Abstract:
:Infusion of renal side population (SP) cells, enriched with adult stem-like cells, can ameliorate acute renal failure. We investigated the effects of an angiotensin II type 1 (AT(1)) receptor antagonist, valsartan on SP cell changes in renal injury by ureteral obstruction. Renal SP fraction was reduced by 38%, and the number of cells expressing CD45, a marker of hematopoietic system, in renal SP cells was increased in obstructed kidneys. Valsartan attenuated renal injury and the associated SP profile changes. Angiotensin AT(1) receptor blockade may exert regenerative effect by preserving adult stem-like cells such as SP cells in the kidney.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Marumo T,Hishikawa K,Matsuzaki Y,Imai N,Takase O,Shimosawa T,Okano H,Fujita Tdoi
10.1016/j.ejphar.2007.07.032subject
Has Abstractpub_date
2007-11-14 00:00:00pages
216-20issue
1-3eissn
0014-2999issn
1879-0712pii
S0014-2999(07)00805-9journal_volume
573pub_type
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