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Facilitation of 8-OHDPAT-induced forepaw treading of rats by the 5-HT2 agonist DOI.

Abstract：

:The potency of the serotonin 1A (5-HT1A) agonist, 8-hydroxy-2-(di-n-propylamino)tetralin (8-OHDPAT), to induce forepaw treading was increased 20-fold after co-treatment with the 5-HT2 agonist, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI). DOI induced head twitches which were inhibited by 8-OHDPAT. The putative 5-HT1B agonist, 1-(3-trifluoromethylphenyl)piperazine (TFMPP), had a weak effect on the responses to DOI or 8-OHDPAT. The forepaw treading induced by 8-OHDPAT plus DOI was inhibited by high doses of (-)-alprenolol, ketanserin or ritanserin, but was not influenced by the beta-adrenoceptor antagonist, ICI 118.551, or the 5-HT3 antagonist, ICS 205-930. A non-effective dose of (-)-alprenolol increased the inhibitory effect of ketanserin and ritanserin. These results indicate a complex and different interaction between 5-HT1A and 5-HT2 receptors in the expression of two behavioural responses mediated by 5-HT.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Arnt J,Hyttel J

doi

10.1016/0014-2999(89)90178-7

subject

Has Abstract

pub_date

1989-02-14 00:00:00

pages

45-51

issue

1

eissn

0014-2999

issn

1879-0712

pii

0014-2999(89)90178-7

journal_volume

161

pub_type

杂志文章

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