In vitro inhibition of allergic histamine release by calcium antagonists.

abstract：:Silybin is a flavonoid with antioxidant and free radical scavenging abilities. Silybin also acts as an iron chelator by binding Fe (III). The present study was undertaken to assess the biological effects of silybin on T leukemia cells in the presence or absence of iron and compare its effects with a well-known iron ch...

journal_title：European journal of pharmacology

authors： Gharagozloo M,Khoshdel Z,Amirghofran Z

更新日期：2008-07-28 00:00:00

abstract：:The composition of final submaxillary saliva and of whole gland homogenates were compared in rats treated with 14 daily doses of guanethidine (20 mg/kg body weight) and in untreated controls after stimulation with pilocarpine (10 mg/kg) or carbamylcholine (50-100 mg/kg). A 44% reduction in the volume of saliva and ele...

journal_title：European journal of pharmacology

authors： Eccher S,Dodson C,Quissell DO,Martinez JR

更新日期：1977-01-21 00:00:00

abstract：:Melatonin is of considerable interest for its regulatory influence on a variety of physiological processes including biological rhythms and neuroendocrine functions. We showed that melatonin potentiates sympathetic neurotransmission in the prostatic portion of the rat vas deferens, by increasing contractions in respon...

journal_title：European journal of pharmacology

authors： Carneiro RC,Toffoleto O,Cipolla-Neto J,Markus RP

更新日期：1994-05-12 00:00:00

abstract：:To determine if the presence of an activator of guanylate cyclase alters the depressor response to a selective inhibitor of low Km cyclic GMP (cGMP) phosphodiesterase (PDE), zaprinast (3-30 mg/kg) was given i.v. to conscious, spontaneously hypertensive rats during a steady state of i.v. infusion of sodium nitroprussid...

journal_title：European journal of pharmacology

authors： Dundore RL,Pratt PF,Hallenbeck WD,Wassey ML,Silver PJ,Buchholz RA

更新日期：1990-08-21 00:00:00

abstract：:The effect of antiepileptic drug di-n-propylacetamide (DPM) on 5-hydroxytryptamine (5-HT) turnover in rat brain and 5-hydroxyindoleacetic acid (5-HIAA) in cat cerebrospinal fluid (CSF) was investigated. DPM (200 mg/kg) increased brain 5-HIAA without altering the 5-HT level. DPM augmented the accumulation of 5-HT induc...

journal_title：European journal of pharmacology

authors： Whitton PS,Oresković D,Marković Z,Skarpa D,Bulat M

更新日期：1983-07-15 00:00:00

abstract：:The nature of the inhbitory non-adrenergic non-cholinergic (NANC) neurotransmitter responsible for neurogenic relaxation of rat duodenum was studied with in vitro techniques. Adenosine 5'-triphosphate (ATP)(1 mM), gamma-aminobutyric acid (GABA, 1 mM), dimethylphenylpiperazinium (DMPP, 0.1 mM) and field stimulation (60...

journal_title：European journal of pharmacology

authors： Manzini S,Maggi CA,Meli A

更新日期：1985-07-31 00:00:00

abstract：:The tension in isolated ring preparations of the thoracic aorta from Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR) was measured isometrically to study if there are any differences in the mechanisms of 17beta-estradiol- or progesterone-induced relaxation between WKY and SHR aortic rings. 17beta-Estr...

journal_title：European journal of pharmacology

authors： Unemoto T,Honda H,Kogo H

更新日期：2003-07-04 00:00:00

abstract：:Activated microglia participate in neuroinflammation which contribute to neuronal damage. Suppression of microglial activation would have therapeutic benefits, which lead to alleviation of the progression of neurodegeneration. In this study, the inhibitory effects of inflexin, a putative antiinflammatory agent isolate...

journal_title：European journal of pharmacology

authors： Ko HM,Koppula S,Kim BW,Kim IS,Hwang BY,Suk K,Park EJ,Choi DK

更新日期：2010-05-10 00:00:00

abstract：:In the present study we examined the effect of the cannabinoid receptor agonist, [[1 a,2-(R)-5-(1,1-dimethylheptyl)-2-[5-hydroxy-2-(3-hydroxypropyl)cyc lohexyl]-phenol; CP 55,940] on [14C]acetylcholine and [3H]norepinephrine release from hippocampal slices and on [14C]acetylcholine release from striatal slices. CP 55,...

journal_title：European journal of pharmacology

authors： Gifford AN,Samiian L,Gatley SJ,Ashby CR Jr

更新日期：1997-04-18 00:00:00

abstract：:The stress-induced hyperthermia procedure, in which effects of drugs on basal (T(1)) and stress-induced body temperature (T(2)) are measured, predicts anxiolytic drug effect. Serotonergic drugs alter these responses and here, we studied the role of 5-HT(1A) receptors in stress-induced hyperthermia by using 5-HT(1A) re...

