Effects of caffeine, L-phenylisopropyladenosine and their combination on local cerebral blood flow in the rat.

abstract：:Enterobacteria are known to deconjugate amino acid-conjugated bile acids in the intestine. Administration of ampicillin (ABPC; 3 days, 100mg/kg) decreased the expression of ileal farnesoid X receptor (Fxr) target genes, and increased the levels of total bile acids in the intestinal lumen. The primary tauro-conjugates ...

journal_title：European journal of pharmacology

authors： Kuribayashi H,Miyata M,Yamakawa H,Yoshinari K,Yamazoe Y

更新日期：2012-12-15 00:00:00

abstract：:The anticancer drugs camptothecin (CPT) and topotecan (TPT) are known DNA topoisomerase I inhibitors which cause DNA damage and lead to cell death. In this study we provide evidence that CPT and TPT also interfere with the elements of cytoskeleton - microtubules and actin filaments which could be partly responsible fo...

journal_title：European journal of pharmacology

authors： Wang X,Tanaka M,Krstin S,Peixoto HS,Moura CCM,Wink M

更新日期：2016-10-15 00:00:00

abstract：:Nitric oxide (NO) is an antiatherogenic vasodilator synthesized from arginine and, indirectly, from citrulline through argininosuccinate synthase (ASS) and argininosuccinate lyase (ASL). Hypercholesterolemia-induced atherosclerosis is usually treated by statins, which decrease cholesterolemia and increase endothelial ...

journal_title：European journal of pharmacology

authors： Berthe MC,Bernard M,Rasmusen C,Darquy S,Cynober L,Couderc R

更新日期：2011-11-30 00:00:00

abstract：:CPP, administered systemically, elicited four distinct responses characteristic of serotonin-receptor activation in the central nervous system. The crossed extensor reflex in the acutely spinalized rat was enhanced by treatment with CPP, 1-16 mg/kg. CPP, 1.11-10 mg/kg, elicited a dose-related increase in head twitches...

journal_title：European journal of pharmacology

authors： Clineschmidt BV,Mcguffin JC,Pflueger AB

更新日期：1977-07-01 00:00:00

abstract：:We compared hypolocomotion and catalepsy mediated by striatal dopamine D2 and adenosine A2A receptors using microinfusions of the adenosine A2A receptor agonist 2-p-(2-carboxyethyl) phenethylamino-5'-N-ethylcarboxamidoadenosine hydrochloride (CGS21680) and the dopamine D2 receptor antagonist raclopride into the nucleu...

journal_title：European journal of pharmacology

authors： Hauber W,Münkle M

更新日期：1997-04-04 00:00:00

abstract：:Treatment of rats with cyclosporine A (50 mg/kg i.p.) for 4 days resulted in the impairment of renal function. Renal membrane and soluble phorbol ester receptor densities were significantly higher in cyclosporine A-treated rats compared to vehicle-treated rats. These data suggest that increased phorbol ester receptor ...

journal_title：European journal of pharmacology

authors： Nambi P,Pullen M,Wu HL,Brooks DP

更新日期：1991-03-19 00:00:00

abstract：:The antinociceptive effect of intraplantar (i.pl.) ICI 204448 ((R,S)-N-[2-(N-methyl-3,4-dichloro-phenylacetamido)-2-(3-carbox yph enyl)- ethyl]pyrrolidine hydrochloride)) (20, 30, 40 and 50 micrograms), a kappa-opioid receptor agonist which has limited access to the central nervous system, was studied in a well-establ...

journal_title：European journal of pharmacology

authors： Keïta H,Kayser V,Guilbaud G

更新日期：1995-04-24 00:00:00

abstract：:N-[3-(1H-Imidazol-4-ylmethyl)phenyl]ethanesulfonamide, maleate (ABT-866) is a novel alpha(1)-adrenoceptor agent with mixed pharmacological properties in vitro. Compared to phenylephrine, ABT-866 demonstrates intrinsic activity at the alpha(1A)-adrenoceptor subtype present in the rabbit urethra (pD(2) = 6.22, with 80% ...

journal_title：European journal of pharmacology

authors： Buckner SA,Milicic I,Daza AV,Meyer MD,Altenbach RJ,Williams M,Sullivan JP,Brioni JD

更新日期：2002-08-02 00:00:00

abstract：:The actions of tumor-promoting phorbol esters in smooth muscle excitation-contraction coupling were studied in isolated guinea pig ileum in the presence of various contractile agents. Muscarinic agonists, histamine and bradykinin elicited an initial transient phasic contraction and a subsequent sustained tonic contrac...

journal_title：European journal of pharmacology

authors： Xu SF,Collins MA,Chang KJ

更新日期：1991-08-29 00:00:00

abstract：:The hypothesis that morphine acts on the serotonergic system to produce analgesia is based on the previous observations that (1) lesions and stimulation of midbrain raphe nuclei after the threshold to nociceptive stimuli; (2) morphine alters the turnover of serotonin (5-hydroxytryptamine; 5-HT). Microiontophoretic exp...

