Effects of the enantiomers of the dihydropyridine derivative 202-791 on contractility, coronary flow and ischemia-related arrhythmias in rat heart.

abstract：:The histamine H2-receptor antagonist cimetidine potently inhibited [3H]muscimol and enhanced [3H]flunitrazepam binding in membranes prepared from several brain regions in the rat, including the dorsal raphe nucleus. As further examined in cortical membranes, this effect on both GABA and benzodiazepine binding sites wa...

journal_title：European journal of pharmacology

authors： Lakoski JM,Aghajanian GK,Gallager DW

更新日期：1983-03-25 00:00:00

abstract：:The influence of (+/-)-tamsulosin, a selective alpha 1A-adrenoceptor antagonist, on the positive inotropic effect and the accumulation of inositol phosphates that are induced via alpha 1-adrenoceptors was studied in comparison with that of another alpha 1A-adrenoceptor ligand oxymetazoline in the rabbit ventricular my...

journal_title：European journal of pharmacology

authors： Yang HT,Endoh M

更新日期：1996-10-03 00:00:00

abstract：:The effect of prolonged administration of high doses of buspirone on its 5-hydroxytryptamine (5-HT) release-inhibitory and anxiolytic-like properties was investigated. The 5-HT release-inhibitory effect of a challenge dose of buspirone (0.5 mg/kg, s.c.) was identical in rats chronically treated with vehicle or buspiro...

journal_title：European journal of pharmacology

authors： Söderpalm B,Lundin B,Hjorth S

更新日期：1993-08-03 00:00:00

abstract：:Infusion of renal side population (SP) cells, enriched with adult stem-like cells, can ameliorate acute renal failure. We investigated the effects of an angiotensin II type 1 (AT(1)) receptor antagonist, valsartan on SP cell changes in renal injury by ureteral obstruction. Renal SP fraction was reduced by 38%, and the...

journal_title：European journal of pharmacology

authors： Marumo T,Hishikawa K,Matsuzaki Y,Imai N,Takase O,Shimosawa T,Okano H,Fujita T

更新日期：2007-11-14 00:00:00

abstract：:Isoflavones are compounds structurally similar to the mammalian estrogens and have received considerable attention for their preventive actions on bone loss. Here, we synthesized the novel isoflavone derivatives and examined their activities in bone cells. We found that the novel isoflavone derivatives markedly inhibi...

journal_title：European journal of pharmacology

authors： Tang CH,Chang CS,Tan TW,Liu SC,Liu JF

更新日期：2010-12-01 00:00:00

abstract：:In view of the co-localization of spinal delta- and kappa-opioid receptors, we have investigated the interaction of selective opioid receptor agonists and antagonists in the spinal cord of mice in order to determine if these receptors are organized as heteromers. The finding that norbinaltorphimine (kappa) antagonized...

journal_title：European journal of pharmacology

authors： Portoghese PS,Lunzer MM

更新日期：2003-04-25 00:00:00

abstract：:We examined the effects of (+/-)-(E)-4-ethyl-2-[(E)-hydroxyimino]-5-nitro-3-hexenamide (FK409), a nitric oxide (NO) donor, on renal actions and norepinephrine overflow induced by renal nerve stimulation in anesthetized dogs, with or without N(G)-nitro-L-arginine (NOARG), a NO synthase inhibitor. Renal nerve stimulatio...

journal_title：European journal of pharmacology

authors： Tadano K,Matsuo G,Hashimoto T,Matsumura Y

更新日期：1998-01-12 00:00:00

abstract：:We tested the hypothesis that relaxation of the rat mesenteric artery in response to insulin is mediated by K(+) channels. Two concentrations of insulin (10 and 100 mU/ml) induced relaxation of the artery by 6+/-1%, 24+/-3% (mean+/-S.E.M.). Denudation of the endothelium or precontraction by KCl (30 mM), clotrimazole (...

journal_title：European journal of pharmacology

authors： Iida S,Taguchi H,Watanabe N,Kushiro T,Kanmatsuse K

更新日期：2001-01-05 00:00:00

abstract：:The present study was conducted with an aim to explore the possible role of naringin against ischemia reperfusion induced-neurobehavioral alterations, oxidative damage, cellular and histopathological alterations in cortex, striatum, hippocampus areas of brain. Male Wistar rats (200-220 g) were subjected to bilateral c...

journal_title：European journal of pharmacology

authors： Gaur V,Aggarwal A,Kumar A

更新日期：2009-08-15 00:00:00

abstract：:Cathepsin S is a major histocompatibility complex (MHC) class II associated invariant chain (Ii) degrading enzyme expressed in antigen presenting cells such as B cells and dendritic cells. This enzyme is essential for MHC class II associated antigen processing and presentation to CD4(+) T cells. Compound I, a selectiv...

