Molecular cloning and characterization of the four rat prostaglandin E2 prostanoid receptor subtypes.

abstract：:In anaesthetised guinea-pigs, bronchoconstriction induced by vagal nerve stimulation was potentiated by low doses of the antimuscarinic bronchodilator drug, ipratropium (0.01-1.0 microgram/kg); the maximum effect was obtained with 1.0 microgram/kg which doubled the bronchoconstriction. When the dose was increased abov...

journal_title：European journal of pharmacology

authors： Fryer AD,Maclagan J

更新日期：1987-07-09 00:00:00

abstract：:In the present study, the interaction of nitric oxide synthase (NOS) inhibitors, L-NAME (N(G)-nitro-L-arginine methyl ester HCl) and L-NA (N(omega)-nitro-L-arginine), and its precursor, L-arginine (2-(S)-2-amino-5-[(aminoiminomethyl)amino] pentatonic acid), with theophylline on mouse body temperature was studied. Intr...

journal_title：European journal of pharmacology

authors： Zarrindast MR,Adl M,Sharifzadeh M,Bahreini T

更新日期：2002-09-06 00:00:00

abstract：:Agomelatine is an antidepressant with a novel mechanism of action. It is a melatonergic agonist for MT1 and MT2 receptors and a serotonin (5-HT2C) receptor antagonist. Agomelatine has been suggested not to have adverse effects on sexual functions. However, the effects of chronic agomelatine administration on reproduct...

journal_title：European journal of pharmacology

authors： Canpolat S,Ulker N,Yardimci A,Bulmus O,Ozdemir G,Sahin Z,Ercan Z,Serhatlioglu I,Kacar E,Ozcan M,Turk G,Ozkan Y,Atmaca M,Yilmaz B,Kelestimur H

更新日期：2016-01-05 00:00:00

abstract：:The purpose of the present study was to characterize the nature of the behavioural response to substance P (SP) infusion into the substantia nigra and to evaluate this response in 6-hydroxydopamine (6-OHDA) caudate lesioned rats. The effects of SP infusions (3 microgram in 1 microliter bilaterally) were assessed in an...

journal_title：European journal of pharmacology

authors： Kelley AE,Iversen SD

更新日期：1979-12-07 00:00:00

abstract：:Ischemia-reperfusion injury(IRI), described as tissue damage caused by reversible ischemic injury or hypoxia prior to the blood supply restoration, is a common pathological phenomenon. In recent study, a hypoxia-reoxygenation (H/R) in the presence or absence of propofol posthypoxia treatment (P-PostH) cell model was b...

journal_title：European journal of pharmacology

authors： Zhang L,Ruan Z,Liang J,Du Y,Lu Z,Feng D,Cai S,Zhang X,Cai W,Hu Z

更新日期：2018-08-15 00:00:00

abstract：:Biphalin (0.3 mg/kg) administered intravenously (i.v.) to urethane-chloralose anaesthetized rats consistently evoked apnoea, followed by breathing at subnormal respiratory rate with increased tidal volume. Mean arterial pressure and heart rate were lowered. Naloxone completely antagonized the respiratory and cardiovas...

journal_title：European journal of pharmacology

authors： Wojciechowski P,Szereda-Przestaszewska M,Lipkowski AW

更新日期：2009-01-05 00:00:00

abstract：:Glucocorticoids inhibit inducible-type NO synthase activity in a variety of cell types. We report here that proteins recovered from the medium of dexamethasone-treated J774 macrophages (1, 10, 100 microg/ml) inhibited lipopolysaccharide-stimulated nitrite generation by 10.0 +/- 3.0%, 32.3 +/- 5.3% and 55.0 +/- 6.0%, r...

journal_title：European journal of pharmacology

authors： D'Acquisto F,Cicatiello L,Iuvone T,Ialenti A,Ianaro A,Esumi H,Weisz A,Carnuccio R

更新日期：1997-11-19 00:00:00

abstract：:Oxidative stress has been implicated in the pathogenesis of acute myocarditis. The imbalance between the occurrence of reactive oxygen species and the cellular antioxidant defense mechanism plays a key role in myocardial injury of viral myocarditis. Carvedilol, a nonselective beta-adrenoceptor antagonist with addition...

journal_title：European journal of pharmacology

authors： Li YC,Ge LS,Yang PL,Tang JF,Lin JF,Chen P,Guan XQ

更新日期：2010-08-25 00:00:00

abstract：:In adult male rats, injection of TRH into a lateral ventricle of the brain 5 min prior to pentobarbital (PB) administration caused a significant dose-related inhibition of prolactin (PRL) release, in doses ranging from 500 to 5 ng. Among 8 TRH analogues devoid of thyrotropin-releasing activity, 6 were found to signifi...

