Delineation of the protective action of zinc sulfate on ulcerative colitis in rats.


:The protective action of zinc compounds in Crohn's disease-like inflammatory bowel disease in animals has been shown. A similar action of zinc sulfate on ulcerative colitis has not been defined. The present study aimed to delineate the protective action of zinc sulfate and the pathogenic mechanisms of 2,4-dinitrobenzene sulfonic acid (DNBS)-induced ulcerative colitis in rats. Zinc sulfate at different concentrations was given either orally (p.o.) or rectally (p.r.) to rats at 42, 48, 66 and 72 h following the induction of colonic inflammation by DNBS. Rats were killed 96 h after instillation of DNBS rectally to assess the severity of colonic damage, myeloperoxidase and xanthine oxidase activities. The involvement of mast cell degranulation and histamine release in the pathogenesis of DNBS-induced colitis was determined by using a mast cell stabilizer (ketotifen) and histamine receptor blockers (terfenadine and ranitidine). DNBS given rectally produced inflammation and ulceration in rats with a pathology resembling ulcerative colitis. Myeloperoxidase activity but not xanthine oxidase activity was sharply increased by this agent. Intrarectal administration of zinc solution and parenteral injection of histamine blockers significantly reduced tissue damage and myeloperoxidase but not xanthine oxidase activity. Ketotifen, a mast cell stabilizer, also significantly decreased mucosal injury and myeloperoxidase activity in the colon. In conclusion, mast cell degranulation followed by histamine release plays an important role in the pathogenesis of DNBS-induced ulcerative colitis. Zinc given rectally has a therapeutic effect against this colitis model, perhaps through the reduction of inflammation and inhibition of the above pathogenic mechanisms.


Eur J Pharmacol


Luk HH,Ko JK,Fung HS,Cho CH





Has Abstract


2002-05-17 00:00:00














  • Neuroprotective effects of the neuronal Ca(2+) channel blockers, LY042826 and LY393615 in vivo.

    abstract::In the present studies, we have examined the effects of two new Ca(2+) channel blockers, LY042826 (N-[2-[(2-methylphenyl)(phenyl)methoxy]ethyl]-1-butanamine hydrochloride) and LY393615 (N-[[5, 5-bis(4-fluorophenyl)tetrahydro-2-furanyl]methyl]-1-butanamine hydrochloride) in the gerbil model of global and the endothelin...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Hicks CA,Ward MA,O'Neill MJ

    更新日期:2000-11-24 00:00:00

  • Differential modulation of nitric oxide and prostacyclin release in senescent rat heart stimulated by angiotensin II.

    abstract::To elucidate the mechanism of age-related changes in the cardiovascular function stimulated with angiotensin II, we examined the effects of angiotensin II on the coronary flow, production of nitric oxide (NO) and prostacyclin, and on the cardiac function in the Langendorff-perfused young and aged rats' hearts. Angiote...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Ishihata A,Katano Y,Nakamura M,Doi K,Tasaki K,Ono A

    更新日期:1999-10-01 00:00:00

  • Specific effects of chronic phenobarbital administration on high- and low-affinity benzodiazepine receptors in mouse cerebellum and forebrain.

    abstract::Characteristics of [3H]flunitrazepam ([3H]FLU) binding to cortical and cerebellar membrane receptors were examined following chronic (six days) administration of phenobarbital (PB) to C57B1 mice. Following PB treatment, the number of [3H]FLU binding sites (Bmax) was significantly reduced in both cerebral cortex and in...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Liljequist S,Garrett KM,Tabakoff B

    更新日期:1984-08-17 00:00:00

  • Effect of an antihypertensive hydrazine derivative on Ca2+ current of single frog cardiac cells.

    abstract::The effects of MP 518, an acylated 2-chlorobenzylidene hydrazidone derivative with antihypertensive properties were investigated on the Ca current, ICa, recorded under whole-cell patch-clamp in single frog ventricular cells. MP 518 (1-100 microM) had no effect on ICa under control conditions. However, at 10 microM it ...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Scamps F,Tran G,Rinjard P,Binet P,Miocque M,Vassort G

    更新日期:1993-01-15 00:00:00

  • Oral treatment with probucol in a pharmacological dose has no beneficial effects on mortality in chronic ischemic heart failure after large myocardial infarction in rats.

    abstract::Cardiac remodeling after myocardial infarction is in part triggered and maintained by reactive oxygen species. Antioxidants such as probucol have shown positive short-term effects on these cardiac interstitial changes in different experimental models after intraperitoneal administration or after per-oral administratio...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Betge S,Lutz K,Roskos M,Figulla HR

