Effect of the antiepileptic di-n-propylacetamide on 5-hydroxytryptamine turnover in the brain and 5-hydroxyindoleacetic acid level in the cerebrospinal fluid.

abstract：:According to the American Society of Clinical Oncology or ASCO's clinical practice guidelines, administration of Tamoxifen for hormone receptor positive patients improved outcomes. However, many studies have been conducted in this issue, with the rise of Tamoxifen resistance in recent decades. There are many alternati...

journal_title：European journal of pharmacology

authors： Mansouri S,Naghavi-Al-Hosseini F,Farahmand L,Majidzadeh-A K

更新日期：2017-06-05 00:00:00

abstract：:The involvement of essential sulfhydryl groups in alpha 2-adrenoceptor function was investigated in the cerebral cortex of 7 and 70 day old rats. N-Ethylmaleimide (NEM) inhibited specific [3H]clonidine binding to cerebral cortical membranes in a concentration-dependent and biphasic manner in both infant and adult rats...

journal_title：European journal of pharmacology

authors： Kawai M,Nomura Y

更新日期：1983-08-05 00:00:00

abstract：:Experiments were performed on 39 male albino rats anaesthetized with pentobarbitone sodium and paralyzed with gallamine triethiodide. Facial motoneurones consistently showed a progressive alteration of spike shape and decrease in spike firing frequency during the continuous microelectrophoretic application of the exci...

journal_title：European journal of pharmacology

authors： Martin MR,Lodge D,Headley PM,Biscoe TJ

更新日期：1977-04-07 00:00:00

abstract：:Taurine influx in the perfused rat heart was characterized and the effect of isoproterenol on this process determined. Hearts were perfused by the Langendorff technique with [3H]-taurine in a non-recirculating system. The rate of taurine influx was constant for at least 20 min and the process was saturable. A Km of 45...

journal_title：European journal of pharmacology

authors： Chubb J,Huxtable R

更新日期：1978-04-15 00:00:00

abstract：:Cetiedil is a potent blocker of acetylcholine and choline fluxes. Several analogs of this compound have been synthesized and their effect on acetylcholine (ACh) and choline fluxes in synaptosomes and on ACh uptake in synaptic vesicles have been studied. The effects of these analogs were compared to those of other drug...

journal_title：European journal of pharmacology

authors： Gaudry-Talarmain YM,Diebler MF,Robba M,Lancelot JC,Lesbats B,Israël M

更新日期：1989-08-03 00:00:00

abstract：:Clearance of apoptotic cells, so-called efferocytosis, by alveolar macrophages (AMs) is important for lung homeostasis and is impaired in pulmonary inflammatory diseases, such as chronic obstructive pulmonary disease and asthma. Carbocisteine, a mucoregulatory drug, corrects the contents of fucose in airway mucus and ...

journal_title：European journal of pharmacology

authors： Inoue M,Ishibashi Y,Nogawa H,Yasue T

更新日期：2012-02-29 00:00:00

abstract：:The present study describes the effects of halothane on morphine activity in the isolated left atria of the rat. Concentration-response curves were obtained for the negative inotropic effects of morphine on electrically stimulated left atria. Morphine significantly decreased the contractile force, with an inhibitory c...

journal_title：European journal of pharmacology

authors： Laorden ML,Hernandez J,Carceles MD,Miralles FS,Puig MM

更新日期：1990-01-17 00:00:00

abstract：:In isolated strips of human urinary bladder detrusor muscle, ATP, alpha, beta-methylene ATP and P1,P6-diadenosine hexaphosphate caused concentration-dependent contractions. ATP was less potent than the two synthetic purine compounds and gave smaller maximum responses. Responses to ATP, P1,P6-diadenosine hexaphosphate ...

journal_title：European journal of pharmacology

authors： Hoyle CH,Chapple C,Burnstock G

更新日期：1989-12-12 00:00:00

abstract：:Many studies have demonstrated that cyclophosphamide (CPA) can affect hepatic cytochrome p450 (CYP) isoenzyme activity in animals. We have investigated the effect of CPA on gene expression of various CYP enzymes as well as beta-actin in the human acute promyelocytic leukemia cell line (HL-60S) and its multidrug-resist...

journal_title：European journal of pharmacology

authors： Xie HJ,Lundgren S,Broberg U,Finnström N,Rane A,Hassan M

更新日期：2002-08-09 00:00:00

abstract：:Recent studies show that 8-iso-prostaglandin F(2alpha), a member of F(2)-isoprostane family, acts as a vasoconstrictor via TP receptor activation; and its local release may contribute to an abnormal vasomotor tone associated with hypercholesterolemia. The purpose of this study was to examine whether ramatroban, a TP r...

journal_title：European journal of pharmacology

authors： Ishizuka T,Matsui T,Kurita A

更新日期：2003-05-02 00:00:00

abstract：:Adenosine has been reported to have beneficial effects against ischemic brain damage, although the mechanisms are not fully clarified. To examine the role of adenosine on the ischemia-evoked release of neurotransmitters, we applied a highly selective agonist for adenosine A1 receptor, 2-chloro-N6-cyclopentyladenosine ...

