. Thus, some NO donors, despite their advantages, might also induce ox...

journal_title：European journal of pharmacology

authors： Jaworski K,Kinard F,Goldstein D,Holvoet P,Trouet A,Schneider YJ,Remacle C

更新日期：2001-08-03 00:00:00

abstract：:The action of antidepressants on cell proliferation (bromodeoxyuridine (BrdU) or [3H]thymidine incorporation) was studied in the adult rat hippocampus in vivo and in neural precursors (immature rat cerebellar granule cells) in vitro. In vivo, prolonged (21 days) but not acute (single) intraperitoneal treatment with fl...

journal_title：European journal of pharmacology

authors： Manev H,Uz T,Smalheiser NR,Manev R

更新日期：2001-01-05 00:00:00

abstract：:The effect of 5,8-dimethyl-4-(2-di-n-propylaminoethyl)carbazol monohydrochloride (FH-510) on the binding of sigma ligands such as [3H](+)-3-(3-hydroxyphenyl)-N-(1-propyl)piperidine ([3H](+)-3-PPP) and [3H]1,3-di-o-tolylguanidine ([3H]DTG) to rat brain membranes was studied. The inhibitory effect of FH-510 on [3H](+)-3...

journal_title：European journal of pharmacology

authors： Chaki S,Tanaka M,Muramatsu M,Otomo S

更新日期：1993-11-30 00:00:00

abstract：:Renal mesangial cells exposed to inflammatory cytokines produce high concentrations of nitric oxide (NO) which may exert cytotoxic actions. We report here that glomerular mesangial cells, endothelial cells and epithelial cells in culture are themselves targets for NO and undergo apoptotic cell death upon exposure to h...

journal_title：European journal of pharmacology

authors： Mühl H,Sandau K,Brüne B,Briner VA,Pfeilschifter J

更新日期：1996-12-12 00:00:00

abstract：:Many atypical antipsychotic drugs, such as olanzapine, induce significant weight gain. However, ziprasidone produces minimal weight gain, the mechanism of which remains unclear. The aim of the present study was to investigate whether ziprasidone would reduce the acute effect of olanzapine on feeding behaviour. The res...

journal_title：European journal of pharmacology

authors： Kirk SL,Neill JC,Jones DN,Reynolds GP

更新日期：2004-11-28 00:00:00

abstract：:We have characterized the rat prostanoid EP1, EP2, EP3alpha and EP4 receptor subtypes cloned from spleen, hepatocyte and/or kidney cDNA libraries. Comparison of the deduced amino acid sequences of the rat EP receptors with their respective homologues from mouse and human showed 91% to 98% and 82% to 89% identity, resp...

journal_title：European journal of pharmacology

authors： Boie Y,Stocco R,Sawyer N,Slipetz DM,Ungrin MD,Neuschäfer-Rube F,Püschel GP,Metters KM,Abramovitz M

更新日期：1997-12-11 00:00:00

abstract：:The pharmacological profiles of tachykinin receptors mediating the release of acetylcholine were examined in the isolated spinal cord of the neonatal rat. The acetylcholine release evoked by neurokinin A or acetyl-[Arg6,Pro9]substance P-(6-11) was depressed by the tachykinin antagonists, spantide and GR71251 at 10 mic...

journal_title：European journal of pharmacology

authors： Suzuki H,Yoshioka K,Maehara T,Hagan RM,Nakanishi S,Otsuka M

更新日期：1993-09-07 00:00:00

abstract：:In strips of pig coronary arteries incubated in oxygenated Krebs-bicarbonate solution at 37 degrees C, dotarizine blocked the phasic contractions evoked by 5-HT (0.5 microM) or K+ depolarization (35 mM K+) with an IC50 of 0.22 and 3.7 microM, respectively. Flunarizine inhibited both types of contractions with IC50 val...

journal_title：European journal of pharmacology

authors： Montiel C,Herrero CJ,García-Palomero E,Renart J,García AG,Lomax RB

更新日期：1997-08-06 00:00:00

abstract：:Mitochondrial oxidative stress followed by membrane permeability transition (MPT) has been considered as a possible mechanism for statins cytotoxicity. Statins use has been associated with reduced risk of cancer incidence, especially prostate cancer. Here we investigated the pathways leading to simvastatin-induced pro...

journal_title：European journal of pharmacology

authors： Costa RA,Fernandes MP,de Souza-Pinto NC,Vercesi AE

更新日期：2013-02-15 00:00:00

abstract：:The therapeutic efficacy of antidepressant drugs that inhibit the reuptake of serotonin (5-hydroxytryptamine, 5-HT) may be enhanced by blocking their indirect activation of 5-HT(1A) autoreceptors, which mediate feedback inhibition of serotonergic neuronal activity. In this study, we examined the effects of venlafaxine...

journal_title：European journal of pharmacology

authors： Bjorvatn B,Fornal CA,Martín FJ,Metzler CW,Jacobs BL

更新日期：2000-09-15 00:00:00

abstract：:The effect of serotonin (5-HT) on the release of tritium from striatal synaptosomes previously loaded with [3H]dopamine ([3H]DA) was studied. 5-HT stimulated both the spontaneous and Ca(2+)-evoked efflux of tritium in a concentration-dependent manner. This effect was not mimicked by the non-selective 5-HT agonist, d-l...