journal_title：European journal of pharmacology

authors： Van Bogaert M,Oosting R,Toth M,Groenink L,van Oorschot R,Olivier B

更新日期：2006-11-21 00:00:00

abstract：:The effect of the anti-allergic drug azelastine, 4-(p-chlorobenzyl)-2-(hexahydro-1-methyl-1H-azepine-4-yl)-1-(2H)-phth alazione), on airway hyperresponsiveness induced by immunologically stimulated pulmonary alveolar macrophages was investigated in canine bronchial segments under isometric conditions in vitro. Macroph...

journal_title：European journal of pharmacology

authors： Tamaoki J,Takemura H,Tagaya E,Sakai A,Yamawaki I,Konno K

更新日期：1995-05-15 00:00:00

abstract：:The effect of adrenaline on the electrically evoked noradrenaline overflow in the portal vein of adrenal demedullated freely moving rats was studied. Adrenaline (100 ng/min) was infused for 2 h into the portal vein. After a 1-h interval when plasma adrenaline had returned to pre-infusion undetectable levels, the porta...

journal_title：European journal of pharmacology

authors： Coppes RP,Smit J,Khali NN,Brouwer F,Zaagsma J

更新日期：1993-10-26 00:00:00

abstract：:The role of flexibility of the alkyl side chain in the tetrahydrocannabinols to cannabinoid activity has been delineated in previous studies with side chain analogs of Delta(8)-tetrahydrocannabinol with double or triple bonds. This study investigated the site of antinociceptive action for these analogs through analysi...

journal_title：European journal of pharmacology

authors： Wiley JL,Patrick GS,Crocker PC,Saha B,Razdan RK,Martin BR

更新日期：2000-06-02 00:00:00

abstract：:Di-isobutyryl apomorphine (5 mg/kg i.p.) and lergotrile (5 mg/kg i.p.) produce long lasting turning behaviour in rats with 6-hydroxydopamine lesions at the level of the substantia nigra. Haloperidol (1.5 and 3.0 mg/kg p.o.) blocks the rotational behaviour due to the apomorphine ester but has no effect on lergotrile tu...

journal_title：European journal of pharmacology

authors： Tye NC,Horsman L,Wright FC,Large BT,Pullar IA

更新日期：1977-09-01 00:00:00

abstract：:We studied the effects of the tyrosine kinase inhibitors genistein and tyrphostin and the tyrosine phosphatase inhibitors sodium orthovanadate and phenylarsine oxide on endotoxin-mediated induction of nitric oxide (NO) synthase in rat aorta and its effects on vascular contractility. Genistein (i.p. 10 mg/kg) inhibited...

journal_title：European journal of pharmacology

authors： Duarte J,Ocete MA,Pérez-Vizcaino F,Zarzuelo A,Tamargo J

更新日期：1997-10-29 00:00:00

abstract：:Choline acetyltransferase activity was measured in rats treated with daily injections of ethanol (0.1 g/kg body wt) and or dexamethasone (1 mg/kg body wt) for 5 consecutive days. Ethanol produced a biphasic reduction of choline acetyltransferase activity in rat cerebral cortex, which at most time points was further de...

journal_title：European journal of pharmacology

authors： Wattanathorn J,Kotchabhakdi N,Casalotti SO,Baldwin BA,Govitrapong P

更新日期：1996-10-10 00:00:00

abstract：:Metformin administration has been reported to influence the carotid intima-media thickness (CIMT) in humans. However, since previously conducted studies have yielded inconsistent results, the exact effect of metformin on CIMT remains unclear. Causes that could lead to inconsistency in reported research could be the du...

journal_title：European journal of pharmacology

authors： Chen Y,Li H,Ye Z,Găman MA,Tan SC,Zhu F

更新日期：2020-11-05 00:00:00

abstract：:The anticonvulsant activity of riluzole against sound-induced seizures was studied in the DBA/2 mouse model. Riluzole (0.1-4 mg kg(-1), intraperitoneal (i.p.)) produced dose-dependent effects with ED(50) values for the suppression of tonic, clonic and wild running phases of 0.72, 1.38 and 2.71 mg kg(-1), respectively....

journal_title：European journal of pharmacology

authors： De Sarro G,Siniscalchi A,Ferreri G,Gallelli L,De Sarro A

更新日期：2000-11-10 00:00:00

abstract：:Spinal 5-HT1A receptor subtypes are involved in regulation of nociception. This study was performed to investigate the effect of stimulation of these receptors on wide dynamic range neurones in the spinal cord. Extracellular single unit recordings of dorsal horn neurones were performed in intact urethane-anaesthetized...

journal_title：European journal of pharmacology

authors： Gjerstad J,Tjolsen A,Hole K

更新日期：1996-12-30 00:00:00

abstract：:Bone marrow mesenchymal stem cells (MSCs) have been shown great potential for cardiac regeneration. However the therapeutic efficiency has become a major obstacle due to the poor survival of transplanted MSCs in ischemic cardiac tissue. Previous studies reported that melatonin could protect many different types of cel...

journal_title：European journal of pharmacology

authors： Wang F,Zhou H,Du Z,Chen X,Zhu F,Wang Z,Zhang Y,Lin L,Qian M,Zhang X,Li X,Hao A