journal_title：European journal of pharmacology

authors： Goda H,Ooboshi H,Nakane H,Ibayashi S,Sadoshima S,Fujishima M

更新日期：1998-09-18 00:00:00

abstract：:An iron-free diet for 28 days caused a reduced level of iron in the blood. Iron deficient rats exhibited a lower level of motor activity and reversed circadian rhythms of thermoregulation and motor activity. The hypothermic effect of d-amphetamine was significantly reduced in iron deficient rats, and the magnitude of ...

journal_title：European journal of pharmacology

authors： Youdim MB,Yehuda S,Ben-Uriah Y

更新日期：1981-09-24 00:00:00

abstract：:The effects of (-)-N(1)phenethyl-norcymserine (PEC, 5 mk/kg, i.p.) on acetylcholine release and cholinesterase activity in the rat cerebral cortex were compared with those of donepezil (1 mg/kg, i.p.), a selective acetylcholinesterase inhibitor, and rivastigmine (0.6 mg/kg, i.p.), an inhibitor of acetylcholinesterase ...

journal_title：European journal of pharmacology

authors： Cerbai F,Giovannini MG,Melani C,Enz A,Pepeu G

更新日期：2007-10-31 00:00:00

abstract：:The kappa-opioid receptor agonist, U50,488H (trans-(+-)-3,4-dichloro-N-methyl-[2-(1-pyrrolidinyl)-cyclohexyl]- benzeneacetamide), has recently been reported to induce dystonia after s.c. administration of 5-10 mg/kg in guinea pigs. The dystonic movements observed in response to U50,488H resembled those previously repo...

journal_title：European journal of pharmacology

authors： Richter A,Löscher W

更新日期：1993-05-19 00:00:00

abstract：:In urethane-chloralose anesthetised rats the muscle relaxant activity of flupirtine was investigated on the monosynaptic Hoffmann reflex recorded from plantar foot muscles and on the polysynaptic flexor reflex recorded from tibialis muscle. Intraperitoneal (i.p.; 2.5-25 mumol/kg) and intrathecal (i.t.; 33-330 nmol) ad...

journal_title：European journal of pharmacology

authors： Schwarz M,Schmitt T,Pergande G,Block F

更新日期：1995-04-04 00:00:00

abstract：:The analgesic effect of cyclazocine microinjected into the diencephalon of rats was studied by using the bradykinin-induced flexor reflex test. The dorsal portion of the medial hypothalamic area was sensitive to cyclazocine with respect to the production of analgesia (ED50 2.6 micrograms/rat). Microinjections of morph...

journal_title：European journal of pharmacology

authors： Kawajiri S,Satoh M

更新日期：1985-04-23 00:00:00

abstract：:Preparations of cauda epididymides were taken from rats unilaterally vasectomised by medial transection of the vas deferens. Responses of preparations from the operated side to field stimulation (10 pulses, 70 V, 1 ms, 0.1-20 Hz) declined in parallel with decreases in catecholamine fluorescence. There were leftward sh...

journal_title：European journal of pharmacology

authors： Ventura S,DeGaris RM,Pennefather JN

更新日期：1989-12-19 00:00:00

abstract：:The present study investigates the role of cGMP and cAMP on the memory performance in the object recognition task in rats. The analogue 8-Br-GMP or 8-Br-cAMP was administered bilaterally into the hippocampus (0, 1, 3 and 10 microg in 0.5 microl saline/site) immediately after the exposure to two identical objects. Afte...

journal_title：European journal of pharmacology

authors： Prickaerts J,de Vente J,Honig W,Steinbusch HW,Blokland A

更新日期：2002-02-01 00:00:00

abstract：:Infusion of tryptamine (1-4 mug/ml) through the pulmonary circulation of rat isolated lung perfused with Krebs solution caused release of a mixture of spasmogens contracting isolated smooth muscle preparations. One component of this mixture had biological activity comparable to E-type prostaglandins. Other components ...

journal_title：European journal of pharmacology

authors： Alabaster VA,Bakhle YS

更新日期：1976-02-01 00:00:00

abstract：:Membrane preparations of guinea-pig lung (containing multiple muscarinic receptor subtypes) and heart (containing M2 receptors only) were incubated with either neuraminidase, parainfluenza virus (which contains neuraminidase), or virus plus 2,3-dehydro-2-deoxy-N-acetylneuraminic acid, a neuraminidase inhibitor. None o...

journal_title：European journal of pharmacology

authors： Fryer AD,el-Fakahany EE,Jacoby DB

更新日期：1990-05-31 00:00:00

abstract：:In recent years, the pilocarpine model of temporal lobe epilepsy has become the most popular and widely used rodent model of this common and difficult-to-treat type of epilepsy. In this model, the cholinomimetic convulsant pilocarpine is used to induce a status epilepticus, which is followed by hippocampal damage and ...

