Effect of naloxone-precipitated morphine withdrawal on noradrenaline release in rat hippocampus in vivo.

abstract：:gamma-Aminobutyric acid B (GABA(B)) receptor is the first discovered G protein-coupled receptor that requires two subunits, GB1 and GB2, to form a functional receptor. Whereas the molecular and functional characteristics of GABA(B) receptors have been recently extensively studied, the mechanisms underlying receptor de...

journal_title：European journal of pharmacology

authors： González-Maeso J,Wise A,Green A,Koenig JA

更新日期：2003-11-14 00:00:00

abstract：:Oxidative stress plays an important role in auditory dysfunction. Exogenous cell therapy has brought new hopes for repairing mammalian inner ear hair cells. However, poor cell viability of transplanted cells under oxidative stress conditions has limited their therapeutic potential. The adipocytokine apelin-13 was isol...

journal_title：European journal of pharmacology

authors： Niknazar S,Abbaszadeh HA,Peyvandi H,Rezaei O,Forooghirad H,Khoshsirat S,Peyvandi AA

更新日期：2019-06-15 00:00:00

abstract：:A series of neurochemical studies evaluated the selectivity of the depletions of norepinephrine produced by intraventricular injections of xylamine. Brain monoamines were assayed by liquid chromatography with electrochemical detection. With ether anesthesia, bilateral injections of 50 or 100 micrograms xylamine reduce...

journal_title：European journal of pharmacology

authors： Geyer MA,Gordon J,Adams LM

更新日期：1984-04-20 00:00:00

abstract：:Metabotropic glutamate mGlu(1) receptors play a modulatory role in the nervous system. They enhance cell excitability, modulate synaptic neurotransmission and are involved in synaptic plasticity. During the last 10 years, several selective metabotropic glutamate mGlu(1) receptor competitive antagonists and potentiator...

journal_title：European journal of pharmacology

authors： Lesage A,Steckler T

更新日期：2010-08-10 00:00:00

abstract：:20(S)-Protopanaxadiol (PPD), a metabolite of ginsenosides, has been demonstrated to possess cytotoxic effects on several cancer cell lines. The molecular mechanism is, however, not well understood. In this study, we have shown that PPD inhibits cell growth and induces apoptosis in human hepatocarcinoma HepG2 cells. PP...

journal_title：European journal of pharmacology

authors： Zhu GY,Li YW,Tse AK,Hau DK,Leung CH,Yu ZL,Fong WF

更新日期：2011-10-01 00:00:00

abstract：:In strips of pig coronary arteries incubated in oxygenated Krebs-bicarbonate solution at 37 degrees C, dotarizine blocked the phasic contractions evoked by 5-HT (0.5 microM) or K+ depolarization (35 mM K+) with an IC50 of 0.22 and 3.7 microM, respectively. Flunarizine inhibited both types of contractions with IC50 val...

journal_title：European journal of pharmacology

authors： Montiel C,Herrero CJ,García-Palomero E,Renart J,García AG,Lomax RB

更新日期：1997-08-06 00:00:00

abstract：:Peripheral type benzodiazepine receptors are differentially modified by arachidonate, diethylpyrocarbonate and thiol reagents, as evidenced by the finding that binding of a proposed agonist ([3H]R05-4864) and a proposed antagonist ([3H]PK 11195) to rat kidney mitochondrial membranes can be modified separately. (1) Ara...

journal_title：European journal of pharmacology

authors： Skowroński R,Beaumont K,Fanestil DD

更新日期：1987-11-17 00:00:00

abstract：:Acetyl-CoA acetyltransferase (1-O-alkyl-sn-glycero-3-phosphocholine) is a key enzyme in paf-acether biosynthesis. Its immunological activation as related to paf-acether formation was investigated in mast cells derived from mouse bone marrow. The action of ketotifen, a prophylactic anti-asthma drug, on the antigen-indu...

journal_title：European journal of pharmacology

authors： Joly F,Bessou G,Benveniste J,Ninio E

更新日期：1987-12-01 00:00:00

abstract：:T-type Ca(2+) currents were recorded in 2 mM Ca(2+) from HEK293 cells stably expressing the low voltage-activated Ca(2+) channel sub-unit alpha(1I). These currents were inhibited by the known Ca(2+) channel antagonist mibefradil with an IC(50) close to 1 microM. SB-209712 (1,6,bis¿1-[4-(3-phenylpropyl)piperidinyl]¿hex...

journal_title：European journal of pharmacology

authors： McNaughton NC,Warre R,Cooper DG,Nasir S,Ranson JL,Randall A

更新日期：2000-10-27 00:00:00

abstract：:We synthesized the o-, m- and p-bromo derivatives of dl-threo-methylphenidate from the corresponding bromophenylacetonitriles by modification of the literature synthesis of methylphenidate (Panizzon, Helv. Chim. Acta 1944, 27, 1748). In in vitro binding assays all three dl-threo bromo compounds had higher affinities t...