journal_title：European journal of pharmacology

authors： Haigler HJ

更新日期：1978-10-15 00:00:00

abstract：:Huperzine A, a promising therapeutic agent for Alzheimer's disease, was examined for its potential to antagonize the deleterious neurochemical, structural, and cognitive effects of infusing beta-amyloid protein-(1-40) into the cerebral ventricles of rats. Daily intraperitoneal administration of huperzine A for 12 cons...

journal_title：European journal of pharmacology

authors： Wang R,Zhang HY,Tang XC

更新日期：2001-06-15 00:00:00

abstract：:The investigation examined the mechanism of the increase in brain tryptophan concentration of rats treated with d-amphetamine. Certain well recognised influences upon brain tryptophan have been excluded as responsible. Thus, the effect is not associated with changes in the plasma concentrations of NEFA or free tryptop...

journal_title：European journal of pharmacology

authors： Fernando JC,Curzon G

更新日期：1978-06-15 00:00:00

abstract：:PPARα belongs to the peroxisome-proliferator-activated receptors (PPARs) family that consists of PPARα, PPARδ, and PAPRγ. Activation of PPARα by ligands including fatty acids and their derivatives as well as some synthetic compounds regulates tumor progression in various tissues. Activated PPARα inhibits or promotes t...

journal_title：European journal of pharmacology

authors： Gao J,Yuan S,Jin J,Shi J,Hou Y

更新日期：2015-10-15 00:00:00

abstract：:The pharmacological profile of (+/-)-domesticine, a novel alpha(1)-adrenoceptor antagonist, was examined in animal tissues and Chinese hamster ovary (CHO) cells expressing cloned human alpha(1)-adrenoceptor subtypes and compared with the properties of BMY-7378 ([8-(2-[4-(2-methoxy-phenyl)-1-piperazinyl]ethyl)-8-azaspi...

journal_title：European journal of pharmacology

authors： Indra B,Matsunaga K,Hoshino O,Suzuki M,Ogasawara H,Muramatsu I,Taniguchi T,Ohizumi Y

更新日期：2002-06-07 00:00:00

abstract：:The excitatory mechanism of central sympathetic outflow induced by interleukin-1 beta was investigated in urethane-anesthetized rats. Intracerebroventricular administration of interleukin-1 beta induced a gradually developing elevation of plasma noradrenaline levels in a dose-dependent manner (50, 100 and 200 ng/anima...

journal_title：European journal of pharmacology

authors： Murakami Y,Yokotani K,Okuma Y,Osumi Y

更新日期：1996-12-12 00:00:00

abstract：:The acetylcholine receptor agonists, acetylcholine (10(-5)-10(-4 M), carbachol (5 x 10(-6)-5 x 10(-5) M), bethanechol (5 x 10(-5)-5 x 10(-4) M) and dimethylphenylpiperazinium (DMPP, 10(-5) M) increased the short-circuit current (Isc) in the rat colon descendens by a tetrodotoxin (TTX)-sensitive mechanism. Blockade by ...

journal_title：European journal of pharmacology

authors： Diener M,Knobloch SF,Bridges RJ,Keilmann T,Rummel W

更新日期：1989-09-13 00:00:00

abstract：:The suppressing effect of acamprosate (calcium-acetyl homotaurinate) on alcohol drinking is well established; however, little is known about its effects upon the alcohol-induced withdrawal syndrome. Male Wistar rats received as a sole drinking fluid a 20% (v/v) alcohol solution for one week. Animals consumed on averag...

journal_title：European journal of pharmacology

authors： Spanagel R,Putzke J,Stefferl A,Schöbitz B,Zieglgänsberger W

更新日期：1996-06-03 00:00:00

abstract：:Systemic administration of the active, sulfated form of cholecystokinin-octapeptide (CCK-8S), at a dose known to inhibit dopamine (DA) release, significantly reduced the latency to ejaculate and number of intromissions preceding ejaculation in sexually active male rats. This effect was identical to that reported for l...

journal_title：European journal of pharmacology

authors： Pfaus JG,Phillips AG

更新日期：1987-09-23 00:00:00

abstract：:H89 (N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide) is a compound characterized in vitro as a potent and selective inhibitor of protein kinase A (PKA). In this study, we found that H89 reduced the phosphorylation of the myosin regulatory light chain (MRLC) at Thr-18/Ser-19 and induced disassembly of stre...

journal_title：European journal of pharmacology

authors： Umeda D,Yamada K,Tachibana H

更新日期：2008-08-20 00:00:00

abstract：:Recent successes as a pharmacological adjunct to exposure therapy has focused attention on the therapeutic potential of the glycine(B) receptor partial agonist, D-cycloserine (DCS), in certain clinical anxiety disorders. Although widely believed to reflect a facilitation of extinction learning, previous research with ...