journal_title：European journal of pharmacology

authors： Taché Y,Ruisseau PD,Ducharme JR,Collu R

更新日期：1977-10-15 00:00:00

abstract：:Continuous monitoring of the foetal electrocorticogram, eye movements and heart rate in ewes during the last month of gestation showed rapid placental transfer from the mother to the foetus of phenothiazine derivatives (acepromazine maleate), short-acting barbiturates (thiopental sodium) and narcotic analgesics (meper...

journal_title：European journal of pharmacology

authors： Ruckebusch Y,Gaujoux M,Eghbali B

更新日期：1976-05-01 00:00:00

abstract：:A decrease of 30% was observed in the density of peripheral-type benzodiazepine binding sites in platelets of nine schizophrenics maintained on chronic neuroleptic treatment as compared to platelets of six untreated schizophrenics and 15 healthy volunteers. The equilibrium dissociation constant for binding by [3H]PK 1...

journal_title：European journal of pharmacology

authors： Gavish M,Weizman A,Karp L,Tyano S,Tanne Z

更新日期：1986-02-18 00:00:00

abstract：:We examined whether danazol has a direct action on ovarian steroid secretion and/or uterine prostaglandin (PG) F2 alpha catabolic activity in immature rats in which the first ovulation was induced and in adult ovariectomized rats. The preovulatory surge of estradiol and progesterone was markedly suppressed together wi...

journal_title：European journal of pharmacology

authors： Kogo H,Takasaki K,Yatabe Y,Nishikawa M,Takeo S,Tamura K

更新日期：1992-01-28 00:00:00

abstract：:We have examined the pharmacology of kainate receptors in cultured hippocampal neurons (6-8 days in vitro (DIV)) from embryonic rats (E17). Cultured neurons were pre-treated with concanavalin A to remove kainate receptor desensitization and whole-cell voltage clamp electrophysiology employed to record inward currents ...

journal_title：European journal of pharmacology

authors： Bleakman D,Ogden AM,Ornstein PL,Hoo K

更新日期：1999-08-13 00:00:00

abstract：:There is evidence that bovine adrenal chromaffin cells are provided with both dihydropyridine-sensitive and -resistant voltage-sensitive Ca2+ influx pathways. Although recent electrophysiological work indicates that the dihydropyridine-resistant pathway is partially mediated by omega-conotoxin-sensitive and -insensiti...

journal_title：European journal of pharmacology

authors： Duarte CB,Tome AR,Forsberg E,Carvalho CA,Carvalho AP,Santos RM,Rosario LM

更新日期：1993-02-15 00:00:00

abstract：:The vasodilator profile of synthetic atrial natriuretic factor (ANF) was characterized using isolated vascular preparations. Nanomolar concentrations of ANF relaxed rabbit aortic rings contracted by serotonin, histamine, methoxamine or angiotensin II. The synthetic peptide was most effective (IC50 = 1.3 X 10(-10) M) i...

journal_title：European journal of pharmacology

authors： Winquist RJ,Faison EP,Nutt RF

更新日期：1984-06-15 00:00:00

abstract：:The stress-induced hyperthermia procedure, in which effects of drugs on basal (T(1)) and stress-induced body temperature (T(2)) are measured, predicts anxiolytic drug effect. Serotonergic drugs alter these responses and here, we studied the role of 5-HT(1A) receptors in stress-induced hyperthermia by using 5-HT(1A) re...

journal_title：European journal of pharmacology

authors： Van Bogaert M,Oosting R,Toth M,Groenink L,van Oorschot R,Olivier B

更新日期：2006-11-21 00:00:00

abstract：:Enterobacteria are known to deconjugate amino acid-conjugated bile acids in the intestine. Administration of ampicillin (ABPC; 3 days, 100mg/kg) decreased the expression of ileal farnesoid X receptor (Fxr) target genes, and increased the levels of total bile acids in the intestinal lumen. The primary tauro-conjugates ...

journal_title：European journal of pharmacology

authors： Kuribayashi H,Miyata M,Yamakawa H,Yoshinari K,Yamazoe Y

更新日期：2012-12-15 00:00:00

abstract：:We have examined the effect of various chemokines on neuronal toxicity in culture. In mixed cortical cultures, challenged with a brief pulse of N-methyl-D-aspartate (NMDA, 60 microM, 10 min), chemokines were either present for 2 h preceding the pulse or they were co-applied with NMDA and then kept in the medium for th...

journal_title：European journal of pharmacology

authors： Bruno V,Copani A,Besong G,Scoto G,Nicoletti F

更新日期：2000-07-07 00:00:00

abstract：:Autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) is a rare monogenic idiopathic partial epilepsy characterized by clusters of frontal lobe motor seizures during sleep. Recently, it has been shown that mutations of the chromosome-20q-located neuronal nicotinic acetylcholine receptor alpha4-subunit (CHRNA4) a...

journal_title：European journal of pharmacology

authors： Steinlein OK

更新日期：2000-03-30 00:00:00

abstract：:The present study describes the effect of sertindole, clozapine and haloperidol on the number of spontaneously active dopamine neurons in ventral tegmental area and substantia nigra pars compacta after daily oral treatment for 1, 2 or 3 weeks. In general, daily administration of high dosages (sertindole: 2.8 mumol/kg/...