    更新日期:2007-03-08 00:00:00

  • Antagonism of pentobarbital-induced hormonal changes by TRH in rats.

    abstract::In adult male rats, injection of TRH into a lateral ventricle of the brain 5 min prior to pentobarbital (PB) administration caused a significant dose-related inhibition of prolactin (PRL) release, in doses ranging from 500 to 5 ng. Among 8 TRH analogues devoid of thyrotropin-releasing activity, 6 were found to signifi...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Taché Y,Ruisseau PD,Ducharme JR,Collu R

    更新日期:1977-10-15 00:00:00

  • Role of ERK1/2 signaling pathways in 4-aminopyridine-induced rat pulmonary vasoconstriction.

    abstract::The aim of the present study was to investigate the contribution of extracellular signal regulated kinase-1/2 (ERK1/2) to pulmonary artery contraction in response to 4-aminopyridione (4-AP), an inhibitor of a voltage-gated K(+) channels that regulate pulmonary vascular tone. Pulmonary artery rings 1-1.5 mm in diameter...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Han W,Tang X,Wu H,Liu Y,Zhu D

    更新日期:2007-08-13 00:00:00

  • Muscarinic receptor mediated signaling pathways in hepatocytes from CCL4 - induced liver fibrotic rat.

    abstract::The pathological changes of parasympathetic nerves are considered as an independent prognostic factor of the survival rate for patients with chronic liver disease. The non-selective muscarinic acetylcholine receptors (mAchR) agonists and antagonists can affect the proliferation of hepatocytes, but little is known abou...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Luo L,Xi C,Xu T,Zhang G,Qun E,Zhang W

    更新日期:2017-07-15 00:00:00

  • Effects of the enantiomers of the dihydropyridine derivative 202-791 on contractility, coronary flow and ischemia-related arrhythmias in rat heart.

    abstract::The (+)-enantiomer of the dihydropyridine 202-791 produced coronary constrictor and positive inotropic effects in Langendorff-perfused rat hearts whereas (--)-202-791 showed coronary dilator and negative inotropic effects. Both enantiomers showed the vascular effects at lower concentrations than the myocardial effects...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Uematsu T,Cook NS,Hof RP,Vozeh S,Follath F

    更新日期:1986-04-29 00:00:00

  • Synaptosomal uptake and levels of serotonin in rat brain areas after p-chloroamphetamine or B-9 lesions.

    abstract::In contrast to the pronounced fall in 5HT levels and synaptosomal uptake caused by p-chloroamphetamine, bilateral lesions of the B-9 cell group caused minimal regional changes, except for 35% decreases in the metathalamus-thalamus. We conclude therefore that the prolonged biochemical effects of p-chloroamphetamine are...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Massari VJ,Sanders-Bush E

    更新日期:1975-09-01 00:00:00

  • Halothane counteracts acetylcholine-induced increase in Ca2+ sensitivity of the contractile apparatus in airway smooth muscle.

    abstract::The direct relaxing effect of halothane on airway smooth muscle has been reported to involve the reduction of the cytosolic Ca2+ concentration ([Ca2+]i) and the [Ca2+]i-independent inhibitory mechanism. To clarify the extent of the contribution of these mechanisms, the effect of halothane on the [Ca2+]i-tension relati...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Kai T,Takahashi S,Kanaide H

    更新日期:1996-11-21 00:00:00

  • [3H]MDL 105,519 binds with equal high affinity to both assembled and unassembled NR1 subunits of the NMDA receptor.

    abstract::[3H]MDL 105,519 (((E)-3-(2-phenyl-2-carboxyethenyl)-4,6-dichloro-1[3H]-indole-2-ca rboxylic acid) is a novel radioligand which binds with high affinity, Kd = 2.5 nM, to the glycine site of adult rodent forebrain, N-methyl-D-aspartate subtype of glutamate receptors. As with other glycine site antagonists, the major det...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Chazot PL,Reiss C,Chopra B,Stephenson FA

    更新日期:1998-07-17 00:00:00

  • Ca2+ release-activated channels in rat stomach smooth muscle cells.

    abstract::In rat stomach fundus, contractions induced by Ca2+ (1.8 mM) were strikingly potentiated by thapsigargin. This potentiation was partially inhibited by the blockers of Ca2+ release activated channels (CRACs), miconazole and SK&F96365 ([1-[beta-[3-(4-methoxyphenyl)propoxy]-4-methoxyphenethyl]-1H-imidazole, HCL]) and sli...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Smaili SS,Cavalcanti PM,Oshiro ME,Ferreira AT,Jurkiewicz A