journal_title：European journal of pharmacology

authors： Müller CJ,Bankstahl M,Gröticke I,Löscher W

更新日期：2009-10-01 00:00:00

abstract：:We investigated, in murine colon circular muscle, the role of adenosine 5'-triphosphate (ATP) and pituitary adenylate cyclase activating peptide (PACAP) as inhibitory neurotransmitters of the fast component of nerve-evoked inhibitory junction potential (fast IJP). Fast IJP was antagonised by apamin or suramin, abolish...

journal_title：European journal of pharmacology

authors： Serio R,Alessandro M,Zizzo MG,Tamburello MP,Mulè F

更新日期：2003-01-24 00:00:00

abstract：:The novel anti-ischemic compound, BMS-204352 ((3S)-(+)-(5-chloro-2-methoxyphenyl)-1,3-dihydro-3-fluoro-6-(trifluoromethyl)-2H-indol-2-one)), strongly activates the voltage-gated K+ channel KCNQ5 in a concentration-dependent manner with an EC50 of 2.4 microM. At 10 microM, BMS-204352 increased the steady state current ...

journal_title：European journal of pharmacology

authors： Dupuis DS,Schrøder RL,Jespersen T,Christensen JK,Christophersen P,Jensen BS,Olesen SP

更新日期：2002-02-22 00:00:00

abstract：:Parkinson's disease is a neuropathological disorder involving the degeneration of dopamine neurons in the substantia nigra, with the resultant loss of their terminals in the striatum. This dopamine loss causes most of the motor disturbances associated with the disease. One animal model of Parkinson's disease involves ...

journal_title：European journal of pharmacology

authors： Boules M,Warrington L,Fauq A,McCormick D,Richelson E

更新日期：2001-10-05 00:00:00

abstract：:The interactions of sulfonylureas and a novel anti-diabetic drug, nateglinide, with rat renal organic anion transporter (rOAT1) expressed in Xenopus laevis oocytes were studied. Uptake of p-aminohippurate via rOAT1 was markedly inhibited by glibenclamide and nateglinide, and moderately by chlorpropamide and tolbutamid...

journal_title：European journal of pharmacology

authors： Uwai Y,Saito H,Hashimoto Y,Inui K

更新日期：2000-06-16 00:00:00

abstract：:Transgenic rabbits expressing loss-of-function pore mutants of the human gene KCNQ1 (K(v)LQT1-Y315S) have a Long QT-Syndrome 1 (LQT1) phenotype. We evaluated for the first time the effect of nicorandil, an opener of ATP-sensitive potassium channels, and of isoproterenol on cardiac action potential duration and heart r...

journal_title：European journal of pharmacology

authors： Biermann J,Wu K,Odening KE,Asbach S,Koren G,Peng X,Zehender M,Bode C,Brunner M

更新日期：2011-01-10 00:00:00

abstract：:The role of nitric oxide (NO) in the vagal cholinergic-mediated cytoprotective effect of intracisternal (i.c.) injection of the stable thyrotropin-releasing hormone (TRH) analog, RX 77368, was investigated in conscious rats. RX 77368 (1.5 ng i.c.) reduced by 88% gastric hemorrhagic lesions induced by oral administrati...

journal_title：European journal of pharmacology

authors： Király A,Sütö G,Taché Y

更新日期：1993-08-24 00:00:00

abstract：:The spasmogenic activity of caffeine (10 mM) was evaluated in tracheal strips obtained from control and sensitized guinea-pigs then pretreated with indomethacin (2.8 microM) and cooled to 20 degrees C. The contraction elicited by caffeine was inhibited by verapamil (100 microM), trifluoperazine (100 and 500 microM) an...

journal_title：European journal of pharmacology

authors： Ortiz JL,Cortijo J,Morcillo EJ,Sanz C,Perpiñá M,Esplugues J

更新日期：1988-12-13 00:00:00

abstract：:We investigated the effect of sevoflurane (fluoromethyl-2,2,2-trifluoro-1-(trifluoromethyl) ethylether) on intracellular calcium concentration ([Ca2+]i) and nitric oxide (NO) release from cultured porcine aortic endothelial cells using fura-2 fluorometry, and direct (ESR spectrometry with NO-trapping by 2-(4-carboxyph...

journal_title：European journal of pharmacology

authors： Az-ma T,Fujii K,Yuge O

更新日期：1995-03-15 00:00:00

abstract：:This study was designed to investigate the effect and mechanism of allicin on hyperhomocysteinemia-induced experimental vascular endothelial dysfunction in rats. Fifty male Wistar rats were randomly divided into five groups: the normal control rats (NC), the high-methionine-diet rats (Met), the high-methionine-diet ra...

journal_title：European journal of pharmacology

authors： Liu DS,Gao W,Liang ES,Wang SL,Lin WW,Zhang WD,Jia Q,Guo RC,Zhang JD

更新日期：2013-08-15 00:00:00