更新日期：2015-02-05 00:00:00

abstract：:The maximal number of binding sites (Bmax) and the equilibrium dissociation constant (KD) values for [3H]PK 11195 binding were determined in the platelet membranes of epileptic patients before and after 4 weeks of carbamazepine (CBZ) treatment, as well as in healthy controls. There was a decrease of 17.1% in the Bmax ...

journal_title：European journal of pharmacology

authors： Weizman A,Tanne Z,Karp L,Martfeld Y,Tyano S,Gavish M

更新日期：1987-09-23 00:00:00

abstract：:The GABA-inhibitory action of bicuculline on lobster muscle was critically re-examined. Bicuculline (20-100 micrometers) depressed the GABA-evoked conductance increase in a reversible manner, the double reciprocal transformation of the GABA dose/conductance curves remaining linear. If bicuculline was assumed to be a p...

journal_title：European journal of pharmacology

authors： Smart TG,Constanti A

更新日期：1981-03-05 00:00:00

abstract：:Acute noise stress decreased [3H]5-hydroxytryptamine ([3H]5-HT) uptake in synaptosomes from rat hypothalamus, hippocampus and cerebral cortex. The decrease was due to the maximum rate of [3H]5-HT uptake, which peaked 30 min after stress and partly returned to resting values within 4 h, with no changes in affinity (Km ...

journal_title：European journal of pharmacology

authors： Mennini T,Taddei C,Codegoni A,Gobbi M,Garattini S

更新日期：1993-09-14 00:00:00

abstract：:We have analyzed the effect of quinolizidine alkaloids from Lupinus species upon insulin secretion. Isolated normal rat islets were incubated with 3.3, 8.3, and 16.7 mM glucose, in the presence or absence of different concentrations of lupanine (0.05, 0.5, and 1.0 mM), 13-alpha-OH lupanine, 17-oxo-lupanine, and 2-thio...

journal_title：European journal of pharmacology

authors： García López PM,de la Mora PG,Wysocka W,Maiztegui B,Alzugaray ME,Del Zotto H,Borelli MI

更新日期：2004-11-03 00:00:00

abstract：:Two major effector systems are frequently implicated in the immune and endothelial cell alternations associated with inflammation. They include the enhanced production of reactive oxygen species and diminished bioavailability of nitric oxide (NO). Importantly, these processes can be regulated by endogenously produced ...

journal_title：European journal of pharmacology

authors： Pekarova M,Kubala L,Martiskova H,Bino L,Twarogova M,Klinke A,Rudolph TK,Kuchtova Z,Kolarova H,Ambrozova G,Kuchta R,Kadlec J,Lojek A

更新日期：2013-08-05 00:00:00

abstract：:The effect of carbachol (10(-3)M) on the membrane potential of rat diaphragm muscle fibres near and remote from the endplate has been investigated by means of a microelectrode technique. In the endplate region a rather slow depolarization was observed followed by spontaneous repolarization. Outside the endplate region...

journal_title：European journal of pharmacology

authors： Mooij JJ,Evers CD,Ras R

更新日期：1976-06-01 00:00:00

abstract：:The significance of the blood pressure elevation caused by N(G)-nitro-L-arginine (L-NNA) to inhibitory mechanism of the drug on depressor responses to acetylcholine in anesthetized dogs was investigated. L-NNA (50 mg kg(-1), i.v.) elevated blood pressure to a plateau of 30-50 mm Hg above baseline level and shifted the...

journal_title：European journal of pharmacology

authors： Nakahara T,Nejishima H,Nakayama K,Ishii K

更新日期：1999-06-04 00:00:00

abstract：:Increased glycolysis under hypoxic stress is a fundamentally important feature of non-small cell lung cancer (NSCLC) cells, but molecular mechanisms of hypoxia on glycolysis remain elusive. Herein, we aimed to explore whether lncRNAs and miRNAs are involved in the glycolytic reprogramming under hypoxic conditions. The...

journal_title：European journal of pharmacology

authors： Shi J,Wang H,Feng W,Huang S,An J,Qiu Y,Wu K

更新日期：2019-11-05 00:00:00

abstract：:To substantiate the notion that cocaine behavioral effects may be influenced by gamma-aminobutyric acid (GABA) neurotransmission male Wistar rats were injected with gabapentin (a cyclic GABA analogue), tiagabine (a GABA reuptake inhibitor), or vigabatrin (a GABA transaminase inhibitor) before acute or repeated treatme...

journal_title：European journal of pharmacology

authors： Filip M,Frankowska M,Gołda A,Zaniewska M,Vetulani J,Przegaliński E

更新日期：2006-07-17 00:00:00

abstract：:Depression is very common in asthmatic patients and may increases risk for morbidity and mortality. The present work aimed to investigate the protective effect of fluoxetine, on behavioral and biochemical changes, associated with ovalbumin (OVA) - induced bronchial asthma and depression in rats. Rats were sensitized w...

journal_title：European journal of pharmacology

authors： Sherkawy MM,Abo-Youssef AM,Salama AAA,Ismaiel IE

更新日期：2018-10-15 00:00:00