    更新日期:1998-01-19 00:00:00

  • Rosuvastatin inhibits norepinephrine-induced cardiac hypertrophy via suppression of Gh.

    abstract::Statins have recently been shown to produce anti-cardiac hypertrophic effects via the regulation of small GTPases. However, the effects of statins on G protein-mediated cardiac hypertrophy, which is the main pathway of cardiac hypertrophy, have not yet been studied. We sought to evaluate whether statin treatment direc...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Choi EY,Chang W,Lim S,Song BW,Cha MJ,Kim HJ,Choi E,Jang Y,Chung N,Hwang KC

    更新日期:2010-02-10 00:00:00

  • Comparison of the antiplatelet effect of YM337 and abciximab in rhesus monkeys.

    abstract::We directly compared the effects of YM337, the Fab fragment of the humanized monoclonal antibody C4G1, on platelet aggregation and template bleeding time with those of abciximab, the Fab fragment of the human/murine chimeric monoclonal antibody 7E3, in rhesus monkeys. The duration of inhibition of platelet aggregation...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Suzuki K,Sakai Y,Hisamichi N,Taniuchi Y,Sato K,Terazaki C,Kaku S,Kawasaki T,Yano S,Inagaki O,Masuho Y

    更新日期:1997-10-08 00:00:00

  • Spinal antinociceptive effects of AA501, a novel chimeric peptide with opioid receptor agonist and tachykinin receptor antagonist moieties.

    abstract::The use of "multimodal" combination analgesic therapies or novel single molecules possessing multiple analgesic targets is becoming increasingly attractive. In previous experiments we showed that a substance P antagonist injected intrathecally potentiated the antinociceptive effects of potent opioid receptor agonist, ...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Bonney IM,Foran SE,Marchand JE,Lipkowski AW,Carr DB

    更新日期:2004-03-19 00:00:00

  • Strong activation of vascular prejunctional beta 2-adrenoceptors in freely moving rats by adrenaline released as a co-transmitter.

    abstract::The effect of adrenaline on the electrically evoked noradrenaline overflow in the portal vein of adrenal demedullated freely moving rats was studied. Adrenaline (100 ng/min) was infused for 2 h into the portal vein. After a 1-h interval when plasma adrenaline had returned to pre-infusion undetectable levels, the porta...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Coppes RP,Smit J,Khali NN,Brouwer F,Zaagsma J

    更新日期:1993-10-26 00:00:00

  • WITHDRAWN: Decreased HCN1 mRNA in hippocampal area CA1 and neocortex after chronic cerebral hypoperfusion.

    abstract::This article has been withdrawn at the request of the author(s). The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at ...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: He Z,Chen C,Huang L,Liu S,Guo L

    更新日期:2008-12-03 00:00:00

  • Behavioural and electrocortical power spectrum effects of 5-methoxytryptoline and other analogs after intraventricular administration in rats.

    abstract::The behavioural and electrocortical power spectrum effects of tryptoline and the 5-hydroxy and 5-methoxy derivatives were studied after microinjection of the drugs into the third cerebral ventricle in freely moving rats. The three compounds produced a dose-dependent desynchronication in electrocortical activity with a...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Nistico G,De Sarro GB,Langer SZ

    更新日期:1987-10-06 00:00:00

  • α1A-Adrenoceptors, but not α1B- or α1D-adrenoceptors, contribute to enhanced contractile response to phenylephrine in cooling conditions in the rat tail artery.

    abstract::Cutaneous arteries show enhanced contraction in response to cooling, which is suggested to be mediated via α2C-adrenoceptors. We have previously shown that α1-adrenoceptors are also involved in the enhanced contraction in cooling conditions. In the present study, we aimed to identify the α1-adrenoceptor subtype involv...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Ishida H,Saito SY,Ishikawa T

    更新日期:2018-11-05 00:00:00

  • Direct and indirect effects of ephedrine on heart rate and blood pressure in vehicle-treated and sympathectomised male rats.

    abstract::We have investigated the cardiac and pressor responses to (±)-ephedrine and (-)-ephedrine in pentobarbitone anaesthetized male wistar rats. The tachycardiac responses to (±)- and (-)-ephedrine were similar, but pressor responses to (-)-ephedrine (10 mg/kg) were significantly greater than those to (±)-ephedrine, and fo...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Alsufyani HA,Docherty JR

    更新日期:2018-04-15 00:00:00

  • Inhibition by sulfur-containing amino acids and GABA of sympathetic neurotransmission in guinea-pig vas deferens.