journal_title：European journal of pharmacology

authors： Desai SN,White DM,O'shea KM,Brown ML,Cywin CL,Spero DM,Panzenbeck MJ

更新日期：2006-05-24 00:00:00

abstract：:[3H]Prostaglandin E2 (PGE2) binding sites were 10-fold enriched from a porcine fundic mucosal homogenate by differential centrifugation and subsequent discontinuous sucrose gradient separation. PGE2 bound with an activation energy of 66 kJ/mol to a single class of sites with an affinity of 1.5 +/- 0.4 nM and a capacit...

journal_title：European journal of pharmacology

authors： Beinborn M,Netz S,Staar U,Sewing KF

更新日期：1988-03-01 00:00:00

abstract：:Neuromedin K, a decapeptide isolated from porcine spinal cord and suggested to have tachykinin-like activity in vitro, produced reciprocal hind-limb scratching when injected intrathecally to mice. Neuromedin K was 20-60 times less potent in producing scratching (on a molar basis) than substance P, kassinin, eledoisin ...

journal_title：European journal of pharmacology

authors： Vaught JL,Post LJ,Jacoby HI,Wright D

更新日期：1984-08-17 00:00:00

abstract：:Kisspeptin (KP), the endogenous ligand of GPR54, is a mammalian amidated neurohormone, which belongs to the RF-amide peptide family. However, in contrast with the related members of the RF-amide family, little information is available regarding its role in the gastrointestinal motility. With regard to the recent data ...

journal_title：European journal of pharmacology

authors： Jiang J,Jin W,Peng Y,He Z,Wei L,Li S,Wang X,Chang M,Wang R

更新日期：2017-01-05 00:00:00

abstract：:Calsequestrin (CASQ) is a major Ca(2+) storage protein within the sarcoplasmic reticulum (SR) of both cardiac and skeletal muscles. CASQ reportedly acts as a Ca(2+) buffer and Ca(2+)-channel regulator through its unique Ca(2+)-dependent oligomerization, maintaining the free Ca(2+) concentration at a low level (0.5-1mM...

journal_title：European journal of pharmacology

authors： Kang C,Nissen MS,Sanchez EJ,Lam KS,Milting H

更新日期：2010-11-10 00:00:00

abstract：:This study showed the effects of baclofen on endogenous excitatory (Glu and Asp) and non-excitatory (Tau, Gly and Ala) amino acid release. (A) Release was stimulated by K+ 30 mM in rat frontal cortex slices in vitro (evoked release in ng/g tissue per 5 min): 3739 +/- 215 (Asp), 3429 +/- 357 (Glu), 763 +/- 181 (Tau), 9...

journal_title：European journal of pharmacology

authors： Losada ME,Acosta GB

更新日期：1992-11-24 00:00:00

abstract：:Electrophysiological and pharmacological studies have shown that peripheral-type benzodiazepine receptors modulate voltage-sensitive calcium channels in the heart. We have compared these binding sites with binding sites for [3H]dihydropyridines, which are believed to label such channels. Although no direct or alloster...

journal_title：European journal of pharmacology

authors： Doble A,Benavides J,Ferris O,Bertrand P,Menager J,Vaucher N,Burgevin MC,Uzan A,Gueremy C,Le Fur G

更新日期：1985-12-17 00:00:00

abstract：:In order to substantiate the concept that cocaine behavioral effects may be influenced by serotonin (5-HT)1B receptors, male Wistar rats were trained to self-administer cocaine intravenously (0.5 mg/kg/injection), and were systemically pretreated with the selective 5-HT1B receptor antagonist N-[3-[3-(dimethylamine)eth...

journal_title：European journal of pharmacology

authors： Przegaliński E,Gołda A,Frankowska M,Zaniewska M,Filip M

更新日期：2007-03-22 00:00:00

abstract：:Local administration of amitriptyline into the rat hindpaw produces peripheral antinociception; this is reduced by adenosine receptor antagonists and appears to involve endogenous adenosine. The present study used peripheral microdialysis: (a) to determine whether amitriptyline could enhance extracellular tissue level...

journal_title：European journal of pharmacology

authors： Sawynok J,Reid AR,Liu XJ,Parkinson FE

更新日期：2005-08-22 00:00:00

abstract：:Chronic nitric oxide synthase (NOS) inhibition results in hypertension and myocardial injury. In a rapid and severe model of chronic NOS inhibition, we determined the role of angiotensin II in these effects by using angiotensin II receptor blockade and by measuring cardiac angiotensin II concentrations before and duri...

journal_title：European journal of pharmacology

authors： Verhagen AM,Hohbach J,Joles JA,Braam B,Boer P,Koomans HA,Gröne H

更新日期：2000-07-21 00:00:00

abstract：:This study examined the potential of the selective extra-synaptic α5-GABAA receptor inhibitor S44819 (Egis-13529) to improve cognitive performance in preclinical models of vascular cognitive impairment (VCI). Chronic hypoperfusion of the brain in mice was induced by permanent occlusion of the right common carotid arte...