journal_title：European journal of pharmacology

authors： Pan D,Gatley SJ,Dewey SL,Chen R,Alexoff DA,Ding YS,Fowler JS

更新日期：1994-10-24 00:00:00

abstract：:After incubation of rat cortical cell cultures with the human immunodeficiency virus type 1 (HIV-1) coat protein gp120 for 12 h, cells showed fragmentation of DNA at internucleosomal linkers, the characteristic feature of apoptosis. In a quantitative approach, it was determined that the percentage of DNA fragmentation...

journal_title：European journal of pharmacology

authors： Müller WE,Schröder HC,Ushijima H,Dapper J,Bormann J

更新日期：1992-07-01 00:00:00

abstract：:The intracerebroventricular (i.c.v.) administration of 10 micrograms of atrial natriuretic peptide (ANP) stimulated spontaneous gastric acid secretion in anaesthetized rats, whereas this dose of ANP was without any effect after i.v. injection. The secretagogue action of i.c.v. administered ANP was totally abolished by...

journal_title：European journal of pharmacology

authors： Puurunen J,Ruskoaho H

更新日期：1987-09-23 00:00:00

abstract：:The effects of Ca2+ channel antagonists on the capsaicin-induced cough reflex in guinea pigs were studied. Intraperitoneal injection of nifedipine, verapamil and flunarizine in doses that ranged from 0.3 to 3.0 mg/kg decreased the number of coughs in a dose-dependent manner. These Ca2+ channel antagonists exhibited an...

journal_title：European journal of pharmacology

authors： Kamei J,Kasuya Y

更新日期：1992-02-25 00:00:00

abstract：:Adenosine has been reported to have beneficial effects against ischemic brain damage, although the mechanisms are not fully clarified. To examine the role of adenosine on the ischemia-evoked release of neurotransmitters, we applied a highly selective agonist for adenosine A1 receptor, 2-chloro-N6-cyclopentyladenosine ...

journal_title：European journal of pharmacology

authors： Goda H,Ooboshi H,Nakane H,Ibayashi S,Sadoshima S,Fujishima M

更新日期：1998-09-18 00:00:00

abstract：:The effects of the [Ti IV (C(5)H(5))(2) NCS(2)] metallocene (BCDT), a Titanocene Dichloride derivative, on the growth and differentiation of granulocyte-macrophage progenitor cells [colony-forming unit-granulocyte-macrophage (CFU-GM)] and bone marrow cellularity in normal and Ehrlich ascites tumour-bearing mice were s...

journal_title：European journal of pharmacology

authors： Valadares MC,Queiroz ML

更新日期：2002-03-29 00:00:00

abstract：:Acid-sensing ion channels (ASICs) are involved in numerous physiological and pathological processes in the central nervous system. Development of pharmacological tools capable to inhibit or potentiate these channels is important for our knowledge about roles of ASICs in the neuronal network and can be promising for tr...

journal_title：European journal of pharmacology

authors： Nagaeva EI,Potapieva NN,Nikolaev MV,Gmiro VE,Magazanik LG,Tikhonov DB

更新日期：2016-10-05 00:00:00

abstract：:CGS7184 (ethyl 1-[[(4-chlorophenyl)amino]oxo]-2-hydroxy-6-trifluoromethyl-1H-indole-3-carboxylate) is a synthetic large-conductance Ca(2+)-activated potassium (BK(Ca)) channel opener. The existing literature suggests that potassium channels are involved in cardioprotection, particularly during ischemia-reperfusion eve...

journal_title：European journal of pharmacology

authors： Wrzosek A,Tomaskova Z,Ondrias K,Lukasiak A,Szewczyk A

更新日期：2012-09-05 00:00:00

abstract：:Cisplatin (CDDP)-induced nephrotoxicity (CIN) is one of the most serious toxicities caused by this potent antitumor agent. It has been reported that Mg premedication attenuates CIN in clinical trials; however, the mechanism underlying its nephroprotection is not fully understood. Therefore, the aim of this study was t...

journal_title：European journal of pharmacology

authors： Saito Y,Okamoto K,Kobayashi M,Narumi K,Yamada T,Iseki K

更新日期：2017-09-15 00:00:00

abstract：:Sham and electrolytic lesions of the dorsal, median, and dorsal + median raphe nuclei were made in different groups of rats. One week later, daily oral treatment with ethanol (5 g/kg p.o. for 25 days) was started. This treatment produced tolerance to the hypothermic and motor impairing (moving belt test) effects of et...

journal_title：European journal of pharmacology

authors： Lê AD,Kalant H,Khanna JM

更新日期：1982-06-04 00:00:00

abstract：:The mechanisms underlying myocardial dysfunction in sepsis remain poorly understood. The theoretical benefits of nitric oxide synthase (NOS) inhibition in reversing the haemodynamic changes that characterise septic shock have not been supported by clinical trials, some of which have demonstrated detrimental myocardial...