    abstract::Electrical stimulation produced a contraction in the isolated guinea-pig vas deferens. This response was blocked by tetrodotoxin, guanethidine and bretylium but not by atropine. The magnitude of the contractile response to electrical stimulation depended on the concentration of the external calcium. Sulfur-containing ...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Morishita H,Sugiyama M,Furukawa T

    更新日期:1983-11-11 00:00:00

  • Anticancer effect of pan-PI3K inhibitor on multiple myeloma cells: Shedding new light on the mechanisms involved in BKM120 resistance.

    abstract::The correlation between the Phosphoinositide 3-kinase (PI3K) axis and crucial mechanisms involved in the maintenance of the neoplastic nature of multiple myeloma (MM) has recently evolved a general agreement that PI3K inhibition-based therapies could construct an exciting perspective for the future treatment strategie...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Safaroghli-Azar A,Bashash D,Kazemi A,Pourbagheri-Sigaroodi A,Momeny M

    更新日期:2019-01-05 00:00:00

  • Dinitrosyl iron complexes with glutathione suppress experimental endometriosis in rats.

    abstract::Dinitrosyl iron complexes (DNIC) with glutathione exert a cytotoxic effect on endometrioid tumours in rats with surgically induced experimental endometriosis. Intraperitoneal treatment of rats (Group 1) with DNIC (12.5μmoles/kg, daily, for 12 days), beginning with day 4 after the surgical operation (implantation of tw...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Burgova EN,Tkachev NА,Adamyan LV,Mikoyan VD,Paklina OV,Stepanyan AA,Vanin AF

    更新日期:2014-03-15 00:00:00

  • Antidepressants: past, present and future.

    abstract::Since the discovery of first antidepressants in mid-1950's, the field has been intensively studied. Several new classes of compounds emerged and several hypotheses on the mechanism of their action were proposed. The novel antidepressants are either selective and reversible monoamine oxidase inhibitors, (e.g., moclobem...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章,评审


    authors: Vetulani J,Nalepa I

    更新日期:2000-09-29 00:00:00

  • Effect of removal and substitution of potassium ions on the adrenergic and cholinergic reactivity in canine femoral artery.

    abstract::Canine femoral arteries responded to acetylcholine with relaxations; these were abolished in potassium free solution, restored by potassium or rubidium but not by cesium or amonium. Potassium and rubidium were equipotent in inducing ouabain-sensitive relaxation, while amonium and cesium were less potent. The results (...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: De Mey J,Vanhoutte PM

    更新日期:1980-10-03 00:00:00

  • Lack of intrinsic activity and significant subtype selectivity of SR 95639A at muscarinic receptors.

    abstract::We assessed the intrinsic activity of the purported selective muscarinic M1 receptor agonist SR 95639A (morpholinoethylamino-3-benzocyclohepta-(5,6-c)-pyridazine) in inducing several receptor-mediated signals. Our results indicate that SR 95639A lacks the ability to activate phosphoinositide hydrolysis in rat cerebral...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Mohamed AS,Forray C,Aly MH,el-Fakahany EE

    更新日期:1992-10-01 00:00:00

  • Effect of diazoxide, verapamil and compound D600 on isoproterenol and calcium-mediated dose-response relationships in isolated rabbit atrium.

    abstract::The effect of diazoxide, verapamil and compound D600 on calcium and isoproterenol dose-response relationships was investigated in isolated rabbit atrial preparations. All three agents shifted calcium dose-force relationships parallel and to the right. D600 acted as a competitive antagonist of calcium, as a plot of log...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Bristow MR,Green RD

    更新日期:1977-10-01 00:00:00

  • Presynaptic depression of inhibitory postsynaptic potentials by metabotropic glutamate receptors in rat hippocampal CA1 pyramidal cells.

    abstract::The effects of the metabotropic glutamate (mGlu) receptor agonists (+/-)-trans-1-aminocyclopentane-1,3-dicarboxylic acid (trans-ACPD) or 1S,3R-ACPD on gamma-aminobutyric acid (GABA)-mediated inhibitory synaptic responses have been investigated in vitro in CA1 pyramidal cells of rat hippocampal slices. Bath application...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Jouvenceau A,Dutar P,Billard JM

    更新日期:1995-08-04 00:00:00

  • Effects of branched-chain amino acids on DNA synthesis and proliferation in primary cultures of adult rat hepatocytes.

    abstract::We investigated the effects of branched-chain amino acids on DNA synthesis and proliferation in primary cultures of adult rat hepatocytes. Of the branched-chain amino acids, only leucine (10(-5)-10(-3) M) induced hepatocyte DNA synthesis and proliferation in a time- and dose-dependent manner. The addition of valine or...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Kimura M,Ogihara M

    更新日期:2005-03-14 00:00:00