journal_title：European journal of pharmacology

authors： Gacsályi I,Móricz K,Gigler G,Megyeri K,Machado P,Antoni FA

更新日期：2018-09-05 00:00:00

abstract：:Vasodilatory responses to bradykinin (BK) and acetylcholine (ACh) were compared in phenylephrine preconstricted perfused kidneys from 30-week-old male stroke-prone spontaneously hypertensive rats (SHRSP) and normotensive Wistar-Kyoto rats (WKY). Responses to ACh did not differ between kidneys from SHRSP and WHY. BK-in...

journal_title：European journal of pharmacology

authors： Stier CT Jr,Selig N,Itskovitz HD

更新日期：1992-01-14 00:00:00

abstract：:Agelanthus dodoneifolius is one of the medicinal plants used in African pharmacopeia and traditional medicine for the treatment of cardiovascular diseases. A chemical analysis has identified one of the active principles: Dodoneine (Ddn). It is a new dihydropyranone which exerts hypotensive and vasorelaxant effects on ...

journal_title：European journal of pharmacology

authors： Carré G,Carreyre H,Ouedraogo M,Becq F,Bois P,Thibaudeau S,Vandebrouck C,Bescond J

更新日期：2014-04-05 00:00:00

abstract：:We recently reported changes in the density of muscarinic acetylcholine receptors in cerebral cortex of mice treated neonatally with DDT (1,1,1-trichloro-2,2-bis(p-chlorophenyl)-ethane) and receiving bioallethrin as adults. We also found behavioural aberrations in adult mice treated with bioallethrin, whether neonatal...

journal_title：European journal of pharmacology

authors： Johansson U,Fredriksson A,Eriksson P

更新日期：1995-07-01 00:00:00

abstract：:Antiarrhythmic drugs have been considered to be transported by the organic cation transport system. The purpose of this study was to elucidate the molecular mechanism underlying the transport of antiarrhythmic drugs using cells from the second segment of the proximal tubule (S2) cells of mice expressing human-organic ...

journal_title：European journal of pharmacology

authors： Hasannejad H,Takeda M,Narikawa S,Huang XL,Enomoto A,Taki K,Niwa T,Jung SH,Onozato ML,Tojo A,Endou H

更新日期：2004-09-19 00:00:00

abstract：:In the present study, the development of tolerance to the motor impairing effects of gamma-hydroxybutyric acid (GHBA) and ethanol was compared (Experiment 1). Rats were required to perform a motor coordination task daily shortly after ethanol (3.5 g/kg) and GHBA (1.0 g/kg) administration for 9 consecutive days. Tolera...

journal_title：European journal of pharmacology

authors： Colombo G,Agabio R,Lobina C,Reali R,Fadda F,Gessa GL

更新日期：1995-02-06 00:00:00

abstract：:A specific binding site for the antiepileptic drug levetiracetam (2S-(oxo-1-pyrrolidinyl)butanamide, Keppra) in rat brain, referred to as the levetiracetam binding site, was discovered several years ago. More recently, this binding site has been identified as the synaptic vesicle protein 2A (SV2A), a protein present i...

journal_title：European journal of pharmacology

authors： Gillard M,Chatelain P,Fuks B

更新日期：2006-04-24 00:00:00

abstract：:To investigate whether argatroban ((2R,4R)-4-methyl-1-[N(2)-((RS)-3-methyl-1,2,3,4-tetrahydro-8-quinolinesulfonyl)-L-arginyl]-2-piperidinecarboxylic acid hydrate, a selective thrombin inhibitor, exerts a direct action on phenotype conversion of vascular smooth muscle cells, cultured rabbit aortic vascular smooth muscl...

journal_title：European journal of pharmacology

authors： Yoshinaga M,Sunagawa M,Shimada S,Nakamura M,Murayama S,Kosugi T

更新日期：2003-02-07 00:00:00

abstract：:In the burying behaviour test allopregnanolone (0.5 mg/rat) reduced the cumulative time of burying, interpreted as a reduction in anxiety. The selective benzodiazepine antagonist, flumazenil (5 and 10 mg/kg), did not affect the burying behaviour when administered alone but effectively prevented the reduction produced ...

journal_title：European journal of pharmacology

authors： Fernández-Guasti A,Picazo O

更新日期：1995-07-25 00:00:00

abstract：:The present study investigated the changes in NMDA receptor subunit proteins in diazepam-withdrawn rat cerebral cortex, using Western blotting analysis. The protein levels of the NR1 and NR2B, but not NR2A, subunits were significantly increased in diazepam-withdrawn rats compared to those in control rats. Therefore, a...

journal_title：European journal of pharmacology

authors： Tsuda M,Chiba Y,Suzuki T,Misawa M

更新日期：1998-01-12 00:00:00

abstract：:The role of presynaptic acetylcholine receptors and Ca2+ channels in the regenerative acetylcholine release was studied in the cut muscle preparation of mouse phrenic nerve hemidiaphragm. The regenerative release shown as a prolonged endplate depolarization was evoked by stimulation of the nerve with a train of pulse ...

journal_title：European journal of pharmacology

authors： Hong SJ,Chang CC

更新日期：1989-03-14 00:00:00