journal_title：European journal of pharmacology

authors： Rodgers RJ,Howard K,Stewart S,Waring P,Wright FL

更新日期：2010-11-10 00:00:00

abstract：:Osteoarthritis (OA) is a common yet destructive disease affecting the articular cartilage, and is a major cause of immense suffering and disability for millions of people. Previous studies have shown that triptolide (TPL), an active compound derived from Tripterygium wilfordii, has potent immunosuppressive and anti-in...

journal_title：European journal of pharmacology

authors： Li EQ,Zhang JL

更新日期：2020-09-15 00:00:00

abstract：:Basic fibroblast growth factor (bFGF) is a heparin-binding polypeptide with potent trophic and protective effects on brain neurons, glia and endothelia. In previous studies, we showed that intravenously administered bFGF reduced the volume of cerebral infarcts following permanent occlusion of the middle cerebral arter...

journal_title：European journal of pharmacology

authors： Ren JM,Finklestein SP

更新日期：1997-05-26 00:00:00

abstract：:This report describes the molecular pharmacological properties of LR-B/081 (methyl 2-[[4-butyl-2-methyl-6-oxo-5-[[2'-(1H-tetrazol-5- yl) [1,1'-biphenyl]-4-yl]methyl]-1 (6H)-pyrimidinyl]methyl]- 3-thiophenecarboxilate), a novel non-peptide angiotensin II receptor antagonist. This compound potently displaced [3H]angiote...

journal_title：European journal of pharmacology

authors： Renzetti AR,Criscuoli M,Salimbeni A,Subissi A

更新日期：1995-07-18 00:00:00

abstract：:Serotonin 1A receptor agonists have attracted much interest recently as potential therapeutic agents for levodopa-induced motor complications, such as dyskinesia and motor fluctuations. The effects of piclozotan (SUN N4057) on a rat model of advanced Parkinson's disease were investigated. Parkinsonian rats, unilateral...

journal_title：European journal of pharmacology

authors： Tani Y,Ogata A,Koyama M,Inoue T

更新日期：2010-12-15 00:00:00

abstract：:The effect of simultaneous topical application of adrenergic agonists was investigated on the polydipsia caused by direct carbachol (CCh) stimulation of the rat brain. In addition, fluid selection (4-choice arrangement) was studied. Noradrenaline and isoprenaline fully antagonized the CCh effect after either intracere...

journal_title：European journal of pharmacology

authors： Schmidt P,Zámbó K,Decsi L,Nagy J

更新日期：1981-10-15 00:00:00

abstract：:Activation of imidazoline receptors in the central nervous system has protective effect on several types of arrhythmias. We demonstrated that centrally administered rilmenidine, a selective imidazoline receptor agonist, prevented adrenaline-induced arrhythmias during halothane anaesthesia. However, detailed myocardial...

journal_title：European journal of pharmacology

authors： Yamanaka H,Hayashi Y,Iwasaki M,Kamibayashi T,Yamatodani A,Mashimo T

更新日期：2010-11-25 00:00:00

abstract：:In the present study, we tested whether the decreased release of calcitonin gene-related peptide (CGRP) observed in nitroglycerin tolerance is associated with the decrease in aldehyde dehydrogenase (ALDH-2) activity. We further investigated the possible involvement of reactive oxygen species in the decrease in ALDH-2 ...

journal_title：European journal of pharmacology

authors： Chen YR,Nie SD,Shan W,Jiang DJ,Shi RZ,Zhou Z,Guo R,Zhang Z,Li YJ

更新日期：2007-09-24 00:00:00

abstract：:The effects of capsaicin on the ability of platelets to aggregate in response to thrombin, platelet-activating factor or calcium ionophore (A23187) were examined. At concentrations previously shown to activate sensory afferent neurons, capsaicin markedly inhibited the responsiveness of platelets to the three agonists....

journal_title：European journal of pharmacology

authors： Hogaboam CM,Wallace JL

更新日期：1991-09-04 00:00:00

abstract：:We have examined the effects of chronic gentamicin treatment on arginine8-vasopressin (AVP)-dependent cyclic AMP (cAMP) metabolism in rat medullary collecting tubules (oMCT) and medullary thick ascending limbs of Henle's loop (mTALH). Gentamicin attenuated AVP-stimulated cAMP accumulation to a greater extent in the mT...

journal_title：European journal of pharmacology

authors： Kidwell D,Subramaniam S,Ott C,Jackson B

更新日期：1990-12-04 00:00:00

abstract：:Leukotriene C4 binding to mouse brain membranes was readily displaced by S-alkylglutathione derivatives, with the affinity of the test compound increasing as the alkyl chain length increases. S-decylglutathione was as potent as leukotriene C4. These data suggest that brain membrane leukotriene C4 binding sites are S-a...

journal_title：European journal of pharmacology

authors： Goffinet AM,Nguyen A

更新日期：1989-02-14 00:00:00