journal_title：European journal of pharmacology

authors： Skarsfeldt T

更新日期：1994-03-21 00:00:00

abstract：:The stimulation of spinal cannabinoid type 2 (CB(2)) receptors is a suitable strategy for the alleviation of experimental pain symptoms. Several reports have described the up-regulation of spinal cannabinoid CB(2) receptors in neuropathic settings together with the analgesic effects derived from their activation. Besi...

journal_title：European journal of pharmacology

authors： Curto-Reyes V,Boto T,Hidalgo A,Menéndez L,Baamonde A

更新日期：2011-10-01 00:00:00

abstract：:We investigated the role of dopamine D1 and D2 receptors in the paw test, an animal model used to assess both the antipsychotic potential and extrapyramidal side effects of drugs. The dopamine D1 receptor antagonist, SCH 39166, as well as the dopamine D2 receptor antagonist raclopride, increased the hindlimb retractio...

journal_title：European journal of pharmacology

authors： Prinssen EP,Ellenbroek BA,Stamatovic B,Cools AR

更新日期：1993-02-09 00:00:00

abstract：:The NMDA receptor is coupled to a cation-selective ion channel, which has been implicated in important brain functions such as long-term potentiation and burst firing, and in neuronal death associated with stroke and epilepsy. We have investigated the binding properties of [3H]MK-801, which binds selectively to the op...

journal_title：European journal of pharmacology

authors： von Euler G,Liu Y

更新日期：1993-05-15 00:00:00

abstract：:The effects of 26 anesthetic agents were studied on the rhythmical discharge activity of a single isolated neuron (crayfish stretch receptor). Many of these agents produced concentration-dependent biphasic responses (excitation and depression), and some also induced altered discharge patterns (burst activity). The dom...

journal_title：European journal of pharmacology

authors： MacIver MB,Roth SH

更新日期：1987-07-02 00:00:00

abstract：:Characteristics of [3H]flunitrazepam ([3H]FLU) binding to cortical and cerebellar membrane receptors were examined following chronic (six days) administration of phenobarbital (PB) to C57B1 mice. Following PB treatment, the number of [3H]FLU binding sites (Bmax) was significantly reduced in both cerebral cortex and in...

journal_title：European journal of pharmacology

authors： Liljequist S,Garrett KM,Tabakoff B

更新日期：1984-08-17 00:00:00

abstract：:The aim of the present study was to correlate the impairment of cognitive function induced by scopolamine with the activity of dopaminergic synapses in brain areas which are innervated by the mesocortical limbic system (e.g. hippocampus and frontal cortex) or by the mesostriatal system (e.g. striatum and nucleus accum...

journal_title：European journal of pharmacology

authors： Memo M,Missale C,Trivelli L,Spano PF

更新日期：1988-05-10 00:00:00

abstract：:(-)-Epigallocatechin-3-gallate (EGCG), a main flavanol of green tea, potently suppressed the urokinase-type plasminogen activator (uPA) expression in human fibrosarcoma HT 1080 cells. EGCG induced not only the suppression of the uPA promoter activity but also the destabilization of uPA mRNA. EGCG inhibited the phospho...

journal_title：European journal of pharmacology

authors： Kim MH,Jung MA,Hwang YS,Jeong M,Kim SM,Ahn SJ,Shin BA,Ahn BW,Jung YD

更新日期：2004-03-08 00:00:00

abstract：:The Cl(-) channel blockers, 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid (DIDS) or 4-acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic acid (SITS) dose-dependently protected against oxygen-glucose deprivation in cultured rat cortical neurons. DIDS or SITS attenuated oxygen-glucose deprivation-induced increases...

journal_title：European journal of pharmacology

authors： Tauskela JS,Mealing G,Comas T,Brunette E,Monette R,Small DL,Morley P

更新日期：2003-03-07 00:00:00

abstract：:1-Phenyl-3-(2-thiazolyl)-2-thiourea (200 mg/kg, 1 h) protected the adrenergic nerve plexus in the mouse atrium against the destructive action of i.v. 5,7-dihydroxytryptamine. Protection was also observed with ethanol (4 g/kg, 1 h) and with nialamide (50 mg/kg, 2 h). ...

journal_title：European journal of pharmacology

authors： Allis B,Cohen G

更新日期：1977-06-01 00:00:00

abstract：:Omega-3 polyunsaturated fatty acids have been reported to be associated with favorable changes in the respiratory system. To determine one of the mechanisms for this effect, membrane currents were recorded in guinea-pig tracheal myocytes by using the whole-cell voltage clamp technique. Without EGTA in the patch pipett...

journal_title：European journal of pharmacology

authors： Hazama H,Nakajima T,Asano M,Iwasawa K,Morita T,Igarashi K,Nagata T,Horiuchi T,Suzuki J,Soma M,Okuda Y

更新日期：1998-08-21 00:00:00