journal_title：European journal of pharmacology

authors： Yi SJ,Gifford AN,Johnson KM

更新日期：1991-06-25 00:00:00

abstract：:The release of [3H]5-hydroxytryptamine ([3H]5-HT) evoked by 15 mM KCl in superfused rat cerebellum synaptosomes was inhibited by 5-HT (pEC30 = 8.73). Methiothepin antagonized 5-HT (pA2 = 9.28); ketanserin, methysergide, cinanserin and spiperone were ineffective. The receptors involved were activated (pEC30 = 8.90) by ...

journal_title：European journal of pharmacology

authors： Bonanno G,Maura G,Raiteri M

更新日期：1986-07-31 00:00:00

abstract：:Choline displaced [3H]QNB binding from rat brain muscarinic receptors competitively, (Ki = 460 microM) but it was only 1/1000th as potent as ACh. Deanol was an extremely weak displacer of [3H]QNB binding while hemicholinium-3 was 50 times more potent than choline. Although brain levels of choline are well below its Ki...

journal_title：European journal of pharmacology

authors： Speth RC,Yamamura HI

更新日期：1979-09-15 00:00:00

abstract：:Whether sulfonylurea therapy, which blocks ATP-sensitive K+ (KATP) channels, impedes endogenous cardioprotective mechanisms during cellular metabolic impairment remains controversial. Therefore, the effect of glyburide, a prototype sulphonylurea drug, on cytosolic Ca2+ concentration and KATP channel activity, was meas...

journal_title：European journal of pharmacology

authors： Brady PA,Zhang S,López JR,Jovanovic A,Alekseev AE,Terzic A

更新日期：1996-07-25 00:00:00

abstract：:The neurochemical control of learning depends on several neurotransmitters, hormones, and neuropeptides. Cortistatin is a neuropeptide with sleep-modulating properties that regulates memory consolidation and evocation. Several reports have suggested that learning processes are expressed under diurnal variations; there...

journal_title：European journal of pharmacology

authors： Méndez-Díaz M,Irwin L,Gómez-Chavarín M,Jiménez-Anguiano A,Cabeza R,Murillo-Rodríguez E,Prospéro-García O

更新日期：2005-01-10 00:00:00

abstract：:Parenterally administered substance P suppressed stress-induced eating (resulting from mild tail pinch) in a dose-related manner, whereas at similar or higher doses of substance P starvation-induced eating was uneffected. This specific effect of substance P on stress-induced eating is possibly associated with alterati...

journal_title：European journal of pharmacology

authors： Morley JE,Levine AS

更新日期：1980-10-17 00:00:00

abstract：:Goniothalamin, a natural occurring styryl-lactone, is a novel compound with putative anticancer activities. In the present study, the mechanism of action of goniothalamin was further investigated in human breast cancer MDA-MB-231 cells. Goniothalamin treatment of cells significantly induced cell cycle arrest at G(2)/M...

journal_title：European journal of pharmacology

authors： Chen WY,Wu CC,Lan YH,Chang FR,Teng CM,Wu YC

更新日期：2005-10-17 00:00:00

abstract：:Isolated and purified leucocytosis promoting factor (LPF), alternatively described as pertussis toxin, reduced the hypotension after beta 2-adrenoceptor stimulation with salbutamol as well as the negative chronotropic activity induced by the muscarinic receptor stimulant arecoline 4 days after its injection into rats....

journal_title：European journal of pharmacology

authors： De Wildt DJ,De Jong Y,Nijkamp FP,Kreeftenberg JG

更新日期：1986-08-15 00:00:00

abstract：:The effects of clozapine on dopamine neurons projecting to the medial-prefrontal cortex, nuclei accumbens and caudatus were compared. Clozapine (1.25 mg/kg i.v.) maximally stimulated the firing rate and burst activity of dopamine neurons projecting to the medialprefrontal cortex. Much higher doses (5 and 10 mg/kg i.v....

journal_title：European journal of pharmacology

authors： Melis M,Diana M,Gessa GL

更新日期：1999-02-05 00:00:00

abstract：:Genetic factors significantly contribute to the determination of human personality traits assessed by self-report questionnaires. However, only in the past few years have common genetic polymorphisms especially the dopamine D4 receptor and the serotonin transporter promoter region been associated with specific persona...

journal_title：European journal of pharmacology

authors： Ebstein RP,Benjamin J,Belmaker RH

更新日期：2000-12-27 00:00:00

abstract：:Oxidative stress plays an important role in auditory dysfunction. Exogenous cell therapy has brought new hopes for repairing mammalian inner ear hair cells. However, poor cell viability of transplanted cells under oxidative stress conditions has limited their therapeutic potential. The adipocytokine apelin-13 was isol...

journal_title：European journal of pharmacology

authors： Niknazar S,Abbaszadeh HA,Peyvandi H,Rezaei O,Forooghirad H,Khoshsirat S,Peyvandi AA

更新日期：2019-06-15 00:00:00

abstract：:The aim of the study was to investigate whether diabetes mellitus modulated the function and expression of P-glycoprotein and the distribution of phenobarbital in the brain of 3-week streptozotocin-induced diabetic mice. P-glycoprotein function in blood-brain barrier was assessed by measuring the brain-to-plasma conce...

journal_title：European journal of pharmacology

authors： Liu H,Zhang D,Xu X,Liu X,Wang G,Xie L,Pang X,Liu L

更新日期：2007-04-30 00:00:00