Abstract:
:Apoptosis or programmed cell death has been suggested as an important mode of neurodegeneration in Alzheimer's disease pathogenesis. The present study explored the neuroprotective effect of 2-ethoxy-4,5-diphenyl-1,3-oxazine-6-one (EDPOO) against H(2)O(2)-induced cell death in rat pheochromocytoma (PC12) cells. We found that H(2)O(2) triggered a range of cellular cascades which leads to cell death, whereas pretreatment of the cells with this oxazine derivative attenuated the extent of apoptosis, as assessed by MTT assay, acridine orange/ethidium bromide staining and caspase-3 expression assay. We further showed that EDPOO exerts its neuroprotective effect by enhancing Hsp-70 level, stabilizing Nrf2 and upregulation of HO-1 and γ-GCS. Moreover, this oxazine derivative regulated cellular redox status via antioxidant enzyme upregulation. The neuroprotective effect of this compound may provide a new potential application for the treatment of neurodegenerative diseases.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Ansari N,Khodagholi F,Amini Mdoi
10.1016/j.ejphar.2011.02.028subject
Has Abstractpub_date
2011-05-11 00:00:00pages
84-90issue
2-3eissn
0014-2999issn
1879-0712pii
S0014-2999(11)00213-5journal_volume
658pub_type
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