Abstract:
:The spasmogenic activity of caffeine (10 mM) was evaluated in tracheal strips obtained from control and sensitized guinea-pigs then pretreated with indomethacin (2.8 microM) and cooled to 20 degrees C. The contraction elicited by caffeine was inhibited by verapamil (100 microM), trifluoperazine (100 and 500 microM) and dantrolene (50 and 500 microM) in the control and the sensitized tissues but was unaffected by disodium cromoglycate (39 microM). However, the same concentration of verapamil produced significantly less inhibition of the caffeine-induced contraction in sensitized compared to control tissues while the reverse was found for trifluoperazine and dantrolene. Exposure to a Ca2+-free, EGTA-containing medium resulted in 33% inhibition of the response to caffeine in control tissues but no inhibition in sensitized tissues. These results suggest the existence of differences in calcium movements in response to caffeine between control and sensitized tissues that may reflect abnormalities in calcium handling by the sensitized tissue.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Ortiz JL,Cortijo J,Morcillo EJ,Sanz C,Perpiñá M,Esplugues Jdoi
10.1016/0014-2999(88)90073-8subject
Has Abstractpub_date
1988-12-13 00:00:00pages
243-9issue
3eissn
0014-2999issn
1879-0712pii
0014-2999(88)90073-8journal_volume
158pub_type
杂志文章abstract::The analgesic effect of cyclazocine microinjected into the diencephalon of rats was studied by using the bradykinin-induced flexor reflex test. The dorsal portion of the medial hypothalamic area was sensitive to cyclazocine with respect to the production of analgesia (ED50 2.6 micrograms/rat). Microinjections of morph...
journal_title:European journal of pharmacology
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journal_title:European journal of pharmacology
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journal_title:European journal of pharmacology
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journal_title:European journal of pharmacology
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journal_title:European journal of pharmacology
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journal_title:European journal of pharmacology
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journal_title:European journal of pharmacology
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journal_title:European journal of pharmacology
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journal_title:European journal of pharmacology
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journal_title:European journal of pharmacology
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journal_title:European journal of pharmacology
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journal_title:European journal of pharmacology
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journal_title:European journal of pharmacology
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journal_title:European journal of pharmacology
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abstract::Berberine, a benzylisoquinoline alkaloid, occurs as an active constituent in numerous medicinal plants and has an array of pharmacological properties. It has been used in Ayurvedic and Chinese medicine for its antimicrobial, antiprotozoal, antidiarrheal and antitrachoma activity. Moreover, several clinical and preclin...
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pub_type: 杂志文章,评审
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