journal_title：European journal of pharmacology

authors： Price S,Evans TW,Mitchell JA

更新日期：2002-08-09 00:00:00

abstract：:The neuroprotective effects of erythropoietin on 1-methyl-4-phenylpyridinium (MPP(+))-induced oxidative stress and apoptosis in cultured PC12 cells as well as the underlying mechanism were investigated. Treatment of PC12 cells with MPP(+) caused the loss of cell viability, which was associated with the elevation in ap...

journal_title：European journal of pharmacology

authors： Wu Y,Shang Y,Sun S,Liu R

更新日期：2007-06-14 00:00:00

abstract：:N6-2-(4-Aminophenyl)ethyl-adenosine (APNEA, a non-selective agonist of the adenosine A3 receptors), at the subprotective dose of 1 mg/kg against electroconvulsions, significantly potentiated the anticonvulsive action of phenobarbital, diphenylhydantoin and valproate against maximal electroshock, being ineffective at l...

journal_title：European journal of pharmacology

authors： Borowicz KK,Kleinrok Z,Czuczwar SJ

更新日期：1997-05-30 00:00:00

abstract：:A mixture of dexamphetamine and chlordiazepoxide induces hyperactivity in both mice and rats. This type of hyperactivity has been proposed as an animal model of mania. Magnesium valproate itself had little influence on the activity of normal mice and rats. Acute pretreatment of mice with magnesium valproate (75-300 mg...

journal_title：European journal of pharmacology

authors： Cao BJ,Peng NA

更新日期：1993-06-24 00:00:00

abstract：:The role of the alpha 1-adrenoceptor subtypes, and their possible change with maturation, in alpha 1-adrenoceptor-induced pressor responses in the rat has not been established. Thus, the effects of the alpha 1D-, alpha 1A/1D- and alpha 1B/1D-adrenoceptor antagonists, BMY 7378 (8-(2-(4-(2-methoxyphenyl)-1-piperazinyl)e...

journal_title：European journal of pharmacology

authors： Ibarra M,Terrón JA,López-Guerrero JJ,Villalobos-Molina R

更新日期：1997-03-19 00:00:00

abstract：:Cultured retina cells released accumulated [3H]GABA (gamma-aminobutyric acid) when stimulated by L-glutamate, N-methyl-D-aspartate (NMDA) and kainate. In the absence of Mg2+, dopamine at 200 microM (IC50 60 microM), inhibited in more than 50% the release of [3H]GABA induced by L-glutamate and NMDA, but not by kainate....

journal_title：European journal of pharmacology

authors： Do Nascimento JL,Kubrusly RC,Reis RA,De Mello MC,De Mello FG

更新日期：1998-02-05 00:00:00

abstract：:Glycyrrhiza (the roots and rhizomes of licorice) has been used worldwide as both an herbal nutraceutical and herbal medicine. In addition, it is well known that Glycyrrhiza contains various compounds with biological effects, such as anti-viral, anti-inflammatory, immunoregulatory, anti-tumor and neuroprotective effect...

journal_title：European journal of pharmacology

authors： Nakatani Y,Kobe A,Kuriya M,Hiroki Y,Yahagi T,Sakakibara I,Matsuzaki K,Amano T

更新日期：2017-11-15 00:00:00

abstract：:In contrast to the pronounced fall in 5HT levels and synaptosomal uptake caused by p-chloroamphetamine, bilateral lesions of the B-9 cell group caused minimal regional changes, except for 35% decreases in the metathalamus-thalamus. We conclude therefore that the prolonged biochemical effects of p-chloroamphetamine are...

journal_title：European journal of pharmacology

authors： Massari VJ,Sanders-Bush E

更新日期：1975-09-01 00:00:00

abstract：:Sirolimus and paclitaxel eluted from stents inhibit cell proliferation and other cellular processes by dramatically different mechanisms. In this study, the effects of sirolimus and paclitaxel on cultured human coronary artery smooth muscle and endothelial cell function or cell cycle changes in balloon-injured arterie...

journal_title：European journal of pharmacology

authors： Parry TJ,Brosius R,Thyagarajan R,Carter D,Argentieri D,Falotico R,Siekierka J

更新日期：2005-11-07 00:00:00

abstract：:The antinociceptive profile of selected histamine H(2) and histamine H(3) receptor antagonists led to the discovery of improgan, a non-brain-penetrating analgesic agent which does not act on known histamine receptors. Because no chemical congener of improgan has yet been discovered which has both antinociceptive and b...

journal_title：European journal of pharmacology

authors： Hough LB,Nalwalk JW,Lu Q,Shan Z,Svokos K,Wentland MP,Montero MJ

更新日期：2005-10-17 00:00:00

abstract：:This work evaluates the antinociceptive and constipating effects of the combination of 3.2 mg/kg s.c. morphine with 177.8 mg/kg s.c. metamizol in acutely and chronically treated (once a day for 12 days) rats. On the 13th day, antinociceptive effects were assessed using a model of inflammatory nociception, pain-induced...

journal_title：European journal of pharmacology

authors： Hernández-Delgadillo GP,Ventura Martínez R,Díaz Reval MI,Domínguez Ramírez AM,López-Muñoz FJ

更新日期：2002-04-26 00:00:00